[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100379260":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":11,"centralContacts":11,"locations":42,"responsibleParty":874,"collaborators":11,"id":876,"slug":877,"hasResults":878,"nctId":879,"briefTitle":880,"officialTitle":881,"acronym":882,"eligibilityCriteria":883,"healthyVolunteers":884,"sex":885,"minAge":886,"maxAge":11,"enrollmentInfo":887,"targetDuration":11,"studyType":890,"phases":891,"briefSummary":893,"conditions":894,"keywords":11,"overallStatus":896,"whyStopped":11,"lastUpdateSubmitDate":897,"lastUpdatePostDateStruct":898,"startDateStruct":900,"completionDateStruct":902,"leadSponsor":904,"locationsCount":905},{"fullName":5,"class":6},"Bayer","INDUSTRY",[8,15,18],{"label":9,"type":10,"description":11,"interventionNames":12},"BAY2433334 50mg+Apixaban matching placebo","EXPERIMENTAL",null,[13,14],"Drug: BAY2433334","Other: Apixaban matching placebo",{"label":16,"type":10,"description":11,"interventionNames":17},"BAY2433334 20mg+Apixaban matching placebo",[13,14],{"label":19,"type":20,"description":21,"interventionNames":22},"BAY2433334 matching placebo+Apixaban","ACTIVE_COMPARATOR","Apixaban usual dose is 5 mg, reduced to 2.5 mg for participants with any 2 of the following criteria: age 80 years or older, body weight less than 60 kg, or serum creatinine level of 1.5 mg per dL or more.",[23,24],"Drug: Apixaban","Other: BAY2433334 matching placebo",[26,31,35,39],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":11},"DRUG","BAY2433334","Tablet, taken orally once a day.",[16,9],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":11},"Apixaban","Capsule, taken orally twice a day.",[19],{"type":36,"name":37,"description":29,"armGroupLabels":38,"otherNames":11},"OTHER","BAY2433334 matching placebo",[19],{"type":36,"name":40,"description":33,"armGroupLabels":41,"otherNames":11},"Apixaban matching placebo",[16,9],[43,56,66,76,85,95,104,113,119,131,140,149,158,167,176,185,197,207,213,217,227,236,242,248,257,266,277,286,295,304,313,322,331,342,351,356,364,373,382,391,400,412,422,432,442,452,457,467,479,489,494,504,513,518,527,533,537,548,554,563,572,578,584,595,604,613,622,631,640,649,658,670,678,684,693,702,713,722,731,740,749,758,764,776,786,796,805,814,823,835,845,855,865],{"facility":44,"status":11,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":11},"Medizinische Universität Graz","Graz","Styria","8036","Austria","AT",{"type":51,"coordinates":52},"Point",[53,54],15.44197,47.06733,{"lat":54,"lon":53},{"facility":57,"status":11,"city":58,"state":59,"zip":60,"country":48,"countryCode":49,"cosmosGeoPoint":61,"geoPoint":65,"contacts":11},"Medizinische Universität Innsbruck","Innsbruck","Tyrol","6020",{"type":51,"coordinates":62},[63,64],11.39454,47.26266,{"lat":64,"lon":63},{"facility":67,"status":11,"city":68,"state":69,"zip":70,"country":48,"countryCode":49,"cosmosGeoPoint":71,"geoPoint":75,"contacts":11},"Krankenhaus St. Josef Braunau","Braunau am Inn","Upper Austria","5280",{"type":51,"coordinates":72},[73,74],13.04343,48.25628,{"lat":74,"lon":73},{"facility":77,"status":11,"city":78,"state":69,"zip":79,"country":48,"countryCode":49,"cosmosGeoPoint":80,"geoPoint":84,"contacts":11},"Ordensklinikum Linz GmbH Elisabethinen","Linz","4020",{"type":51,"coordinates":81},[82,83],14.28611,48.30639,{"lat":83,"lon":82},{"facility":86,"status":11,"city":87,"state":88,"zip":89,"country":48,"countryCode":49,"cosmosGeoPoint":90,"geoPoint":94,"contacts":11},"Landeskrankenhaus Feldkirch","Feldkirch","Vorarlberg","6807",{"type":51,"coordinates":91},[92,93],9.59734,47.23645,{"lat":93,"lon":92},{"facility":96,"status":11,"city":97,"state":11,"zip":98,"country":48,"countryCode":49,"cosmosGeoPoint":99,"geoPoint":103,"contacts":11},"Uniklinikum Salzburg - Landeskrankenhaus","Salzburg","5020",{"type":51,"coordinates":100},[101,102],13.04399,47.79941,{"lat":102,"lon":101},{"facility":105,"status":11,"city":106,"state":11,"zip":107,"country":48,"countryCode":49,"cosmosGeoPoint":108,"geoPoint":112,"contacts":11},"Universitätsklinikum AKH Wien","Vienna","1090",{"type":51,"coordinates":109},[110,111],16.37208,48.20849,{"lat":111,"lon":110},{"facility":114,"status":11,"city":106,"state":11,"zip":115,"country":48,"countryCode":49,"cosmosGeoPoint":116,"geoPoint":118,"contacts":11},"Klinik Floridsdorf - Krankenhaus Nord","1210",{"type":51,"coordinates":117},[110,111],{"lat":111,"lon":110},{"facility":120,"status":11,"city":121,"state":122,"zip":123,"country":124,"countryCode":125,"cosmosGeoPoint":126,"geoPoint":130,"contacts":11},"UZ Leuven Gasthuisberg","Leuven","Vlaams Brabant","3000","Belgium","BE",{"type":51,"coordinates":127},[128,129],4.70093,50.87959,{"lat":129,"lon":128},{"facility":132,"status":11,"city":133,"state":11,"zip":134,"country":124,"countryCode":125,"cosmosGeoPoint":135,"geoPoint":139,"contacts":11},"Imeldaziekenhuis - St-Elisabethkliniek","Bonheiden","2820",{"type":51,"coordinates":136},[137,138],4.54714,51.02261,{"lat":138,"lon":137},{"facility":141,"status":11,"city":142,"state":11,"zip":143,"country":124,"countryCode":125,"cosmosGeoPoint":144,"geoPoint":148,"contacts":11},"AZ St-Jan Brugge Oostende AV","Bruges","8000",{"type":51,"coordinates":145},[146,147],3.22424,51.20892,{"lat":147,"lon":146},{"facility":150,"status":11,"city":151,"state":11,"zip":152,"country":124,"countryCode":125,"cosmosGeoPoint":153,"geoPoint":157,"contacts":11},"UZ Antwerpen","Edegem","2650",{"type":51,"coordinates":154},[155,156],4.44504,51.15662,{"lat":156,"lon":155},{"facility":159,"status":11,"city":160,"state":11,"zip":161,"country":124,"countryCode":125,"cosmosGeoPoint":162,"geoPoint":166,"contacts":11},"Jessa Ziekenhuis","Hasselt","3500",{"type":51,"coordinates":163},[164,165],5.33781,50.93106,{"lat":165,"lon":164},{"facility":168,"status":11,"city":169,"state":11,"zip":170,"country":124,"countryCode":125,"cosmosGeoPoint":171,"geoPoint":175,"contacts":11},"VZW Emmaus","Mechelen","2800",{"type":51,"coordinates":172},[173,174],4.47762,51.02574,{"lat":174,"lon":173},{"facility":177,"status":11,"city":178,"state":11,"zip":179,"country":124,"countryCode":125,"cosmosGeoPoint":180,"geoPoint":184,"contacts":11},"AZ Delta","Roeselare","8800",{"type":51,"coordinates":181},[182,183],3.12269,50.94653,{"lat":183,"lon":182},{"facility":186,"status":11,"city":187,"state":188,"zip":189,"country":190,"countryCode":191,"cosmosGeoPoint":192,"geoPoint":196,"contacts":11},"Queen Elizabeth II Health Sciences Centre","Halifax","Nova Scotia","B3H 3A7","Canada","CA",{"type":51,"coordinates":193},[194,195],-63.57688,44.64269,{"lat":195,"lon":194},{"facility":198,"status":11,"city":199,"state":200,"zip":201,"country":190,"countryCode":191,"cosmosGeoPoint":202,"geoPoint":206,"contacts":11},"Montreal Heart Institute","Montreal","Quebec","H1T 1C8",{"type":51,"coordinates":203},[204,205],-73.58781,45.50884,{"lat":205,"lon":204},{"facility":208,"status":11,"city":199,"state":200,"zip":209,"country":190,"countryCode":191,"cosmosGeoPoint":210,"geoPoint":212,"contacts":11},"Clinique Sante Cardio MC","H1T 3Y7",{"type":51,"coordinates":211},[204,205],{"lat":205,"lon":204},{"facility":214,"status":11,"city":215,"state":200,"zip":216,"country":190,"countryCode":191,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"Institut universitaire de cardiologie et de pneumologie","Ste-Foy","G1V 4G5",{"facility":218,"status":11,"city":219,"state":11,"zip":220,"country":221,"countryCode":11,"cosmosGeoPoint":222,"geoPoint":226,"contacts":11},"Fakultni nemocnice Plzen - Lochotin","Pilsen","304 60","Czechia",{"type":51,"coordinates":223},[224,225],13.37759,49.74747,{"lat":225,"lon":224},{"facility":228,"status":11,"city":229,"state":11,"zip":230,"country":221,"countryCode":11,"cosmosGeoPoint":231,"geoPoint":235,"contacts":11},"Fakultni nemocnice