[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100224683":3},{"organization":4,"armGroups":7,"interventions":34,"overallOfficials":54,"centralContacts":23,"locations":57,"responsibleParty":69,"collaborators":23,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":23,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":23,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":23,"overallStatus":91,"whyStopped":23,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Boehringer Ingelheim","INDUSTRY",[8,15,20,26,30],{"label":9,"type":10,"description":11,"interventionNames":12},"BI 1060469 low dose","EXPERIMENTAL","Low-Dose,Tablet,oral administration with 240 ml water,over 10 days",[13,14],"Drug: Placebo","Drug: BI 1060469 low dose",{"label":16,"type":10,"description":17,"interventionNames":18},"BI 1060469 high dose","High-Dose,Tablets,oral administration with 240 ml water, over 10 days",[13,19],"Drug: BI 1060469 high dose",{"label":21,"type":22,"description":23,"interventionNames":24},"Cimetidine","ACTIVE_COMPARATOR",null,[25],"Drug: Cimetidine",{"label":27,"type":22,"description":23,"interventionNames":28},"Naproxen",[29],"Drug: Naproxen",{"label":31,"type":10,"description":17,"interventionNames":32},"BI 1021958",[13,33],"Drug: BI 1021958",[35,40,42,44,46,48,50,52],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":23},"DRUG","Placebo","tablets",[9],{"type":36,"name":21,"description":23,"armGroupLabels":41,"otherNames":23},[21],{"type":36,"name":37,"description":38,"armGroupLabels":43,"otherNames":23},[16],{"type":36,"name":37,"description":38,"armGroupLabels":45,"otherNames":23},[31],{"type":36,"name":16,"description":38,"armGroupLabels":47,"otherNames":23},[16],{"type":36,"name":9,"description":38,"armGroupLabels":49,"otherNames":23},[9],{"type":36,"name":27,"description":23,"armGroupLabels":51,"otherNames":23},[27],{"type":36,"name":31,"description":38,"armGroupLabels":53,"otherNames":23},[31],[55],{"name":5,"affiliation":5,"role":56},"STUDY_CHAIR",[58],{"facility":59,"status":23,"city":60,"state":23,"zip":23,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":23},"1333.43.1 Boehringer Ingelheim Investigational Site","Berlin","Germany","DE",{"type":64,"coordinates":65},"Point",[66,67],13.41053,52.52437,{"lat":67,"lon":66},{"type":70,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100224683","phase-1-effect-of-repeated-doses-of-bi-1060469-and-bi-1021958-on-glomerular-filtration-rate-gfr-in-healthy-volunteers-100224683",false,"NCT02202512","Effect of Repeated Doses of BI 1060469 and BI 1021958 on Glomerular Filtration Rate (GFR) in Healthy Volunteers","Effect of Repeated Oral Doses of BI 1060469, BI 1021958 and Active Controls, Cimetidine and Naproxen, on Measured GFR Via Renal Clearance of Iohexol in Healthy Male Subjects (a Phase I Study; Single-blind, Randomized, Placebo-controlled Within BI Groups and Open-label for the Active Controls)","Inclusion criteria:\n\n* Healthy male subjects according to the investigators assessment, as based on the following criteria: a complete medical history including a physical examination, vital signs (blood pressure (BP), pulse rate (PR)), 12-lead electrocardiogram (ECG), and clinical laboratory tests, including negative test result on occult blood in stool (only for subjects assigned to Naproxen)\n* Age 18 to 45 years (incl.)\n* Body Mass Index (BMI) 18.5 to 29.9 kg\u002Fm2 (incl.)\n* Signed and dated written informed consent prior to admission to the study in accordance with good clinical practice (GCP) and local legislation\n\nExclusion criteria:\n\n* Any finding in the medical examination (including BP, PR or ECG) deviating from normal and judged clinically relevant by the investigator\n* Repeated measurement of systolic blood pressure greater than 140 mm Hg, diastolic blood pressure greater than 90 mm Hg, or pulse rate outside the range of 50 to 90 mmHg\n* Any laboratory value outside the reference range that the investigator considers to be of clinical relevance\n* Serum creatinine laboratory value out of the normal range\n* GFR (Glomerular Filtration Rate) \\\u003C 90 mL\u002F min at screening\n* Urinary toral protein\u002Fcreatinine ratio \\> 0,1 mg protein\u002F mg creatinine\n* Current or history of relevant kidney, urinary tract diseases or abnormalities (i.e. nephrolithiasis, hydronephrosis, acute or chronic nephritis, renal injury, renal failure, infections)\n* Further exclusion criteria may apply",true,"MALE","18 Years","40 Years",{"count":83,"type":84},53,"ACTUAL","INTERVENTIONAL",[87],"PHASE1","Main objective is to investigate the measured glomerular filtration rate (mGFR) as assessed by iohexol clearance in healthy male normovolemic subjects after oral administration of single and repeated doses of BI 1060469, and BI 1021958.\n\nThe secondary objective of this trial is to investigate the glomerular filtration rate (GFR) as assessed by 24 hours creatinine clearance in healthy male normovolemic subjects after oral administration of single and repeated doses of BI 1060469, and BI 1021958.",[90],"Healthy","COMPLETED","2014-12-23",{"date":94,"type":95},"2014-12-24","ESTIMATED",{"date":97,"type":23},"2014-09",{"date":99,"type":84},"2014-12",{"name":5,"class":6},1]