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Clinical Research Network (CRN) System Stage 1 to 3\n* Meeting any of the 3 major criteria (a, b, c):\n\n  1. Documented evidence of type 2 diabetes mellitus\n  2. High body mass index (\\> 25 kg\u002Fm\\^2) with at least one of the following criteria of metabolic syndrome, as defined by the National Cholesterol Education Program:\n\n     * Central obesity: waist circumference ≥ 102 cm or 40 inches (male), ≥ 88 cm or 35 inches (female)\n     * Dyslipidemia: Triglycerides ≥ 1.7 mmol\u002FL (150 mg\u002FdL)\n     * Dyslipidemia: High-density lipoprotein (HDL)-cholesterol \\\u003C 40 mg\u002FdL (male), \\\u003C 50 mg\u002FdL (female)\n     * Blood pressure ≥ 130\u002F85 mmHg (or currently being treated for hypertension)\n     * Fasting plasma glucose ≥ 6.1 mmol\u002FL (110 mg\u002FdL)\n  3. Bridging fibrosis (NASH CRN Stage 3) and\u002For definite NASH (NAS ≥ 5)\n* Agree to have one liver biopsy at Screening, one at Year 1, and one at the end of study treatment (Year 2)\n* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 5 × upper limit of normal (ULN)\n\nExclusion Criteria:\n\n* Hepatitis B surface Antigen (HBsAg) positive\n* Hepatitis C antibody (HCVAb) positive with the following 2 exceptions:\n\n  1. Participants previously treated for viral hepatitis C with at least a 1-year period since documented sustained virologic response at Week 12 (post-treatment) may be eligible if all other eligibility criteria are met\n  2. Participants with presence of hepatitis C antibody but negative hepatitis C virus ribonucleic acid RNA without treatment (i.e., spontaneous clearance) may be eligible if all other eligibility criteria are met\n* Prior or planned liver transplantation\n* Other known causes of chronic liver disease, including alcoholic liver disease\n* History of cirrhosis and\u002For hepatic decompensation including ascites, hepatic encephalopathy or variceal bleeding\n* Alcohol consumption greater than 21 units\u002Fweek for males or 14 units\u002Fweek for females (one unit of alcohol is ½ pint of beer \\[285 mL\\], 1 glass of spirits \\[25 mL\\] or 1 glass of wine \\[125 mL\\])\n* Human immunodeficiency virus (HIV)-1 or HIV-2 infection\n* Weight reduction through bariatric surgery in the past 5 years or planned during the conduct of the study (including gastric banding)\n* Females who are pregnant or breastfeeding\n* Any other clinically significant disorders or prior therapy that, in the opinion of the investigator, would make the participant unsuitable for the study or unable to comply with the dosing and protocol requirements.",false,"ALL","18 Years","75 Years",{"count":808,"type":809},289,"ACTUAL","INTERVENTIONAL",[812],"PHASE2","The purpose of this study is to determine whether cenicriviroc is effective and safe in the treatment of nonalcoholic steatohepatitis (NASH) in adult participants with liver fibrosis.",[815],"Nonalcoholic Steatohepatitis","COMPLETED","2019-04-19",{"date":819,"type":809},"2019-05-10",{"date":821,"type":809},"2014-09-18",{"date":823,"type":809},"2017-06-22",{"name":5,"class":6},91]