[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100217567":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":10,"locations":32,"responsibleParty":60,"collaborators":62,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":10,"maxAge":10,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":10,"overallStatus":81,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Maastricht Radiation Oncology","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Diabetes and metformin",null,"Patients with diabetes mellitus treated with metformin only.",{"label":13,"type":10,"description":14,"interventionNames":10},"Insulin-diabetes without metformin","Patients with insulin-dependent diabetes mellitus not treated with metformin",{"label":16,"type":10,"description":17,"interventionNames":10},"Controlgroup","The remaining patients serve as control group.",[19,23,26,29],{"name":20,"affiliation":21,"role":22},"Philippe Lambin, MD, PhD","Maastro Clinic, The Netherlands","PRINCIPAL_INVESTIGATOR",{"name":24,"affiliation":21,"role":25},"Esther Troost","STUDY_CHAIR",{"name":27,"affiliation":28,"role":22},"José Belderbos","NKI Amsterdam",{"name":30,"affiliation":31,"role":22},"Edith Dieleman","Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",[33,45,51],{"facility":34,"status":10,"city":35,"state":10,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":10},"The Netherlands Cancer Institute (NKI)","Amsterdam","1066 CX","Netherlands","NL",{"type":40,"coordinates":41},"Point",[42,43],4.88969,52.37403,{"lat":43,"lon":42},{"facility":46,"status":10,"city":35,"state":10,"zip":47,"country":37,"countryCode":38,"cosmosGeoPoint":48,"geoPoint":50,"contacts":10},"AMC","1105 AZ",{"type":40,"coordinates":49},[42,43],{"lat":43,"lon":42},{"facility":52,"status":10,"city":53,"state":10,"zip":54,"country":37,"countryCode":38,"cosmosGeoPoint":55,"geoPoint":59,"contacts":10},"MAASTRO clinic","Maastricht","6229 ET",{"type":40,"coordinates":56},[57,58],5.68889,50.84833,{"lat":58,"lon":57},{"type":61,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[63,64],{"name":21,"class":6},{"name":31,"class":6},"100217567","influence-of-the-use-of-the-diabetic-drug-metformin-on-the-overall-survival-and-treatment-related-toxicity-in-advanced-stage-non-small-cell-lung-cancer-patients-100217567",false,"NCT02109549","Influence of the Use of the Diabetic Drug Metformin on the Overall Survival and Treatment-related Toxicity in Advanced Stage Non-small Cell Lung Cancer Patients.","Influence of Metformin Use on Treatment Outcome in NSCLC Patients","Metformin","Inclusion Criteria:\n\nAdvanced non-small cell lung cancer patients undergoing primary concurrent radiochemotherapy; patients treated with metformin or insulin will be analyzed as separate cohorts.","ALL",{"count":75,"type":76},70,"ACTUAL","OBSERVATIONAL","There are preliminary data suggesting that patients suffering from non-insulin-dependent diabetes mellitus, treated with metformin, have improved local tumor control. A reduction in the tumor's hypoxia may be responsible for this phenomenon.\n\nTherefore, the aim of this study is to test the hypothesis in three cohorts of patients suffering from advanced stage non-small cell lung cancer and all undergoing concurrent radiochemotherapy: 1. Patients with diabetes mellitus treated with metformin only; 2. Patients with insulin-dependent diabetes mellitus not treated with metformin; 3. The remaining patients serving as controls. Furthermore, tumor and treatment-related parameters will be correlated with overall survival and morbidity.",[80],"Non Small Cell Lung Cancer","COMPLETED","2016-05-31",{"date":84,"type":85},"2016-06-01","ESTIMATED",{"date":87,"type":10},"2014-03",{"date":89,"type":76},"2016-02",{"name":5,"class":6},3]