[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640958":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":42,"responsibleParty":62,"collaborators":25,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":25,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":25,"overallStatus":84,"whyStopped":25,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Miswak group.","EXPERIMENTAL","The test group that will be assigned to use miswak chewing sticks for personal plaque",[13],"Behavioral: Salvadora Persica Root",{"label":15,"type":10,"description":16,"interventionNames":17},"Toothbrush group","The control group that will be assigned to use the toothbrush for personal plaque",[18],"Behavioral: Toothbrushing",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Salvadora Persica Root","Miswak chewing sticks will be used as an alternative to the toothbrush",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Toothbrushing","Modified Bass technique will be employed",[15],[31],{"name":32,"affiliation":33,"role":34},"Noha Shaaban Shams, Associate professor","Ahram Canadian University","STUDY_DIRECTOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Marwa ElSayed Abbas ElSayed, PhD\u002FLecturer","CONTACT","01092221005","+02","marwah.elsayed2015@gmail.com",[43],{"facility":33,"status":25,"city":44,"state":25,"zip":25,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Giza","Egypt","EG",{"type":48,"coordinates":49},"Point",[50,51],31.20861,30.00944,{"lat":51,"lon":50},[54,58,61],{"name":55,"role":38,"phone":56,"phoneExt":40,"email":57},"Noha Shaaban Shams Shams, Associate professor","01011459366","noha.shams@gmail.com",{"name":59,"role":60,"phone":25,"phoneExt":25,"email":25},"Marwa ElSayed Abbas ElSayed, Lecturer","PRINCIPAL_INVESTIGATOR",{"name":32,"role":60,"phone":25,"phoneExt":25,"email":25},{"type":60,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Marwa El Sayed Abbas Ahmed","Lecturer of Oral Medicine and Periodontology, Ahram Canadian University","100640958","early-phase-1-evaluation-of-the-changes-in-matrix-metalloproteinase-9-levels-with-salvadora-persica-miswak-in-periodontal-fibroblasts-and-gingival-crevicular-fluid-in-patients-with-periodontitis-100640958",false,"NCT07599397","Evaluation of the Changes in Matrix Metalloproteinase-9 Levels With Salvadora Persica (Miswak) in Periodontal Fibroblasts and Gingival Crevicular Fluid in Patients With Periodontitis","Evaluation of the Anti-inflammatory Effects of Salvadora Persica on Matrix Metalloproteinase-9 Levels in Periodontal Fibroblasts and Gingival Crevicular Fluid in Patients With Periodontitis: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Stage II or III, grade B periodontitis\n\nExclusion Criteria:\n\n* Have poor manual dexterity\n\n  * Systemic condition that may affect healing\n  * Administration of certain medications that may modify the outcomes\n  * Smoking patients\n  * Pregnant females\n  * Periapical involvement in teeth\n  * Habitual or experienced users of miswak chewing sticks\n  * History of topical or systemic chemical plaque control during the past 6 months\n  * History of periodontal surgery during the past 6 months\n  * Local risk factor that interfere with accessibility for regular personal plaque control aids","ALL","20 Years","60 Years",{"count":76,"type":77},24,"ESTIMATED","INTERVENTIONAL",[80],"EARLY_PHASE1","The study is conducted to evaluate the invitro effect of Salvadora persica (miswak) extract on periodontal fibroblasts production of matrix metalloproteinase-9 (MMP-9) and prostaglandin E2 (PGE2) and correlating the results to clinical outcomes and biomarkers by assessing the MMP-9 and PGE2 levels in gingival crevicular fluid by a randomized controlled clinical trial comparing the use of toothbrush as the control group with miswak chewing stick as a substitute to personal mechanical plaque control in patients with stage II or III grade B periodontitis.",[83],"Stage II or Stage III Grade B Periodontitis","NOT_YET_RECRUITING","2026-05-14",{"date":87,"type":88},"2026-05-20","ACTUAL",{"date":90,"type":77},"2026-06-01",{"date":92,"type":77},"2026-12-01",{"name":5,"class":6},1]