[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570725":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":30,"responsibleParty":47,"collaborators":26,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":26,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":26,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":26,"overallStatus":68,"whyStopped":26,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Tan Tock Seng Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Safety of Intracameral levofloxacin in cataract surgery","EXPERIMENTAL","Eligible and recruited patients are randomized to intracameral levofloxacin or intracameral cefazolin during cataract surgery",[13,14],"Drug: Safety of intracameral levofloxacin in cataract surgery","Drug: Use of intracameral cefazolin in cataract surgery",{"label":16,"type":17,"description":18,"interventionNames":19},"Use of intracameral cefazolin in cataract surgery","ACTIVE_COMPARATOR","Eligible and recruited patients were randomized to intracameral levofloxacin or intracameral cefazolin during cataract surgery",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Safety of intracameral levofloxacin in cataract surgery","Intracameral levofloxacin (0.1ml\u002F0.5mg)",[9,16],null,{"type":22,"name":16,"description":28,"armGroupLabels":29,"otherNames":26},"Intracameral cefazolin (0.1ml\u002F1mg)",[9,16],[31,41],{"facility":5,"status":26,"city":32,"state":26,"zip":33,"country":32,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":26},"Singapore","308433","SG",{"type":36,"coordinates":37},"Point",[38,39],103.85007,1.28967,{"lat":39,"lon":38},{"facility":42,"status":26,"city":32,"state":26,"zip":43,"country":32,"countryCode":34,"cosmosGeoPoint":44,"geoPoint":46,"contacts":26},"Ang Mo Kio Specialist Center","560723",{"type":36,"coordinates":45},[38,39],{"lat":39,"lon":38},{"type":48,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100570725","early-phase-1-to-compare-the-safety-and-efficacy-of-intracameral-levofloxacin-and-intracameral-cefazolin-in-reducing-rates-of-endophthalmitis-following-cataract-surgery-100570725",false,"NCT06710977","To Compare the Safety and Efficacy of Intracameral Levofloxacin and Intracameral Cefazolin in Reducing Rates of Endophthalmitis Following Cataract Surgery.","A Double-blind, Randomized Controlled Pilot Study Comparing the Safety and Efficacy of Intracameral Levofloxacin and Intracameral Cefazolin in Cataract Surgery","Inclusion Criteria:\n\n* Aged ≥50 to \\\u003C80 years\n* Undergoing cataract surgery under the care of one of three study investigators, all of whom were consultant level cataract surgeons\n* Only those with senile cataracts, assessed using the Lens Opacities Classification System III scale (LOCS III) and without features of complex cataracts were included\n\nExclusion Criteria:\n\n* \\\u003C50 or \\>80 years old\n* Prior ocular trauma, pregnant, previous history of refractive, corneal or intraocular surgery, cornea endothelial cell count \\\u003C1500\u002Fsqmm², concomitant ocular disease, allergy to penicillin, fluoroquinolone or cephalosporin, and abnormal biometric measurements","ALL","50 Years","80 Years",{"count":60,"type":61},50,"ACTUAL","INTERVENTIONAL",[64],"EARLY_PHASE1","Patients with senile cataracts undergoing phacoemulsification were assigned to receive intracameral levofloxacin (0.1ml\u002F0.5mg) or intracameral cefazolin (0.1ml\u002F1mg). The primary endpoint was the occurrence of endophthalmitis during the 3 month follow-up period. Secondary endpoints included best-corrected visual acuity (BVCA), the presence of anterior chamber (AC) inflammation with grading of AC cells and presence of flare, along with intraocular pressure (IOP), corneal cell thickness (CCT), central foveal thickness (CFT) and cell density.",[67],"Cataract","COMPLETED","2024-11-27",{"date":71,"type":61},"2024-12-02",{"date":73,"type":61},"2022-01-01",{"date":75,"type":61},"2024-09-01",{"name":5,"class":6},2]