[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100459224":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":54,"centralContacts":42,"locations":58,"responsibleParty":518,"collaborators":42,"id":520,"slug":521,"hasResults":522,"nctId":523,"briefTitle":524,"officialTitle":525,"acronym":42,"eligibilityCriteria":526,"healthyVolunteers":522,"sex":527,"minAge":528,"maxAge":42,"enrollmentInfo":529,"targetDuration":42,"studyType":532,"phases":533,"briefSummary":535,"conditions":536,"keywords":538,"overallStatus":541,"whyStopped":42,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":543,"startDateStruct":545,"completionDateStruct":547,"leadSponsor":550,"locationsCount":551},{"fullName":5,"class":6},"AbbVie","INDUSTRY",[8,16,21,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Part 1: Arm A (Etentamig with Pomalidomide and Dexamethasone)","EXPERIMENTAL","Participants with relapsed or refractory (R\u002FR) multiple myeloma (MM) who meet the criteria outline in the protocol will receive etentamig with Pomalidomide and Dexamethasone.",[13,14,15],"Drug: Etentamig","Drug: Dexamethasone","Drug: Pomalidomide",{"label":17,"type":10,"description":18,"interventionNames":19},"Part 1: Arm B (Etentamig with Lenalidomide and Dexamethasone)","Participants with R\u002FR MM who meet the criteria outline in the protocol will receive etentamig with Lenalidomide and Dexamethasone.",[13,14,20],"Drug: Lenalidomide",{"label":22,"type":10,"description":23,"interventionNames":24},"Part 1: Arm C (Etentamig with Daratumumab and Dexamethasone)","Participants with R\u002FR MM who meet the criteria outline in the protocol will receive etentamig with Daratumumab and Dexamethasone.",[13,14,25],"Drug: Daratumumab",{"label":27,"type":10,"description":28,"interventionNames":29},"Part 2: Arm E (Etentamig with Pomalidomide and Dexamethasone)","Participants with R\u002FR MM who meet the criteria outline in the protocol will receive etentamig with Pomalidomide and Dexamethasone, after 1-3 prior lines of therapy.",[13,14,15],[31,38,43,47,50],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DRUG","Etentamig","Intravenous (IV) Infusion",[9,17,22,27],[37],"ABBV-383",{"type":32,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Dexamethasone","Oral; Tablet or IV Infusion",[9,17,22,27],null,{"type":32,"name":44,"description":45,"armGroupLabels":46,"otherNames":42},"Lenalidomide","Oral; Capsule",[17],{"type":32,"name":48,"description":45,"armGroupLabels":49,"otherNames":42},"Pomalidomide",[9,27],{"type":32,"name":51,"description":52,"armGroupLabels":53,"otherNames":42},"Daratumumab","Subcutaneous Injection (SC)",[22],[55],{"name":56,"affiliation":5,"role":57},"ABBVIE INC.","STUDY_DIRECTOR",[59,72,82,91,101,111,120,130,140,149,155,165,175,185,195,205,217,226,236,240,249,258,268,280,290,299,308,317,329,339,349,358,366,378,383,393,403,413,422,429,438,448,458,470,480,488,494,503,509],{"facility":60,"status":42,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":42},"University of Arkansas for Medical Sciences \u002FID# 243096","Little Rock","Arkansas","72205","United States","US",{"type":67,"coordinates":68},"Point",[69,70],-92.28959,34.74648,{"lat":70,"lon":69},{"facility":73,"status":42,"city":74,"state":75,"zip":76,"country":64,"countryCode":65,"cosmosGeoPoint":77,"geoPoint":81,"contacts":42},"Sylvester Comprehensive Cancer Center \u002FID# 243673","Miami","Florida","33136-1002",{"type":67,"coordinates":78},[79,80],-80.19366,25.77427,{"lat":80,"lon":79},{"facility":83,"status":42,"city":84,"state":75,"zip":85,"country":64,"countryCode":65,"cosmosGeoPoint":86,"geoPoint":90,"contacts":42},"Moffitt Cancer Center \u002FID# 