[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100152319":3},{"organization":4,"armGroups":7,"interventions":32,"overallOfficials":55,"centralContacts":11,"locations":59,"responsibleParty":263,"collaborators":265,"id":268,"slug":269,"hasResults":270,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":11,"eligibilityCriteria":274,"healthyVolunteers":275,"sex":276,"minAge":277,"maxAge":11,"enrollmentInfo":278,"targetDuration":11,"studyType":281,"phases":282,"briefSummary":284,"conditions":285,"keywords":11,"overallStatus":287,"whyStopped":288,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":298},{"fullName":5,"class":6},"Pfizer","INDUSTRY",[8,14,17,22,25,28],{"label":9,"type":10,"description":11,"interventionNames":12},"LRV 500mg","EXPERIMENTAL",null,[13],"Drug: lersivirine",{"label":15,"type":10,"description":11,"interventionNames":16},"LRV 750mg +TVD",[13],{"label":18,"type":19,"description":11,"interventionNames":20},"EFV","ACTIVE_COMPARATOR",[21],"Drug: efavirenz",{"label":23,"type":10,"description":11,"interventionNames":24},"LRV 750mg+ DRV\u002Fr + OBT",[13],{"label":26,"type":10,"description":11,"interventionNames":27},"LRV 1000mg +DRV\u002Fr + OBT",[13],{"label":29,"type":19,"description":11,"interventionNames":30},"ETR",[31],"Drug: etravirine",[33,38,41,45,48,51],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":11},"DRUG","lersivirine","Lersivirine 500 mg tablets PO taken once daily + tenofovir DF 300 mg\u002Femtricitabine 200 mg tablets PO once daily",[9],{"type":34,"name":35,"description":39,"armGroupLabels":40,"otherNames":11},"Lersivirine 750 mg tablets PO taken once daily + tenofovir DF 300 mg\u002Femtricitabine 200 mg tablets PO once daily",[15],{"type":34,"name":42,"description":43,"armGroupLabels":44,"otherNames":11},"efavirenz","Efavirenz 600 mg tablets PO taken once daily + tenofovir DF 300 mg\u002Femtricitabine 200 mg tablets PO once daily",[18],{"type":34,"name":35,"description":46,"armGroupLabels":47,"otherNames":11},"Lersivirine 750 mg tablets PO taken once daily + darunavir 600 mg tablets\u002Fritonavir 100 mg tablets or capsules PO taken twice daily + 1 optimized NRTI",[23],{"type":34,"name":35,"description":49,"armGroupLabels":50,"otherNames":11},"Lersivirine 1000 mg PO tablets + darunavir 600 mg tablets\u002Fritonavir 100 mg tablets or capsules PO taken twice daily + 1 optimized NRTI",[26],{"type":34,"name":52,"description":53,"armGroupLabels":54,"otherNames":11},"etravirine","Etravirine 200 mg PO tablets + darunavir 600 mg tablets\u002Fritonavir 100 mg tablets or capsules taken twice daily + 1 optimized NRTI",[29],[56],{"name":57,"affiliation":5,"role":58},"Pfizer CT.gov Call Center","STUDY_DIRECTOR",[60,73,82,93,104,113,118,128,136,146,156,164,175,183,191,200,209,213,223,231,239,250,258],{"facility":61,"status":11,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":11},"Pfizer Investigational Site","Darlinghurst","New South Wales","2010","Australia","AU",{"type":68,"coordinates":69},"Point",[70,71],151.21925,-33.87939,{"lat":71,"lon":70},{"facility":61,"status":11,"city":74,"state":75,"zip":76,"country":65,"countryCode":66,"cosmosGeoPoint":77,"geoPoint":81,"contacts":11},"Melbourne","Victoria","3004",{"type":68,"coordinates":78},[79,80],144.96332,-37.814,{"lat":80,"lon":79},{"facility":61,"status":11,"city":83,"state":84,"zip":85,"country":86,"countryCode":87,"cosmosGeoPoint":88,"geoPoint":92,"contacts":11},"Nova