[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100296838":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":54,"collaborators":23,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":23,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":23,"enrollmentInfo":67,"targetDuration":23,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":80,"whyStopped":23,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of Manchester","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental","EXPERIMENTAL","Topical anti-aging cosmetic cream (active)",[13],"Other: Topical anti-aging cosmetic cream",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Basic formulation without active ingredients (vehicle)",[13],[20],{"type":6,"name":21,"description":21,"armGroupLabels":22,"otherNames":23},"Topical anti-aging cosmetic cream",[9,15],null,[25],{"name":26,"affiliation":5,"role":27},"Rachel E Watson, PhD","PRINCIPAL_INVESTIGATOR",[29,33],{"name":26,"role":30,"phone":31,"phoneExt":23,"email":32},"CONTACT","+441612755505","rachel.watson@manchester.ac.uk",{"name":34,"role":30,"phone":35,"phoneExt":23,"email":36},"Jean Y Bastrilles, RCN","+442064282","jean.bastrilles@manchester.ac.uk",[38],{"facility":39,"status":23,"city":40,"state":23,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Dermatopharmacology Unit, Salford Royal NHS Foundation Trust","Salford","M6 8HD","United Kingdom","UK",{"type":45,"coordinates":46},"Point",[47,48],-2.29042,53.48771,{"lat":48,"lon":47},[51,53],{"name":34,"role":30,"phone":52,"phoneExt":23,"email":36},"+441612064282",{"name":26,"role":27,"phone":23,"phoneExt":23,"email":23},{"type":27,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Dr Rachel Watson","Reader in Dermatology","100296838","efficacy-in-daily-use-of-a-novel-skin-care-product-for-the-treatment-of-photoaged-skin-100296838",false,"NCT03144193","Efficacy in Daily Use of a Novel Skin Care Product for the Treatment of Photoaged Skin","Assessment of Efficacy in Daily Use of a Novel Skin Care Product (CG Skin Ltd.) for the Treatment of Photoaged Skin","Inclusion Criteria:\n\n* Have moderate to severe photoaging of facial skin (grade 6 or above on the Griffiths scale);\n* Willing to submit to examination of facial skin, hands and forearms;\n* Willing to submit to self-treatment with product or placebo cream on face, hands and forearms, including wrists and extensor forearms, for 6 months;\n* Willing to submit to clinical photography;\n* Willing to submit to 3 mm punch biopsies from the wrist at beginning and end of trial;\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Skin disease that would impair evaluation of the test sites;\n* Topical or systemic retinoid within the past 6 months and 12 months respectively prior to entry to the study;\n* Topical steroid or other topical drugs at treatment sites for at least two weeks prior to study entry;\n* History of use of experimental drug or experimental device in the 30 days prior to entry into the study;\n* Any significant cosmetic treatment for skin rejuvenation i.e. dermabrasion, chemical peels, face-lifts;\n* Known allergy to any of the product or placebo ingredients;\n* History of keloid scars.",true,"ALL","40 Years",{"count":68,"type":69},60,"ESTIMATED","INTERVENTIONAL",[72],"NA","Photoaged or chronically sun-exposed skin is characterised by a number of clinical features including fine and coarse wrinkles. The pathogenesis of wrinkle formation has yet to be determined fully but recent work suggests that ultraviolet radiation-induced reduction in dermal fibrillin (in the form of fibrillin-rich microfibrils) is important. Using an extended in vivo patch test assay, it has been identified that skin care products - currently marketed by CG Skin Ltd - increase the deposition of these microfibrils in photoaged dermis and hence have the potential to repair photoaged skin. The Investigators now propose to examine the efficacy of the product in randomized, placebo-controlled clinical trial.",[75],"Photoaging",[77,78,79],"topical treatment","wrinkles","extracellular matrix","UNKNOWN","2017-05-08",{"date":83,"type":84},"2017-05-09","ACTUAL",{"date":86,"type":69},"2017-06-01",{"date":88,"type":69},"2018-03-31",{"name":5,"class":6},1]