Kralovske Vinohrady","Prague","100 34",{"type":51,"coordinates":232},[233,234],14.42076,50.08804,{"lat":234,"lon":233},{"facility":237,"status":11,"city":229,"state":11,"zip":238,"country":221,"countryCode":11,"cosmosGeoPoint":239,"geoPoint":241,"contacts":11},"Institut Klinicke a Experimentalni Mediciny","140 21",{"type":51,"coordinates":240},[233,234],{"lat":234,"lon":233},{"facility":243,"status":11,"city":229,"state":11,"zip":244,"country":221,"countryCode":11,"cosmosGeoPoint":245,"geoPoint":247,"contacts":11},"Fakultni nemocnice v Motole","150 06",{"type":51,"coordinates":246},[233,234],{"lat":234,"lon":233},{"facility":249,"status":11,"city":250,"state":11,"zip":251,"country":221,"countryCode":11,"cosmosGeoPoint":252,"geoPoint":256,"contacts":11},"Nemocnice Slany","Slaný","274 01",{"type":51,"coordinates":253},[254,255],14.08693,50.23046,{"lat":255,"lon":254},{"facility":258,"status":11,"city":259,"state":11,"zip":260,"country":221,"countryCode":11,"cosmosGeoPoint":261,"geoPoint":265,"contacts":11},"Krajska nemocnice T. Bati, a.s.","Zlín","762 75",{"type":51,"coordinates":262},[263,264],17.67065,49.22645,{"lat":264,"lon":263},{"facility":267,"status":11,"city":268,"state":11,"zip":269,"country":270,"countryCode":271,"cosmosGeoPoint":272,"geoPoint":276,"contacts":11},"Hôpital Henri Mondor","Créteil","94010","France","FR",{"type":51,"coordinates":273},[274,275],2.46569,48.79266,{"lat":275,"lon":274},{"facility":278,"status":11,"city":279,"state":11,"zip":280,"country":270,"countryCode":271,"cosmosGeoPoint":281,"geoPoint":285,"contacts":11},"Centre Hospitalier Départemental Vendée","La Roche-sur-Yon","85025",{"type":51,"coordinates":282},[283,284],-1.42757,46.66974,{"lat":284,"lon":283},{"facility":287,"status":11,"city":288,"state":11,"zip":289,"country":270,"countryCode":271,"cosmosGeoPoint":290,"geoPoint":294,"contacts":11},"Centre Hospitalier Louis Pasteur","Le Coudray","28630",{"type":51,"coordinates":291},[292,293],1.50057,48.42115,{"lat":293,"lon":292},{"facility":296,"status":11,"city":297,"state":11,"zip":298,"country":270,"countryCode":271,"cosmosGeoPoint":299,"geoPoint":303,"contacts":11},"Hopital Bichat - Paris","Paris","75018",{"type":51,"coordinates":300},[301,302],2.3488,48.85341,{"lat":302,"lon":301},{"facility":305,"status":11,"city":306,"state":11,"zip":307,"country":270,"countryCode":271,"cosmosGeoPoint":308,"geoPoint":312,"contacts":11},"Centre Hospitalier Régional - Saint Brieuc","Saint-Brieuc","22000",{"type":51,"coordinates":309},[310,311],-2.76838,48.51513,{"lat":311,"lon":310},{"facility":314,"status":11,"city":315,"state":11,"zip":316,"country":270,"countryCode":271,"cosmosGeoPoint":317,"geoPoint":321,"contacts":11},"Hôpital de Rangueil - Toulouse","Toulouse","31403",{"type":51,"coordinates":318},[319,320],1.44367,43.60426,{"lat":320,"lon":319},{"facility":323,"status":11,"city":324,"state":11,"zip":325,"country":270,"countryCode":271,"cosmosGeoPoint":326,"geoPoint":330,"contacts":11},"Centre Hospitalier - Valenciennes Cedex","Valenciennes","59322",{"type":51,"coordinates":327},[328,329],3.52506,50.35909,{"lat":329,"lon":328},{"facility":332,"status":11,"city":333,"state":11,"zip":334,"country":335,"countryCode":336,"cosmosGeoPoint":337,"geoPoint":341,"contacts":11},"Tagore Medical Center","Balatonfüred","8230","Hungary","HU",{"type":51,"coordinates":338},[339,340],17.87187,46.96188,{"lat":340,"lon":339},{"facility":343,"status":11,"city":344,"state":11,"zip":345,"country":335,"countryCode":336,"cosmosGeoPoint":346,"geoPoint":350,"contacts":11},"University of Semmelweis\u002F Semmelweis Egyetem","Budapest","1122",{"type":51,"coordinates":347},[348,349],19.04045,47.49835,{"lat":349,"lon":348},{"facility":352,"status":11,"city":344,"state":11,"zip":11,"country":335,"countryCode":336,"cosmosGeoPoint":353,"geoPoint":355,"contacts":11},"Magyar Honvedseg Egeszsegugyi