[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100303212":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":24,"locations":34,"responsibleParty":840,"collaborators":24,"id":842,"slug":843,"hasResults":844,"nctId":845,"briefTitle":846,"officialTitle":847,"acronym":24,"eligibilityCriteria":848,"healthyVolunteers":849,"sex":850,"minAge":851,"maxAge":852,"enrollmentInfo":853,"targetDuration":24,"studyType":856,"phases":857,"briefSummary":859,"conditions":860,"keywords":24,"overallStatus":862,"whyStopped":24,"lastUpdateSubmitDate":863,"lastUpdatePostDateStruct":864,"startDateStruct":866,"completionDateStruct":868,"leadSponsor":870,"locationsCount":871},{"fullName":5,"class":6},"Janssen Research & Development, LLC","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","Participants will receive 2 placebo capsules matching JNJ-42847922 once daily orally from Day 1 to Day 41 (Week 6).",[13],"Drug: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"JNJ-42847922","EXPERIMENTAL","Participants will receive 2 capsules of JNJ-42847922 once daily orally from Day 1 to Day 41 (Week 6).",[19],"Drug: JNJ-42847922",[21,25],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"DRUG",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":26,"otherNames":27},[15],[28,29],"MIN-202;","Seltorexant",[31],{"name":32,"affiliation":5,"role":33},"Janssen Research & Development, LLC Clinical Trial","STUDY_DIRECTOR",[35,48,57,66,75,84,93,102,111,121,130,139,148,157,166,175,183,189,199,205,211,217,227,233,242,251,260,270,276,286,295,305,315,325,336,345,354,363,372,381,390,396,402,408,417,421,430,439,450,459,468,477,488,497,506,515,524,535,544,553,562,573,582,586,590,599,603,612,616,620,624,628,632,636,638,641,645,648,651,662,671,676,682,688,697,706,715,721,730,734,743,752,763,772,781,790,799,808,817,826,835],{"facility":36,"status":24,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":24},"California Pharmaceutical Research Institute, Inc.","Anaheim","California","92804","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-117.9145,33.83529,{"lat":46,"lon":45},{"facility":49,"status":24,"city":50,"state":38,"zip":51,"country":40,"countryCode":41,"cosmosGeoPoint":52,"geoPoint":56,"contacts":24},"Catalina Research Institute","Chino","91710",{"type":43,"coordinates":53},[54,55],-117.68894,34.01223,{"lat":55,"lon":54},{"facility":58,"status":24,"city":59,"state":38,"zip":60,"country":40,"countryCode":41,"cosmosGeoPoint":61,"geoPoint":65,"contacts":24},"Synergy Clinical Research Center Of Escondido","Lemon Grove","91945",{"type":43,"coordinates":62},[63,64],-117.03142,32.74255,{"lat":64,"lon":63},{"facility":67,"status":24,"city":68,"state":38,"zip":69,"country":40,"countryCode":41,"cosmosGeoPoint":70,"geoPoint":74,"contacts":24},"Asclepes Research","Panorama City","91402",{"type":43,"coordinates":71},[72,73],-118.44981,34.22473,{"lat":73,"lon":72},{"facility":76,"status":24,"city":77,"state":38,"zip":78,"country":40,"countryCode":41,"cosmosGeoPoint":79,"geoPoint":83,"contacts":24},"Sharp Mesa Vista Hospital","San Diego","92123",{"type":43,"coordinates":80},[81,82],-117.16472,32.71571,{"lat":82,"lon":81},{"facility":85,"status":24,"city":86,"state":38,"zip":87,"country":40,"countryCode":41,"cosmosGeoPoint":88,"geoPoint":92,"contacts":24},"SF-Care, Inc","San Rafael","94901",{"type":43,"coordinates":89},[90,91],-122.53109,37.97353,{"lat":91,"lon":90},{"facility":94,"status":24,"city":95,"state":38,"zip":96,"country":40,"countryCode":41,"cosmosGeoPoint":97,"geoPoint":101,"contacts":24},"Collaborative NeuroScience Network","Torrance","90502",{"type":43,"coordinates":98},[99,100],-118.34063,33.83585,{"lat":100,"lon":99},{"facility":103,"status":24,"city":104,"state":38,"zip":105,"country":40,"countryCode":41,"cosmosGeoPoint":106,"geoPoint":110,"contacts":24},"Elite Clinical Trials","Wildomar","92595-7007",{"type":43,"coordinates":107},[108,109],-117.28004,33.59891,{"lat":109,"lon":108},{"facility":112,"status":24,"city":113,"state":114,"zip":115,"country":40,"countryCode":41,"cosmosGeoPoint":116,"geoPoint":120,"contacts":24},"Sarkis Clinical Trials","Gainesville","Florida","32607",{"type":43,"coordinates":117},[118,119],-82.32483,29.65163,{"lat":119,"lon":118},{"facility":122,"status":24,"city":123,"state":114,"zip":124,"country":40,"countryCode":41,"cosmosGeoPoint":125,"geoPoint":129,"contacts":24},"Velocity