[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100395260":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":10,"centralContacts":33,"locations":43,"responsibleParty":59,"collaborators":10,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":78,"studyType":79,"phases":10,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":88,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Oslo University Hospital","OTHER",[8,14,19,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Women with submucosal leiomyoma(s)",null,"Women with submucosal leimyomas undergoing hysteroscopical removal of the leiomyoma",[13],"Procedure: Transcervical resection of fibroids",{"label":15,"type":10,"description":16,"interventionNames":17},"Women with intramural leiomyomas","Women with intramural leiomyomas undergoing myomectomy",[18],"Procedure: Myomectomy per laparoscopy or laparotomy",{"label":20,"type":10,"description":21,"interventionNames":10},"Infertility patients","Patients treated at the Department for Reproductive Medicine at the Oslo University hospital failing to conceive after 3 or more embryo transfers with good quality embryos.",{"label":23,"type":10,"description":24,"interventionNames":10},"Fertile women","Healthy, volunteering women with proved fertility with 1 or more deliveries and no history of infertility",[26,30],{"type":27,"name":28,"description":28,"armGroupLabels":29,"otherNames":10},"PROCEDURE","Transcervical resection of fibroids",[9],{"type":27,"name":31,"description":31,"armGroupLabels":32,"otherNames":10},"Myomectomy per laparoscopy or laparotomy",[15],[34,39],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Thea F. Mikkelsen, MD","CONTACT","004797612934","themik@ous-hf.no",{"name":40,"role":36,"phone":41,"phoneExt":10,"email":42},"Kirsten Hald, PhD","004795224181","UXKILD@ous-hf.no",[44],{"facility":5,"status":45,"city":46,"state":10,"zip":10,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Oslo","Norway","NO",{"type":50,"coordinates":51},"Point",[52,53],10.74609,59.91273,{"lat":53,"lon":52},[56,58],{"name":57,"role":36,"phone":37,"phoneExt":10,"email":38},"Thea F Mikkelsen, MD",{"name":40,"role":36,"phone":41,"phoneExt":10,"email":42},{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Kirsten Hald, MD, PhD","Senior Consultant","100395260","fibroids-and-infertility---a-study-of-the-significance-of-removal-of-fibroids-with-regard-to-endometrial-receptivity-100395260",false,"NCT04426760","Fibroids and Infertility - a Study of the Significance of Removal of Fibroids With Regard to Endometrial Receptivity","Mechanisms of Reduced Fertility in Women With Uterine Leiomyomas","FIN","Inclusion Criteria:\n\n* Age: 18 to 40 years\n* Presence of leiomyoma(s)\n* Regular menstrual cycle (28 +\u002F- 7 days)\n* Having had at least 2 normal menstrual cycles after ending the treatment if previously treated with GnRH analogue\n* Signed informed consent\n\nExclusion Criteria:\n\n* No treatment indication (no symptoms and\u002For no desire for fertility)\n* Contraindication for surgery\n* Known endometriosis\n* Known PCOS\n* Untreated hydrosalpinx\n* Malignancy; gynaecological or other location\n* Pre-malignant or malignant pap smear or endometrial biopsy\n* Hormonal treatment including ulipristal acetat and levonorgestrel intrauterine device last three months before inclusion in the study\n* Ongoing treatment with GnRH analogue\n* Pregnancy last 3 months\n* Ongoing lactation",true,"FEMALE","18 Years","40 Years",{"count":76,"type":77},80,"ESTIMATED","2 Years","OBSERVATIONAL","We aim to explore some of the molecular factors that reduce fertility for women with leiomyomas, taking into account leiomyoma location, size, number and vascularity. Tissue samples from the endometrium and leiomyomas will be obtained during the mid secretory phase before and 3-6 months after surgical excision for a comprehensive search for key molecular derangements.",[82],"Leiomyoma, Uterine",[84,85,86,87],"Infertility","Endometrial receptivity","Leiomyoma","Fibroid","UNKNOWN","2020-06-08",{"date":91,"type":92},"2020-06-11","ACTUAL",{"date":94,"type":92},"2019-03-01",{"date":96,"type":77},"2024-09-15",{"name":5,"class":6},1]