[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100139394":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":10,"locations":28,"responsibleParty":41,"collaborators":10,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":68,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Parkinson",null,"1. without gait impairment\n2. with gait and\u002For balance impairment\n3. with sleep disorders (RBD)\n\nabnormalities of the brainstem and basal ganglia will be studied in relation with parkinsonism, gait and presence of RBD",[13],"Other: 3T and 7T MR imaging",{"label":15,"type":10,"description":16,"interventionNames":17},"PSP","supranuclear palsy patients study the abnormalities with the brainstem and basal ganglia and relation with the observed neurological signs (eye movements, balance, neuropsychological assessment and parkinsonism)",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"controls","age matched controls",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"OTHER","3T and 7T MR imaging","all patients and controls will be explored using a 3T and 7T MR imaging",[15,9,19],[29],{"facility":30,"status":10,"city":31,"state":10,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":10},"Salpetriere Hospital","Paris","75013","France","FR",{"type":36,"coordinates":37},"Point",[38,39],2.3488,48.85341,{"lat":39,"lon":38},{"type":42,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100139394","nucleiparkhigh-field-mr-imaging-7t-and-3t-of-the-brainstem-the-deep-nuclei-and-their-connections-in-the-parkinsonian-syndromes-applications-to-prognosis-pathophysiology-and-improvement-of-therapeutic-strategies-100139394",false,"NCT01085253","Nucleipark:High Field MR Imaging (7T and 3T) of the Brainstem, the Deep Nuclei and Their Connections in the Parkinsonian Syndromes. Applications to Prognosis, Pathophysiology and Improvement of Therapeutic Strategies","High Field MR Imaging (7T and 3T) of the Brainstem, the Deep Nuclei and Their Connections in the Parkinsonian Syndromes. Applications to Prognosis, Pathophysiology and Improvement of Therapeutic Strategies","Nucleipark","Inclusion Criteria:\n\n* PD according to the UK brain bank diagnosis criteria\n* PSP according to the NINDS diagnosis criteria\n\nExclusion Criteria:\n\n* contra indication to MRI",true,"ALL","18 Years","85 Years",{"count":56,"type":57},85,"ACTUAL","OBSERVATIONAL","To date except for the larger striato-pallidal complex, there are no reliable imaging markers of small deep nuclei. Major improvement of the spatial resolution resulting from the use of ultra-high field MRI systems offers new perspectives of imaging of these deep structures.\n\nWe will use the new contrast mechanisms available in data acquired with ultra-high field MR systems (7T) as well as the most recent high angular diffusion imaging techniques in order to characterize the cytoarchitectonics of the deep brain structures and brainstem lesions in parkinsonian syndromes (with special interest in substantia nigra (SN) pathology and nigro-striatal fiber pathways; subthalamic nucleus (STN), red nucleus (RN), oculomotor structures (involved in PSP); pedonculo-pontine nucleus (involved in gait and posture control disorders) and the locus sub-coeruleus area (implicated in sleep disorders) The optimized MR sequences at 7T will be adapted and validated at 3T (on a more clinically oriented MRI approach).\n\nThe clinical goal of the project (via the characterization of deep brain structures) is the detection of new neuroimaging markers of neuronal lesions in PD. These biomarkers will be used to create a diagnostic tool at early stage of the disease that could be correlated to clinical signs such as gait disorders and help to identify predictive factors. In addition, this could contribute to establish an adequate therapeutic strategy (as for example with deep brain stimulation).",[61,62],"Parkinson's Disease","MRI",[64,65,66,67,62],"Parkinson's","supranuclear palsy","substantia nigra","sub thalamic nucleus","COMPLETED","2025-01-21",{"date":71,"type":57},"2025-01-23",{"date":73,"type":57},"2010-04-06",{"date":75,"type":57},"2017-12-31",{"name":5,"class":6},1]