Clinical Research, Hallandale Beach","Hallandale","33009",{"type":43,"coordinates":126},[127,128],-80.14838,25.9812,{"lat":128,"lon":127},{"facility":131,"status":24,"city":132,"state":114,"zip":133,"country":40,"countryCode":41,"cosmosGeoPoint":134,"geoPoint":138,"contacts":24},"Clinical NeuroScience Solutions Inc","Jacksonville","32256",{"type":43,"coordinates":135},[136,137],-81.65565,30.33218,{"lat":137,"lon":136},{"facility":140,"status":24,"city":141,"state":114,"zip":142,"country":40,"countryCode":41,"cosmosGeoPoint":143,"geoPoint":147,"contacts":24},"Innovative Clinical Research Inc","Lauderhill","33319",{"type":43,"coordinates":144},[145,146],-80.21338,26.14036,{"lat":146,"lon":145},{"facility":149,"status":24,"city":150,"state":114,"zip":151,"country":40,"countryCode":41,"cosmosGeoPoint":152,"geoPoint":156,"contacts":24},"Qps-Mra, Llc","Miami","33143",{"type":43,"coordinates":153},[154,155],-80.19366,25.77427,{"lat":155,"lon":154},{"facility":158,"status":24,"city":159,"state":114,"zip":160,"country":40,"countryCode":41,"cosmosGeoPoint":161,"geoPoint":165,"contacts":24},"Galiz Research","Miami Springs","33166",{"type":43,"coordinates":162},[163,164],-80.2895,25.82232,{"lat":164,"lon":163},{"facility":167,"status":24,"city":168,"state":114,"zip":169,"country":40,"countryCode":41,"cosmosGeoPoint":170,"geoPoint":174,"contacts":24},"Behavioral Clinical Research , Inc","North Miami","33162",{"type":43,"coordinates":171},[172,173],-80.18671,25.89009,{"lat":173,"lon":172},{"facility":131,"status":24,"city":176,"state":114,"zip":177,"country":40,"countryCode":41,"cosmosGeoPoint":178,"geoPoint":182,"contacts":24},"Orlando","32801",{"type":43,"coordinates":179},[180,181],-81.37924,28.53834,{"lat":181,"lon":180},{"facility":184,"status":24,"city":176,"state":114,"zip":185,"country":40,"countryCode":41,"cosmosGeoPoint":186,"geoPoint":188,"contacts":24},"Compass Research LLC","32806",{"type":43,"coordinates":187},[180,181],{"lat":181,"lon":180},{"facility":190,"status":24,"city":191,"state":192,"zip":193,"country":40,"countryCode":41,"cosmosGeoPoint":194,"geoPoint":198,"contacts":24},"Emory University","Atlanta","Georgia","30022",{"type":43,"coordinates":195},[196,197],-84.38798,33.749,{"lat":197,"lon":196},{"facility":200,"status":24,"city":191,"state":192,"zip":201,"country":40,"countryCode":41,"cosmosGeoPoint":202,"geoPoint":204,"contacts":24},"Radiant Research, Inc.","30328",{"type":43,"coordinates":203},[196,197],{"lat":197,"lon":196},{"facility":206,"status":24,"city":191,"state":192,"zip":207,"country":40,"countryCode":41,"cosmosGeoPoint":208,"geoPoint":210,"contacts":24},"Atlanta Center for Medical Research","30331",{"type":43,"coordinates":209},[196,197],{"lat":197,"lon":196},{"facility":212,"status":24,"city":191,"state":192,"zip":213,"country":40,"countryCode":41,"cosmosGeoPoint":214,"geoPoint":216,"contacts":24},"NeuroTrials Research, Inc.","30342",{"type":43,"coordinates":215},[196,197],{"lat":197,"lon":196},{"facility":218,"status":24,"city":219,"state":220,"zip":221,"country":40,"countryCode":41,"cosmosGeoPoint":222,"geoPoint":226,"contacts":24},"Chicago Research Center","Chicago","Illinois","60634",{"type":43,"coordinates":223},[224,225],-87.65005,41.85003,{"lat":225,"lon":224},{"facility":228,"status":24,"city":219,"state":220,"zip":229,"country":40,"countryCode":41,"cosmosGeoPoint":230,"geoPoint":232,"contacts":24},"Great Lakes Clinical Trials","60640",{"type":43,"coordinates":231},[224,225],{"lat":225,"lon":224},{"facility":234,"status":24,"city":235,"state":220,"zip":236,"country":40,"countryCode":41,"cosmosGeoPoint":237,"geoPoint":241,"contacts":24},"Joliet Center for Clinical Research","Joliet","60435",{"type":43,"coordinates":238},[239,240],-88.0834,41.52519,{"lat":240,"lon":239},{"facility":243,"status":24,"city":244,"state":244,"zip":245,"country":40,"countryCode":41,"cosmosGeoPoint":246,"geoPoint":250,"contacts":24},"Clinilabs","New York","10019",{"type":43,"coordinates":247},[248,249],-74.00597,40.71427,{"lat":249,"lon":248},{"facility":252,"status":24,"city":253,"state":244,"zip":254,"country":40,"countryCode":41,"cosmosGeoPoint":255,"geoPoint":259,"contacts":24},"Richmond Behavioral Associates","Staten Island","10312",{"type":43,"coordinates":256},[257,258],-74.13986,40.56233,{"lat":258,"lon":257},{"facility":261,"status":24,"city":262,"state":263,"zip":264,"country":40,"countryCode":41,"cosmosGeoPoint":265,"geoPoint":269,"contacts":24},"Clinical