Kozpont",{"type":51,"coordinates":354},[348,349],{"lat":349,"lon":348},{"facility":357,"status":11,"city":358,"state":11,"zip":179,"country":335,"countryCode":336,"cosmosGeoPoint":359,"geoPoint":363,"contacts":11},"Kanizsai Dorottya Hospital","Nagykanizsa",{"type":51,"coordinates":360},[361,362],16.99104,46.45347,{"lat":362,"lon":361},{"facility":365,"status":11,"city":366,"state":11,"zip":367,"country":335,"countryCode":336,"cosmosGeoPoint":368,"geoPoint":372,"contacts":11},"Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.","Nyíregyháza","4400",{"type":51,"coordinates":369},[370,371],21.71671,47.95539,{"lat":371,"lon":370},{"facility":374,"status":11,"city":375,"state":11,"zip":376,"country":335,"countryCode":336,"cosmosGeoPoint":377,"geoPoint":381,"contacts":11},"Pecsi Tudomanyegyetem Klinikai Kozpont","Pécs","7624",{"type":51,"coordinates":378},[379,380],18.22814,46.07617,{"lat":380,"lon":379},{"facility":383,"status":11,"city":384,"state":11,"zip":385,"country":335,"countryCode":336,"cosmosGeoPoint":386,"geoPoint":390,"contacts":11},"Tolna Megyei Balassa Janos Korhaz","Szekszárd","7100",{"type":51,"coordinates":387},[388,389],18.71189,46.34723,{"lat":389,"lon":388},{"facility":392,"status":11,"city":393,"state":11,"zip":394,"country":335,"countryCode":336,"cosmosGeoPoint":395,"geoPoint":399,"contacts":11},"Csongrad-Csanad Megyei Dr. Bugyi Istvan Korhaz","Szentes","6600",{"type":51,"coordinates":396},[397,398],20.2608,46.65834,{"lat":398,"lon":397},{"facility":401,"status":11,"city":402,"state":403,"zip":404,"country":405,"countryCode":406,"cosmosGeoPoint":407,"geoPoint":411,"contacts":11},"A.O.U. Policlinico Umberto I","Rome","Lazio","00161","Italy","IT",{"type":51,"coordinates":408},[409,410],12.51133,41.89193,{"lat":410,"lon":409},{"facility":413,"status":11,"city":414,"state":415,"zip":416,"country":405,"countryCode":406,"cosmosGeoPoint":417,"geoPoint":421,"contacts":11},"IRCCS Ospedale Policlinico San Martino","Genoa","Liguria","16132",{"type":51,"coordinates":418},[419,420],8.94439,44.40478,{"lat":420,"lon":419},{"facility":423,"status":11,"city":424,"state":425,"zip":426,"country":405,"countryCode":406,"cosmosGeoPoint":427,"geoPoint":431,"contacts":11},"ASST Spedali Civili di Brescia","Brescia","Lombardy","25123",{"type":51,"coordinates":428},[429,430],10.21472,45.53558,{"lat":430,"lon":429},{"facility":433,"status":11,"city":434,"state":435,"zip":436,"country":405,"countryCode":406,"cosmosGeoPoint":437,"geoPoint":441,"contacts":11},"ASUR Marche - Area Vasta 5","Ascoli Piceno","The Marches","63074",{"type":51,"coordinates":438},[439,440],13.57395,42.85351,{"lat":440,"lon":439},{"facility":443,"status":11,"city":444,"state":445,"zip":446,"country":405,"countryCode":406,"cosmosGeoPoint":447,"geoPoint":451,"contacts":11},"AUSL Toscana Sud-Est","Arezzo","Tuscany","52044",{"type":51,"coordinates":448},[449,450],11.88068,43.46276,{"lat":450,"lon":449},{"facility":443,"status":11,"city":444,"state":445,"zip":453,"country":405,"countryCode":406,"cosmosGeoPoint":454,"geoPoint":456,"contacts":11},"52100",{"type":51,"coordinates":455},[449,450],{"lat":450,"lon":449},{"facility":458,"status":11,"city":459,"state":460,"zip":461,"country":405,"countryCode":406,"cosmosGeoPoint":462,"geoPoint":466,"contacts":11},"A.O. di Perugia","Perugia","Umbria","06129",{"type":51,"coordinates":463},[464,465],12.38878,43.1122,{"lat":465,"lon":464},{"facility":468,"status":11,"city":469,"state":470,"zip":471,"country":472,"countryCode":473,"cosmosGeoPoint":474,"geoPoint":478,"contacts":11},"Nakamura Cardiovascular Clinic","Itoshima","Fukuoka","819-1104","Japan","JP",{"type":51,"coordinates":475},[476,477],130.18421,33.54225,{"lat":477,"lon":476},{"facility":480,"status":11,"city":481,"state":482,"zip":483,"country":472,"countryCode":473,"cosmosGeoPoint":484,"geoPoint":488,"contacts":11},"Hyogo Prefectural Harima-Himeji General Medical