[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100107666":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":43,"centralContacts":11,"locations":47,"responsibleParty":70,"collaborators":11,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":11,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":11,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":11,"overallStatus":93,"whyStopped":94,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Novo Nordisk A\u002FS","INDUSTRY",[8,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":12},"A","EXPERIMENTAL",null,[13,14],"Drug: NNC 0070-0002-0182","Drug: placebo",{"label":16,"type":10,"description":11,"interventionNames":17},"B",[14,13],{"label":19,"type":10,"description":11,"interventionNames":20},"C",[14,13],{"label":22,"type":10,"description":11,"interventionNames":23},"D",[14,13],[25,30,34,37,40],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":11},"DRUG","NNC 0070-0002-0182","4mg initial dose (12 subjects active; 3 subjects placebo); 2mg weekly maintenance dose; for s.c. injection 20mg\u002Fvial",[9],{"type":26,"name":31,"description":32,"armGroupLabels":33,"otherNames":11},"placebo","Placebo for s.c. injection",[9,16,19,22],{"type":26,"name":27,"description":35,"armGroupLabels":36,"otherNames":11},"12mg initial dose (12 subjects active; 3 subjects placebo); 6mg weekly maintenance dose; for s.c. injection 20mg\u002Fvial",[16],{"type":26,"name":27,"description":38,"armGroupLabels":39,"otherNames":11},"32mg initial dose (12 subjects active; 3 subjects placebo); 16mg weekly maintenance dose; for s.c. injection 20mg\u002Fvial",[19],{"type":26,"name":27,"description":41,"armGroupLabels":42,"otherNames":11},"60mg initial dose (12 subjects active; 3 subjects placebo); 30mg weekly maintenance dose; for s.c. injection 20mg\u002Fvial",[22],[44],{"name":45,"affiliation":5,"role":46},"Global Clinical Registry (GCR, 1452)","STUDY_DIRECTOR",[48,61],{"facility":49,"status":11,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":11},"Novo Nordisk Investigational Site","Evansville","Indiana","47710","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-87.55585,37.97476,{"lat":59,"lon":58},{"facility":49,"status":11,"city":62,"state":63,"zip":64,"country":53,"countryCode":54,"cosmosGeoPoint":65,"geoPoint":69,"contacts":11},"Madison","Wisconsin","53704",{"type":56,"coordinates":66},[67,68],-89.40123,43.07305,{"lat":68,"lon":67},{"type":71,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100107666","phase-1-safety-efficacy-tolerability-and-pharmacokinetics-of-nnc-0070-0002-0182-in-overweight-or-obese-male-and-female-volunteers-100107666",false,"NCT00665665","Safety, Efficacy, Tolerability and Pharmacokinetics of NNC 0070-0002-0182 in Overweight or Obese Male and Female Volunteers","Safety, Efficacy, Tolerability and Pharmacokinetics of NNC 0070-0002-0182 in Overweight or Obese Healthy Male and Female Volunteers","Inclusion Criteria:\n\n* Body mass index (BMI) between 30.0-39.0 kg\u002Fm2 (obese)\n* Females who consent to using double barrier method of contraception, are post-menopausal and older than 50 years, or have had total hysterectomy\n\nExclusion Criteria:\n\n* Clinically significant diseases\n* Blood pressure greater than 140\u002F90 mmHg\n* Evidence of depression\n* Recent diet attempts, treatment with diet drugs (within 3 months)\n* Liposuction or other surgery for weight loss within the last year\n* Evidence of eating disorders (bulimia, binge eating)\n* Restricted diets (Kosher, vegetarian)\n* Smoker or history of drug or alcohol abuse\n* Females of childbearing potential: positive pregnancy test",true,"ALL","18 Years","55 Years",{"count":84,"type":85},101,"ACTUAL","INTERVENTIONAL",[88],"PHASE1","This trial will be conducted in the United States of America (USA). The aim of the trial is to investigate whether the drug is safe, well tolerated and to investigate the efficacy of NNC 0070-0002-0182 for the treatment of obesity. The subjects will be treated with drug and placebo. This registration covers the phase 2 part of a combined phase 1\u002Fphase 2 trial (phase 1 part of trial conducted between November 2007 and April 2008).",[91,92],"Metabolism and Nutrition Disorder","Obesity","TERMINATED","The trial is terminated due to re-evaluation of the compound","2016-12-22",{"date":97,"type":98},"2016-12-23","ESTIMATED",{"date":100,"type":11},"2007-11",{"date":102,"type":85},"2008-10",{"name":5,"class":6},2]