Trials of America","Winston-Salem","North Carolina","27103",{"type":43,"coordinates":266},[267,268],-80.24422,36.09986,{"lat":268,"lon":267},{"facility":271,"status":24,"city":262,"state":263,"zip":272,"country":40,"countryCode":41,"cosmosGeoPoint":273,"geoPoint":275,"contacts":24},"Wake Forest Baptist Medical Center","27157",{"type":43,"coordinates":274},[267,268],{"lat":268,"lon":267},{"facility":277,"status":24,"city":278,"state":279,"zip":280,"country":40,"countryCode":41,"cosmosGeoPoint":281,"geoPoint":285,"contacts":24},"Neuro Behavioral Clinical Research","Canton","Ohio","44708",{"type":43,"coordinates":282},[283,284],-81.37845,40.79895,{"lat":284,"lon":283},{"facility":287,"status":24,"city":288,"state":279,"zip":289,"country":40,"countryCode":41,"cosmosGeoPoint":290,"geoPoint":294,"contacts":24},"Midwest Clinical Research Center","Dayton","45417",{"type":43,"coordinates":291},[292,293],-84.19161,39.75895,{"lat":293,"lon":292},{"facility":296,"status":24,"city":297,"state":298,"zip":299,"country":40,"countryCode":41,"cosmosGeoPoint":300,"geoPoint":304,"contacts":24},"Suburban Research Associates","Media","Pennsylvania","19063",{"type":43,"coordinates":301},[302,303],-75.38769,39.91678,{"lat":303,"lon":302},{"facility":306,"status":24,"city":307,"state":308,"zip":309,"country":40,"countryCode":41,"cosmosGeoPoint":310,"geoPoint":314,"contacts":24},"Family Psychiatry of The Woodlands","The Woodlands","Texas","77381",{"type":43,"coordinates":311},[312,313],-95.48938,30.15799,{"lat":313,"lon":312},{"facility":316,"status":24,"city":317,"state":318,"zip":319,"country":40,"countryCode":41,"cosmosGeoPoint":320,"geoPoint":324,"contacts":24},"Core Clinical Research","Everett","Washington","98201",{"type":43,"coordinates":321},[322,323],-122.20208,47.97898,{"lat":323,"lon":322},{"facility":326,"status":24,"city":327,"state":24,"zip":328,"country":329,"countryCode":330,"cosmosGeoPoint":331,"geoPoint":335,"contacts":24},"Mental Health Center Prof. Dr. Ivan Temkov","Burgas","8000","Bulgaria","BG",{"type":43,"coordinates":332},[333,334],27.46886,42.50651,{"lat":334,"lon":333},{"facility":337,"status":24,"city":338,"state":24,"zip":339,"country":329,"countryCode":330,"cosmosGeoPoint":340,"geoPoint":344,"contacts":24},"State Psychiatric Hospital Kardzhali","Kardzhali","6600",{"type":43,"coordinates":341},[342,343],25.36578,41.64502,{"lat":343,"lon":342},{"facility":346,"status":24,"city":347,"state":24,"zip":348,"country":329,"countryCode":330,"cosmosGeoPoint":349,"geoPoint":353,"contacts":24},"State Psychiatric Hospital - Lovech","Lovech","5500",{"type":43,"coordinates":350},[351,352],24.71763,43.13227,{"lat":352,"lon":351},{"facility":355,"status":24,"city":356,"state":24,"zip":357,"country":329,"countryCode":330,"cosmosGeoPoint":358,"geoPoint":362,"contacts":24},"UMHAT 'Dr. Georgi Stranski', EAD","Pleven","5800",{"type":43,"coordinates":359},[360,361],24.61666,43.41791,{"lat":361,"lon":360},{"facility":364,"status":24,"city":365,"state":24,"zip":366,"country":329,"countryCode":330,"cosmosGeoPoint":367,"geoPoint":371,"contacts":24},"MC 'Hipokrat - N', EOOD","Plovdiv","4002",{"type":43,"coordinates":368},[369,370],24.75001,42.15387,{"lat":370,"lon":369},{"facility":373,"status":24,"city":374,"state":24,"zip":375,"country":329,"countryCode":330,"cosmosGeoPoint":376,"geoPoint":380,"contacts":24},"Mental Health Center - Rousse","Rousse","7003",{"type":43,"coordinates":377},[378,379],25.9534,43.84872,{"lat":379,"lon":378},{"facility":382,"status":24,"city":383,"state":24,"zip":384,"country":329,"countryCode":330,"cosmosGeoPoint":385,"geoPoint":389,"contacts":24},"MHC - Sofia, EOOD","Sofia","1202",{"type":43,"coordinates":386},[387,388],23.32415,42.69751,{"lat":388,"lon":387},{"facility":391,"status":24,"city":383,"state":24,"zip":392,"country":329,"countryCode":330,"cosmosGeoPoint":393,"geoPoint":395,"contacts":24},"University Multiprofile Hospital for Active Treatment - UMHAT Alexandrovska EAD","1431",{"type":43,"coordinates":394},[387,388],{"lat":388,"lon":387},{"facility":397,"status":24,"city":383,"state":24,"zip":398,"country":329,"countryCode":330,"cosmosGeoPoint":399,"geoPoint":401,"contacts":24},"Medical Center 