[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100505984":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":55,"centralContacts":54,"locations":59,"responsibleParty":72,"collaborators":74,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":54,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":86,"minAge":87,"maxAge":54,"enrollmentInfo":88,"targetDuration":54,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":54,"overallStatus":98,"whyStopped":54,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"City of Hope Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Whole Body MRI and Liquid Biopsy","EXPERIMENTAL","Patients undergo WBM without contrast and blood sample collection for liquid biopsy",[13,14,15,16,17],"Procedure: Biospecimen Collection","Genetic: Genetic Testing for Cancer Risk","Procedure: Liquid Biopsy","Procedure: Magnetic Resonance Imaging of the Whole Body without Contrast","Other: Survey Administration",[19,28,35,41,50],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Biospecimen Collection","Undergo blood sample collection",[9],[25,26,27],"Biological Sample Collection","Biospecimen Collected","Specimen Collection",{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"GENETIC","Genetic Testing for Cancer Risk","Undergo germline testing",[9],[34],"Cancer Risk Assessment with Genetic Testing and Counseling",{"type":20,"name":36,"description":37,"armGroupLabels":38,"otherNames":39},"Liquid Biopsy","Undergo liquid biopsy testing",[9],[40],"Plasma Biopsy",{"type":20,"name":42,"description":43,"armGroupLabels":44,"otherNames":45},"Magnetic Resonance Imaging of the Whole Body without Contrast","Undergo whole body MRI without contrast",[9],[46,47,48,49],"WB-MRI without Contrast","Whole Body Magnetic Resonance Imaging without Contrast","Whole Body MRI without Contrast","Whole-body MRI without Contrast",{"type":6,"name":51,"description":52,"armGroupLabels":53,"otherNames":54},"Survey Administration","Complete surveys",[9],null,[56],{"name":57,"affiliation":5,"role":58},"Dan Raz","PRINCIPAL_INVESTIGATOR",[60],{"facility":5,"status":54,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":54},"Duarte","California","91010","United States","US",{"type":67,"coordinates":68},"Point",[69,70],-117.97729,34.13945,{"lat":70,"lon":69},{"type":73,"investigatorFullName":54,"investigatorTitle":54,"investigatorAffiliation":54,"oldNameTitle":54,"oldOrganization":54},"SPONSOR",[75],{"name":76,"class":77},"National Cancer Institute (NCI)","NIH","100505984","early-phase-1-analysis-of-whole-body-magnetic-resonance-imaging-and-liquid-biopsy-for-early-detection-of-cancer-in-patients-with-a-strong-family-history-of-cancer-100505984",false,"NCT05868486","Analysis of Whole Body Magnetic Resonance Imaging and Liquid Biopsy for Early Detection of Cancer in Patients With a Strong Family History of Cancer","Whole Body MRI and Liquid Biopsy for Early Cancer Detection","Inclusion Criteria:\n\n* Age \\>= 50 years, or age within 10 years of first degree relative with cancer at age of diagnosis (as long as age is \\>= 18)\n* Have a strong family history of cancer ( \\>= 2 first-degree relatives with cancer, one first and second degree relative with cancer in one lineage (side of family), or at least three first or second degree relatives with cancer in one lineage (side of the family). Non-melanoma skin cancer excluded from family history eligibility\n* Have a family history of early-onset cancer (age \\>40) in at least one first-degree relative\n* Willing to have 50 mL of blood (approximately 3.5 tablespoons) drawn (40 ml if germline testing already performed)\n* Able to undergo MRI (no implants, metal, or claustrophobia that would preclude MRI)\n* Any cancer diagnosis within past 5 years, excluding non-melanoma skin cancer\n* Positron emission tomography\u002Fcomputed tomography (PET\u002FCT) or other whole body imaging modality (including combination of CT chest and abdomen) within 3 years\n* No signs\u002Fsymptoms of possible cancer (e.g. hemoptysis, breast mass, blood per rectum, unexplained weight loss)\n* Willing to undergo standard of care genetic counseling and germline testing, or has already undergone genetic counseling and germline testing\n* Documented informed consent of the participant\n\nExclusion Criteria:\n\n* Unable to provide informed consent\n* Contraindications to MRI (implants, metal, or claustrophobia that would preclude MRI)",true,"ALL","18 Years",{"count":89,"type":90},100,"ACTUAL","INTERVENTIONAL",[93],"EARLY_PHASE1","This study evaluates patient acceptability of whole body magnetic resonance imaging (WBM) and liquid biopsies (LB) in detecting early stage cancer in patients with a strong family history of cancer. Collecting family history and testing for genes passed on from parent to child (germline testing) can be used to predict the likelihood of a patient developing cancer. Currently, detection of early cancers focuses on screening specific organ systems such as breast and colon cancer. Magnetic resonance imaging (MRI) uses a large magnet and radio waves to look at organs and structures inside the body. Health care professionals use MRI scans to diagnose a variety of conditions, from torn ligaments to cancer. Liquid biopsy is test that analyzes blood samples to determine if cancer cells are present. This study may help researchers determine the feasibility of WBM and liquid biopsies to detect early stage cancer in patients that have a strong family history of cancer.",[96,97],"Hematopoietic and Lymphoid System Neoplasm","Malignant Solid Neoplasm","ACTIVE_NOT_RECRUITING","2025-12-31",{"date":101,"type":90},"2026-01-02",{"date":103,"type":90},"2022-05-20",{"date":105,"type":106},"2026-10-19","ESTIMATED",{"name":5,"class":6},1]