[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608831":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":30,"responsibleParty":46,"collaborators":20,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":20,"enrollmentInfo":57,"targetDuration":20,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":70,"whyStopped":20,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University Hospital, Brest","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Single arm (all patients)","EXPERIMENTAL","During the two routine MRI scans, a T1 GRE GADO MRI sequence (specific to the study) will be added. It lasts approximately 3 minutes.",[13],"Procedure: T1 GRE GADO MRI sequence",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","T1 GRE GADO MRI sequence","Addition of a T1 gradient echo sequence with gadolinium (T1 TFE GADO) during the two MRI scans performed in routine practice before and after neurosurgery.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Romuald SEIZEUR, Pr","CONTACT","+33 230 337 802","romuald.seizeur@chu-brest.fr",{"name":28,"role":24,"phone":25,"phoneExt":20,"email":29},"Marie DUIGOU","marie.duigou@chu-brest.fr",[31],{"facility":32,"status":20,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"CHU Brest","Brest","Brittany Region","29200","France","FR",{"type":39,"coordinates":40},"Point",[41,42],-4.48628,48.39029,{"lat":42,"lon":41},[45],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"type":47,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100608831","improved-understanding-of-venous-drainage-at-the-cranio-cervical-junction--study-of-postoperative-venous-remodeling-following-surgical-treatment-of-lesions-of-the-posterior-fossa-or-posterior-approach-of-the-upper-cervical-spine-100608831",false,"NCT07206667","Improved Understanding of Venous Drainage at the Cranio-cervical Junction : Study of Postoperative Venous Remodeling Following Surgical Treatment of Lesions of the Posterior Fossa or Posterior Approach of the Upper Cervical Spine.","VENAMAP 2","Inclusion Criteria:\n\nPatient:\n\n* Adult\n* Surgery of the posterior cranial fossa or posterior approach to the upper cervical spine, regardless of indication, performed in the neurosurgery department at Brest University Hospital\n* Having undergone an MRI with T1 echo gradient sequence with gadolinium (T1 TFE GADO)\n* Affiliated with a Social Security scheme\n* Having given written consent to participate in the study\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women\n* Allergy to gadolinium\n* Any contraindications to undergoing an MRI scan (incompatible medical device implant, claustrophobia, etc.)\n* Patients unable to understand the protocol\n* Patients under guardianship or conservatorship\n* Patients subject to a future protection order, family authorization, or legal protection","ALL","18 Years",{"count":58,"type":59},30,"ESTIMATED","INTERVENTIONAL",[62],"NA","In the literature, a dichotomous view of cerebral venous drainage is most commonly found. Thus, two drainage pathways are most often considered: the jugular vein network and the vertebral artery plexus. However, several clinical observations seem to indicate a much more complex situation.\n\nThe following hypothesis is therefore put forward: there are alternative drainage pathways to these main pathways, which are physiologically present and capable of draining a significant volume of blood. A set of alternative pathways, which can be described as \"deep,\" has been described: in particular, drainage pathways surrounding the vertebral artery (vertebral artery venous plexus), epidural plexuses, and deep cervical veins. However, the so-called \"superficial\" systems (subcutaneous and muscular) do not appear to have been studied.\n\nThere appears to be a change in venous drainage of the craniocervical junction postoperatively (posterior cranial fossa surgery and posterior approach to the upper cervical spine).\n\nThese modifications would vary depending on the venous drainage configuration present in each patient. If this hypothesis is confirmed, it could have an impact on the management of each patient. Thus, if venous remodeling models are established, this could enable personalized perioperative patient management: better optimization of body position during installation in the operating room, more effective anticipation of potential intraoperative venous bleeding, and explanation of persistent headaches in the postoperative period due to insufficient compensation of venous drainage. Confirmation of this hypothesis would also improve the understanding of certain pathologies for which the venous hypothesis has been raised (chronic hydrocephalus in adults, idiopathic intracranial hypertension, etc.).",[65],"Craniocervical Surgery",[67,68,69],"neurosurgery","cerebral venous drainage","MRI","NOT_YET_RECRUITING","2026-05-27",{"date":73,"type":74},"2026-05-29","ACTUAL",{"date":76,"type":59},"2026-07-01",{"date":78,"type":59},"2029-11-01",{"name":5,"class":6},1]