[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100478068":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":21,"centralContacts":21,"locations":26,"responsibleParty":40,"collaborators":42,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":21,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":21,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":71,"whyStopped":21,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"AstraZeneca","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Zibotentan and EE\u002FLNG","EXPERIMENTAL","Participants will receive two tablets of combined oral EE\u002FLNG on Day 1 with PK samples obtained from pre-dose on Day 1 until post-dose on Day 6.\n\nParticipants will receive two capsules of zibotentan orally QD from Day 6 to Day 14. From Day 15 until Day 19 participants will continue to receive two capsules of zibotentan QD administered orally.\n\nOn Day 15, participants will receive two tablets of combined oral EE and LNG with PK samples obtained pre-dose on Day 15 until post-dose (Day 20).",[13,14],"Drug: Zibotentan","Drug: EE\u002FLNG",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DRUG","Zibotentan","Participants will receive two capsules of Zibotentan orally QD from day 6-19.",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"EE\u002FLNG","Participants will receive two tablets of EE and LNG once on Day 1 and Day 15 as a combined oral dose.",[9],[27],{"facility":28,"status":21,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":21},"Research Site","Brooklyn","Maryland","21225","United States","US",{"type":35,"coordinates":36},"Point",[37,38],-76.60219,39.23039,{"lat":38,"lon":37},{"type":41,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR",[43],{"name":44,"class":6},"Parexel","100478068","phase-1-assessing-the-effect-of-multiple-doses-of-zibotentan-on-the-pharmacokinetics-of-single-doses-of-combined-oral-contraceptives-in-healthy-female-participants-of-non-childbearing-potential-100478068",false,"NCT05505162","Assessing the Effect of Multiple Doses of Zibotentan on the Pharmacokinetics of Single Doses of Combined Oral Contraceptives in Healthy Female Participants of Non-childbearing Potential.","An Open-Label, Single-Sequence Study to Assess the Effect of Multiple Doses of Zibotentan on the Pharmacokinetics of Single Doses of Combined Oral Ethinyl Estradiol and Levonorgestrel in Healthy Female Participants of Non-Child-Bearing Potential","Inclusion Criteria:\n\n* Provision of signed and dated, written informed consent prior to any study specific procedures.\n* Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the protocol.\n* Healthy female participants aged 35 to 75 years (inclusive) at Day -1 with suitable veins for cannulation or repeated venipuncture.\n* Females must have a negative pregnancy test at screening and within 24 hours prior to dosing with EE\u002FLNG on Day 1 and Day 15, must not be lactating and must be of non childbearing potential, confirmed at screening by fulfilling one of the following criteria:\n\n  (i) Postmenopausal defined as amenorrhea for at least 12 months or more following cessation of all exogenous hormonal treatments and follicle-stimulating hormone (FSH) levels in the postmenopausal range \\[FSH \\> 40 mIU\u002FmL\\].\n\n(ii) Documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy or bilateral salpingectomy but not tubal ligation.\n\n* Have a body mass index (BMI) between 18.5 and 35 kg\u002Fm2 inclusive at Day -1.\n\nExclusion Criteria:\n\n* History of any clinically significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or influence the results or the participant's ability to participate in the study. Clinically significant diseases or disorders also include, but are not limited to:\n\n  (i) Undiagnosed abnormal uterine bleeding, (ii) Current diagnosis of, or history of breast cancer, which may be hormone sensitive, (iii) Liver tumors, benign or malignant, or liver disease. Acute viral hepatitis, or severe (decompensated) cirrhosis or use of hepatitis C drug combinations containing ombitasvir\u002Fparitaprevir\u002Fritonavir, with or without dasabuvir, due to the potential for alanine aminotransferase (ALT) elevations.\n* Sex hormone therapy within 1 month before study.\n* Current diagnosis or history of arterial or venous thrombosis (eg, deep vein thrombosis (DVT), pulmonary embolism (PE)), or known heredity risk factors (eg, activated protein C resistance), or coronary artery disease.\n* Have inherited or acquired hypercoagulopathy.\n* Participants treated with strong or moderate Cytochrome P450 3A4 (CYP3A4) inhibitors or inducers within 3 months or longer (5 half-lives) prior to first administration of IMP in this study.\n* History or presence of gastrointestinal, hepatic or renal disease, or any other condition known to interfere with absorption, distribution, metabolism, or excretion of drugs.\n* Any laboratory values with the following deviations:\n\n  (i) Alanine aminotransferase \\> Upper limit of normal (ULN) (ii) Aspartate aminotransferase \\> ULN (iii) estimated glomerular filtration rate (eGFR) \\\u003C 60 mL\u002Fmin\u002F1.73 m2 (iv) Creatinine \\> 1.5 ULN (v) White blood cell count \\\u003C 3.5 x 109\u002FL (vi) Hemoglobin \\\u003C lower limit of normal (LLN)\n* Prolonged QT interval (QTcF \\> 470 ms) on ECG at check in into the clinical unit on Day 1 of Treatment Period 1, known congenital long QT syndrome or history of QT prolongation associated with other medications.\n* History of severe allergy\u002Fhypersensitivity or ongoing clinically important allergy\u002Fhypersensitivity, as judged by the investigator or history of hypersensitivity to drugs with a similar chemical structure or class to zibotentan.\n* Participants who have received zibotentan within 1 month prior to Day 1 dosing.\n* Any of the following signs or confirmation of COVID-19 infection:\n\n  (i) Positive COVID-19 test result on check in into the clinical unit on Day -1 and on Day 14.\n\n(ii) Clinical signs and symptoms consistent with COVID-19 (eg, fever, dry cough, dyspnoea, sore throat, and fatigue) on check in into the clinical unit on Day 1.\n\n(iii) Previously hospitalized with COVID-19 infection within the last 3 months prior to the screening visit.",true,"FEMALE","35 Years","75 Years",{"count":57,"type":58},24,"ACTUAL","INTERVENTIONAL",[61],"PHASE1","A study to assess the Pharmacokinetics (PK) of combined oral ethinyl estradiol (EE) and levonorgestrel (LNG) in healthy female participants of non-child-bearing potential, when administered alone and in combination with multiple oral doses of zibotentan.",[64],"Healthy Female Participants",[66,67,18,68,69,70],"Ethinyl estradiol","Levonorgestrel","Chronic Kidney Disease","Non-Child-Bearing Potential","Drug-drug interaction","COMPLETED","2023-02-08",{"date":74,"type":58},"2023-02-09",{"date":76,"type":58},"2022-08-24",{"date":78,"type":58},"2023-01-10",{"name":5,"class":6},1]