'Doverie'","1632",{"type":43,"coordinates":400},[387,388],{"lat":388,"lon":387},{"facility":403,"status":24,"city":383,"state":24,"zip":404,"country":329,"countryCode":330,"cosmosGeoPoint":405,"geoPoint":407,"contacts":24},"Medical Center Intermedica, OOD","1680",{"type":43,"coordinates":406},[387,388],{"lat":388,"lon":387},{"facility":409,"status":24,"city":410,"state":24,"zip":411,"country":329,"countryCode":330,"cosmosGeoPoint":412,"geoPoint":416,"contacts":24},"MHAT-Targovishte, AD","Targovishte","7700",{"type":43,"coordinates":413},[414,415],26.57215,43.2512,{"lat":415,"lon":414},{"facility":418,"status":24,"city":419,"state":24,"zip":420,"country":329,"countryCode":330,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"State Psychiatric Hospital - Tzarev Brod","Tzarev Brod","9747",{"facility":422,"status":24,"city":423,"state":24,"zip":424,"country":329,"countryCode":330,"cosmosGeoPoint":425,"geoPoint":429,"contacts":24},"Diagnostic Consulting Center Mladost - M Varna","Varna","9020",{"type":43,"coordinates":426},[427,428],27.91024,43.21912,{"lat":428,"lon":427},{"facility":431,"status":24,"city":432,"state":24,"zip":433,"country":329,"countryCode":330,"cosmosGeoPoint":434,"geoPoint":438,"contacts":24},"Mental Health Center - Veliko Tarnovo EOOD","Veliko Tarnovo","5000",{"type":43,"coordinates":435},[436,437],25.62904,43.08124,{"lat":437,"lon":436},{"facility":440,"status":24,"city":441,"state":24,"zip":442,"country":443,"countryCode":444,"cosmosGeoPoint":445,"geoPoint":449,"contacts":24},"Mederon Oy","Helsinki","00100","Finland","FI",{"type":43,"coordinates":446},[447,448],24.93545,60.16952,{"lat":448,"lon":447},{"facility":451,"status":24,"city":452,"state":24,"zip":453,"country":443,"countryCode":444,"cosmosGeoPoint":454,"geoPoint":458,"contacts":24},"Savon Psykiatripalvelu","Kuopio","70110",{"type":43,"coordinates":455},[456,457],27.67703,62.89238,{"lat":457,"lon":456},{"facility":460,"status":24,"city":461,"state":24,"zip":462,"country":443,"countryCode":444,"cosmosGeoPoint":463,"geoPoint":467,"contacts":24},"Oulu Mentalcare Oy","Oulu","90100",{"type":43,"coordinates":464},[465,466],25.46816,65.01236,{"lat":466,"lon":465},{"facility":469,"status":24,"city":470,"state":24,"zip":471,"country":443,"countryCode":444,"cosmosGeoPoint":472,"geoPoint":476,"contacts":24},"Satakunnan Psykiatripalvelu","Rauma","26100",{"type":43,"coordinates":473},[474,475],21.51127,61.12724,{"lat":475,"lon":474},{"facility":478,"status":24,"city":479,"state":24,"zip":480,"country":481,"countryCode":482,"cosmosGeoPoint":483,"geoPoint":487,"contacts":24},"CHU Clermont-Ferrand - Hopital Gabriel Montpied","Clermont-Ferrand","63000","France","FR",{"type":43,"coordinates":484},[485,486],3.08682,45.77969,{"lat":486,"lon":485},{"facility":489,"status":24,"city":490,"state":24,"zip":491,"country":481,"countryCode":482,"cosmosGeoPoint":492,"geoPoint":496,"contacts":24},"Cabinet Medical des Drs Prizac-Desbonnet Scottez","Douai","59500",{"type":43,"coordinates":493},[494,495],3.07922,50.37069,{"lat":495,"lon":494},{"facility":498,"status":24,"city":499,"state":24,"zip":500,"country":481,"countryCode":482,"cosmosGeoPoint":501,"geoPoint":505,"contacts":24},"CHU Nimes Hopital Caremeau","Nîmes","30029",{"type":43,"coordinates":502},[503,504],4.35788,43.83665,{"lat":504,"lon":503},{"facility":507,"status":24,"city":508,"state":24,"zip":509,"country":481,"countryCode":482,"cosmosGeoPoint":510,"geoPoint":514,"contacts":24},"Hopital Sainte Anne","Paris","75674",{"type":43,"coordinates":511},[512,513],2.3488,48.85341,{"lat":513,"lon":512},{"facility":516,"status":24,"city":517,"state":24,"zip":518,"country":481,"countryCode":482,"cosmosGeoPoint":519,"geoPoint":523,"contacts":24},"Centre Hospitalier Guillaume Regnier","Rennes","35011",{"type":43,"coordinates":520},[521,522],-1.67431,48.11109,{"lat":522,"lon":521},{"facility":525,"status":24,"city":526,"state":24,"zip":527,"country":528,"countryCode":529,"cosmosGeoPoint":530,"geoPoint":534,"contacts":24},"Neurologische Praxis Dr. Schoell & Kollegen","Bad Homburg","61348","Germany","DE",{"type":43,"coordinates":531},[532,533],8.61816,50.22683,{"lat":533,"lon":532},{"facility":536,"status":24,"city":537,"state":24,"zip":538,"country":528,"countryCode":529,"cosmosGeoPoint":539,"geoPoint":543,"contacts":24},"Klinikum Chemnitz