[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100317617":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":50,"centralContacts":36,"locations":54,"responsibleParty":506,"collaborators":508,"id":511,"slug":512,"hasResults":513,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":517,"eligibilityCriteria":518,"healthyVolunteers":519,"sex":520,"minAge":521,"maxAge":36,"enrollmentInfo":522,"targetDuration":36,"studyType":525,"phases":526,"briefSummary":529,"conditions":530,"keywords":36,"overallStatus":532,"whyStopped":36,"lastUpdateSubmitDate":533,"lastUpdatePostDateStruct":534,"startDateStruct":536,"completionDateStruct":538,"leadSponsor":540,"locationsCount":541},{"fullName":5,"class":6},"Bristol-Myers Squibb","INDUSTRY",[8,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm A","EXPERIMENTAL","Nivo + SOC",[13,14,15,16,17],"Biological: Nivolumab","Drug: Oxaliplatin","Drug: Leucovorin","Drug: Fluorouracil","Drug: Bevacizumab",{"label":19,"type":20,"description":21,"interventionNames":22},"Arm B","ACTIVE_COMPARATOR","SOC",[14,15,16,17],[24,32,37,42,45],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"BIOLOGICAL","Nivolumab","Specified dose on specified days",[9],[30,31],"BMS-936558","Opdivo",{"type":33,"name":34,"description":27,"armGroupLabels":35,"otherNames":36},"DRUG","Oxaliplatin",[9,19],null,{"type":33,"name":38,"description":27,"armGroupLabels":39,"otherNames":40},"Leucovorin",[9,19],[41],"Calcium Folinate",{"type":33,"name":43,"description":27,"armGroupLabels":44,"otherNames":36},"Fluorouracil",[9,19],{"type":33,"name":46,"description":27,"armGroupLabels":47,"otherNames":48},"Bevacizumab",[9,19],[49],"Avastin",[51],{"name":5,"affiliation":52,"role":53},"Bristol-Myers Suibb","STUDY_DIRECTOR",[55,68,78,88,97,107,117,126,136,146,156,166,171,176,181,191,200,210,220,230,238,248,258,268,277,287,297,306,316,325,334,343,352,362,371,381,393,403,412,422,431,440,449,461,466,471,482,493,502],{"facility":56,"status":36,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":36},"Uab Comprehensive Cancer Center","Birmingham","Alabama","35294-3300","United States","US",{"type":63,"coordinates":64},"Point",[65,66],-86.80249,33.52066,{"lat":66,"lon":65},{"facility":69,"status":36,"city":70,"state":71,"zip":72,"country":60,"countryCode":61,"cosmosGeoPoint":73,"geoPoint":77,"contacts":36},"Local Institution - 0004","Los Angeles","California","90033",{"type":63,"coordinates":74},[75,76],-118.24368,34.05223,{"lat":76,"lon":75},{"facility":79,"status":36,"city":80,"state":81,"zip":82,"country":60,"countryCode":61,"cosmosGeoPoint":83,"geoPoint":87,"contacts":36},"Local Institution - 0010","Aurora","Colorado","80045",{"type":63,"coordinates":84},[85,86],-104.83192,39.72943,{"lat":86,"lon":85},{"facility":89,"status":36,"city":90,"state":81,"zip":91,"country":60,"countryCode":61,"cosmosGeoPoint":92,"geoPoint":96,"contacts":36},"Local Institution - 0027","Denver","80218",{"type":63,"coordinates":93},[94,95],-104.9847,39.73915,{"lat":95,"lon":94},{"facility":98,"status":36,"city":99,"state":100,"zip":101,"country":60,"countryCode":61,"cosmosGeoPoint":102,"geoPoint":106,"contacts":36},"Local Institution - 0020","New Haven","Connecticut","06520",{"type":63,"coordinates":103},[104,105],-72.92816,41.30815,{"lat":105,"lon":104},{"facility":108,"status":36,"city":109,"state":110,"zip":111,"country":60,"countryCode":61,"cosmosGeoPoint":112,"geoPoint":116,"contacts":36},"Local