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Rocío","Seville","41013",{"type":76,"coordinates":1729},[1730,1731],-5.97317,37.38283,{"lat":1731,"lon":1730},{"facility":1734,"status":38,"city":1735,"state":38,"zip":1736,"country":1737,"countryCode":1738,"cosmosGeoPoint":1739,"geoPoint":1743,"contacts":38},"Universitätsspital Basel","Basel","4031","Switzerland","CH",{"type":76,"coordinates":1740},[1741,1742],7.57327,47.55839,{"lat":1742,"lon":1741},{"facility":1745,"status":38,"city":1746,"state":38,"zip":1747,"country":1748,"countryCode":1749,"cosmosGeoPoint":1750,"geoPoint":1754,"contacts":38},"Kaohsiung Medical University Chung-Ho Memorial Hospital","Kaohsiung City","807","Taiwan","TW",{"type":76,"coordinates":1751},[1752,1753],120.31333,22.61626,{"lat":1753,"lon":1752},{"facility":1756,"status":38,"city":1757,"state":38,"zip":1758,"country":1748,"countryCode":1749,"cosmosGeoPoint":1759,"geoPoint":1763,"contacts":38},"China Medical University Hospital","Taichung","40447",{"type":76,"coordinates":1760},[1761,1762],120.6839,24.1469,{"lat":1762,"lon":1761},{"facility":1765,"status":38,"city":1766,"state":38,"zip":1767,"country":1748,"countryCode":1749,"cosmosGeoPoint":1768,"geoPoint":1772,"contacts":38},"Chi-Mei Hospital, Liouying","Tainan","736",{"type":76,"coordinates":1769},[1770,1771],120.21333,22.99083,{"lat":1771,"lon":1770},{"facility":1774,"status":38,"city":1775,"state":38,"zip":1776,"country":1748,"countryCode":1749,"cosmosGeoPoint":1777,"geoPoint":1781,"contacts":38},"National Taiwan University Hospital","Taipei","10002",{"type":76,"coordinates":1778},[1779,1780],121.52639,25.05306,{"lat":1780,"lon":1779},{"facility":1783,"status":38,"city":1775,"state":38,"zip":1784,"country":1748,"countryCode":1749,"cosmosGeoPoint":1785,"geoPoint":1787,"contacts":38},"Taipei Veterans General Hospital","11211",{"type":76,"coordinates":1786},[1779,1780],{"lat":1780,"lon":1779},{"facility":1789,"status":38,"city":1790,"state":38,"zip":1791,"country":1792,"countryCode":38,"cosmosGeoPoint":1793,"geoPoint":1797,"contacts":38},"Ankara University Faculty of Medicine Cebeci Hospital","Ankara","06700","Turkey (Türkiye)",{"type":76,"coordinates":1794},[1795,1796],32.85427,39.91987,{"lat":1796,"lon":1795},{"facility":1799,"status":38,"city":1800,"state":38,"zip":1801,"country":1792,"countryCode":38,"cosmosGeoPoint":1802,"geoPoint":1806,"contacts":38},"Dokuz Eylul Universitesi Tip Fakultesi","Balçova","35330",{"type":76,"coordinates":1803},[1804,1805],27.04258,38.39201,{"lat":1805,"lon":1804},{"facility":1808,"status":38,"city":1809,"state":38,"zip":1810,"country":1792,"countryCode":38,"cosmosGeoPoint":38,"geoPoint":38,"contacts":38},"Ege Üniversitesi Tip Fakültesi","Lzmir","35100",{"facility":1812,"status":38,"city":1813,"state":1814,"zip":1293,"country":1815,"countryCode":1816,"cosmosGeoPoint":1817,"geoPoint":1821,"contacts":38},"Communal Institution 'Cherkassy Regional Oncology Dispensary' of the Cherkassy Regional Council","Cherkassy","Chernihiv Governorate","Ukraine","UA",{"type":76,"coordinates":1818},[1819,1820],32.05738,49.44452,{"lat":1820,"lon":1819},{"facility":1823,"status":38,"city":1824,"state":1814,"zip":1825,"country":1815,"countryCode":1816,"cosmosGeoPoint":1826,"geoPoint":1830,"contacts":38},"MNE Lviv Territorial Medical Association Clinical Hospital for Palliative Care","Lviv","79007",{"type":76,"coordinates":1827},[1828,1829],24.02324,49.83826,{"lat":1829,"lon":1828},{"facility":1832,"status":38,"city":1833,"state":1834,"zip":1835,"country":1815,"countryCode":1816,"cosmosGeoPoint":1836,"geoPoint":1840,"contacts":38},"Khmelnytskyi Regional Hospital","Khmelnytskyi","Kharkiv Governorate","29000",{"type":76,"coordinates":1837},[1838,1839],26.97936,49.41835,{"lat":1839,"lon":1838},{"facility":1842,"status":38,"city":1843,"state":38,"zip":1844,"country":1845,"countryCode":1846,"cosmosGeoPoint":1847,"geoPoint":1851,"contacts":38},"Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital","Cambridge","CB2 0QQ","United Kingdom","UK",{"type":76,"coordinates":1848},[1849,1850],0.11667,52.2,{"lat":1850,"lon":1849},{"facility":1853,"status":38,"city":1854,"state":38,"zip":1855,"country":1845,"countryCode":1846,"cosmosGeoPoint":1856,"geoPoint":1860,"contacts":38},"East Kent Hospitals University NHS Foundation Trust","Canterbury","CT1 3NG",{"type":76,"coordinates":1857},[1858,1859],1.07992,51.27904,{"lat":1859,"lon":1858},{"facility":1862,"status":38,"city":1863,"state":38,"zip":1864,"country":1845,"countryCode":1846,"cosmosGeoPoint":1865,"geoPoint":1869,"contacts":38},"University Hospitals of Leicester NHS Trust - Leicester Royal Infirmary","Leicester","LE1 