gGmbH","Chemnitz","09131",{"type":43,"coordinates":540},[541,542],12.92922,50.8357,{"lat":542,"lon":541},{"facility":545,"status":24,"city":546,"state":24,"zip":547,"country":528,"countryCode":529,"cosmosGeoPoint":548,"geoPoint":552,"contacts":24},"Universitatsklinikum Carl Gustav Carcus Dresden","Dresden","01307",{"type":43,"coordinates":549},[550,551],13.73832,51.05089,{"lat":551,"lon":550},{"facility":554,"status":24,"city":555,"state":24,"zip":556,"country":528,"countryCode":529,"cosmosGeoPoint":557,"geoPoint":561,"contacts":24},"Somni Bene GmbH","Schwerin","19053",{"type":43,"coordinates":558},[559,560],11.41316,53.62937,{"lat":560,"lon":559},{"facility":563,"status":24,"city":564,"state":24,"zip":565,"country":566,"countryCode":567,"cosmosGeoPoint":568,"geoPoint":572,"contacts":24},"Hongo Todaimae Mental Clinic","Bunkyō City","113-0033","Japan","JP",{"type":43,"coordinates":569},[570,571],139.4217,35.5331,{"lat":571,"lon":570},{"facility":574,"status":24,"city":575,"state":24,"zip":576,"country":566,"countryCode":567,"cosmosGeoPoint":577,"geoPoint":581,"contacts":24},"Kuramitsu Hospital","Fukuoka","819-0037",{"type":43,"coordinates":578},[579,580],130.41667,33.6,{"lat":580,"lon":579},{"facility":583,"status":24,"city":584,"state":24,"zip":585,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"National Center for Global Health and Medicine Kohnodai hospital","Ichikawa-shi","272-8516",{"facility":587,"status":24,"city":588,"state":24,"zip":589,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"National Hospital Organization Hizen Psychiatric Center","Kanzaki-gun","842-0192",{"facility":591,"status":24,"city":592,"state":24,"zip":593,"country":566,"countryCode":567,"cosmosGeoPoint":594,"geoPoint":598,"contacts":24},"Nara Medical University Hospital","Kashihara-shi","634-8522",{"type":43,"coordinates":595},[596,597],135.7929,34.50896,{"lat":597,"lon":596},{"facility":600,"status":24,"city":601,"state":24,"zip":602,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Senzoku Mental Clinic","Meguro-ku","152-0012",{"facility":604,"status":24,"city":605,"state":24,"zip":606,"country":566,"countryCode":567,"cosmosGeoPoint":607,"geoPoint":611,"contacts":24},"Heart Care Ginga Clinic","Nakano","164-0012",{"type":43,"coordinates":608},[609,610],131.31144,25.94567,{"lat":610,"lon":609},{"facility":613,"status":24,"city":614,"state":24,"zip":615,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Shiranui Hospital","Omuta-shi","836-0004",{"facility":617,"status":24,"city":618,"state":24,"zip":619,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Seiwakai Yutaka Clinic","Sagamihara-shi","252-0303",{"facility":621,"status":24,"city":622,"state":24,"zip":623,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Sangenjaya Nakamura Mental Clinic","Setagaya-ku","154-0004",{"facility":625,"status":24,"city":626,"state":24,"zip":627,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Yoyogi Mental Clinic","Shibuya-ku","151-0051",{"facility":629,"status":24,"city":630,"state":24,"zip":631,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Etoh Mental Clinic","Shinagawa-ku","141-0021",{"facility":633,"status":24,"city":634,"state":24,"zip":635,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Nishi-Shinjuku Concieria Clinic","Shinjuku-ku","160-0023",{"facility":637,"status":24,"city":634,"state":24,"zip":635,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Tamaki Clinic",{"facility":639,"status":24,"city":634,"state":24,"zip":640,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Shinjuku Research Park Clinic","169-0073",{"facility":642,"status":24,"city":643,"state":24,"zip":644,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Ohwa Mental Clinic","Toshima-ku","170-0002",{"facility":646,"status":24,"city":643,"state":24,"zip":647,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Sekino Hospital","171-0014",{"facility":649,"status":24,"city":643,"state":24,"zip":650,"country":566,"countryCode":567,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Jisenkai Hozumi Himorogi Clinic","171-0022",{"facility":652,"status":24,"city":653,"state":24,"zip":654,"country":655,"countryCode":656,"cosmosGeoPoint":657,"geoPoint":661,"contacts":24},"SHI Arkhangelsk Regional Clinical Psychiatric Hospital","Arkhangelsk","163530","Russia","RU",{"type":43,"coordinates":658},[659,660],40.55183,64.5461,{"lat":660,"lon":659},{"facility":663,"status":24,"city":664,"state":24,"zip":665,"country":655,"countryCode":656,"cosmosGeoPoint":666,"geoPoint":670,"contacts":24},"City