243437","Tampa","33612-9416",{"type":67,"coordinates":87},[88,89],-82.45843,27.94752,{"lat":89,"lon":88},{"facility":92,"status":42,"city":93,"state":94,"zip":95,"country":64,"countryCode":65,"cosmosGeoPoint":96,"geoPoint":100,"contacts":42},"University of Maryland, Baltimore \u002FID# 243679","Baltimore","Maryland","21201",{"type":67,"coordinates":97},[98,99],-76.61219,39.29038,{"lat":99,"lon":98},{"facility":102,"status":42,"city":103,"state":104,"zip":105,"country":64,"countryCode":65,"cosmosGeoPoint":106,"geoPoint":110,"contacts":42},"Dana-Farber Cancer Institute \u002FID# 249529","Boston","Massachusetts","02215",{"type":67,"coordinates":107},[108,109],-71.05977,42.35843,{"lat":109,"lon":108},{"facility":112,"status":42,"city":113,"state":104,"zip":114,"country":64,"countryCode":65,"cosmosGeoPoint":115,"geoPoint":119,"contacts":42},"University of Massachusetts - Worcester \u002FID# 243977","Worcester","01655",{"type":67,"coordinates":116},[117,118],-71.80229,42.26259,{"lat":118,"lon":117},{"facility":121,"status":42,"city":122,"state":123,"zip":124,"country":64,"countryCode":65,"cosmosGeoPoint":125,"geoPoint":129,"contacts":42},"University of Michigan Comprehensive Cancer Center Michigan Medicine \u002FID# 243438","Ann Arbor","Michigan","48109",{"type":67,"coordinates":126},[127,128],-83.74088,42.27756,{"lat":128,"lon":127},{"facility":131,"status":42,"city":132,"state":133,"zip":134,"country":64,"countryCode":65,"cosmosGeoPoint":135,"geoPoint":139,"contacts":42},"The Valley Hospital \u002FID# 243829","Paramus","New Jersey","07652",{"type":67,"coordinates":136},[137,138],-74.07542,40.94454,{"lat":138,"lon":137},{"facility":141,"status":42,"city":142,"state":142,"zip":143,"country":64,"countryCode":65,"cosmosGeoPoint":144,"geoPoint":148,"contacts":42},"Rutenberg Cancer Center \u002FID# 244647","New York","10029-6030",{"type":67,"coordinates":145},[146,147],-74.00597,40.71427,{"lat":147,"lon":146},{"facility":150,"status":42,"city":142,"state":142,"zip":151,"country":64,"countryCode":65,"cosmosGeoPoint":152,"geoPoint":154,"contacts":42},"Memorial Sloan Kettering Cancer Center \u002FID# 244656","10065-6007",{"type":67,"coordinates":153},[146,147],{"lat":147,"lon":146},{"facility":156,"status":42,"city":157,"state":158,"zip":159,"country":64,"countryCode":65,"cosmosGeoPoint":160,"geoPoint":164,"contacts":42},"Atrium Health Levine Cancer Institute \u002FID# 242851","Charlotte","North Carolina","28204",{"type":67,"coordinates":161},[162,163],-80.84313,35.22709,{"lat":163,"lon":162},{"facility":166,"status":42,"city":167,"state":168,"zip":169,"country":64,"countryCode":65,"cosmosGeoPoint":170,"geoPoint":174,"contacts":42},"University of Texas - Southwestern Medical Center \u002FID# 243273","Dallas","Texas","75235",{"type":67,"coordinates":171},[172,173],-96.80667,32.78306,{"lat":173,"lon":172},{"facility":176,"status":42,"city":177,"state":178,"zip":179,"country":64,"countryCode":65,"cosmosGeoPoint":180,"geoPoint":184,"contacts":42},"Huntsman Cancer Institute \u002FID# 242872","Salt Lake City","Utah","84112-5500",{"type":67,"coordinates":181},[182,183],-111.89105,40.76078,{"lat":183,"lon":182},{"facility":186,"status":42,"city":187,"state":188,"zip":189,"country":64,"countryCode":65,"cosmosGeoPoint":190,"geoPoint":194,"contacts":42},"University of Washington \u002FID# 243172","Seattle","Washington","98109",{"type":67,"coordinates":191},[192,193],-122.33207,47.60621,{"lat":193,"lon":192},{"facility":196,"status":42,"city":197,"state":198,"zip":199,"country":64,"countryCode":65,"cosmosGeoPoint":200,"geoPoint":204,"contacts":42},"Froedtert Memorial Lutheran Hospital \u002FID# 