Iguaçu","Rio de Janeiro","26030-381","Brazil","BR",{"type":68,"coordinates":89},[90,91],-43.45111,-22.75917,{"lat":91,"lon":90},{"facility":61,"status":11,"city":94,"state":95,"zip":96,"country":97,"countryCode":98,"cosmosGeoPoint":99,"geoPoint":103,"contacts":11},"Toronto","Ontario","M5G 1K2","Canada","CA",{"type":68,"coordinates":100},[101,102],-79.39864,43.70643,{"lat":102,"lon":101},{"facility":61,"status":11,"city":105,"state":106,"zip":107,"country":97,"countryCode":98,"cosmosGeoPoint":108,"geoPoint":112,"contacts":11},"Montreal","Quebec","H2L 4P9",{"type":68,"coordinates":109},[110,111],-73.58781,45.50884,{"lat":111,"lon":110},{"facility":61,"status":11,"city":105,"state":106,"zip":114,"country":97,"countryCode":98,"cosmosGeoPoint":115,"geoPoint":117,"contacts":11},"H2L 5B1",{"type":68,"coordinates":116},[110,111],{"lat":111,"lon":110},{"facility":61,"status":11,"city":119,"state":11,"zip":120,"country":121,"countryCode":122,"cosmosGeoPoint":123,"geoPoint":127,"contacts":11},"Milan","20127","Italy","IT",{"type":68,"coordinates":124},[125,126],12.59836,42.78235,{"lat":126,"lon":125},{"facility":61,"status":11,"city":129,"state":11,"zip":130,"country":121,"countryCode":122,"cosmosGeoPoint":131,"geoPoint":135,"contacts":11},"Torino","10149",{"type":68,"coordinates":132},[133,134],11.99138,44.88856,{"lat":134,"lon":133},{"facility":61,"status":11,"city":137,"state":137,"zip":138,"country":139,"countryCode":140,"cosmosGeoPoint":141,"geoPoint":145,"contacts":11},"Mexico City","14050","Mexico","MX",{"type":68,"coordinates":142},[143,144],-99.12766,19.42847,{"lat":144,"lon":143},{"facility":61,"status":11,"city":147,"state":11,"zip":148,"country":149,"countryCode":150,"cosmosGeoPoint":151,"geoPoint":155,"contacts":11},"Bydgoszcz","85-030","Poland","PL",{"type":68,"coordinates":152},[153,154],18.00762,53.1235,{"lat":154,"lon":153},{"facility":61,"status":11,"city":157,"state":11,"zip":158,"country":149,"countryCode":150,"cosmosGeoPoint":159,"geoPoint":163,"contacts":11},"Warsaw","01-201",{"type":68,"coordinates":160},[161,162],21.01178,52.22977,{"lat":162,"lon":161},{"facility":61,"status":11,"city":165,"state":166,"zip":167,"country":168,"countryCode":169,"cosmosGeoPoint":170,"geoPoint":174,"contacts":11},"Johannesburg","Gauteng","2193","South Africa","ZA",{"type":68,"coordinates":171},[172,173],28.04363,-26.20227,{"lat":173,"lon":172},{"facility":61,"status":11,"city":176,"state":166,"zip":177,"country":168,"countryCode":169,"cosmosGeoPoint":178,"geoPoint":182,"contacts":11},"Pretoria","0083",{"type":68,"coordinates":179},[180,181],28.18783,-25.74486,{"lat":181,"lon":180},{"facility":61,"status":11,"city":184,"state":166,"zip":185,"country":168,"countryCode":169,"cosmosGeoPoint":186,"geoPoint":190,"contacts":11},"Soweto","2013",{"type":68,"coordinates":187},[188,189],27.85849,-26.26781,{"lat":189,"lon":188},{"facility":61,"status":11,"city":192,"state":193,"zip":194,"country":168,"countryCode":169,"cosmosGeoPoint":195,"geoPoint":199,"contacts":11},"Durban","KwaZulu-Natal","4001",{"type":68,"coordinates":196},[197,198],31.0292,-29.8579,{"lat":198,"lon":197},{"facility":61,"status":11,"city":201,"state":202,"zip":203,"country":168,"countryCode":169,"cosmosGeoPoint":204,"geoPoint":208,"contacts":11},"Cape Town","Western