Clinical Psychiatric Hopsital 3","Moscow","107076",{"type":43,"coordinates":667},[668,669],37.61781,55.75204,{"lat":669,"lon":668},{"facility":672,"status":24,"city":664,"state":24,"zip":665,"country":655,"countryCode":656,"cosmosGeoPoint":673,"geoPoint":675,"contacts":24},"FSI Moscow SRI of Psychiatry of Minzdravsocrazvitia",{"type":43,"coordinates":674},[668,669],{"lat":669,"lon":668},{"facility":677,"status":24,"city":664,"state":24,"zip":678,"country":655,"countryCode":656,"cosmosGeoPoint":679,"geoPoint":681,"contacts":24},"Closed corporation 'Scientific Center of Personalized Psychiatry'","119180",{"type":43,"coordinates":680},[668,669],{"lat":669,"lon":668},{"facility":683,"status":24,"city":664,"state":24,"zip":684,"country":655,"countryCode":656,"cosmosGeoPoint":685,"geoPoint":687,"contacts":24},"First Moscow State Medical University n.a. I.M. Sechenov","119991",{"type":43,"coordinates":686},[668,669],{"lat":669,"lon":668},{"facility":689,"status":24,"city":690,"state":24,"zip":691,"country":655,"countryCode":656,"cosmosGeoPoint":692,"geoPoint":696,"contacts":24},"Clinical Psychiatry Hospital n.a. N.N. Solodovnikov","Omsk","644070",{"type":43,"coordinates":693},[694,695],73.36859,54.99244,{"lat":695,"lon":694},{"facility":698,"status":24,"city":699,"state":24,"zip":700,"country":655,"countryCode":656,"cosmosGeoPoint":701,"geoPoint":705,"contacts":24},"Medical and Rehabilitation Research Center Phoenix","Rostov-on-Don","344010",{"type":43,"coordinates":702},[703,704],39.70769,47.21997,{"lat":704,"lon":703},{"facility":707,"status":24,"city":708,"state":24,"zip":709,"country":655,"countryCode":656,"cosmosGeoPoint":710,"geoPoint":714,"contacts":24},"City Psychiatric Hospital of St. Nikolay Chudotvorets","Saint Petersburg","190121",{"type":43,"coordinates":711},[712,713],30.31413,59.93863,{"lat":713,"lon":712},{"facility":716,"status":24,"city":708,"state":24,"zip":717,"country":655,"countryCode":656,"cosmosGeoPoint":718,"geoPoint":720,"contacts":24},"St-Petersburg Bekhterev Psychoneurological Research Institute","192019",{"type":43,"coordinates":719},[712,713],{"lat":713,"lon":712},{"facility":722,"status":24,"city":723,"state":24,"zip":724,"country":655,"countryCode":656,"cosmosGeoPoint":725,"geoPoint":729,"contacts":24},"SHI 'Saratov City Clinical Hospital 2 n.a V.I. Razumovsky","Saratov","410028",{"type":43,"coordinates":726},[727,728],45.9901,51.54048,{"lat":728,"lon":727},{"facility":731,"status":24,"city":732,"state":24,"zip":733,"country":655,"countryCode":656,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Engels psychiatric hospital","Saratov Region","413124",{"facility":735,"status":24,"city":736,"state":24,"zip":737,"country":655,"countryCode":656,"cosmosGeoPoint":738,"geoPoint":742,"contacts":24},"Research Institute of Mental Health","Tomsk","634014",{"type":43,"coordinates":739},[740,741],84.98216,56.50049,{"lat":741,"lon":740},{"facility":744,"status":24,"city":745,"state":24,"zip":746,"country":655,"countryCode":656,"cosmosGeoPoint":747,"geoPoint":751,"contacts":24},"Sverdlov Regional Psychiatric Clinical Hospital","Yekaterinburg","620030",{"type":43,"coordinates":748},[749,750],60.61529,56.85733,{"lat":750,"lon":749},{"facility":753,"status":24,"city":754,"state":24,"zip":755,"country":756,"countryCode":757,"cosmosGeoPoint":758,"geoPoint":762,"contacts":24},"CNCE'Precarpathian Regional Clinical Mental Health Center Ivano-Frankivsk RC'","Ivano-Frankivsk","76014","Ukraine","UA",{"type":43,"coordinates":759},[760,761],24.71248,48.92312,{"lat":761,"lon":760},{"facility":764,"status":24,"city":765,"state":24,"zip":766,"country":756,"countryCode":757,"cosmosGeoPoint":767,"geoPoint":771,"contacts":24},"Mnpe of Kharkiv Regional Council 'Regional Clinical Psychiatric Hospital #3'","Kharkiv","61068",{"type":43,"coordinates":768},[769,770],36.25475,49.98177,{"lat":770,"lon":769},{"facility":773,"status":24,"city":774,"state":24,"zip":775,"country":756,"countryCode":757,"cosmosGeoPoint":776,"geoPoint":780,"contacts":24},"Cnce 'Kyiv City Psychoneurological Hospital #2' of Executive Body of Kyiv City Council (Kcsa)","Kyiv","2660",{"type":43,"coordinates":777},[778,779],30.5238,50.45466,{"lat":779,"lon":778},{"facility":782,"status":24,"city":783,"state":24,"zip":784,"country":756,"countryCode":757,"cosmosGeoPoint":785,"geoPoint":789,"contacts":24},"CNCE