242654","Milwaukee","Wisconsin","53226-3522",{"type":67,"coordinates":201},[202,203],-87.90647,43.0389,{"lat":203,"lon":202},{"facility":206,"status":42,"city":207,"state":208,"zip":209,"country":210,"countryCode":211,"cosmosGeoPoint":212,"geoPoint":216,"contacts":42},"St George Hospital - 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IRCCS \u002FID# 242584","Meldola","Forlì-Cesena","47014","Italy","IT",{"type":67,"coordinates":325},[326,327],12.0626,44.12775,{"lat":327,"lon":326},{"facility":330,"status":42,"city":331,"state":332,"zip":333,"country":322,"countryCode":323,"cosmosGeoPoint":334,"geoPoint":338,"contacts":42},"IRCCS Ospedale San Raffaele \u002FID# 242583","Milan","Milano","20132",{"type":67,"coordinates":335},[336,337],9.18951,45.46427,{"lat":337,"lon":336},{"facility":340,"status":42,"city":341,"state":342,"zip":343,"country":322,"countryCode":323,"cosmosGeoPoint":344,"geoPoint":348,"contacts":42},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica \u002FID# 242582","Rome","Roma","00168",{"type":67,"coordinates":345},[346,347],12.51133,41.89193,{"lat":347,"lon":346},{"facility":350,"status":42,"city":351,"state":42,"zip":352,"country":322,"countryCode":323,"cosmosGeoPoint":353,"geoPoint":357,"contacts":42},"IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi \u002FID# 242581","Bologna","40138",{"type":67,"coordinates":354},[355,356],11.33875,44.49381,{"lat":356,"lon":355},{"facility":359,"status":42,"city":331,"state":42,"zip":360,"country":322,"countryCode":323,"cosmosGeoPoint":361,"geoPoint":365,"contacts":42},"Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico \u002FID# 244057","20122",{"type":67,"coordinates":362},[363,364],12.59836,42.78235,{"lat":364,"lon":363},{"facility":367,"status":42,"city":368,"state":369,"zip":370,"country":371,"countryCode":372,"cosmosGeoPoint":373,"geoPoint":377,"contacts":42},"Nagoya City University Hospital \u002FID# 249094","Nagoya","Aichi-ken","467-8602","Japan","JP",{"type":67,"coordinates":374},[375,376],136.90641,35.18147,{"lat":376,"lon":375},{"facility":379,"status":42,"city":380,"state":381,"zip":382,"country":371,"countryCode":372,"cosmosGeoPoint":42,"geoPoint":42,"contacts":42},"National Cancer Center Hospital East \u002FID# 245889","Kashiwa-shi","Chiba","277-8577",{"facility":384,"status":42,"city":385,"state":386,"zip":387,"country":371,"countryCode":372,"cosmosGeoPoint":388,"geoPoint":392,"contacts":42},"Hokkaido University Hospital \u002FID# 245966","Sapporo","Hokkaido","060-8648",{"type":67,"coordinates":389},[390,391],141.35,43.06667,{"lat":391,"lon":390},{"facility":394,"status":42,"city":395,"state":396,"zip":397,"country":371,"countryCode":372,"cosmosGeoPoint":398,"geoPoint":402,"contacts":42},"Kanazawa University Hospital \u002FID# 246812","Kanazawa","Ishikawa-ken","920-8641",{"type":67,"coordinates":399},[400,401],136.61667,36.6,{"lat":401,"lon":400},{"facility":404,"status":42,"city":405,"state":406,"zip":407,"country":371,"countryCode":372,"cosmosGeoPoint":408,"geoPoint":412,"contacts":42},"Okayama Medical Center \u002FID# 245882","Okayama","Okayama-ken","701-1192",{"type":67,"coordinates":409},[410,411],133.93333,34.65,{"lat":411,"lon":410},{"facility":414,"status":42,"city":415,"state":415,"zip":416,"country":371,"countryCode":372,"cosmosGeoPoint":417,"geoPoint":421,"contacts":42},"Yamagata University Hospital \u002FID# 245888","Yamagata","990-9585",{"type":67,"coordinates":418},[419,420],140.36667,38.23333,{"lat":420,"lon":419},{"facility":423,"status":42,"city":424,"state":425,"zip":426,"country":427,"countryCode":428,"cosmosGeoPoint":42,"geoPoint":42,"contacts":42},"Szpital Wojewodzki w Opolu sp. z o.o. \u002FID# 243954","Opole","Lower