Cape","7925",{"type":68,"coordinates":205},[206,207],18.42322,-33.92584,{"lat":207,"lon":206},{"facility":61,"status":11,"city":176,"state":11,"zip":177,"country":168,"countryCode":169,"cosmosGeoPoint":210,"geoPoint":212,"contacts":11},{"type":68,"coordinates":211},[180,181],{"lat":181,"lon":180},{"facility":61,"status":11,"city":214,"state":11,"zip":215,"country":216,"countryCode":217,"cosmosGeoPoint":218,"geoPoint":222,"contacts":11},"Lugano","6903","Switzerland","CH",{"type":68,"coordinates":219},[220,221],8.96004,46.01008,{"lat":221,"lon":220},{"facility":61,"status":11,"city":224,"state":11,"zip":225,"country":216,"countryCode":217,"cosmosGeoPoint":226,"geoPoint":230,"contacts":11},"Sankt Gallen","9007",{"type":68,"coordinates":227},[228,229],9.37477,47.42391,{"lat":229,"lon":228},{"facility":61,"status":11,"city":232,"state":11,"zip":233,"country":216,"countryCode":217,"cosmosGeoPoint":234,"geoPoint":238,"contacts":11},"Zurich","8091",{"type":68,"coordinates":235},[236,237],8.55,47.36667,{"lat":237,"lon":236},{"facility":61,"status":11,"city":240,"state":241,"zip":242,"country":243,"countryCode":244,"cosmosGeoPoint":245,"geoPoint":249,"contacts":11},"Brighton","East Sussex","BN2 1ES","United Kingdom","UK",{"type":68,"coordinates":246},[247,248],-0.13947,50.82838,{"lat":248,"lon":247},{"facility":61,"status":11,"city":251,"state":11,"zip":252,"country":243,"countryCode":244,"cosmosGeoPoint":253,"geoPoint":257,"contacts":11},"London","NW3 2QG",{"type":68,"coordinates":254},[255,256],-0.12574,51.50853,{"lat":256,"lon":255},{"facility":61,"status":11,"city":251,"state":11,"zip":259,"country":243,"countryCode":244,"cosmosGeoPoint":260,"geoPoint":262,"contacts":11},"SW10 9NH",{"type":68,"coordinates":261},[255,256],{"lat":256,"lon":255},{"type":264,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[266],{"name":267,"class":6},"ViiV Healthcare","100152319","phase-2-a-long-term-safety-study-of-lersivirine-for-the-treatment-of-hiv-1-infection-in-subjects-who-have-completed-treatment-with-lersivirine-in-studies-a5271015-and-a5271022-100152319",true,"NCT01254656","A Long Term Safety Study Of Lersivirine For The Treatment Of HIV-1 Infection In Subjects Who Have Completed Treatment With Lersivirine In Studies A5271015 And A5271022","A Long Term Open-Label Extension Study Of Lersivirine For The Treatment Of HIV-1 Infection","Inclusion Criteria:\n\n* Patients must complete of 96 weeks of treatment with lersivirine (or comparator where required by local regulation) in one of the parent protocols (A5271015 or A5271022).\n* Patients must have had a viral load less than 50 copies\u002FmL at Week 84 of the parent protocol.\n* For women who can have children, a negative urine pregnancy test at the Day 1 visit.\n\nExclusion Criteria:\n\n* Patients with any Grade 4 Division of AIDS toxicity (except for lipids and asymptomatic glucose elevations will not be included in this trial.\n* Patients being treated with another investigational product or in another clinical trial, except the lersivirine parent protocols will not be included in this trial.",false,"ALL","18 Years",{"count":279,"type":280},108,"ACTUAL","INTERVENTIONAL",[283],"PHASE2","This is a study to assess long-term safety and efficacy of lersivirine in patients who have completed 96 weeks of treatment with lersivirine in studies A5271015 and A5271022.",[286],"HIV-1","TERMINATED","See termination reason in detailed description.","2014-05-27",{"date":291,"type":292},"2014-06-09","ESTIMATED",{"date":294,"type":11},"2011-02",{"date":296,"type":280},"2013-04",{"name":5,"class":6},23]