Center","Himeji","Hyōgo","670-8560",{"type":51,"coordinates":485},[486,487],134.7,34.81667,{"lat":487,"lon":486},{"facility":490,"status":11,"city":491,"state":492,"zip":493,"country":472,"countryCode":473,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"Hayama Heart Center","Miura-gun","Kanagawa","240-0116",{"facility":495,"status":11,"city":496,"state":497,"zip":498,"country":472,"countryCode":473,"cosmosGeoPoint":499,"geoPoint":503,"contacts":11},"Kishiwada Tokushukai Hospital","Kishiwada","Osaka","596-0042",{"type":51,"coordinates":500},[501,502],135.36667,34.46667,{"lat":502,"lon":501},{"facility":505,"status":11,"city":506,"state":497,"zip":507,"country":472,"countryCode":473,"cosmosGeoPoint":508,"geoPoint":512,"contacts":11},"Yao Tokushukai General Hospital","Yao","581-0011",{"type":51,"coordinates":509},[510,511],135.6,34.61667,{"lat":511,"lon":510},{"facility":514,"status":11,"city":515,"state":516,"zip":517,"country":472,"countryCode":473,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"Nishiarai Heart Central Clinic","Adachi-ku","Tokyo","123-0845",{"facility":519,"status":11,"city":520,"state":516,"zip":521,"country":472,"countryCode":473,"cosmosGeoPoint":522,"geoPoint":526,"contacts":11},"Minamino Cardiovascular Hospital","Hachiōji","192-0918",{"type":51,"coordinates":523},[524,525],139.32389,35.65583,{"lat":525,"lon":524},{"facility":528,"status":11,"city":520,"state":516,"zip":529,"country":472,"countryCode":473,"cosmosGeoPoint":530,"geoPoint":532,"contacts":11},"Tokyo Angel Hospital","193-0811",{"type":51,"coordinates":531},[524,525],{"lat":525,"lon":524},{"facility":534,"status":11,"city":535,"state":516,"zip":536,"country":472,"countryCode":473,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"Koto Hospital","Koto-ku","136-0072",{"facility":538,"status":11,"city":539,"state":11,"zip":540,"country":541,"countryCode":542,"cosmosGeoPoint":543,"geoPoint":547,"contacts":11},"Doctor's Practice in Cardiology","Daugavpils","LV-5401","Latvia","LV",{"type":51,"coordinates":544},[545,546],26.53333,55.88333,{"lat":546,"lon":545},{"facility":549,"status":11,"city":539,"state":11,"zip":550,"country":541,"countryCode":542,"cosmosGeoPoint":551,"geoPoint":553,"contacts":11},"Daugavpils Regional Hospital","LV-5417",{"type":51,"coordinates":552},[545,546],{"lat":546,"lon":545},{"facility":555,"status":11,"city":556,"state":11,"zip":557,"country":541,"countryCode":542,"cosmosGeoPoint":558,"geoPoint":562,"contacts":11},"Liepaja Regional Hospital","Liepāja","LV-3414",{"type":51,"coordinates":559},[560,561],21.01085,56.50474,{"lat":561,"lon":560},{"facility":564,"status":11,"city":565,"state":11,"zip":566,"country":541,"countryCode":542,"cosmosGeoPoint":567,"geoPoint":571,"contacts":11},"1st Riga Clinical Hospital","Riga","LV-1001",{"type":51,"coordinates":568},[569,570],24.10589,56.946,{"lat":570,"lon":569},{"facility":573,"status":11,"city":565,"state":11,"zip":574,"country":541,"countryCode":542,"cosmosGeoPoint":575,"geoPoint":577,"contacts":11},"P. Stradins Clinical University Hospital","LV-1002",{"type":51,"coordinates":576},[569,570],{"lat":570,"lon":569},{"facility":579,"status":11,"city":565,"state":11,"zip":580,"country":541,"countryCode":542,"cosmosGeoPoint":581,"geoPoint":583,"contacts":11},"Riga East Clinical University Hospital \"Gailezers\"","LV-1038",{"type":51,"coordinates":582},[569,570],{"lat":570,"lon":569},{"facility":585,"status":11,"city":586,"state":11,"zip":587,"country":588,"countryCode":589,"cosmosGeoPoint":590,"geoPoint":594,"contacts":11},"Academisch Medisch Centrum (AMC)","Amsterdam","1105 AZ","Netherlands","NL",{"type":51,"coordinates":591},[592,593],4.88969,52.37403,{"lat":593,"lon":592},{"facility":596,"status":11,"city":597,"state":11,"zip":598,"country":588,"countryCode":589,"cosmosGeoPoint":599,"geoPoint":603,"contacts":11},"Ziekenhuis Rijnstate","Arnhem","6815 