[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100250140":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":28,"centralContacts":32,"locations":33,"responsibleParty":46,"collaborators":32,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":32,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":32,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":70,"whyStopped":32,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"AbbVie","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ABT-450\u002Fr\u002FABT-267 + ABT-333","EXPERIMENTAL","ABT-450\u002Fr\u002FABT-267 will be administered once daily in the morning and ABT-333 will be administered in the morning and evening for 14 days.",[13,14],"Drug: ABT-450\u002Fr\u002FABT-267","Drug: ABT-333",[16,23],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DRUG","ABT-450\u002Fr\u002FABT-267","Tablet",[9],[22],"Paritaprevir\u002FRitonavir\u002FOmbitasvir",{"type":17,"name":24,"description":19,"armGroupLabels":25,"otherNames":26},"ABT-333",[9],[27],"Dasabuvir",[29],{"name":30,"affiliation":5,"role":31},"Yan Luo, MD","STUDY_DIRECTOR",null,[34],{"facility":35,"status":32,"city":36,"state":32,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":32},"Site Reference ID\u002FInvestigator# 137655","Shanghai","200031","China","CN",{"type":41,"coordinates":42},"Point",[43,44],121.45806,31.22222,{"lat":44,"lon":43},{"type":47,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100250140","phase-1-pharmacokinetics-and-safety-of-the-co-administration-of-abt-450ritonavirabt-267-abt-450rabt-267-and-abt-333-in-healthy-chinese-subjects-100250140",false,"NCT02534870","Pharmacokinetics and Safety of the Co-administration of ABT-450\u002FRitonavir\u002FABT-267 (ABT-450\u002Fr\u002FABT-267) and ABT-333 in Healthy Chinese Subjects","Multiple-Dose Pharmacokinetics, Safety and Tolerability of the Co-administration of ABT-450\u002FRitonavir\u002FABT-267 (ABT-450\u002Fr\u002FABT-267) and ABT-333 in Healthy Chinese Subjects","Inclusion Criteria: Participant must be Chinese (i.e., of Chinese ancestry).\n\nIf female, participant must be either postmenopausal for at least 2 years, surgically sterile (bilateral tubal ligation, bilateral oophorectomy or hysterectomy), or practicing at least one of the following methods of birth control with male partner(s): total abstinence from sexual intercourse as the preferred life style of the subject, periodic abstinence is not acceptable; vasectomized partner(s); hormonal contraceptives (oral, parenteral or transdermal) for at least 3 months prior to study drug administration; intrauterine device (IUD); or double-barrier method (condoms, contraceptive sponge, or diaphragm with spermicidal jellies or creams)\n\nHormonal contraceptives, including but not limited to oral, topical, injectable or implantable varieties, may not be used during the study.\n\nIf male, the participant must be surgically sterile or practicing at least 1 of the following methods of contraception, and refrain from sperm donation, from initial study drug administration until 90 days after the last dose of study drug: partner(s) using an IUD; partner(s) using oral, injected, intravaginal, or implanted methods of hormonal contraceptives; participant and\u002For partner(s) using double-barrier method (condoms, contraceptive sponge, diaphragm with spermicidal jellies or creams, or vaginal ring); or total abstinence from sexual intercourse as the preferred life style of the subject; periodic abstinence is not acceptable\n\nBody Mass Index (BMI) is ≥ 18 to \\\u003C 30 kg\u002Fm\\^2.\n\nA condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile, a 12-lead electrocardiogram (ECG) and chest x-ray (CXR).\n\nExclusion Criteria: Use of any medications (prescription and over-the-counter), vitamins and\u002For herbal supplements within the 2-week period prior to the first dose of study drug administration or within 10 half-lives of the respective medication, whichever is longer.\n\nHistory of epilepsy, any clinically significant cardiovascular, respiratory (except mild asthma), renal, hepatic, gastrointestinal, hematologic, neurologic, thyroid, or any uncontrolled medical illness or psychiatric disease or disorder.\n\nClinically significant abnormal ECG: ECG with QT interval corrected for heart rate using Fridericia's correction formula (QTcF) \\> 450 msec in females and \\> 430 msec in males, or ECG with second or third degree atrioventricular block.\n\nPrevious exposure to more than a single dose of ABT-450\u002Fr\u002FABT-267, or ABT-333 within the past 12 weeks, or previous participation in this study.\n\nConsideration by the investigator, for any reason, that the subject is an unsuitable candidate to receive ABT-450, ritonavir, ABT-267, or ABT-333.",true,"ALL","18 Years","45 Years",{"count":60,"type":61},18,"ACTUAL","INTERVENTIONAL",[64],"PHASE1","The purpose of this study is to assess the pharmacokinetics and safety of multiple oral doses of ABT-450\u002Fritonavir\u002FABT-267 and ABT-333 when co-administered under non-fasting conditions in healthy Chinese adult participants.",[67],"Healthy Volunteer",[69],"Volunteer","COMPLETED","2015-10-15",{"date":73,"type":74},"2015-10-19","ESTIMATED",{"date":76,"type":32},"2015-09",{"date":76,"type":61},{"name":5,"class":6},1]