[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568187":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":26,"locations":39,"responsibleParty":53,"collaborators":26,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":26,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":26,"overallStatus":75,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Genentech, Inc.","INDUSTRY",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment A","EXPERIMENTAL","Participants will receive a single oral dose of Digoxin and Rosuvastatin drug cocktail.",[13,14],"Drug: Digoxin","Drug: Rosuvastatin",{"label":16,"type":10,"description":17,"interventionNames":18},"Treatment B","Participants will receive a single dose of Digoxin and Rosuvastatin drug cocktail administered 2 hours after the Divarasib dose on Day 5.",[13,19,14],"Drug: Divarasib",[21,27,31],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Digoxin","Digoxin will be administered together with Rosuvastatin as a drug cocktail as specified for the respective period",[9,16],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Divarasib","Divarasib will be administered in combination with Digoxin and Rosuvastatin as specified for the respective period",[16],{"type":22,"name":32,"description":33,"armGroupLabels":34,"otherNames":26},"Rosuvastatin","Rosuvastatin will be administered together with Digoxin as a drug cocktail as specified for the respective period",[9,16],[36],{"name":37,"affiliation":5,"role":38},"Clinical Trials","STUDY_DIRECTOR",[40],{"facility":41,"status":26,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":26},"Daytona Beach Clinical Rsch Unit","Daytona Beach","Florida","32117","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-81.02283,29.21081,{"lat":51,"lon":50},{"type":54,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100568187","phase-1-a-clinical-trial-to-investigate-the-clinical-drug-drug-interaction-of-divarasib-with-probe-substrates-of-p-glycoprotein-and-breast-cancer-resistance-protein-in-healthy-participants-100568187",false,"NCT06677957","A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants","A Phase I, Open-Label, Two-Period, One-Sequence, Crossover Study in Healthy Subjects to Evaluate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein (Digoxin) and Breast Cancer Resistance Protein (Rosuvastatin)","Inclusion Criteria:\n\n* Males or females of non-childbearing potential\n* Within body mass index (BMI) range of 18.0 to 32.0 kg\u002Fm2, inclusive\n\nExclusion Criteria:\n\n* Significant history or clinical manifestation of any metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal (GI), neurological, or psychiatric disorder\n* History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance, unless approved by the investigator\n* Poor peripheral venous access",true,"ALL","18 Years","60 Years",{"count":67,"type":68},19,"ACTUAL","INTERVENTIONAL",[71],"PHASE1","This is a Phase 1, open-label, two-period, one-sequence, crossover drug-drug interaction study to assess the P-gp and BCRP inhibition potential of divarasib using digoxin and rosuvastatin as probe substrates, respectively, in healthy participants.",[74],"Healthy Participants","COMPLETED","2025-01-02",{"date":78,"type":68},"2025-01-03",{"date":80,"type":68},"2024-11-06",{"date":82,"type":68},"2024-12-30",{"name":5,"class":6},1]