AD",{"type":51,"coordinates":600},[601,602],5.91111,51.98,{"lat":602,"lon":601},{"facility":605,"status":11,"city":606,"state":11,"zip":607,"country":588,"countryCode":589,"cosmosGeoPoint":608,"geoPoint":612,"contacts":11},"Amphia Ziekenhuis, locatie Molengracht","Breda","4818 CK",{"type":51,"coordinates":609},[610,611],4.77596,51.58656,{"lat":611,"lon":610},{"facility":614,"status":11,"city":615,"state":11,"zip":616,"country":588,"countryCode":589,"cosmosGeoPoint":617,"geoPoint":621,"contacts":11},"Albert Schweitzer Ziekenhuis, Dordwijk","Dordrecht","3318 AT",{"type":51,"coordinates":618},[619,620],4.67361,51.81,{"lat":620,"lon":619},{"facility":623,"status":11,"city":624,"state":11,"zip":625,"country":588,"countryCode":589,"cosmosGeoPoint":626,"geoPoint":630,"contacts":11},"Medisch Spectrum Twente","Enschede","7511 JX",{"type":51,"coordinates":627},[628,629],6.89583,52.21833,{"lat":629,"lon":628},{"facility":632,"status":11,"city":633,"state":11,"zip":634,"country":588,"countryCode":589,"cosmosGeoPoint":635,"geoPoint":639,"contacts":11},"Martini Ziekenhuis, Locatie van Swieten","Groningen","9728 NT",{"type":51,"coordinates":636},[637,638],6.56667,53.21917,{"lat":638,"lon":637},{"facility":641,"status":11,"city":642,"state":11,"zip":643,"country":588,"countryCode":589,"cosmosGeoPoint":644,"geoPoint":648,"contacts":11},"Spaarne Gasthuis - locatie Zuid","Haarlem","2035 RC",{"type":51,"coordinates":645},[646,647],4.63683,52.38084,{"lat":647,"lon":646},{"facility":650,"status":11,"city":651,"state":11,"zip":652,"country":588,"countryCode":589,"cosmosGeoPoint":653,"geoPoint":657,"contacts":11},"Maastricht UMC","Maastricht","6229 HX",{"type":51,"coordinates":654},[655,656],5.68889,50.84833,{"lat":656,"lon":655},{"facility":659,"status":11,"city":660,"state":661,"zip":662,"country":663,"countryCode":664,"cosmosGeoPoint":665,"geoPoint":669,"contacts":11},"Ciutat Sanitària i Universitària de Bellvitge","L'Hospitalet de Llobregat","Barcelona","08907","Spain","ES",{"type":51,"coordinates":666},[667,668],2.10028,41.35967,{"lat":668,"lon":667},{"facility":671,"status":11,"city":661,"state":11,"zip":672,"country":663,"countryCode":664,"cosmosGeoPoint":673,"geoPoint":677,"contacts":11},"Ciutat Sanitària i Universitaria de la Vall d'Hebron","08035",{"type":51,"coordinates":674},[675,676],2.15899,41.38879,{"lat":676,"lon":675},{"facility":679,"status":11,"city":661,"state":11,"zip":680,"country":663,"countryCode":664,"cosmosGeoPoint":681,"geoPoint":683,"contacts":11},"Hospital de la Santa Creu i de Sant Pau | Cardiología","08041",{"type":51,"coordinates":682},[675,676],{"lat":676,"lon":675},{"facility":685,"status":11,"city":686,"state":11,"zip":687,"country":663,"countryCode":664,"cosmosGeoPoint":688,"geoPoint":692,"contacts":11},"Hospital Universitario 12 de Octubre","Madrid","28041",{"type":51,"coordinates":689},[690,691],-3.70256,40.4165,{"lat":691,"lon":690},{"facility":694,"status":11,"city":695,"state":11,"zip":696,"country":663,"countryCode":664,"cosmosGeoPoint":697,"geoPoint":701,"contacts":11},"Hospital Virgen de la Victoria","Málaga","29010",{"type":51,"coordinates":698},[699,700],-4.42034,36.72016,{"lat":700,"lon":699},{"facility":703,"status":11,"city":704,"state":11,"zip":705,"country":706,"countryCode":707,"cosmosGeoPoint":708,"geoPoint":712,"contacts":11},"Falu Lasarett","Falun","791 82","Sweden","SE",{"type":51,"coordinates":709},[710,711],15.62597,60.60357,{"lat":711,"lon":710},{"facility":714,"status":11,"city":715,"state":11,"zip":716,"country":706,"countryCode":707,"cosmosGeoPoint":717,"geoPoint":721,"contacts":11},"Clemenstorget Hjärtmottagning","Lund","222 21",{"type":51,"coordinates":718},[719,720],13.19321,55.70584,{"lat":720,"lon":719},{"facility":723,"status":11,"city":724,"state":11,"zip":725,"country":706,"countryCode":707,"cosmosGeoPoint":726,"geoPoint":730,"contacts":11},"Avdelningen för kliniska prövningar AKP","Örebro","703 