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Multi-center, Randomized Open Label Study to Assess the Systemic Exposure, Effiacy, and Safety of 450 mg Ceritinib Taken With a Low-fat Meal and 600 mg Ceritinib Taken With a Low-fat Meal as Compared With That of 750 mg Ceritinib Taken in the Fasted State in Adult Patients With ALK Rearranged (ALK-positive) Metastatic Non-small Cell Lung Cancer (NSCLC)","Inclusion Criteria:\n\n* Histologically or cytologically confirmed diagnosis of stage IIIB (and is not a candidate for definitive multimodality therapy) or IV ALK-positive NSCLC.\n* Patients may have received one prior treatment regimen with crizotinib (all other ALK inhibitors are excluded).\n* Patients may have received prior chemotherapy, biologic therapy, or other investigational agents. ALK inhibitors other than crizotinib are excluded.\n* Patient has a World Health Organization (WHO) performance status 0-2.\n\nExclusion Criteria:\n\n* Prior treatment with an ALK inhibitor other than crizotinib.\n* History of carcinomatous meningitis.\n* Presence or history of a malignant disease other than an ALK-positive advanced tumor that has been diagnosed and\u002For required therapy within the past 3 years.\n* Clinically significant, uncontrolled heart disease and\u002For recent cardiac event (within 6 months)\n* Patient has history of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention).\n* Patient has other severe, acute, or chronic medical conditions\n* Patient is currently receiving treatment with warfarin sodium (Coumadin®) or any other coumarin-derivative anticoagulants.","ALL","18 Years",{"count":679,"type":680},306,"ACTUAL","INTERVENTIONAL",[683],"PHASE1","A Phase I study to assess the systemic exposure, effiacy, and safety of 450 mg ceritinib taken with a low-fat meal and 600 mg ceritinib taken with a low-fat meal as compared with that of 750 mg ceritinib taken in the fasted state in adult patients with ALK rearranged (ALK-positive) metastatic non-small cell lung cancer (NSCLC)",[686],"Non-Small Cell Lung Cancer",[30,26,688,689,690,691],"Alk+","Alk positive","NSCLC","lung Cancer","COMPLETED","2022-02-07",{"date":695,"type":680},"2022-02-09",{"date":697,"type":680},"2015-04-09",{"date":699,"type":680},"2020-03-06",{"name":33,"class":6},73]