[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100158207":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":7,"locations":21,"responsibleParty":86,"collaborators":88,"id":119,"slug":120,"hasResults":121,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":7,"eligibilityCriteria":125,"healthyVolunteers":121,"sex":126,"minAge":7,"maxAge":127,"enrollmentInfo":128,"targetDuration":7,"studyType":131,"phases":132,"briefSummary":134,"conditions":135,"keywords":139,"overallStatus":143,"whyStopped":7,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":153},{"fullName":5,"class":6},"ANRS, Emerging Infectious Diseases","OTHER_GOV",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"OTHER","Development of a diagnosis algorithm","At entry in the study, HIV infected children with suspected tuberculosis will undergo a complete evaluation including:\n\n* interview on anamnesis\n* clinical examination\n* evaluation of HIV infection stage\n* hematology and biochemistry tests\n* CD4 count\n* HIV viral load\n* IGRA\n* chest radiograph\n* Abdominal ultrasonograph to detect abdominal lymphadenopathy\n* Tuberculin skin test\n* gastric aspirates, sputum and string tests according to the age of children\n* nasopharyngeal aspirate\n* stool sample\n* lymph node fine needle aspirate or other specimen collection if applicable\n\nDiagnosis and treatment of all participating children will be done according to national guidelines. The children will be followed-up for 6 months until the end of their anti-TB treatment. For the analysis of data and the validation of the algorithm, children will be randomized into 2 groups. Data from Group I will be used to develop the algorithm; data from Group II will be used to validate it.",[14,18],{"name":15,"affiliation":16,"role":17},"Olivier Marcy, MD","Institut Pasteur in Cambodia, Phnom Penh, Cambodia","STUDY_CHAIR",{"name":19,"affiliation":20,"role":17},"Vibol Ung, MD","National Pediatric Hospital, Phnom Penh, Cambodia",[22,33,43,51,61,66,76,81],{"facility":23,"status":7,"city":24,"state":7,"zip":7,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":7},"CHU Sourô Sanou","Bobo-Dioulasso","Burkina Faso","BF",{"type":28,"coordinates":29},"Point",[30,31],-4.29489,11.18064,{"lat":31,"lon":30},{"facility":34,"status":7,"city":35,"state":7,"zip":7,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":42,"contacts":7},"National Pediatric Hospital","Phnom Penh","Cambodia","KH",{"type":28,"coordinates":39},[40,41],104.91601,11.56245,{"lat":41,"lon":40},{"facility":44,"status":7,"city":45,"state":7,"zip":7,"country":36,"countryCode":37,"cosmosGeoPoint":46,"geoPoint":50,"contacts":7},"Angkor Hospital for Children","Siem Reap",{"type":28,"coordinates":47},[48,49],103.86056,13.36179,{"lat":49,"lon":48},{"facility":52,"status":7,"city":53,"state":7,"zip":7,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":60,"contacts":7},"Centre Hospitalier d'Essos","Yaoundé","Cameroon","CM",{"type":28,"coordinates":57},[58,59],11.51667,3.86667,{"lat":59,"lon":58},{"facility":62,"status":7,"city":53,"state":7,"zip":7,"country":54,"countryCode":55,"cosmosGeoPoint":63,"geoPoint":65,"contacts":7},"Centre Mère Enfant Chantal Biya",{"type":28,"coordinates":64},[58,59],{"lat":59,"lon":58},{"facility":67,"status":7,"city":68,"state":7,"zip":7,"country":69,"countryCode":70,"cosmosGeoPoint":71,"geoPoint":75,"contacts":7},"Pediatric Hospital Nhi Dong 1","Ho Chi Minh City","Vietnam","VN",{"type":28,"coordinates":72},[73,74],106.62965,10.82302,{"lat":74,"lon":73},{"facility":77,"status":7,"city":68,"state":7,"zip":7,"country":69,"countryCode":70,"cosmosGeoPoint":78,"geoPoint":80,"contacts":7},"Pediatric Hospital Nhi Dong 2",{"type":28,"coordinates":79},[73,74],{"lat":74,"lon":73},{"facility":82,"status":7,"city":68,"state":7,"zip":7,"country":69,"countryCode":70,"cosmosGeoPoint":83,"geoPoint":85,"contacts":7},"Pham Ngoc Thach Hospital",{"type":28,"coordinates":84},[73,74],{"lat":74,"lon":73},{"type":87,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[89,91,94,95,97,99,101,103,105,107,109,111,113,115,117],{"name":90,"class":10},"Institut Pasteur, Cambodia",{"name":92,"class":93},"National Pediatric Hospital, Cambodia","UNKNOWN",{"name":44,"class":10},{"name":96,"class":10},"Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam",{"name":98,"class":93},"Pediatric Hospital Nhi Dong 1, Ho Chi Minh City, Vietnam",{"name":100,"class":10},"Number 2 Children's Hospital, Ho Chi Minh City",{"name":102,"class":10},"Hôpital Necker-Enfants Malades",{"name":104,"class":10},"Groupe Hospitalier Pitie-Salpetriere",{"name":106,"class":93},"CHRU Arnaud de Villeveuve, Montpellier, France",{"name":108,"class":93},"IRD, Yaounde, Cameroon",{"name":110,"class":93},"Fondation Chantal Biya,Yaounde, Cameroon",{"name":112,"class":93},"CHU Sourô Sanou, Bobo Dioulasso, Burkina Faso",{"name":114,"class":10},"Centre Muraz",{"name":116,"class":10},"Centre Pasteur du Cameroun",{"name":118,"class":10},"Centre Hospitalier D'essos","100158207","improving-diagnosis-of-tuberculosis-in-hiv-infected-children-in-asia-cambodia-vietnamand-africa-burkina-faso-cameroon-100158207",false,"NCT01331811","Improving Diagnosis of Tuberculosis in HIV Infected Children in Asia (Cambodia, Vietnam)and Africa (Burkina Faso, Cameroon)","Improving Diagnosis of Tuberculosis in HIV Infected Children in Asia (Cambodia, Vietnam) and Africa (Burkina Faso, Cameroon) ANRS 12229 PAANTHER 01 (Pediatric Asian African Network for Tuberculosis and HIV Research)","Inclusion Criteria:\n\n* children aged from 0 to 13 years\n* confirmed HIV infection\n* suspicion of tuberculosis\n* informed consent signed by at least one parent or guardian\n* on ARVs or not\n\nExclusion Criteria:\n\n* history of anti TB treatment started in the past 2 years\n* on going tuberculosis treatment\n* Suspicion of exclusive extra-thoracic tuberculosis","ALL","13 Years",{"count":129,"type":130},441,"ACTUAL","INTERVENTIONAL",[133],"NA","Childhood tuberculosis (TB) accounts for 11% of the total 9 million annual TB cases and the difficulty of its diagnosis is increased in case of HIV infection in children.\n\nThe aim of this study is to improve TB diagnosis in HIV-infected children by developing a new diagnostic algorithm incorporating new tools available such as:\n\n* interferon gamma release assays (IGRAs), as alternative to the tuberculin skin test\n* alternative specimen collection methods such as string test (or Enterotest (R)), nasopharyngeal aspirates and stools samples, as alternatives to gastric aspirate\n* the Xpert MTB\u002FRIF assay",[136,137,138],"HIV","Tuberculosis","Pediatrics",[136,137,140,138,141,142],"Diagnosis","Asia","Africa","COMPLETED","2015-08-04",{"date":146,"type":147},"2015-08-05","ESTIMATED",{"date":149,"type":7},"2011-04",{"date":151,"type":130},"2014-05",{"name":5,"class":6},8]