[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652870":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":42,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":67,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Research Center Borstel","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Patients with extrapulmonary tuberculosis and lymph node swelling",null,[12],"Diagnostic Test: MBLA from routine lymph node aspirate",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DIAGNOSTIC_TEST","MBLA from routine lymph node aspirate","Lymph node aspirates that are collected for routine diagnosis will be split if material is sufficient. A part of the material will be assessed with MBLA for living Mycobacterium tuberculosis.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Thomas Theo Brehm, PD Dr. med.","CONTACT","0049 4537 188 8080","tbrehm@fz-borstel.de",[26],{"facility":27,"status":10,"city":28,"state":10,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Research Center Borstel, Leibniz Lung Center","Borstel","23845","Germany","DE",{"type":33,"coordinates":34},"Point",[35,36],8.96896,52.67034,{"lat":36,"lon":35},[39],{"name":40,"role":22,"phone":23,"phoneExt":10,"email":41},"Niklas Köhler, Dr. med.","studienzentrum@fz-borstel.de",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Thomas Theo Brehm","PD Dr. med.","100652870","mbla-to-differentiate-iris-from-treatment-failure-in-extrapulmonary-tuberculosis-100652870",false,"NCT07778082","MBLA to Differentiate IRIS From Treatment Failure in Extrapulmonary Tuberculosis","The Molecular Bacterial Load Assay (MBLA) to Differentiate Immune Reconstitution Inflammatory Syndrome (IRIS) From Treatment Failure in Extrapulmonary Tuberculosis With Paradoxical Lymph Node Swelling.","MBLA_IRIS","Inclusion Criteria:\n\n* Patient with extrapulmonary tuberculosis\n* Progressive or persistant lymphadenopathy\n* Treatment for tuberculosis for at least 3 months\n* Age ≥ 18 years\n* Capacity to provide informed consent\n* Written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Lack of capacity to provide informed consent\n* Age \\\u003C 18 years","ALL","18 Years",{"count":57,"type":58},100,"ESTIMATED","OBSERVATIONAL","This prospective, multi-center study aims to evaluate the Molecular Bacterial Load Assay (MBLA) on lymph node aspirates as a tool to distinguish between late immune reconstitution inflammatory syndrome (IRIS) and treatment failure in patients with extrapulmonary tuberculosis (TB) presenting with paradoxical lymph node swelling. The study will compare MBLA results with Xpert MTB\u002FRIF and culture findings and assess their correlation with patient outcomes. By quantifying viable M. tuberculosis via 16S rRNA detection, MBLA may offer a rapid, culture-independent method to inform clinical decisions and reduce overtreatment.",[62],"Extrapulmonary Tuberculosis",[64,65,66],"MBLA","IRIS","Lymph node swelling","NOT_YET_RECRUITING","2026-08-17",{"date":70,"type":71},"2026-08-21","ACTUAL",{"date":73,"type":58},"2026-09",{"date":75,"type":58},"2030-09",{"name":5,"class":6},1]