62",{"type":51,"coordinates":727},[728,729],15.2066,59.27412,{"lat":729,"lon":728},{"facility":732,"status":11,"city":733,"state":11,"zip":734,"country":706,"countryCode":707,"cosmosGeoPoint":735,"geoPoint":739,"contacts":11},"Östersunds Sjukhus","Östersund","831 83",{"type":51,"coordinates":736},[737,738],14.63566,63.1792,{"lat":738,"lon":737},{"facility":741,"status":11,"city":742,"state":11,"zip":743,"country":706,"countryCode":707,"cosmosGeoPoint":744,"geoPoint":748,"contacts":11},"Skellefteå Lasarett","Skellefteå","931 86",{"type":51,"coordinates":745},[746,747],20.95279,64.75067,{"lat":747,"lon":746},{"facility":750,"status":11,"city":751,"state":11,"zip":752,"country":706,"countryCode":707,"cosmosGeoPoint":753,"geoPoint":757,"contacts":11},"Södersjukhuset AB","Stockholm","118 83",{"type":51,"coordinates":754},[755,756],18.06871,59.32938,{"lat":756,"lon":755},{"facility":759,"status":11,"city":751,"state":11,"zip":760,"country":706,"countryCode":707,"cosmosGeoPoint":761,"geoPoint":763,"contacts":11},"Danderyds sjukhus","182 88",{"type":51,"coordinates":762},[755,756],{"lat":756,"lon":755},{"facility":765,"status":11,"city":766,"state":767,"zip":768,"country":769,"countryCode":770,"cosmosGeoPoint":771,"geoPoint":775,"contacts":11},"Kantonsspital Aarau","Aarau","Canton of Aargau","5001","Switzerland","CH",{"type":51,"coordinates":772},[773,774],8.04422,47.39254,{"lat":774,"lon":773},{"facility":777,"status":11,"city":778,"state":779,"zip":780,"country":769,"countryCode":770,"cosmosGeoPoint":781,"geoPoint":785,"contacts":11},"Universitätsspital Basel","Basel","Canton of Basel-City","4031",{"type":51,"coordinates":782},[783,784],7.57327,47.55839,{"lat":784,"lon":783},{"facility":787,"status":11,"city":788,"state":789,"zip":790,"country":769,"countryCode":770,"cosmosGeoPoint":791,"geoPoint":795,"contacts":11},"Kantonsspital St. Gallen","Sankt Gallen","Canton of St. Gallen","9007",{"type":51,"coordinates":792},[793,794],9.37477,47.42391,{"lat":794,"lon":793},{"facility":797,"status":11,"city":798,"state":11,"zip":799,"country":769,"countryCode":770,"cosmosGeoPoint":800,"geoPoint":804,"contacts":11},"Inselspital Universitätsspital Bern","Bern","3010",{"type":51,"coordinates":801},[802,803],7.44744,46.94809,{"lat":803,"lon":802},{"facility":806,"status":11,"city":807,"state":11,"zip":808,"country":769,"countryCode":770,"cosmosGeoPoint":809,"geoPoint":813,"contacts":11},"Hôpital Cantonal Universitaire de Genève","Geneva","1211",{"type":51,"coordinates":810},[811,812],6.14569,46.20222,{"lat":812,"lon":811},{"facility":815,"status":11,"city":816,"state":11,"zip":817,"country":769,"countryCode":770,"cosmosGeoPoint":818,"geoPoint":822,"contacts":11},"Ospedale regionale di Lugano","Lugano","6900",{"type":51,"coordinates":819},[820,821],8.96004,46.01008,{"lat":821,"lon":820},{"facility":824,"status":11,"city":825,"state":826,"zip":827,"country":828,"countryCode":829,"cosmosGeoPoint":830,"geoPoint":834,"contacts":11},"Staploe Medical Centre","Ely","Cambridgeshire","CB7 5SQ","United Kingdom","UK",{"type":51,"coordinates":831},[832,833],0.26196,52.39964,{"lat":833,"lon":832},{"facility":836,"status":11,"city":837,"state":838,"zip":839,"country":828,"countryCode":829,"cosmosGeoPoint":840,"geoPoint":844,"contacts":11},"Queen Elizabeth II Hospital","Welwyn Garden City","Hertfordshire","AL7 4HQ",{"type":51,"coordinates":841},[842,843],-0.20691,51.80174,{"lat":843,"lon":842},{"facility":846,"status":11,"city":847,"state":848,"zip":849,"country":828,"countryCode":829,"cosmosGeoPoint":850,"geoPoint":854,"contacts":11},"Northwick Park Hospital","Harrow","London","HA1 3UJ",{"type":51,"coordinates":851},[852,853],-0.33208,51.57835,{"lat":853,"lon":852},{"facility":856,"status":11,"city":857,"state":858,"zip":859,"country":828,"countryCode":829,"cosmosGeoPoint":860,"geoPoint":864,"contacts":11},"St Richard's Hospital","Chichester","West Sussex","PO19 