[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100360820":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":38,"centralContacts":29,"locations":42,"responsibleParty":54,"collaborators":56,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":29,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":29,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":92,"whyStopped":29,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"National University of Singapore","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Okara biscuits","EXPERIMENTAL","Subjects will consume their habitual diet with daily okara biscuit consumption accounting to 20 grams\u002F day of dry okara powder for 21 days.",[13],"Dietary Supplement: Okara biscuits",{"label":15,"type":10,"description":16,"interventionNames":17},"Bio-okara biscuits","Subjects will consume their habitual diet with daily bio-okara biscuit consumption accounting to 20 grams\u002F day of dry bio-okara powder for 21 days.",[18],"Dietary Supplement: Bio-okara biscuits",{"label":20,"type":10,"description":21,"interventionNames":22},"Control biscuits","Subjects will consume their habitual diet with daily control biscuit consumption for 21 days.",[23],"Dietary Supplement: Control biscuits",[25,30,35],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"DIETARY_SUPPLEMENT","Consumption of okara-enriched biscuits together with habitual diet.",[9],null,{"type":26,"name":15,"description":31,"armGroupLabels":32,"otherNames":33},"Consumption of bio-okara-enriched biscuits together with habitual diet. Bio-okara is a form of fermented okara.",[15],[34],"Fermented okara biscuits",{"type":26,"name":20,"description":36,"armGroupLabels":37,"otherNames":29},"Consumption of control biscuits together with habitual diet.",[20],[39],{"name":40,"affiliation":5,"role":41},"Jung Eun Kim","PRINCIPAL_INVESTIGATOR",[43],{"facility":44,"status":29,"city":45,"state":29,"zip":46,"country":45,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":29},"Department of Food Science and Technology; National University of Singapore","Singapore","117546","SG",{"type":49,"coordinates":50},"Point",[51,52],103.85007,1.28967,{"lat":52,"lon":51},{"type":41,"investigatorFullName":40,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Assistant Professor",[57],{"name":58,"class":59},"Ministry of Education, Singapore","OTHER_GOV","100360820","impact-of-okara-and-bio-okara-food-product-on-gut-and-glycaemic-health-in-middle-aged-and-older-adults-in-singapore-100360820",false,"NCT03978104","Impact of Okara and Bio-okara Food Product on Gut and Glycaemic Health in Middle-aged and Older Adults in Singapore","Inclusion Criteria:\n\n1. Ability to give an informed consent\n2. Age 50 to 75 years\n3. Willing to follow the study procedures\n\nExclusion Criteria:\n\nAll subjects meeting any of the exclusion criteria at baseline will be excluded from participation\n\n1. Significant change in weight (≥ 3 kg body weight) during the past 3 months\n2. Allergy to soy-based products\n3. Acute illness at the study baseline\n4. Exercising vigorously over the past 3 months\n5. Following any restricted diet (e.g. vegetarian)\n6. Smoking\n7. Have a daily intake of more than 2 alcoholic drinks per day\n8. Prescribed and taking antihypertensive\u002Fcholesterol-lowering\u002F type-2 diabetic medication which started less than 5 years prior to the intervention participation\n9. Taking dietary supplements which may impact the outcome of interests (e.g. vitamin supplements, probiotic supplement etc.)\n10. Pregnant, lactating, or planning pregnancy in the next 6 months\n11. Insufficient venous access to allow the blood collection\n12. Very high intake of fibre\u002F vegetables on a daily basis",true,"ALL","50 Years","75 Years",{"count":71,"type":72},20,"ESTIMATED","INTERVENTIONAL",[75],"NA","This research project aims to provide the scientific findings about the beneficial effects of okara (soybean pulp) consumption on gut and glycaemic health in middle-aged and older individuals in Singapore. In addition, it aims to examine the health promoting impact of bio-transformed okara in this population. We hypothesise that consuming a habitual diet with an okara (untreated or bio-transformed) incorporated food product will improve the gut microbiome composition and will increase the production of short chain fatty acids when compared to a same diet with no okara. Okara-based food product can also improve the glycaemic response in individuals compared to a product without okara in meal tolerance test (acute).",[78,79,80,81],"Microbiota","Gastrointestinal Microbiome","Blood Glucose","Aging",[83,84,85,86,87,78,88,89,90,91,45],"Okara","Soybean pulp","Soybean","Fibre","Gut microbiome","Gastrointestinal microbiome","Glycemic","Glycaemic","Middle-aged and older adults","UNKNOWN","2022-03-23",{"date":95,"type":96},"2022-03-24","ACTUAL",{"date":98,"type":96},"2019-11-01",{"date":100,"type":72},"2022-09",{"name":5,"class":6},1]