Institution - 0039","Miami","Florida","33176",{"type":63,"coordinates":113},[114,115],-80.19366,25.77427,{"lat":115,"lon":114},{"facility":118,"status":36,"city":119,"state":110,"zip":120,"country":60,"countryCode":61,"cosmosGeoPoint":121,"geoPoint":125,"contacts":36},"Local Institution - 0047","St. Petersburg","33705",{"type":63,"coordinates":122},[123,124],-82.67927,27.77086,{"lat":124,"lon":123},{"facility":127,"status":36,"city":128,"state":129,"zip":130,"country":60,"countryCode":61,"cosmosGeoPoint":131,"geoPoint":135,"contacts":36},"Local Institution - 0033","Arlington Heights","Illinois","60005",{"type":63,"coordinates":132},[133,134],-87.98063,42.08836,{"lat":134,"lon":133},{"facility":137,"status":36,"city":138,"state":139,"zip":140,"country":60,"countryCode":61,"cosmosGeoPoint":141,"geoPoint":145,"contacts":36},"Local Institution - 0044","Indianapolis","Indiana","46260",{"type":63,"coordinates":142},[143,144],-86.15804,39.76838,{"lat":144,"lon":143},{"facility":147,"status":36,"city":148,"state":149,"zip":150,"country":60,"countryCode":61,"cosmosGeoPoint":151,"geoPoint":155,"contacts":36},"Local Institution - 0021","Bethesda","Maryland","20817",{"type":63,"coordinates":152},[153,154],-77.10026,38.98067,{"lat":154,"lon":153},{"facility":157,"status":36,"city":158,"state":159,"zip":160,"country":60,"countryCode":61,"cosmosGeoPoint":161,"geoPoint":165,"contacts":36},"Local Institution - 0003","Boston","Massachusetts","02114",{"type":63,"coordinates":162},[163,164],-71.05977,42.35843,{"lat":164,"lon":163},{"facility":167,"status":36,"city":158,"state":159,"zip":160,"country":60,"countryCode":61,"cosmosGeoPoint":168,"geoPoint":170,"contacts":36},"Local Institution - 0049",{"type":63,"coordinates":169},[163,164],{"lat":164,"lon":163},{"facility":172,"status":36,"city":158,"state":159,"zip":160,"country":60,"countryCode":61,"cosmosGeoPoint":173,"geoPoint":175,"contacts":36},"Local Institution - 0052",{"type":63,"coordinates":174},[163,164],{"lat":164,"lon":163},{"facility":177,"status":36,"city":158,"state":159,"zip":160,"country":60,"countryCode":61,"cosmosGeoPoint":178,"geoPoint":180,"contacts":36},"Local Institution - 0053",{"type":63,"coordinates":179},[163,164],{"lat":164,"lon":163},{"facility":182,"status":36,"city":183,"state":184,"zip":185,"country":60,"countryCode":61,"cosmosGeoPoint":186,"geoPoint":190,"contacts":36},"Local Institution - 0035","Minneapolis","Minnesota","55404",{"type":63,"coordinates":187},[188,189],-93.26384,44.97997,{"lat":189,"lon":188},{"facility":192,"status":36,"city":193,"state":184,"zip":194,"country":60,"countryCode":61,"cosmosGeoPoint":195,"geoPoint":199,"contacts":36},"Local Institution - 0002","Rochester","55905",{"type":63,"coordinates":196},[197,198],-92.4699,44.02163,{"lat":198,"lon":197},{"facility":201,"status":36,"city":202,"state":203,"zip":204,"country":60,"countryCode":61,"cosmosGeoPoint":205,"geoPoint":209,"contacts":36},"Local Institution - 0032","Papillion","Nebraska","68046",{"type":63,"coordinates":206},[207,208],-96.04224,41.15444,{"lat":208,"lon":207},{"facility":211,"status":36,"city":212,"state":213,"zip":214,"country":60,"countryCode":61,"cosmosGeoPoint":215,"geoPoint":219,"contacts":36},"Local Institution - 