of the Lviv Regional Council 'Lviv Regional Clinical Psychiatric Hospital'","Lviv","79021",{"type":43,"coordinates":786},[787,788],24.02324,49.83826,{"lat":788,"lon":787},{"facility":791,"status":24,"city":792,"state":24,"zip":793,"country":756,"countryCode":757,"cosmosGeoPoint":794,"geoPoint":798,"contacts":24},"CI Odesa Regional Medical Center of Mental Health","Odesa","65006",{"type":43,"coordinates":795},[796,797],30.74383,46.48572,{"lat":797,"lon":796},{"facility":800,"status":24,"city":801,"state":24,"zip":802,"country":756,"countryCode":757,"cosmosGeoPoint":803,"geoPoint":807,"contacts":24},"CNCE Odesa regional psychiatric hospital #2 Odesa regional council","Oleksandrivka","67513",{"type":43,"coordinates":804},[805,806],32.23968,48.968,{"lat":806,"lon":805},{"facility":809,"status":24,"city":810,"state":24,"zip":811,"country":756,"countryCode":757,"cosmosGeoPoint":812,"geoPoint":816,"contacts":24},"Poltava O.F. Maltsev RC Psychiatric Hospital Dept #9 (Ad-P Dept) HSEIU Ukrainian MSA","Poltava","36006",{"type":43,"coordinates":813},[814,815],34.55367,49.58925,{"lat":815,"lon":814},{"facility":818,"status":24,"city":819,"state":24,"zip":820,"country":756,"countryCode":757,"cosmosGeoPoint":821,"geoPoint":825,"contacts":24},"Ternopil RCCPH Depts of Psychiatry #2 (m) & Psychiatry #4 (f) Ternopil I.Ya. Gorbachevskyi SMU","Ternopil","46020",{"type":43,"coordinates":822},[823,824],25.59067,49.55404,{"lat":824,"lon":823},{"facility":827,"status":24,"city":828,"state":24,"zip":829,"country":756,"countryCode":757,"cosmosGeoPoint":830,"geoPoint":834,"contacts":24},"CI O.I. Yuschenko VRPsH Depts #7 & #10 M.I. Pyrogov VNMU","Vinnytsia","21005",{"type":43,"coordinates":831},[832,833],28.46871,49.2322,{"lat":833,"lon":832},{"facility":836,"status":24,"city":828,"state":24,"zip":829,"country":756,"countryCode":757,"cosmosGeoPoint":837,"geoPoint":839,"contacts":24},"CNCE 'Vinnytsya RC Psychoneurological Hospital n.a. O.I. Yushchenko Vinnytsya RC'",{"type":43,"coordinates":838},[832,833],{"lat":833,"lon":832},{"type":841,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100303212","phase-2-a-study-to-evaluate-the-efficacy-and-safety-of-jnj-42847922-as-adjunctive-therapy-to-antidepressants-in-adult-participants-with-major-depressive-disorder-who-have-responded-inadequately-to-antidepressant-therapy-100303212",true,"NCT03227224","A Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy","A Multicenter, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Adaptive Dose-Finding Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Subjects With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy","Inclusion Criteria:\n\n* Men or women of non-childbearing potential (WONCBP), aged 18 to 70 years (inclusive). A WONCBP is defined as: a).Postmenopausal: A postmenopausal state is defined as no menses for 12 months without an alternative medical cause. b). Permanently sterile: Permanent sterilization methods include hysterectomy, bilateral salpingectomy, bilateral tubal occlusion\u002Fligation procedures, and bilateral oophorectomy. c). If reproductive status is questionable, additional evaluation should be considered\n* Meet Diagnostic and Statistical Manual of Mental Disorders-5th Edition (DSM-5) diagnostic criteria for major depressive disorder (MDD), without psychotic features, based upon clinical assessment and confirmed by the Structured Clinical Interview for DSM-5 Axis I Disorders- Clinical Trials Version (SCID-CT). In addition their major depressive episode must be deemed \"valid\" using the SCID Screening Questionnaire (SSQ) interview administered by remote, independent raters. The length of the current depressive episode must be less than or equal to (\\\u003C=) 18 months\n* Have had an inadequate response to at least 1 but no more than 3 antidepressants, administered at an adequate dose and duration in the current episode of depression, as measured by the Massachusetts General Hospital-Antidepressant Treatment Response Questionnaire (MGH-ATRQ). An inadequate response is defined as less than (\\\u003C)50 percent (%) reduction in depressive symptom severity, as assessed by the MGH-ATRQ. An adequate trial is defined as an antidepressant treatment for at least 4 weeks at or above