[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100252322":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":18,"responsibleParty":40,"collaborators":10,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":45,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":57,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":10,"overallStatus":62,"whyStopped":10,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},{"fullName":5,"class":6},"Evangelismos Hospital","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Dippers",null,"Dipping pattern is defined as daytime-nighttime BP\u002Fdaytime BP reduction - based on either ABP monitoring- greater than 10% for systolic and\u002For diastolic BP.\n\nExtreme dipping is marked nocturnal systolic and\u002For diastolic BP fall\\>20% of daytime systolic and\u002For diastolic values or night\u002Fday systolic and\u002For diastolic BP ratio \\\u003C0.8.\n\nPatients in this group will be dippers or extreme dippers. We aim to examine the association of this BP pattern with the development of asymptomatic episodes of paroxysmal atrial fibrillation, in hypertensive subjects.",{"label":13,"type":10,"description":14,"interventionNames":10},"Non-dippers","Non-dipping and rising: no reduction or increase in nocturnal systolic and\u002For diastolic BP or night\u002Fday systolic and\u002For diastolic BP ratio ≥1.\n\nIn this group we aim to examine whether an association exists between the non-dipping pattern and the development of asymptomatic episodes of paroxysmal atrial fibrillation in hypertensive subjects.",{"label":16,"type":10,"description":17,"interventionNames":10},"Morning Hypertensives","It is known that morning surge is the excessive systolic and\u002For diastolic BP elevation rising in the morning.\n\nPatients in this group will have morning hypertension that is classified into two types:\n\nthe \"morning-surge\" type, characterized by a marked increase in blood pressure in the early morning, and the \"nocturnal-hypertension\" type, characterized by high blood pressure that persists from nighttime until early morning.\n\nIn our study we will examine whether an association between morning hypertension and asymptomatic episodes of paroxysmal atrial fibrillation exists in hypertensive subjects.",[19],{"facility":20,"status":10,"city":21,"state":22,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"Evangelismos General Hospital","Athens","Attica","10676","Greece","GR",{"type":27,"coordinates":28},"Point",[29,30],23.72784,37.98376,{"lat":30,"lon":29},[33,38],{"name":34,"role":35,"phone":36,"phoneExt":10,"email":37},"Emmanuel A. Andreadis, MD","CONTACT","+30210-7205149","andreadise@usa.net",{"name":34,"role":39,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":39,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Emmanuel A. Andreadis","HEAD OF THE FOURTH INTERNAL MEDICINE DEPARTMENT","100252322","association-of-dipping-pattern-or-early-morning-surge-of-bp-with-asymptomatic-episodes-of-paroxysmal-atrial-fibrillation-in-subjects-with-hypertension-dimospaf-100252322",false,"NCT02563379","Association of Dipping Pattern or Early Morning Surge of BP With Asymptomatic Episodes of Paroxysmal Atrial Fibrillation in Subjects With Hypertension (DIMOSPAF)","Association Between Circadian Blood Pressure Patterns With Asymptomatic Episodes of Paroxysmal Atrial Fibrillation in Hypertensive Subjects","DIMOSPAF","Inclusion Criteria:\n\n* Patients diagnosed with essential HTN (office BP\\>140\u002F90mmHg) or patients receiving at least one antihypertensive medication (ie. RAAA inhibitors or diuretic), aged 18-85 years of age.\n* Patients with at least one of the following risk factors, organ damage or other evidence of cardiovascular disease:\n* Previous stroke\n* Transient ischemic attack (TIA)\n* Systemic embolism\n* Diabetes mellitus type 2\n* Obesity\n* Obstructive sleep apnea (OSA)\n* Dyslipidemia\n* History of coronary artery disease (CAD)\n* Valvular heart disease (VHD)\n* Echocardiographic findings attributed to HTN (ie. diastolic dysfunction, LVH)\n* White coat hypertension (WCH), masked hypertension (MH)\n* Positive family history for rhythm disturbances\n\nExclusion Criteria:\n\n* Patients already diagnosed with paroxysmal or permanent AF\n* Severe renal insufficiency (eGFR according to MDRD formula \\\u003C25ml\u002Fmin\u002F1.73m2)\n* Patients unable to attend follow-up visits\n* Clinical evidence of severe heart failure\n* Suspected secondary HTN\n* Mental disorders\n* Patients with cancer","ALL","18 Years","85 Years",{"count":55,"type":56},200,"ESTIMATED","12 Months","OBSERVATIONAL","The goals of our study are to determine a).the association between abnormal circadian BP and the development of paroxysmal AF in hypertensive patients, b).at which level of TOD, paroxysmal AF episodes are detected in hypertensive subjects, c).if there is any association between systolic and\u002For diastolic BP levels with AF occurrence, d).whether the mean heart rate during a 24-hr interval is associated with the development of paroxysmal AF, and finally e).examine the relationship between a wide PP and asymptomatic AF episodes in patients with HTN.",[61],"Hypertension - Atrial Fibrillation","UNKNOWN","2015-09-30",{"date":65,"type":56},"2015-10-01",{"date":67,"type":10},"2015-09",{"date":69,"type":56},"2016-09",{"name":5,"class":6},1]