[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642627":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":42,"responsibleParty":60,"collaborators":31,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":31,"enrollmentInfo":71,"targetDuration":31,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":84,"whyStopped":31,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Louis Pasteur Santé Lorraine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1: Microfractures","ACTIVE_COMPARATOR","For patients randomized to the Microfracture arm, the procedure will be as follows: under arthroscopy, the lesion is prepared by debriding it.\n\nUsing a specific punch, perforations are made perpendicular to the exposed bone surface.\n\nThe technical principles are as follows:\n\n* Perforation depth: approximately 3 to 4 mm, allowing access to the bone marrow,\n* Regular spacing between perforations: 3 to 4 mm,\n* Preservation of the integrity of the interfracture bone bridges to avoid excessive weakening of the bone endplate.",[13],"Procedure: Management of focal cartilage lesions of the knee: micro-fracture",{"label":15,"type":16,"description":17,"interventionNames":18},"Arm 2: Minced Cartilage Implantation (MCI)","EXPERIMENTAL","For patients randomized to the MCI arm, the procedure will be as follows: during surgery, after visualization and debridement of the lesion, cartilage tissue is harvested from a low-weight, and therefore low-stress, area. This cartilage tissue is then fragmented and mixed with PRP (Platelet-Rich Plasma), collected from the patient's blood. Platelets are unique in their high concentration of universal growth factors, and therefore have the ability to promote the healing of almost all organic tissues. This addition of PRP to the fragmented cartilage tissue will thus promote cartilage regeneration and the incorporation of the graft within the lesion. To ensure the graft adheres to the bone tissue, the entire structure is secured biologically (thrombin). Postoperative recovery is standard, with a gradual resumption of walking and activities.",[19],"Procedure: Minced Cartilage Implantation (MCI)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Management of focal cartilage lesions of the knee: micro-fracture","Patients will be randomized in the study to:\n\n* Either the Microfracture arm\n* Or the Minced Cartilage Implantation (MCI) arm",[9],[27],"Management of focal cartilage lesions of the knee: Minced Cartilage Implantation (MCI)",{"type":22,"name":29,"description":24,"armGroupLabels":30,"otherNames":31},"Minced Cartilage Implantation (MCI)",[15],null,[33],{"name":34,"affiliation":5,"role":35},"Frank WEIN","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":31,"email":41},"Charlotte BOUVET","CONTACT","+33383188340","charlotte.bouvet@louispasteursante.fr",[43],{"facility":44,"status":31,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Clinique Louis Pasteur - Louis Pasteur Santé Lorraine","Essey-lès-Nancy","Grand Est","54270","France","FR",{"type":51,"coordinates":52},"Point",[53,54],6.22691,48.705,{"lat":54,"lon":53},[57,59],{"name":34,"role":39,"phone":40,"phoneExt":31,"email":58},"frankwein@yahoo.fr",{"name":34,"role":35,"phone":31,"phoneExt":31,"email":31},{"type":61,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100642627","management-of-focal-cartilage-lesions-of-the-knee-the-benefits-of-an-autograft-procedure-100642627",false,"NCT07641868","Management of Focal Cartilage Lesions of the Knee: The Benefits of an Autograft Procedure","CART-MCI Knee","Inclusion Criteria:\n\n* Male or female, aged over 18 years.\n* Patient who has signed an informed consent form.\n* Patient with focal cartilage lesions of the knee, classified as grade 4 on MRI according to the International Cartilage Repair Society classification (exposure of subchondral bone), regardless of size, and for which surgery is indicated.\n* Be affiliated with or a beneficiary of a social security scheme.\n\nExclusion Criteria:\n\n* Revision knee surgery\n* Body Mass Index (BMI) \\> 27 kg\u002Fm²\n* Joint space narrowing on standard radiographic examination\n* Refusal of consent\n* Patient unable to read, write, or understand French\n* Vulnerable patient according to Article L1121-6 of the French Public Health Code (CSP)\n* Adult patient under guardianship, curatorship, or legal protection\n* Patient unable to give Personally, their consent according to Article L.1121-8 of the French Public Health Code (CSP) or an adult protected by law\n* Pregnant or breastfeeding woman according to Article L1121-5 of the French Public Health Code (CSP)\n* Patient who has already participated in a study within the last 12 months\n* Patient already enrolled in another ongoing clinical trial","ALL","18 Years",{"count":72,"type":73},80,"ESTIMATED","INTERVENTIONAL",[76],"NA","Cartilage is a tissue whose primary function is to transmit and distribute loads when joints are under stress. It acts as a buffer between bones at the joints. Over time, or due to diseases and\u002For trauma, this surface can disappear, leading to pain and limited movement. Cartilage lesions are particularly difficult to treat because cartilage has a limited capacity for regeneration.\n\nWhen cartilage lesions are characterized by a localized defect, several surgical techniques are available to restore cartilage tissue to the affected area.\n\nThe most frequently used surgical technique is bone marrow stimulation, also known as microfracture. The cartilage lesion is debrided, the subchondral bone exposed, and then a punch is used to perforate the subchondral bone, allowing a clot to form within the defect. This clot will proliferate and differentiate into scar tissue. However, this cellular differentiation results in fibrocartilaginous tissue rather than hyaline cartilage, sometimes with disappointing clinical outcomes.\n\nOther techniques for cartilage restoration exist and are used routinely, including more biological techniques such as Minced Cartilage Implantation (MCI). Autologous cartilage is first harvested from around the defect, chopped into very small fragments, and then reimplanted. Cartilage fragmentation activates cell proliferation and migration, followed by the synthesis of an extracellular, cartilaginous matrix. The effectiveness of this fragmentation is increased with fine fragments (\\\u003C0.3 mm). Cell proliferation and activity appear to be stimulated by the systematic addition of PRP (Platelet-Rich Plasma) during the MCI procedure.\n\nThe expected benefit of an MCI approach lies in clinical improvement and better cartilage regeneration (observed on imaging) compared to microfracture.\n\nThe objective is to conduct a controlled, randomized, blinded study (blinded to both the patient and the MRI assessor of the bone graft) to determine the benefit of an MCI approach versus microfracture.",[79],"Focal Cartilage Lesions of the Knee",[81,82,83],"Minced Cartilage Implantation","Micro-fracture","Knee","NOT_YET_RECRUITING","2026-06-09",{"date":87,"type":88},"2026-06-11","ACTUAL",{"date":90,"type":73},"2026-07-01",{"date":92,"type":73},"2030-02-01",{"name":5,"class":6},1]