[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592768":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":31,"locations":41,"responsibleParty":54,"collaborators":31,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":31,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":31,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":84,"whyStopped":31,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Kafrelsheikh University","OTHER",[8,15,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Scaling and Root Planing with placebo gel","PLACEBO_COMPARATOR","Twenty sites received oral hygiene instruction and scaling\\& root planning with placebo gel.\n\n* Full mouth scaling and root planning were performed in a single visit using hand instruments (scaler and universal curette). This was followed by application of a placebo gel to each studied site.\n* Oral hygiene was performed by twice daily brushing for 2 minutes.",[13,14],"Procedure: Non -surgical treatment and oral hygiene instruction","Drug: local application of placebo gel",{"label":16,"type":17,"description":18,"interventionNames":19},"Scaling& root planning followed by placement of local minocycline and Gengigel® gel","EXPERIMENTAL","Ten patients were treated with scaling\\& root planning followed by placement of local minocycline and Gengigel® gel twice weekly for 3-week 1cc for each pocket.",[13,20],"Drug: Application of minocycline and hyaluronic acid gel.",{"label":22,"type":17,"description":23,"interventionNames":24},"minocycline and Gengigel® gel without scaling and root planing","ten patients were treated with minocycline and Gengigel® topical twice weekly for 3 week 1cc for each pocket without scaling \\&root planning.",[20],[26,32,37],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","Non -surgical treatment and oral hygiene instruction","Scaling and root planing which involves mechanical removal of sup-gingival calculus and necrotic cementum. Tis will be associated with oral hygiene instruction in the form of twice daily brushing for 2 minutes.",[9,16],null,{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":31},"DRUG","Application of minocycline and hyaluronic acid gel.","application of minocycline and Gengigel® topical gel twice weekly for 3-week 1cc for each.",[16,22],{"type":33,"name":38,"description":39,"armGroupLabels":40,"otherNames":31},"local application of placebo gel","The placebo gel will be applied in the periodontal pocket twice weekly for 3-week 1cc for each.",[9],[42],{"facility":43,"status":31,"city":44,"state":45,"zip":31,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":31},"Enas Elgendy","Tanta","Gharbia Governorate","Egypt","EG",{"type":49,"coordinates":50},"Point",[51,52],31.00192,30.78847,{"lat":52,"lon":51},{"type":55,"investigatorFullName":43,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Professor of oral medicine and periodontology","100592768","phase-1-clinical-efficacy-of-local-delivery-of-minocycline-and-hyaluronan-gel-to-treat-periodontitis-in-diabetic-patients-100592768",false,"NCT06997731","Clinical Efficacy of Local Delivery of Minocycline and Hyaluronan Gel to Treat Periodontitis in Diabetic Patients","Local Delivery of Hyaluronan and Minocycline as an Adjunct to Scaling and Root Planing in the Treatment of Stage 2 Grade B Periodontitis in Diabetic Patients: A Randomize Control Clinical Trial With Clinical and Microbiological Study","Inclusion Criteria:\n\n* Patients with stage II, grade B periodontitis (Attachment loss 3-4 mm and probing pocket depth ≤ 5mm) in both sides.\n* Adult controlled diabetic patients (Glycosylated hemoglobin (HbA1C) in controlled diabetics ≤7%)\n* Patients who can maintain good oral hygiene\n\nExclusion Criteria:\n\n* History of systemic diseases other than type II diabetes\n* Smoking\n* Pregnant or lactating women\n* Previous treatment of periodontal diseases in the last six months (People who take anti-inflammatory drugs, antibiotics, or vitamins within the previous 6 month).\n* People who use mouth washes regularly ·\n* Participation in other clinical trials.","ALL","30 Years","60 Years",{"count":68,"type":69},20,"ACTUAL","INTERVENTIONAL",[72],"PHASE1","The goal of this clinical trial is to investigate the local delivery of minocycline gel 2% and 0.2% hyaluronan gel to treat periodontitis in diabetic patients as adjunctive to subgingival instrumentation. The main question it aims to answer is: Does local use of minocycline gel and hyaluronan gel as an adjunct to SRP have resulted in significant additional improvement in the clinical conditions of stage II grade B periodontitis patients when compared with SRP alone?",[75,76],"Periodontitis and Diabetes","Periodontitis",[78,79,80,81,82,83],"minocycline gel","hyaluronan gel","periodontitis","Diabetes mellitus","microbiology","scaling and root palning","COMPLETED","2025-05-22",{"date":87,"type":69},"2025-05-30",{"date":89,"type":69},"2023-05-20",{"date":91,"type":69},"2025-02-01",{"name":5,"class":6},1]