0029","Henderson","Nevada","89074",{"type":63,"coordinates":216},[217,218],-114.98194,36.0397,{"lat":218,"lon":217},{"facility":221,"status":36,"city":222,"state":223,"zip":224,"country":60,"countryCode":61,"cosmosGeoPoint":225,"geoPoint":229,"contacts":36},"Local Institution - 0031","Johnson City","New York","13790",{"type":63,"coordinates":226},[227,228],-75.95881,42.11563,{"lat":228,"lon":227},{"facility":231,"status":36,"city":223,"state":223,"zip":232,"country":60,"countryCode":61,"cosmosGeoPoint":233,"geoPoint":237,"contacts":36},"Local Institution - 0046","10016",{"type":63,"coordinates":234},[235,236],-74.00597,40.71427,{"lat":236,"lon":235},{"facility":239,"status":36,"city":240,"state":241,"zip":242,"country":60,"countryCode":61,"cosmosGeoPoint":243,"geoPoint":247,"contacts":36},"Levine Cancer Institute","Charlotte","North Carolina","28262",{"type":63,"coordinates":244},[245,246],-80.84313,35.22709,{"lat":246,"lon":245},{"facility":249,"status":36,"city":250,"state":251,"zip":252,"country":60,"countryCode":61,"cosmosGeoPoint":253,"geoPoint":257,"contacts":36},"Local Institution - 0038","Portland","Oregon","97227",{"type":63,"coordinates":254},[255,256],-122.67621,45.52345,{"lat":256,"lon":255},{"facility":259,"status":36,"city":260,"state":261,"zip":262,"country":60,"countryCode":61,"cosmosGeoPoint":263,"geoPoint":267,"contacts":36},"Local Institution - 0005","Philadelphia","Pennsylvania","19104",{"type":63,"coordinates":264},[265,266],-75.16362,39.95238,{"lat":266,"lon":265},{"facility":269,"status":36,"city":270,"state":261,"zip":271,"country":60,"countryCode":61,"cosmosGeoPoint":272,"geoPoint":276,"contacts":36},"Local Institution - 0024","Pittsburgh","15212",{"type":63,"coordinates":273},[274,275],-79.99589,40.44062,{"lat":275,"lon":274},{"facility":278,"status":36,"city":279,"state":280,"zip":281,"country":60,"countryCode":61,"cosmosGeoPoint":282,"geoPoint":286,"contacts":36},"Local Institution - 0023","Sioux Falls","South Dakota","57104",{"type":63,"coordinates":283},[284,285],-96.72796,43.54369,{"lat":285,"lon":284},{"facility":288,"status":36,"city":289,"state":290,"zip":291,"country":60,"countryCode":61,"cosmosGeoPoint":292,"geoPoint":296,"contacts":36},"Erlanger Oncology & Hematology - Univ. of TN","Chattanooga","Tennessee","37403",{"type":63,"coordinates":293},[294,295],-85.30968,35.04563,{"lat":295,"lon":294},{"facility":298,"status":36,"city":299,"state":290,"zip":300,"country":60,"countryCode":61,"cosmosGeoPoint":301,"geoPoint":305,"contacts":36},"Local Institution - 0019","Nashville","37203",{"type":63,"coordinates":302},[303,304],-86.78444,36.16589,{"lat":304,"lon":303},{"facility":307,"status":36,"city":308,"state":309,"zip":310,"country":60,"countryCode":61,"cosmosGeoPoint":311,"geoPoint":315,"contacts":36},"Local Institution - 0026","Bedford","Texas","76022",{"type":63,"coordinates":312},[313,314],-97.14307,32.84402,{"lat":314,"lon":313},{"facility":317,"status":36,"city":318,"state":309,"zip":319,"country":60,"countryCode":61,"cosmosGeoPoint":320,"geoPoint":324,"contacts":36},"Local Institution - 0034","Dallas","75246",{"type":63,"coordinates":321},[322,323],-96.80667,32.78306,{"lat":323,"lon":322},{"facility":326,"status":36,"city":327,"state":309,"zip":328,"country":60,"countryCode":61,"cosmosGeoPoint":329,"geoPoint":333,"contacts":36},"Local Institution - 0037","Fort Worth","76104",{"type":63,"coordinates":330},[331,332],-97.32085,32.72541,{"lat":332,"lon":331},{"facility":335,"status":36,"city":336,"state":309,"zip":337,"country":60,"countryCode":61,"cosmosGeoPoint":338,"geoPoint":342,"contacts":36},"Local