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275479","Nagoya","Aichi-ken","464-8681","Japan","JP",{"type":51,"coordinates":357},[358,359],136.90641,35.18147,{"lat":359,"lon":358},{"facility":362,"status":44,"city":363,"state":364,"zip":365,"country":354,"countryCode":355,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"National Cancer Center Hospital East \u002FID# 273614","Kashiwa-shi","Chiba","277-8577",{"facility":367,"status":44,"city":368,"state":368,"zip":369,"country":354,"countryCode":355,"cosmosGeoPoint":370,"geoPoint":374,"contacts":26},"Kyushu University Hospital \u002FID# 273710","Fukuoka","812-8582",{"type":51,"coordinates":371},[372,373],130.41667,33.6,{"lat":373,"lon":372},{"facility":376,"status":44,"city":377,"state":377,"zip":378,"country":354,"countryCode":355,"cosmosGeoPoint":379,"geoPoint":383,"contacts":26},"Gifu University Hospital \u002FID# 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274306","Osaka","540-0006",{"type":51,"coordinates":409},[410,411],135.50107,34.69379,{"lat":411,"lon":410},{"facility":414,"status":44,"city":415,"state":416,"zip":417,"country":354,"countryCode":355,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"Shizuoka Cancer Center \u002FID# 275480","Sunto-gun","Shizuoka","411-8777",{"facility":419,"status":44,"city":420,"state":421,"zip":422,"country":423,"countryCode":26,"cosmosGeoPoint":424,"geoPoint":428,"contacts":26},"Seoul National University Hospital \u002FID# 274451","Seoul","Seoul Teugbyeolsi","03080","South Korea",{"type":51,"coordinates":425},[426,427],126.9784,37.566,{"lat":427,"lon":426},{"facility":430,"status":44,"city":420,"state":421,"zip":431,"country":423,"countryCode":26,"cosmosGeoPoint":432,"geoPoint":434,"contacts":26},"Asan Medical Center \u002FID# 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273718","Madrid","28046",{"type":51,"coordinates":458},[459,460],-3.70256,40.4165,{"lat":460,"lon":459},{"facility":463,"status":44,"city":464,"state":26,"zip":465,"country":446,"countryCode":447,"cosmosGeoPoint":466,"geoPoint":470,"contacts":26},"Hospital Universitario de Salamanca \u002FID# 273719","Salamanca","37007",{"type":51,"coordinates":467},[468,469],-5.66388,40.96882,{"lat":469,"lon":468},{"facility":472,"status":44,"city":473,"state":26,"zip":474,"country":475,"countryCode":476,"cosmosGeoPoint":477,"geoPoint":481,"contacts":26},"Kaohsiung Medical University Chung-Ho Memorial Hospital \u002FID# 273745","Kaohsiung City","807","Taiwan","TW",{"type":51,"coordinates":478},[479,480],120.31333,22.61626,{"lat":480,"lon":479},{"facility":483,"status":44,"city":484,"state":26,"zip":485,"country":475,"countryCode":476,"cosmosGeoPoint":486,"geoPoint":490,"contacts":26},"China Medical University Hospital \u002FID# 274644","Taichung","40447",{"type":51,"coordinates":487},[488,489],120.6839,24.1469,{"lat":489,"lon":488},{"facility":492,"status":44,"city":493,"state":26,"zip":494,"country":475,"countryCode":476,"cosmosGeoPoint":495,"geoPoint":499,"contacts":26},"National Taiwan University Hospital \u002FID# 273580","Taipei","100",{"type":51,"coordinates":496},[497,498],121.52639,25.05306,{"lat":498,"lon":497},{"type":501,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100594733","phase-2-a-study-to-assess-adverse-events-and-change-in-disease-activity-in-adult-participants-receiving-intravenously-infused-telisotuzumab-adizutecan-alone-or-with-standard-of-care-in-participants-with-post-adjuvant-circulating-tumor-dna-positive-colorectal-cancer-and-no-radiographic-evidence-of-disease-100594733",false,"NCT07023289","A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease","A Phase 2, Randomized, Open-Label Study Comparing Telisotuzumab Adizutecan (ABBV-400) Monotherapy to the Current Standard of Care in Subjects With Post Adjuvant ctDNA Positive Colorectal Cancer and No Radiographic Evidence of Disease (NED)","Inclusion Criteria:\n\n* Has histologically or cytologically confirmed adenocarcinoma of the colon or rectum.\n* Surgical tumor material should be available for Signatera ctDNA personalized panel design.\n* Must have received at least 3 months of platinum-based doublet adjuvant and\u002For neoadjuvant chemotherapy but may not have been treated with topoisomerase inhibitors as part of adjuvant therapy.\n* Has no radiographic evidence of disease (NED) confirmed by chest, abdominal, and pelvic computed tomography (CT) scans within 6 weeks prior to Cycle 1 Day 1 (C1D1) dosing.\n* Circulating tumor deoxyribonucleic acid (ctDNA) positive within 1 year either after the end of adjuvant therapy or after tumor resection in subjects who are receiving neoadjuvant therapy and begin treatment within 6 weeks after ctDNA positivity is confirmed (reported).\n* For participants with rectal cancer a total of at least 3 months of perioperative and\u002For adjuvant platinum-based doublet must have been administered. Please note that short course radiation or long-course chemoradiation does not count towards this 3-month minimum of platinum-doublet perioperative and\u002For adjuvant therapy.\n\nExclusion Criteria:\n\n* No availability of surgical tissue sample.\n* History of interstitial lung disease (ILD) or pneumonitis that required treatment with systemic steroids, or any evidence of active ILD or pneumonitis on screening chest computed tomography (CT) scan.","ALL","18 Years",{"count":512,"type":513},140,"ESTIMATED","INTERVENTIONAL",[516],"PHASE2","Colorectal cancer (CRC) is the third most common type of cancer diagnosed worldwide. The purpose of this study is to assess change in disease activity when telisotuzumab adizutecan is given alone compared to standard of care (SOC) given alone.\n\nTelisotuzumab adizutecan is an investigational drug being developed for the treatment of CRC. This study will be divided into two groups called treatment arms. In arm 1 participants will receive telisotuzumab adizutecan alone. In arm 2 participants will receive SOC alone. Approximately 140 adult participants with CRC will be enrolled in the study in 45 sites worldwide.\n\nIn arm 1, participants will receive intravenous (IV) doses of telisotuzumab adizutecan alone. In arm 2 Participants will receive SOC alone. The study will run for a duration of approximately 51 months.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.",[519],"Colorectal Cancer",[519,23,521,522],"ABBV-400, Stand of Care","Cancer","2026-07-08",{"date":525,"type":526},"2026-07-10","ACTUAL",{"date":528,"type":526},"2025-09-02",{"date":530,"type":513},"2029-11",{"name":5,"class":6},48]