[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100352789":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":17,"centralContacts":18,"locations":29,"responsibleParty":64,"collaborators":17,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":17,"enrollmentInfo":76,"targetDuration":17,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":89,"whyStopped":17,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Centre Georges Francois Leclerc","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"FES PET","1 ) inclusion; 2 ) FGD PET \u002F FES PET; 3) Hormone therapy",[12],"Other: FES PET",[14],{"type":6,"name":9,"description":15,"armGroupLabels":16,"otherNames":17},"FES injection",[9],null,[19,24],{"name":20,"role":21,"phone":22,"phoneExt":17,"email":23},"Claire Tabouret-Viaud, MD","CONTACT","+ 33 3 80 73 75 22","ctabouret@cgfl.fr",{"name":25,"role":21,"phone":26,"phoneExt":27,"email":28},"Emilie REDERSTORFF, PhD","+33(0)3 80 73 75 00","34 61","ERederstorff@cgfl.fr",[30,50],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Centre Georges-François Leclerc","RECRUITING","Dijon","Bourgogne-Franche-Comté","21000","France","FR",{"type":39,"coordinates":40},"Point",[41,42],5.01391,47.31344,{"lat":42,"lon":41},[45],{"name":46,"role":21,"phone":47,"phoneExt":48,"email":49},"Jean-Louis ALBERINI, Pr","03 80 73 75 22","§33","JLAlberini@cgfl.fr",{"facility":51,"status":52,"city":33,"state":17,"zip":53,"country":36,"countryCode":37,"cosmosGeoPoint":54,"geoPoint":56,"contacts":57},"CGFL","NOT_YET_RECRUITING","21079",{"type":39,"coordinates":55},[41,42],{"lat":42,"lon":41},[58,60],{"name":20,"role":21,"phone":59,"phoneExt":17,"email":23},"33 3 80 73 75 22",{"name":61,"role":21,"phone":62,"phoneExt":17,"email":63},"Emilie REDERSTORFF","33 3 45 34 81 16","erederstorff@cgfl.fr",{"type":65,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR","100352789","evaluation-of-the-unconformity-of-the-hormonal-status-of-metastatic-lesions-during-a-first-relapse-of-breast-cancer-initially-expressing-estrogen-receptors-a-pilot-study-on-the-interest-of-pet-with-fes-100352789",false,"NCT03873428","Evaluation of the Unconformity of the Hormonal Status of Metastatic Lesions During a First Relapse of Breast Cancer Initially Expressing Estrogen Receptors: a Pilot Study on the Interest of PET With FES","Evaluation of the Unconformity of the Hormonal Status of Metastatic Lesions During a First Relapse of Breast Cancer Initially Expressing Estrogen Receptors: a Pilot Study on the Interest of Positron Emission Tomography (PET) With 16α- [18F] -Fluoro-17β-estradiol (FES).","EstroTEPCompar","Inclusion Criteria:\n\n1. ECOG score (Eastern Cooperative Oncology Group) ≤ 2.\n2. Stage IV breast cancer (AJCC TNM).\n3. Primitive tumor expressing RO (\\> 10%).\n4. Patient candidate for hormone therapy treatment targeting estrogen receptors as a first-line treatment in a context of first metastatic recurrence.\n5. No overexpression of HER2 in the tumor.\n6. Lack of previous treatment for metastatic disease\n7. Metastatic status confirmed by 18F-FDG PET \u002F CT performed in the month prior to inclusion\n8. Life expectancy estimated at more than 3 months.\n9. Patient able to understand and give informed informed consent for participation in the study.\n10. Patient affiliated with the social security scheme or equivalent.\n\nExclusion Criteria:\n\n1. Triple negative breast cancer\n2. Overexpression HER2 +++\n3. Metastatic involvement exclusively in the liver\n4. Unable to lie down or maintain the position during the PET \u002F CT scan\n5. Uncontrolled intercurrent pathology that is life-threatening in the short term\n6. Uncontrolled diabetes\n7. History of an allergic reaction attributed to a chemical or biological compound related to FDG or FES\n8. Psychiatric impairment or social conditions that would limit patient availability and compliance at different stages of the study.\n9. Pregnant woman (mandatory pregnancy test at baseline) or who is breastfeeding.","FEMALE","18 Years",{"count":77,"type":78},25,"ESTIMATED","INTERVENTIONAL",[81],"NA","Breast cancer is a major public health issue despite therapeutic advances, it is the first cause of death cancer of women in Europe.\n\nSeveral treatments may be proposed depending on the general condition of the patient, the characteristics of the initial tumor and the stage of the disease. The different treatments in metastatic relapse of hormone receptor-positive breast cancer are systemic treatments, such as hormone therapy, chemotherapy, targeted therapies, and possible supportive care, but also in some cases local treatments such as surgery and radiotherapy.\n\nComparative analysis of primary mammary tumors and their metastases has demonstrated the essential role of tumor heterogeneity, both in time and space, in the progression of the disease and the occurrence of resistance to treatments. Taking into account this intratumoral heterogeneity represents a major axis of improvement in the management of patients with breast cancer.\n\nThe use of innovative radiotracers such as 16α- \\[18F\\] -fluoro-17β-estradiol (FES) may allow in the future to better evaluate this tumor heterogeneity in patients with metastatic breast cancer through non-metastatic characterization. invasive different lesions. It will be possible to propose to each patient a more personalized care with possibly the administration, in addition to the systemic treatment, of a local treatment adapted to the characteristics of some secondary lesions likely to respond less well to the systemic treatment.\n\nIn this pilot study, the investigators would like to estimate the number of patients and the number of metastatic sites affected by tumor heterogeneity of estrogen receptor expression, which could benefit from specific management.\n\nThis study will concern a population of patients with first metastatic recurrence of hormone receptor-positive breast cancer initially, with at least one metastasis, who are candidates for treatment with hormone therapy.",[84],"FES TEP in Detection of Estrogen Receptors",[86,87,88],"breast cancer","first metastatic relapse","PET","UNKNOWN","2024-02-12",{"date":92,"type":93},"2024-02-13","ACTUAL",{"date":95,"type":93},"2021-10-18",{"date":97,"type":78},"2025-10-18",{"name":5,"class":6},2]