Institution - 0040","San Antonio","78217",{"type":63,"coordinates":339},[340,341],-98.49363,29.42412,{"lat":341,"lon":340},{"facility":344,"status":36,"city":345,"state":309,"zip":346,"country":60,"countryCode":61,"cosmosGeoPoint":347,"geoPoint":351,"contacts":36},"Local Institution - 0036","Tyler","75702",{"type":63,"coordinates":348},[349,350],-95.30106,32.35126,{"lat":350,"lon":349},{"facility":353,"status":36,"city":354,"state":355,"zip":356,"country":60,"countryCode":61,"cosmosGeoPoint":357,"geoPoint":361,"contacts":36},"Local Institution - 0025","Richmond","Virginia","23229",{"type":63,"coordinates":358},[359,360],-77.46026,37.55376,{"lat":360,"lon":359},{"facility":363,"status":36,"city":364,"state":355,"zip":365,"country":60,"countryCode":61,"cosmosGeoPoint":366,"geoPoint":370,"contacts":36},"Local Institution - 0028","Roanoke","24014",{"type":63,"coordinates":367},[368,369],-79.94143,37.27097,{"lat":369,"lon":368},{"facility":372,"status":36,"city":373,"state":374,"zip":375,"country":60,"countryCode":61,"cosmosGeoPoint":376,"geoPoint":380,"contacts":36},"Local Institution - 0006","Madison","Wisconsin","53705",{"type":63,"coordinates":377},[378,379],-89.40123,43.07305,{"lat":379,"lon":378},{"facility":382,"status":36,"city":383,"state":384,"zip":385,"country":386,"countryCode":387,"cosmosGeoPoint":388,"geoPoint":392,"contacts":36},"Local Institution - 0017","Edmonton","Alberta","T6G 1Z2","Canada","CA",{"type":63,"coordinates":389},[390,391],-113.46871,53.55014,{"lat":391,"lon":390},{"facility":394,"status":36,"city":395,"state":396,"zip":397,"country":386,"countryCode":387,"cosmosGeoPoint":398,"geoPoint":402,"contacts":36},"Local Institution - 0015","Ottawa","Ontario","K1H 8L6",{"type":63,"coordinates":399},[400,401],-75.69812,45.41117,{"lat":401,"lon":400},{"facility":404,"status":36,"city":405,"state":396,"zip":406,"country":386,"countryCode":387,"cosmosGeoPoint":407,"geoPoint":411,"contacts":36},"Local Institution - 0014","Toronto","M5G 2M9",{"type":63,"coordinates":408},[409,410],-79.39864,43.70643,{"lat":410,"lon":409},{"facility":413,"status":36,"city":414,"state":415,"zip":416,"country":386,"countryCode":387,"cosmosGeoPoint":417,"geoPoint":421,"contacts":36},"Local Institution - 0048","Montreal","Quebec","H2X 1P1",{"type":63,"coordinates":418},[419,420],-73.58781,45.50884,{"lat":420,"lon":419},{"facility":423,"status":36,"city":424,"state":415,"zip":425,"country":386,"countryCode":387,"cosmosGeoPoint":426,"geoPoint":430,"contacts":36},"Local Institution - 0012","Québec","G1J 1Z4",{"type":63,"coordinates":427},[428,429],-71.21454,46.81228,{"lat":429,"lon":428},{"facility":432,"status":36,"city":433,"state":415,"zip":434,"country":386,"countryCode":387,"cosmosGeoPoint":435,"geoPoint":439,"contacts":36},"Local Institution - 0013","Sherbrooke","J1H 5N4",{"type":63,"coordinates":436},[437,438],-71.89908,45.40008,{"lat":438,"lon":437},{"facility":441,"status":36,"city":442,"state":415,"zip":443,"country":386,"countryCode":387,"cosmosGeoPoint":444,"geoPoint":448,"contacts":36},"Local Institution - 0016","Trois-Rivières","G8Z 3R9",{"type":63,"coordinates":445},[446,447],-72.5477,46.34515,{"lat":447,"lon":446},{"facility":450,"status":36,"city":451,"state":452,"zip":453,"country":454,"countryCode":455,"cosmosGeoPoint":456,"geoPoint":460,"contacts":36},"Local