[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100109787":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":34,"locations":34,"responsibleParty":35,"collaborators":34,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":34,"eligibilityCriteria":43,"healthyVolunteers":40,"sex":44,"minAge":45,"maxAge":34,"enrollmentInfo":46,"targetDuration":34,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":62,"whyStopped":34,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":34},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"R","ACTIVE_COMPARATOR","Rosuvastatin treatment for 6 weeks and after that combined treatment with rosuvastatin and vitamin supplementation for additional 6 weeks",[13],"Drug: folic acid, vitamin B12 and B6 and rosuvastatin",{"label":15,"type":10,"description":16,"interventionNames":17},"V","Vitamin supplementation with folic acid, vitamin B12 and B6 for 6 weeks and after that combined treatment with vitamin supplementation and rosuvastatin",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","folic acid, vitamin B12 and B6 and rosuvastatin","Vitamin supplementation with folic acid 1mg\u002Fd, vitamin B12 0.4mg\u002Fd and B6 10mg\u002Fd po for 6 weeks alone vs. rosuvastatin 10mg\u002Fd for 6 weeks alone and thereafter combined treatment for 6 weeks",[9,15],[25],"Crestor",[27,31],{"name":28,"affiliation":29,"role":30},"Kerstin Wustmann, MD","Cardiology, Inselspital, University hospital Bern","STUDY_DIRECTOR",{"name":32,"affiliation":29,"role":33},"Yves Allemann, MD","STUDY_CHAIR",null,{"type":34,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":36,"oldOrganization":37},"Allemann, Y., MD","Cardiology, Inselspital Berne","100109787","phase-2-effect-of-homocysteine-lowering-therapy-with-folic-acid-vitamin-b12-and-vitamin-b6-on-endothelium-dependent-vasodilatation-of-forearm-resistance-vessels-in-patients-with-coronary-heart-disease-100109787",false,"NCT00693589","Effect of Homocysteine-lowering Therapy With Folic Acid, Vitamin B12, and Vitamin B6 on Endothelium-dependent Vasodilatation of Forearm Resistance Vessels in Patients With Coronary Heart Disease","Inclusion Criteria:\n\n* CAD or PAD (\\>50% luminal stenosis), previous myocardial infarction or bypass surgery \\>3 month ago\n* history of percutaneous coronary intervention (PTCA or stenting)\n* confirmed consent\n\nExclusion Criteria:\n\n* myocardial infarction or acute coronary syndrome or bypass surgery \\\u003C3 month ago\n* ongoing treatment with statins\n* ongoing vitamin supplementation with folic acid and B vitamins\n* \\\u003C18 years\n* active smokers\n* uncontrolled arterial hypertension\n* renal insufficiency\n* atrial fibrillation\n* liver disease\n* NYHA class \\>2\n* familial hypercholesterolemia","ALL","18 Years",{"count":47,"type":48},36,"ACTUAL","INTERVENTIONAL",[51],"PHASE2","Endothelial dysfunction is an early marker of atherosclerosis and is found in patients (pts) with coronary (CAD) and peripheral artery disease (PAD). Statin-therapy has been shown to improve endothelial function in pts with CAD or PAD by reducing LDL-cholesterol and inflammatory markers. B-group vitamin-supplements have variable been reported to have positive or neutral effects on endothelial function. Therefore, we want to compare the effect of rosuvastatin and B-group vitamin supplementation on endothelial function of the forearm resistance vessels in pts with cardiovascular disease.",[54,55],"Cardiovascular Disease","Endothelial Dysfunction",[57,58,59,60,61],"endothelial function","flow mediated dilatation","rosuvastatin","folic acid","B vitamins","COMPLETED","2024-11-06",{"date":65,"type":48},"2024-11-07",{"date":67,"type":34},"2005-01",{"date":69,"type":48},"2007-04",{"name":5,"class":6}]