[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100510501":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":25,"locations":37,"responsibleParty":62,"collaborators":25,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":25,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":25,"overallStatus":84,"whyStopped":25,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"study group","ACTIVE_COMPARATOR","Patients who will receive (conventional treatment of acute organophosphorus poisoning plus NAC)",[13,14],"Drug: n acetyl cysteine","Drug: standard treatment",{"label":16,"type":6,"description":17,"interventionNames":18},"control group","Patients who will receive conventional treatment only",[14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","n acetyl cysteine","A patients received NAC 140 mg\u002FKg IV infusion (as a loading dose), then 70 mg\u002FKgIV infusion every 4 hours up to 17 doses",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"standard treatment","stabilization and antidotes",[16,9],[31],"atropine and oximes",[33],{"name":34,"affiliation":35,"role":36},"Sarah S Mohammed","faculty of medicine ain shams university","PRINCIPAL_INVESTIGATOR",[38,51,56],{"facility":39,"status":25,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":25},"faculty of medicine Ain shams university","Cairo","None Selected","11566","Egypt","EG",{"type":46,"coordinates":47},"Point",[48,49],31.24967,30.06263,{"lat":49,"lon":48},{"facility":52,"status":25,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":53,"geoPoint":55,"contacts":25},"Faculty of Medicine",{"type":46,"coordinates":54},[48,49],{"lat":49,"lon":48},{"facility":57,"status":25,"city":40,"state":25,"zip":58,"country":43,"countryCode":44,"cosmosGeoPoint":59,"geoPoint":61,"contacts":25},"Poison Control Center Ain Shams University Hospitals","02",{"type":46,"coordinates":60},[48,49],{"lat":49,"lon":48},{"type":36,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Sarah Saeed Mohammed","lecturer of clinical toxicology","100510501","early-phase-1-the-role-of-n-acetylcysteine-as-a-novel-adjuvant-treatment-in-acute-organophosphorus-pesticide-poisoning-100510501",false,"NCT05927259","The Role of N-acetylcysteine as a Novel Adjuvant Treatment in Acute Organophosphorus Pesticide Poisoning","The Role of N-acetylcysteine as a Novel Adjuvant Treatment in Acute Organophosphorus.A Randomized, Clinical Trial in Poison Control Center -Ain Shams University Hospitals","Inclusion Criteria:\n\nAll patients (above 16 years) admitted to the ICU of the PCC-ASUH due to acute poisoning by acute organophosphorus poisoning will be included in the study. The diagnosis of intoxication will be based on history of acute exposure, clinical examination and laboratory investigations. -\n\nExclusion Criteria:\n\n* Based on the possibility of alteration in measured parameters and\u002For biomarkers, patients below 16 years or above 60 years Patients with history of diabetes, cardiac disease, respiratory, renal disease and hepatic disease.","ALL","16 Years","60 Years",{"count":76,"type":77},40,"ACTUAL","INTERVENTIONAL",[80],"EARLY_PHASE1","All patients admitted in the ICU of the PCC-ASUH due to acute poisoning by acute organophosphorus poisoning will be included in the study. The diagnosis of intoxication will be based on history of acute exposure , clinical examination and laboratory investigations. Patients will be randomly allocated into 2 equal groups.\n\nGroup 1 -. Patients who will receive (conventional treatment of acute organophosphorus poisoning plus NAC) and Group 2 - Patients who will receive conventional treatment only",[83],"Acute Organophosphorus Poisoned Patients","COMPLETED","2023-06-22",{"date":87,"type":77},"2023-07-03",{"date":89,"type":77},"2022-01-01",{"date":91,"type":77},"2023-06-01",{"name":5,"class":6},3]