Silesian Voivodeship","45-372","Poland","PL",{"facility":430,"status":42,"city":431,"state":425,"zip":432,"country":427,"countryCode":428,"cosmosGeoPoint":433,"geoPoint":437,"contacts":42},"Uniwersytecki Szpital Kliniczny We Wroclawiu \u002FID# 243246","Wroclaw","50-556",{"type":67,"coordinates":434},[435,436],17.03006,51.10286,{"lat":436,"lon":435},{"facility":439,"status":42,"city":440,"state":441,"zip":442,"country":427,"countryCode":428,"cosmosGeoPoint":443,"geoPoint":447,"contacts":42},"Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie \u002FID# 243500","Lublin","Lublin Voivodeship","20-081",{"type":67,"coordinates":444},[445,446],22.57009,51.25058,{"lat":446,"lon":445},{"facility":449,"status":42,"city":450,"state":451,"zip":452,"country":427,"countryCode":428,"cosmosGeoPoint":453,"geoPoint":457,"contacts":42},"Uniwersyteckie Centrum Kliniczne \u002FID# 243249","Gdansk","Pomeranian Voivodeship","80-214",{"type":67,"coordinates":454},[455,456],18.64912,54.35227,{"lat":456,"lon":455},{"facility":459,"status":42,"city":460,"state":461,"zip":462,"country":463,"countryCode":464,"cosmosGeoPoint":465,"geoPoint":469,"contacts":42},"Hospital Duran i Reynals \u002FID# 242979","L'Hospitalet de Llobregat","Barcelona","08907","Spain","ES",{"type":67,"coordinates":466},[467,468],2.10028,41.35967,{"lat":468,"lon":467},{"facility":471,"status":42,"city":472,"state":473,"zip":474,"country":463,"countryCode":464,"cosmosGeoPoint":475,"geoPoint":479,"contacts":42},"Clinica Universidad de Navarra - Pamplona \u002FID# 242977","Pamplona","Navarre","31008",{"type":67,"coordinates":476},[477,478],-1.64323,42.81687,{"lat":478,"lon":477},{"facility":481,"status":42,"city":461,"state":42,"zip":482,"country":463,"countryCode":464,"cosmosGeoPoint":483,"geoPoint":487,"contacts":42},"Hospital Universitario Vall de Hebron \u002FID# 242976","08035",{"type":67,"coordinates":484},[485,486],2.15899,41.38879,{"lat":486,"lon":485},{"facility":489,"status":42,"city":461,"state":42,"zip":490,"country":463,"countryCode":464,"cosmosGeoPoint":491,"geoPoint":493,"contacts":42},"Hospital Clinic de Barcelona \u002FID# 242978","08036",{"type":67,"coordinates":492},[485,486],{"lat":486,"lon":485},{"facility":495,"status":42,"city":496,"state":42,"zip":497,"country":463,"countryCode":464,"cosmosGeoPoint":498,"geoPoint":502,"contacts":42},"CLINICA UNIVERSIDAD DE NAVARRA-Madrid \u002FID# 244145","Madrid","28027",{"type":67,"coordinates":499},[500,501],-3.70256,40.4165,{"lat":501,"lon":500},{"facility":504,"status":42,"city":496,"state":42,"zip":505,"country":463,"countryCode":464,"cosmosGeoPoint":506,"geoPoint":508,"contacts":42},"Hospital Universitario 12 de Octubre \u002FID# 242975","28041",{"type":67,"coordinates":507},[500,501],{"lat":501,"lon":500},{"facility":510,"status":42,"city":511,"state":42,"zip":512,"country":463,"countryCode":464,"cosmosGeoPoint":513,"geoPoint":517,"contacts":42},"Hospital Universitario Virgen del Rocio \u002FID# 242974","Seville","41013",{"type":67,"coordinates":514},[515,516],-5.97317,37.38283,{"lat":516,"lon":515},{"type":519,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100459224","phase-1-a-study-to-assess-adverse-events-and-change-in-disease-activity-of-intravenously-iv-infused-etentamig-abbv-383-in-combination-with-anti-cancer-regimens-for-the-treatment-of-adult-participants-with-relapsedrefractory-multiple-myeloma-100459224",false,"NCT05259839","A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed\u002FRefractory Multiple Myeloma","A Dose Escalation and Expansion Study of Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Patients With Newly Diagnosed or Relapsed\u002FRefractory Multiple Myeloma","Inclusion Criteria:\n\n* Eastern Cooperative Oncology Group (ECOG) performance of \\\u003C= 2.