the minimum therapeutic dose specified in the MGH-ATRQ, for any particular antidepressant. The inadequate response must include the participant's current antidepressant treatment\n* Participants receiving monotherapy treatment for depressive symptoms with one of the following selective serotonin reuptake inhibitor\u002Fserotonin-norepinephrine reuptake inhibitor (SSRI\u002FSNRI) antidepressants, in any formulation: citalopram, duloxetine, escitalopram, fluvoxamine, fluoxetine, milnacipran, levomilnacipran, paroxetine, sertraline, venlafaxine, desvenlafaxine, vilazodone, or vortioxetine at a stable dose (at or above the minimum therapeutic dose level) for at least 4 weeks, and for no greater than 12 months, at screening. Modification of an effective preexisting therapy should not be made for the explicit purpose of entering a subject into the study\n* Have a Montgomery-Asberg Depression Rating Scale (MADRS) total score greater than or equal to (\\>=)25 (performed by independent, centralized remote raters) at screening and must not demonstrate a clinically significant improvement (that is, an improvement of greater than \\[\\>\\]20% on their MADRS total score) from the screening to baseline visit\n* Must be otherwise healthy on the basis of physical examination, medical history, vital signs, 12-lead electrocardiogram (ECG), and clinical laboratory tests performed at screening. If the results of the clinical laboratory tests are outside the normal reference ranges, the participant could be included only if the investigator judges the abnormalities or deviations from normal to be not clinically significant or to be appropriate and reasonable for the population under study. This determination must be recorded in the participant's source documents and initialed by the investigator\n\nExclusion Criteria:\n\n* Has a history of, or current signs and symptoms of, severe renal insufficiency (creatinine clearance \\\u003C30 milliliter per minute \\[mL\u002Fmin\\]); moderate to severe hepatic insufficiency (Child-Pugh Score 7-9), significant or unstable cardiovascular, respiratory, gastrointestinal, neurologic (including narcolepsy), hematologic, rheumatologic, immunologic or endocrine disorders (including uncontrolled hypo- or hyperthyroidism or diabetes, or insulin-dependent diabetes mellitus). Participants with non-insulin dependent diabetes mellitus who are well-controlled (hemoglobin A1C \\[HbA1C\\] \\\u003C=7.5% and fasting glucose \\\u003C126 milligram per deciliter \\[mg\u002FdL\\] at screening) could be eligible to participate if otherwise medically healthy, and if on a stable regimen of glucose-lowering medications for at least 2 months prior to screening\n* Has signs and symptoms of Cushing's Disease, Addison's Disease, primary amenorrhea, or other evidence of significant medical disorders of the hypothalamic-pituitary-adrenal (HPA) axis\n* Has a history of lack of response to 3 or more adequate antidepressant treatments, as indicated by no or minimal (\\\u003C= 25% improvement in symptoms) when treated with an antidepressant of adequate dose (per MGH-ATRQ) and duration (at least 4 weeks)\n* Has history or current diagnosis of a psychotic disorder, bipolar disorder, mental retardation, autism spectrum disorder, or borderline personality disorder, somatoform disorders, chronic fatigue syndrome or fibromyalgia\n* Has any significant primary sleep disorder, including but not limited to obstructive sleep apnea, restless leg syndrome, or parasomnias",false,"ALL","18 Years","70 Years",{"count":854,"type":855},287,"ACTUAL","INTERVENTIONAL",[858],"PHASE2","The purpose of this study is to assess the dose-response relationship of 2 doses of JNJ-42847922 before interim analysis, and potentially 3 doses based on interim analysis results, compared to placebo as adjunctive therapy to an antidepressant drug in improving depressive symptoms in participants with Major Depressive Disorder (MDD) who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI); and to assess the safety and tolerability of JNJ-42847922 compared to placebo as adjunctive therapy to an antidepressant in participants with MDD.",[861],"Depressive Disorder, Major","COMPLETED","2025-04-25",{"date":865,"type":855},"2025-04-29",{"date":867,"type":855},"2017-08-16",{"date":869,"type":855},"2019-01-19",{"name":5,"class":6},101]