Institution - 0055","Nagoya","Aichi-ken","4648681","Japan","JP",{"type":63,"coordinates":457},[458,459],136.90641,35.18147,{"lat":459,"lon":458},{"facility":462,"status":36,"city":463,"state":464,"zip":465,"country":454,"countryCode":455,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Local Institution - 0051","Kashiwa-shi","Chiba","2778577",{"facility":467,"status":36,"city":468,"state":469,"zip":470,"country":454,"countryCode":455,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Local Institution - 0050","Sunto-gun","Shizuoka","4118777",{"facility":472,"status":36,"city":473,"state":36,"zip":474,"country":475,"countryCode":476,"cosmosGeoPoint":477,"geoPoint":481,"contacts":36},"Local Institution - 0009","San Juan","00927","Puerto Rico","PR",{"type":63,"coordinates":478},[479,480],-66.10572,18.46633,{"lat":480,"lon":479},{"facility":483,"status":36,"city":484,"state":36,"zip":485,"country":486,"countryCode":487,"cosmosGeoPoint":488,"geoPoint":492,"contacts":36},"Local Institution - 0043","Barcelona","08035","Spain","ES",{"type":63,"coordinates":489},[490,491],2.15899,41.38879,{"lat":491,"lon":490},{"facility":494,"status":36,"city":495,"state":36,"zip":496,"country":486,"countryCode":487,"cosmosGeoPoint":497,"geoPoint":501,"contacts":36},"Local Institution - 0042","Madrid","28034",{"type":63,"coordinates":498},[499,500],-3.70256,40.4165,{"lat":500,"lon":499},{"facility":503,"status":36,"city":504,"state":36,"zip":505,"country":486,"countryCode":487,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Local Institution - 0041","Majadahonda - Madrid","28222",{"type":507,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR",[509],{"name":510,"class":6},"Ono Pharmaceutical Co., Ltd.","100317617","phase-2-an-investigational-immunotherapy-study-of-nivolumab-with-standard-of-care-therapy-vs-standard-of-care-therapy-for-first-line-treatment-of-colorectal-cancer-that-has-spread-100317617",true,"NCT03414983","An Investigational Immunotherapy Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Colorectal Cancer That Has Spread","An Open-Label Exploratory Phase 2\u002F3 Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Metastatic Colorectal Cancer","CheckMate 9X8","Inclusion Criteria:\n\n* Histologically confirmed metastatic colorectal cancer, not amenable to curative resection\n* No prior chemotherapy for metastatic colorectal cancer\n* ECOG Performance Status of 0-1\n* Ability to provide adequate tissue sample\n\nExclusion Criteria:\n\n* Patients with clinically relevant medical history, including autoimmune disease, cardiovascular disease, hepatic disease or bleeding disorders\n* Prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways\n* Any positive test result for hepatitis B virus or hepatitis C virus indicating presence of virus\n\nOther protocol-defined inclusion\u002Fexclusion criteria apply",false,"ALL","18 Years",{"count":523,"type":524},196,"ACTUAL","INTERVENTIONAL",[527,528],"PHASE2","PHASE3","This purpose of this study is to evaluate nivolumab (BMS-936558) in combination with standard of care (SOC) chemotherapy with bevacizumab for the treatment of first-line metastatic colorectal cancer (mCRC).",[531],"Colorectal Cancer","COMPLETED","2023-10-27",{"date":535,"type":524},"2023-11-18",{"date":537,"type":524},"2018-02-20",{"date":539,"type":524},"2022-12-28",{"name":5,"class":6},49]