\n* Must have confirmed diagnosis of Relapsed\u002FRefractory (R\u002FR) Multiple Myeloma (MM) with documented evidence of progression during or after the participant's last treatment regimen based on the investigator's determination of the International Myeloma Working Group (IMWG) criteria.\n* Must have measurable disease as determined by central lab as outlined in the protocol.\n* Must be naïve to treatment with Etentamig.\n* Must have never received BCMA-targeted therapy. Participants who have received targeted therapy against non-BCMA targets will not be excluded.\n* Arms A, B and C: Participant has received at least 3 prior lines of MM treatment.\n* Arm E: Participant has received 1-3 prior lines of MM treatment.\n\nExclusion Criteria:\n\n* Received a peripheral autologous stem cell transplant (SCT) within 12 weeks, or an allogeneic SCT within 1 year of the first dose of study treatment.\n* Unresolved adverse event (AE)s \\>= Grade 2 (National Cancer Institute \\[NCI\\] Common Terminology Criteria for Adverse Events \\[CTCAE\\] version 5.0) from prior anticancer therapy.\n* Has any of the following conditions:\n\n  * Nonsecretory Multiple Myeloma (MM).\n  * Active Plasma cell leukemia i.e., either 20% of peripheral white blood cells or \\> 2.0 × 10\\^9L circulating plasma cells by standard differential.\n  * Waldenstrom's macroglobulinemia.\n  * Light chain amyloidosis.\n  * Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes (POEMS) syndrome.\n  * Major surgery within 4 weeks prior to first dose or planned study participation.\n  * Acute infections within 14 days prior to first dose of study requiring therapy (antibiotic, antifungal or antiviral).\n  * Uncontrolled diabetes or hypertension within 14 days prior to first dose.\n  * Peripheral neuropathy \\>= Grade 3 or \\>= Grade 2 with pain within 2 weeks prior to first dose.","ALL","18 Years",{"count":530,"type":531},283,"ACTUAL","INTERVENTIONAL",[534],"PHASE1","Multiple myeloma (MM) is a plasma cell disease characterized by the growth of clonal plasma cells in the bone marrow. The purpose of this study is to assess the safety and toxicity of etentamig (ABBV-383) when co-administered with pomalidomide-dexamethasone (Pd), lenalidomide-dexamethasone (Rd), or daratumumab-dexamethasone (Dd), in adult participants with relapsed\u002Frefractory (R\u002FR) multiple myeloma (MM). Adverse events and change in disease activity will be assessed.\n\nEtentamig is an investigational drug being developed for the treatment of R\u002FR MM. Study doctors put the participants in groups called treatment arms. Etentamig co-administered with Pd, Rd, or Dd, will be explored. Each treatment arm receives a different treatment combination depending on stage of the study and eligibility. This study will include a dose escalation phase to determine the best dose of etentamig, followed by a dose expansion phase to confirm the dose. Approximately 320 adult participants with R\u002FR MM will be enrolled in the study in approximately 48 sites worldwide.\n\nParticipants will receive intravenous (IV) etentamig co-administered with oral\u002FIV Pd, oral\u002FIV Rd, or oral\u002FIV\u002Fsubcutaneous (SC) Dd in 28-day cycles.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.",[537],"Relapsed\u002FRefractory Multiple Myeloma",[537,48,39,44,51,539,33,37,540],"Nirogacestat","Cancer","ACTIVE_NOT_RECRUITING","2026-08-13",{"date":544,"type":531},"2026-08-14",{"date":546,"type":531},"2022-10-20",{"date":548,"type":549},"2033-09","ESTIMATED",{"name":5,"class":6},49]