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Clinical diagnosis of NTDT as described in the protocol\n2. IOL, defined as LIC ≥ 5 mg Fe\u002Fg DW as measured by R2\\* MRI at screening\n3. Serum ferritin ≥ 300 ng\u002FmL as described in the protocol\n\nKey Exclusion Criteria:\n\n1. Hemoglobin ≤ 8 g\u002FdL at screening\n2. Any RBC transfusion within 12 weeks of visit 3\n3. For Part A only: Any Iron Chelation Therapy (ICT) use in approximately 12 weeks prior to screening as described in the protocol\n4. For Part B only: If on ICT, any change in ICT dose in approximately 12 weeks prior to screening as described in the protocol\n5. Any use of luspatercept or mitapivat in 6 months prior to screening as described in the protocol\n6. Absolute contraindication to MRI\n7. Diagnosis of cirrhosis of the liver\n8. Diagnosis of Chronic kidney disease (CKD) stage 4 or higher\n\nNote: Other protocol-defined Inclusion\u002F Exclusion Criteria apply","ALL","18 Years","65 Years",{"count":303,"type":304},19,"ACTUAL","INTERVENTIONAL",[307],"PHASE2","This study is researching an experimental drug called REGN7999 (called \"study drug\"). The study is focused on patients with non-transfusion dependent beta-thalassemia. The aim of the study is to see how safe and effective the study drug is.\n\nThe study is looking at several other research questions, including:\n\n* Whether the study drug lowers extra iron levels in the body\n* What side effects may happen from taking the study drug\n* How much study drug is in the blood at different times\n* Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)",[310],"Non-Transfusion Dependent Beta-Thalassemia (NTDT)",[312,313],"Beta-Thalassemia","Resultant Iron Overload (IOL)","ACTIVE_NOT_RECRUITING","2026-06-30",{"date":317,"type":304},"2026-07-01",{"date":319,"type":304},"2024-09-30",{"date":321,"type":322},"2026-12-03","ESTIMATED",{"name":5,"class":6},26]