[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600434":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":40,"responsibleParty":53,"collaborators":39,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":39,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":39,"studyType":71,"phases":72,"briefSummary":75,"conditions":76,"keywords":39,"overallStatus":82,"whyStopped":39,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Ziauddin University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Neostigmine group ( Group B )","ACTIVE_COMPARATOR","This group will reeive neostigmine ( reversal agent ) at the end of surgery before extubation and then haemodynamic parameters will be observed",[13],"Drug: neostigmine (reversal agent)",{"label":15,"type":16,"description":17,"interventionNames":18},"normal saline group ( Group A )","EXPERIMENTAL","This group will receive normal saline ( no reversal ) at the end of surgery before extubation and then haemodynamic parameters will be observed",[19],"Drug: Placebo drug ( normal saline )",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Placebo drug ( normal saline )","At the end of surgery patients will be given placebo ( normal saline ) instead of neostigmine ( reversal agent of atracurium ) , to observe Heart rate, blood pressure , respiratory rate and oxygen saturation on extubation and post operative airway reflexes and residual paralysis",[15],[27],"Group A",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"neostigmine (reversal agent)","At the end of surgery patients will be given neostigmine ( reversal agenr ) , to observe Heart rate, blood pressure , respiratory rate and oxygen saturation on extubation and post operative airway reflexes and residual paralysis",[9],[33],"Group B",[35],{"name":36,"affiliation":37,"role":38},"Asma Abdus Salam, Consultant anaesthesiology","Ziauddin university clifton","STUDY_CHAIR",null,[41],{"facility":42,"status":39,"city":43,"state":44,"zip":39,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":39},"Ziauddin university","Karachi","Sindh","Pakistan","PK",{"type":48,"coordinates":49},"Point",[50,51],67.0104,24.8608,{"lat":51,"lon":50},{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":39,"oldOrganization":39},"PRINCIPAL_INVESTIGATOR","Fariha Ahmed","Resident anaesthesiology R4","100600434","phase-1-to-observe-haemodynamic-parameters-including-heart-rate-blood-pressure-respiratory-rate--and-oxygen-saturation-with-or-without-giving-reversal-agent-on-extubation-in-patients-receiving-single-shot-of-atracurium--and-to-observe-post-operative-residual-paralysis-and-airway-reflexes-in-pacu-100600434",false,"NCT07097441","To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU.","Effect of the Use of Atracurium With or Without Reversal Agent on Haemodynamic Parameters During Extubation: a Randomized Controlled Trial","Inclusion Criteria:\n\n* American society of anaesthesiology class 1 and 2\n* Surgeries lasting for 60 mins\n* .Surgeries requiring general anaesthesia and tracheal intubation and single intubation dose of atracurium\n\nExclusion Criteria:\n\n* American society of anaesthesiology class 3 and above\n* Any previous reaction to atracurium\n* Active asthma\n* Severe pulmonary cardiac kindney and liver disease",true,"ALL","16 Years","70 Years",{"count":69,"type":70},100,"ACTUAL","INTERVENTIONAL",[73,74],"PHASE1","PHASE2","The goal of this clinical trial is to to observe the haemodynamic parameters including Heart Rate Blood pressure Respiratory rate and Oxygen Saturation with or without giving reversal agent on extubation in patients receiving atracurium on induction , it will also observe post operative residual paralysis respiratory depression and airway reflexes in the post anaesthesia care unit Researchers will compare neostigmine which is the reversal agent and the placebo drug by giving it at the end on surgery before extubation to observe haemodynamic parameters The main questions it aims to answer are Will participants have a stable haemodymaics if no reversal ( neostigmine ) is used during extubation Will it provide a safe extubation and no complications post operatively Participants will be given Either neostigmine or placebo drug at the end of surgery before extubation Will be obseved and monitored for two hours postoperatively in the post anaesthesia care unit Will be monitored for post operative complications like respiratory depression or residual paralysis\n\n.",[77,78,79,80,81],"Tachycardia","Hypertension","Hypoxia","Hyperventilation","Residual Paralysis, Post Anesthesia","COMPLETED","2025-07-24",{"date":85,"type":70},"2025-07-31",{"date":87,"type":70},"2025-03-12",{"date":89,"type":70},"2025-06-04",{"name":5,"class":6},1]