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751","Swansea",{"type":34,"coordinates":1270},[1271,1272],-3.94323,51.62079,{"lat":1272,"lon":1271},{"facility":1275,"status":19,"city":1268,"state":19,"zip":19,"country":1251,"countryCode":1252,"cosmosGeoPoint":1276,"geoPoint":1278,"contacts":19},"Ep0093 753",{"type":34,"coordinates":1277},[1271,1272],{"lat":1272,"lon":1271},{"facility":1280,"status":19,"city":1268,"state":19,"zip":19,"country":1251,"countryCode":1252,"cosmosGeoPoint":1281,"geoPoint":1283,"contacts":19},"Ep0093 764",{"type":34,"coordinates":1282},[1271,1272],{"lat":1272,"lon":1271},{"type":1285,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100314179","phase-2-study-to-test-the-safety-and-efficacy-of-padsevonil-as-adjunctive-treatment-of-focal-onset-seizures-in-adult-subjects-with-drug-resistant-epilepsy-100314179",true,"NCT03370120","Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy","An Open-Label, Multicenter, Extension Study to Evaluate the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-Onset Seizures in Adult Subjects With Drug-Resistant Epilepsy","Inclusion Criteria:\n\n* Subject is an adult (18 years of age or more )\n* Subject with epilepsy who has completed 1 of the previous Padsevonil (PSL) studies which allow access to the present study\n* Female subjects of child bearing potential must have a serum negative pregnancy test at the Entry Visit, which is confirmed to be negative by urine testing prior to further dispensing at each study visit thereafter. Subjects will be withdrawn from the study as soon as pregnancy is known. Female subjects will use an efficient form of contraception for the duration of the study and for a period of 3 months after their final dose of PSL.\n\nExclusion Criteria:\n\n* Subject has any severe medical, neurological, or psychiatric condition, or laboratory value which may have an impact on the safety of the subject\n* Subject has active suicidal ideation as indicated by a positive response ('Yes') to either Question 4 or Question 5 of the 'Since Last Visit' version of the Columbia-Suicide Severity Rating Scale (C-SSRS)\n* Subject has \\>2x upper limit of normal (ULN) of any of the following: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), or \\>ULN total bilirubin (\\>= l.5x ULN total bilirubin if known Gilbert's syndrome) at the Entry Visit\n* Subject has a clinically-significant abnormality on electrocardiogram (ECG) that, in the opinion of the investigator, increases the risks associated with participating in the study\n* Subject has an abnormality on echocardiogram at last echocardiogram assessment, or foreseen in parent study as assessed by central reader that is accompanied by clinical symptoms or a Grade 2\\* (or higher)\u002Fmoderate severity abnormality, or a history of rheumatic heart disease, or other known valvular abnormalities (\\*according to the ASE Guidelines, 2017; Zoghbi et al 2017)\n* Female subject who plans to be pregnant or is breastfeeding",false,"ALL","18 Years",{"count":1297,"type":1298},406,"ACTUAL","INTERVENTIONAL",[1301],"PHASE2","The purpose of the study is to evaluate the long-term safety and tolerability of Padsevonil administered at individualized doses as adjunctive treatment for subjects with drug-resistant epilepsy.",[1304,1305],"Drug-Resistant Epilepsy","Focal-Onset Seizures",[1304,9],"TERMINATED","Based on available data, UCB has decided to stop development of padsevonil as adjunctive treatment of focal-onset seizure","2021-11-30",{"date":1311,"type":1298},"2021-12-29",{"date":1313,"type":1298},"2018-08-27",{"date":1315,"type":1298},"2020-12-11",{"name":1317,"class":6},"UCB Biopharma SRL",156]