[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651126":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":17,"centralContacts":38,"locations":44,"responsibleParty":64,"collaborators":17,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":17,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":17,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":47,"whyStopped":17,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Mansoura University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"pigallocatechin-3-gallate (EGCG)-loaded chitosan nanoparticulate gel","EXPERIMENTAL","epigallocatechin-3-gallate (EGCG)-loaded chitosan nanoparticulate gel injected into the periodontal pockets. This will be administered immediately after thorough scaling and root planing (SRP) and every 2 weeks for 6 weeks.",[13],"Drug: Ten patients with stage II periodontitis will receive epigallocatechin-3-gallate (EGCG)-loaded chitosan nanoparticulate gel injected into the periodontal pockets",{"label":15,"type":16,"description":17,"interventionNames":18},"treated with chitosan nanoparticulate gel (CTN gel)","PLACEBO_COMPARATOR",null,[19],"Drug: chitosan nanoparticulate gel (CTN gel)",{"label":21,"type":6,"description":22,"interventionNames":23},"scaling and root planing (SRP) only","Ten patients with stage II periodontitis will undergo scaling and root planing (SRP) only. They will then be re-evaluated for SRP for 6 weeks.",[24],"Other: scaling and root planing (SRP) only.",[26,31,35],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":17},"DRUG","Ten patients with stage II periodontitis will receive epigallocatechin-3-gallate (EGCG)-loaded chitosan nanoparticulate gel injected into the periodontal pockets","Ten patients with stage II periodontitis will receive epigallocatechin-3-gallate (EGCG)-loaded chitosan nanoparticulate gel injected into the periodontal pockets. This will be administered immediately after thorough scaling and root planing (SRP) and every 2 weeks for 6 weeks.",[9],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":17},"chitosan nanoparticulate gel (CTN gel)","Ten patients with stage II periodontitis will be treated with chitosan nanoparticulate gel (CTN gel) injected in the pockets after SRP. Moreover, the gel application will follow the same timeframe as group I.",[15],{"type":6,"name":36,"description":22,"armGroupLabels":37,"otherNames":17},"scaling and root planing (SRP) only.",[21],[39],{"name":40,"role":41,"phone":42,"phoneExt":17,"email":43},"Mohamed Ghanem Aldhafeeri","CONTACT","0021500676990","Dr.m.aldhafeeri@gmail.com",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Mansoura university","RECRUITING","Al Mansurah","Dakahlia Governorate","22132","Egypt","EG",{"type":54,"coordinates":55},"Point",[56,57],31.38069,31.03637,{"lat":57,"lon":56},[60],{"name":61,"role":41,"phone":62,"phoneExt":17,"email":63},"Hisham Mohamed Alsharkwi, Profsser","0021555373368","dental.salah.az@gmail.com",{"type":65,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR","100651126","effectiveness-of-epigallocatechin-3-gallate-green-tea-extract-as-adjunctive-locally-delivered-nanotherapeutic-in-the-treatment-of-stage-ii-periodontitis-100651126",false,"NCT07754253","Effectiveness of Epigallocatechin-3-Gallate (Green Tea Extract) as Adjunctive Locally Delivered Nanotherapeutic in the Treatment of Stage II Periodontitis","Effectiveness of Epigallocatechin-3-Gallate (Green Tea Extract) as Adjunctive Locally Delivered Nanotherapeutic in the Treatment of Stage II Periodontitis (A Randomized Controlled Clinical Trial)Man","Inclusion Criteria:\n\nHealthy patients diagnosed with stage II and grade B periodontitis (pocket depth ≤ 5mm and CAL = 3-4 mm).\n\n* Patients within the age range of 25-60 years.\n* Good compliance with the plaque control instructions following initial therapy. 9\n* Patients willing to participate in the study and will give written informed consent.\n\nExclusion Criteria:\n\n* Patients with active systemic disease.\n* Periodontal treatment during the last 6 months.\n* Patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study.\n* Pregnant and lactating females.\n* Smokers",true,"ALL","25 Years","60 Years",{"count":78,"type":79},30,"ESTIMATED","INTERVENTIONAL",[82],"PHASE1","The main objective of the current study is to clinically and biochemically evaluate the effectiveness of epigallocatechin-3-gallate-loaded chitosan nanoparticulate gel as a local drug delivery system, when used in conjunction with mechanical debridement, for treating periodontal pockets in patients with stage II periodontitis.\n\nThe primary endpoint will be the assessment of pocket depth reduction after 3 months of therapy, whereas the secondary endpoints include the changes in clinical attachment gain, bleeding on probing, plaque and gingival indices and gingival crevicular fluid level of tumor necrosis factor alpha (TNF-α).",[85],"Peridontitis",[87],"gum","2026-08-04",{"date":90,"type":91},"2026-08-10","ACTUAL",{"date":93,"type":91},"2026-03-16",{"date":95,"type":79},"2026-12-20",{"name":5,"class":6},1]