[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100166647":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":53,"centralContacts":11,"locations":57,"responsibleParty":69,"collaborators":11,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":11,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":11,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":95,"whyStopped":11,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Janssen Research & Development, LLC","INDUSTRY",[8,14,18,22,27],{"label":9,"type":10,"description":11,"interventionNames":12},"1","EXPERIMENTAL",null,[13],"Drug: JNJ-38518168 (30 mg)",{"label":15,"type":10,"description":11,"interventionNames":16},"2",[17],"Drug: JNJ-38518168 (10 mg)",{"label":19,"type":10,"description":11,"interventionNames":20},"3",[21],"Drug: JNJ-38518168 (3 mg)",{"label":23,"type":24,"description":11,"interventionNames":25},"4","PLACEBO_COMPARATOR",[26],"Drug: Placebo",{"label":28,"type":10,"description":11,"interventionNames":29},"5",[30],"Drug: Midazolam and JNJ-38518168",[32,37,41,45,49],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"DRUG","JNJ-38518168 (30 mg)","Type=range, unit=mg, number=30, form=tablet, route=oral use, in single and multiple doses for 14 days",[9],{"type":33,"name":38,"description":39,"armGroupLabels":40,"otherNames":11},"JNJ-38518168 (10 mg)","Type=range, unit=mg, number=10, form=tablet, route=oral use, in single and multiple doses for 14 days",[15],{"type":33,"name":42,"description":43,"armGroupLabels":44,"otherNames":11},"JNJ-38518168 (3 mg)","Type=range, unit=mg, number=3, form=tablet, route=oral use, in single and multiple doses for 14 days",[19],{"type":33,"name":46,"description":47,"armGroupLabels":48,"otherNames":11},"Placebo","Form=tablet, route=oral use, for 14 days",[23],{"type":33,"name":50,"description":51,"armGroupLabels":52,"otherNames":11},"Midazolam and JNJ-38518168","Midazolam: Type=exact, unit=mg, number=2.5, form=oral solution; route=oral use, on Days 1 and 15; JNJ-38518168: Type=exact, unit=mg, number=30, form=tablet, route=oral use, once daily from Day 2 through Day 15",[28],[54],{"name":55,"affiliation":5,"role":56},"Janssen Research & Development, LLC & Development, L.L.C., Clinical Trial","STUDY_DIRECTOR",[58],{"facility":11,"status":11,"city":59,"state":60,"zip":11,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":11},"Cypress","California","United States","US",{"type":64,"coordinates":65},"Point",[66,67],-118.03729,33.81696,{"lat":67,"lon":66},{"type":70,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100166647","phase-1-a-study-of-the-safety-and-pharmacokinetics-of-jnj-38518168-in-japanese-and-caucasian-male-participants-and-the-effect-of-jnj-38518168-on-the-blood-levels-of-midazolam-100166647",false,"NCT01442532","A Study of the Safety and Pharmacokinetics of JNJ-38518168 in Japanese and Caucasian Male Participants and the Effect of JNJ-38518168 on the Blood Levels of Midazolam","A Double-Blind, Randomized, Single- and Multiple-Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of JNJ-38518168 in Japanese and Caucasian Healthy Adult Male Subjects and an Open-Label Drug-Drug Interaction Study to Evaluate the Effect of JNJ-38518168 on the Pharmacokinetics of Midazolam, a CYP3A4 Substrate","Inclusion Criteria:\n\nPart 1 only:\n\n* Male, 20 to 55 years of age.\n* Be either:\n* Of Japanese descent who has resided outside of Japan for no more than 5 years and whose parents and maternal and paternal grandparents are Japanese, as determined by participant's verbal report. Japanese participants must have a valid Japanese passport.\n\nor\n\n* A non-Hispanic Caucasian participant who has Caucasian parents as determined by participant's verbal report.\n* Have a body mass index (BMI) of 18.5 kg\u002Fm2 to 25 kg\u002Fm2 for participants of Japanese descent and between 18.5 kg\u002Fm2 and 30 kg\u002Fm2 for Caucasian participants.\n* Have a body weight of not less than 50 kg.\n\nPart 2 only:\n\n* Male, 18 to 55 years of age\n* Have a BMI of 18.5 kg\u002Fm2 to 30 kg\u002Fm2 and have a body weight of not less than 50 kg.\n\nFor both Parts 1 and 2:\n\n* Be otherwise healthy with no clinically significant abnormalities as determined by medical history, physical examination, blood chemistry assessments, hematologic assessments, coagulation and urinalysis, measurement of vital signs, and ECG. If the results of the serum chemistry panel, hematology, or urinalysis are outside the normal reference ranges, the participant may be included only if the investigator judge the abnormalities or deviations from normal to be not clinically significant.\n* If a man is heterosexually active with a woman of childbearing potential, he must be surgically sterile or agree to use a double-barrier method of birth control and to not donate sperm during the study and for 3 months after receiving the last dose of study drug.\n* Have a blood pressure measurement between 90 and 140 mmHg systolic, inclusive, and between 50 and 90 mmHg diastolic, at screening.\n* Have a 12-lead ECG consistent with normal cardiac conduction and function at screening.\n* Non-smoker.\n\nExclusion Criteria:\n\n* History of or current clinically significant medical illness including (but not limited to) cardiac arrhythmias or other cardiac disease, hematologic disease, coagulation disorders (including any abnormal bleeding or blood dyscrasias), lipid abnormalities, significant pulmonary disease, including bronchospastic respiratory disease, diabetes mellitus, renal or hepatic insufficiency, thyroid disease, neurologic or psychiatric disease, infection, or any other illness that the investigator considers should exclude the participant or that could interfere with the interpretation of the study results.\n* History of hypersensitivity to or intolerance of midazolam (Part 2 only)\n* Clinically significant abnormal values for hematology, clinical chemistry, or urinalysis at screening or admission to the study center in Period 1 as deemed appropriate by the investigator.\n* Clinically significant abnormal physical examination, vital signs, or 12-lead ECG at screening or admission to the study center in Period 1 as deemed appropriate by the investigator.\n* Has any known malignancy or a history of malignancy (with the exception of basal cell carcinoma, squamous cell carcinoma in situ of the skin, or squamous cell carcinoma of the skin that has been treated with no evidence of recurrence within 5 years prior to the first administration of study drug).",true,"MALE","18 Years","55 Years",{"count":83,"type":84},94,"ACTUAL","INTERVENTIONAL",[87],"PHASE1","The purpose of Part 1 of this study is to evaluate the safety, tolerability, and pharmacokinetics (\"PK\", how the drug is absorbed in the body, distributed within the body, and how it is removed from the body over time) of JNJ-38518168 in comparison with placebo following single dose and 14 days of consecutive dosing in healthy Japanese and Caucasian adult male participants. Part 2 of this study will evaluate the effect of JNJ-38518168 on the pharmacokinetics of midazolam in healthy participants.",[90],"Healthy Male Volunteer",[92,93,94],"Healthy male volunteer","JNJ-38518168","Midazolam","COMPLETED","2013-03-01",{"date":98,"type":99},"2013-03-04","ESTIMATED",{"date":101,"type":11},"2011-09",{"date":103,"type":84},"2012-07",{"name":5,"class":6},1]