6SE",{"type":51,"coordinates":861},[862,863],-0.78003,50.83673,{"lat":863,"lon":862},{"facility":866,"status":11,"city":867,"state":11,"zip":868,"country":828,"countryCode":829,"cosmosGeoPoint":869,"geoPoint":873,"contacts":11},"Heart and Chest Hospital","Liverpool","L14 3PE",{"type":51,"coordinates":870},[871,872],-2.97794,53.41058,{"lat":872,"lon":871},{"type":875,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100379260","phase-2-study-to-gather-information-about-the-proper-dosing-of-the-oral-fxia-inhibitor-bay-2433334-and-to-compare-the-safety-of-the-study-drug-to-apixaban-a-non-vitamin-k-oral-anticoagulant-noac-in-patients-with-irregular-heartbeat-atrial-fibrillation-that-can-lead-to-heart-related-complications-100379260",true,"NCT04218266","Study to Gather Information About the Proper Dosing of the Oral FXIa Inhibitor BAY 2433334 and to Compare the Safety of the Study Drug to Apixaban, a Non-vitamin K Oral Anticoagulant (NOAC) in Patients With Irregular Heartbeat (Atrial Fibrillation) That Can Lead to Heart-related Complications.","Multicenter, Randomized, Active Comparator-controlled, Double-blind, Double-dummy, Parallel Group, Dose-finding Phase 2 Study to Compare the Safety of the Oral FXIa Inhibitor BAY2433334 to Apixaban in Patients With Atrial Fibrillation","PACIFIC-AF","Inclusion Criteria:\n\n* Participant must be 45 years of age or older at the time of signing the informed consent.\n* Participant with AF documented by ECG evidence with\n\n  * CHA2DS2-VASc score ≥ 2 if male or CHA2DS2-VASc score ≥ 3 if female\n  * Indication for treatment with an oral anticoagulant in\n\n    * any participant currently not treated with an oral anticoagulant (e.g. treatment naïve) or alternatively,\n    * participant on a NOAC in case of at least one bleeding risk feature (history of a prior bleed within the last 12 months requiring medical attention and \u002F or moderate renal dysfunction with eGFR 30-50 ml\u002Fmin and \u002F or current clinically indicated antiplatelet therapy with Acetylsalicylic acid(ASA) ≤ 100 mg)\n* Written informed consent\n\nExclusion Criteria:\n\n* Mechanical heart valve prosthesis\n* Any degree of rheumatic mitral stenosis or moderate-to-severe, non-rheumatic mitral stenosis\n* Atrial fibrillation due to a reversible cause, participants in sinus rhythm after successful ablation, or plan for cardioversion or ablation during study conduct\n* Requirement for chronic anticoagulation (for a different indication than AF) or antiplatelet therapy (up to 100 mg ASA is allowed). Anticipated need for chronic therapy with Nonsteroidal anti-inflammatory drugs (NSAIDs)\n* Treated with a Vitamin K antagonist in the 30 days prior to screening",false,"ALL","45 Years",{"count":888,"type":889},755,"ACTUAL","INTERVENTIONAL",[892],"PHASE2","The purpose of this study is to try to find the best dose of the new drug BAY 2433334 to give to participants and to look at how well BAY 2433334 works in patients with irregular heartbeat (atrial fibrillation) that can lead to blood clots, stroke and other heart-related complications. In addition researchers want to compare the safety of the study drug to apixaban, a non-vitamin K oral anticoagulant (NOAC) in patients with atrial fibrillation. This study is also done to learn how the drug in this study moves into, through and out of the body. BAY 2433334, works by blocking a step of the blood clotting process in our body and thins the blood and is a so called oral FXIa inhibitor.\n\nApixaban, works by reducing the production of blood clotting factors in our body and thins the blood and is a so called non-vitamin K oral anticoagulant (NOAC). Thinning the blood can prevent you from blood clots which can cause a stroke.",[895],"Atrial Fibrillation (AF)","COMPLETED","2022-10-26",{"date":899,"type":889},"2022-10-27",{"date":901,"type":889},"2020-01-30",{"date":903,"type":889},"2021-10-08",{"name":5,"class":6},93]