[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100177972":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":15,"collaborators":10,"id":19,"slug":20,"hasResults":21,"nctId":22,"briefTitle":23,"officialTitle":24,"acronym":10,"eligibilityCriteria":25,"healthyVolunteers":21,"sex":26,"minAge":10,"maxAge":10,"enrollmentInfo":27,"targetDuration":10,"studyType":30,"phases":10,"briefSummary":31,"conditions":32,"keywords":10,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":10},{"fullName":5,"class":6},"NHO - Matsumoto Medical Center","OTHER_GOV",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Bevacizumab including chemotherapy",null,"Patients treated with bevacizumab including chemotherapy for metastatic liver tumor derived from colorectal cancer before metastasectomy.",{"label":13,"type":10,"description":14,"interventionNames":10},"no adjuvant chemotherapy","Patients with no adjuvant chemotherapy including bevacizumab",{"type":16,"investigatorFullName":17,"investigatorTitle":18,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Hiroshi Kitamura","Chief of Surgical Department","100177972","a-reversal-in-the-vascularity-of-metastatic-liver-tumors-from-colorectal-cancer-after-the-cessation-of-anti-vegf-therapy-100177972",false,"NCT01591109","A Reversal in the Vascularity of Metastatic Liver Tumors From Colorectal Cancer After the Cessation of Anti-VEGF Therapy","A Reversal in the Vascularity of Metastatic Liver Tumors in Patients With Colorectal Cancer After the Cessation of Anti-VEGF Therapy: A Study Using Contrast-enhanced Ultrasonography and Histological Techniques.","Inclusion Criteria:\n\n* patients who received chemotherapy (FOLFOX) including bevacizumab. The patients had an associated reduction in tumor vascularity as estimated by ultrasonography and consequently underwent surgical resection of the metastatic liver tumors for curative purposes.\n\nExclusion Criteria:\n\n* none","ALL",{"count":28,"type":29},20,"ACTUAL","OBSERVATIONAL","Objective: To assess the effect of bevacizumab on tumor vessels, and the reversibility of the effect, using contrast-enhanced ultrasonography (CEUS) and histology in patients with metastatic liver tumors derived from colorectal cancer.\n\nBackground Data: Direct evidence on the reversibility of any change in tumor vascularity upon bevacizumab cessation in the clinical setting is lacking.\n\nMethods: The study included 10 patients who received chemotherapy including bevacizumab, experienced a reduction in tumor vascularity as demonstrated by CEUS and consequently underwent liver resection. CEUS was performed before and immediately after 4 courses of chemotherapy and one day before surgery. The number of microvessels highlighted by anti-CD34 antibody in the viable tumor tissue was counted to quantify the microvessel density (MVD). As a control, 10 surgical specimens from 10 patients who had not received chemotherapy were examined.",[33],"Colorectal Cancer","COMPLETED","2012-05-02",{"date":37,"type":38},"2012-05-03","ESTIMATED",{"date":40,"type":10},"2010-01",{"date":42,"type":29},"2012-04",{"name":5,"class":6}]