[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100239083":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":24,"locations":24,"responsibleParty":25,"collaborators":24,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":32,"acronym":24,"eligibilityCriteria":33,"healthyVolunteers":34,"sex":35,"minAge":36,"maxAge":37,"enrollmentInfo":38,"targetDuration":24,"studyType":41,"phases":42,"briefSummary":44,"conditions":45,"keywords":47,"overallStatus":51,"whyStopped":24,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":24},{"fullName":5,"class":6},"Bulent Ecevit University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Chronic periodontitis","ACTIVE_COMPARATOR","GCF samples were taken before and after treatment chronic periodontitis patients.\n\nIntervention: Non- surgical periodontal treatment (SRP and oral hygiene instructions)",[13],"Other: non surgical periodontal treatment",{"label":15,"type":16,"description":17,"interventionNames":18},"clinically healthy periodontium","PLACEBO_COMPARATOR","GCF samples were taken at baseline Intervention: oral hygiene instructions",[13],[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"non surgical periodontal treatment","1. SRP under local anaesthesia, in a total of four clinical visits\n2. Oral hygiene instructions including the modified Bass technique, regular toothpaste, and an appropriate interdental cleaning device with dental floss and interdental brush.",[9,15],null,{"type":26,"investigatorFullName":27,"investigatorTitle":5,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","Umut BALLI","100239083","early-phase-1-gingival-crevicular-fluid-levels-of-sclerostin-osteoprotegerin-opg-and-rankl-in-health-disease-and-after-treatment-100239083",false,"NCT02390479","Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin (OPG) and RANKL in Health, Disease and After Treatment","Inclusion Criteria:\n\n* Criteria for the healthy group were GI = 0, PPD and CAL ≤ 3 mm, and no signs of attachment and bone loss\n* Criteria for the chronic periodontitis group were clinical signs of inflammation, such as red color and swelling of the gingival margin, GI ≥ 2, PPD and CAL ≥ 5 mm with bone loss (\\>30% of the existing teeth)\n\nExclusion Criteria:\n\n* Aggressive periodontitis, systemic diseases (i.e., diabetes mellitus, cancer, human immunodeficiency virus, bone-related diseases that compromise sclerostin, OPG or RANKL levels and collagen-metabolic diseases, or disorders), chronic high-dose steroid therapy, radiation or immunosuppressive therapy, allergy or sensitivity to any drug, pregnancy, lactation, and current smoking, smoking within the past 5 years. The individuals had no history of periodontal therapy or drug therapy (e.g. anti-inflammatory, antibiotic treatment or any other pharmacological treatment) for at least six months.",true,"ALL","25 Years","49 Years",{"count":39,"type":40},54,"ACTUAL","INTERVENTIONAL",[43],"EARLY_PHASE1","The primary objective of this case-control intervention study to explore the effectiveness of non surgical periodontal therapy on the gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis (CP) so as to get a more detailed insight into its diagnostic and prognostic potential as a biomarker of periodontal disease.",[46],"Periodontitis",[48,49,50],"Sclerostin","OPG","RANKL","COMPLETED","2015-09-28",{"date":54,"type":55},"2015-09-30","ESTIMATED",{"date":57,"type":24},"2013-12",{"date":59,"type":40},"2014-10",{"name":27,"class":6}]