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Manchester Centre for Genomic Medicine","Manchester","M13 9WL",{"type":40,"coordinates":117},[118,119],-2.23743,53.48095,{"lat":119,"lon":118},{"type":122,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100312023","phase-2-a-study-to-evaluate-the-safety-tolerability-pharmacokinetics-and-pharmacodynamics-of-ro7234292-isis-443139-in-huntingtons-disease-patients-who-participated-in-prior-investigational-studies-of-ro7234292-isis-443139-100312023",true,"NCT03342053","A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7234292 (ISIS 443139) in Huntington's Disease Patients Who Participated in Prior Investigational Studies of RO7234292 (ISIS 443139)","An Open-Label Extension Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7234292 (ISIS 443139) in Huntington's Disease Patients Who Participated in Prior Investigational Studies of RO7234292 (ISIS 443139)","Key Inclusion Criteria:\n\n* Must have completed dosing in ISIS 443139-CS1\n\nKey Exclusion Criteria:\n\n* Any new condition or worsening of existing condition that could make the patient unsuitable for participation or interfere with the patient participating in and\u002For completing the study",false,"ALL","25 Years",{"count":134,"type":135},46,"ACTUAL","INTERVENTIONAL",[138],"PHASE2","This study will test the safety, tolerability, pharmacokinetics and pharmacodynamics of RO7234292 administered intrathecally to adult patients with Huntington's Disease.",[141],"Huntington's Disease","COMPLETED","2022-03-01",{"date":145,"type":135},"2022-03-24",{"date":147,"type":135},"2018-01-02",{"date":149,"type":135},"2019-10-08",{"name":5,"class":6},9]