5WW",{"type":76,"coordinates":1866},[1867,1868],-1.13169,52.6386,{"lat":1868,"lon":1867},{"facility":1871,"status":38,"city":1872,"state":38,"zip":1873,"country":1845,"countryCode":1846,"cosmosGeoPoint":1874,"geoPoint":1878,"contacts":38},"Barts Health NHS Trust - St Bartholomew's Hospital","London","EC1M 6BQ",{"type":76,"coordinates":1875},[1876,1877],-0.12574,51.50853,{"lat":1877,"lon":1876},{"facility":1880,"status":38,"city":1881,"state":38,"zip":1882,"country":1845,"countryCode":1846,"cosmosGeoPoint":1883,"geoPoint":1887,"contacts":38},"The Christie NHS Foundation Trust","Manchester","M20 4BX",{"type":76,"coordinates":1884},[1885,1886],-2.23743,53.48095,{"lat":1886,"lon":1885},{"facility":1889,"status":38,"city":1890,"state":38,"zip":1891,"country":1845,"countryCode":1846,"cosmosGeoPoint":1892,"geoPoint":1896,"contacts":38},"Freeman Hospital","Newcastle upon Tyne","NE7 7DN",{"type":76,"coordinates":1893},[1894,1895],-1.61396,54.97328,{"lat":1895,"lon":1894},{"facility":1898,"status":38,"city":1899,"state":38,"zip":1900,"country":1845,"countryCode":1846,"cosmosGeoPoint":1901,"geoPoint":1905,"contacts":38},"Nottingham University Hospitals NHS Trust - City Hospital","Nottingham","NG5 1PB",{"type":76,"coordinates":1902},[1903,1904],-1.15047,52.9536,{"lat":1904,"lon":1903},{"facility":1907,"status":38,"city":1908,"state":38,"zip":1909,"country":1845,"countryCode":1846,"cosmosGeoPoint":1910,"geoPoint":1914,"contacts":38},"Oxford University Hospitals NHS Foundation Trust","Oxford","OX3 7LE",{"type":76,"coordinates":1911},[1912,1913],-1.25596,51.75222,{"lat":1913,"lon":1912},{"type":1916,"investigatorFullName":38,"investigatorTitle":38,"investigatorAffiliation":38,"oldNameTitle":38,"oldOrganization":38},"SPONSOR","100306841","phase-3-a-study-comparing-the-efficacy-and-safety-of-polatuzumab-vedotin-with-rituximab-cyclophosphamide-doxorubicin-and-prednisone-r-chp-versus-rituximab-cyclophosphamide-doxorubicin-vincristine-and-prednisone-r-chop-in-participants-with-diffuse-large-b-cell-lymphoma-100306841",false,"NCT03274492","A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma","A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing the Efficacy and Safety of Polatuzumab Vedotin in Combination With Rituximab and CHP (R-CHP) Versus Rituximab and CHOP (R-CHOP) in Previously Untreated Patients With Diffuse Large B-Cell Lymphoma","POLARIX","Inclusion Criteria:\n\n* Previously untreated participants with cluster of differentiation 20 (CD20)-positive DLBCL, including one of the following diagnoses by 2016 World Health Organization (WHO) classification of lymphoid neoplasms: DLBCL, not otherwise specified (NOS) including germinal center B-cell type, activated B-cell type; T-cell\u002Fhistiocyte-rich large B-cell lymphoma; Epstein-Barr virus-positive DLBCL, NOS; anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma; human herpesvirus-8 (HHV8)-positive DLBCL, NOS; High-grade B-cell lymphoma with MYC and B-cell lymphoma 2 (BCL2) and\u002For B-cell lymphoma 6 (BCL6) rearrangements (double-hit or triple-hit lymphoma); High-grade B-cell lymphoma, NOS\n* Availability of archival or freshly collected tumor tissue before study enrolment\n* International Prognostic Index (IPI) score of 2-5\n* Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1, or 2\n* Life expectancy greater than or equal to (\\>\u002F=)12 months\n* Left ventricular ejection fraction (LVEF) \\>\u002F= 50 percent (%) on cardiac multiple-gated acquisition (MUGA) scan or cardiac echocardiogram (ECHO)\n* Adequate hematologic function\n* Female participants: Agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive methods and refrain from donating eggs.\n* Male participants: agreement to remain abstinent (refrain from heterosexual intercourse) or use a condom and agreement to refrain from donating sperm.\n\nExclusion Criteria:\n\n* History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies or known sensitivity or allergy to murine products\n* Contraindication to any of the individual components of CHOP, including prior receipt of anthracyclines\n* Prior organ transplantation\n* Current Grade greater than (\\>) 1 peripheral neuropathy by clinical examination\n* Demyelinating form of Charcot-Marie-Tooth disease\n* History of indolent lymphoma\n* History of follicular lymphoma grade 3B\n* B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma (grey-zone lymphoma)\n* Primary mediastinal (thymic) large B-cell lymphoma\n* Burkitt lymphoma\n* Prior treatment with cytotoxic drugs within 5 years of screening for any condition (example \\[e.g.\\], cancer, rheumatoid arthritis) or prior use of any anti-CD20 antibody\n* Prior use of any monoclonal antibody within 3 months of the start of Cycle 1\n* Prior therapy for DLBCL, with the exception of nodal biopsy\n* Corticosteroid use \\>30 mg\u002Fday of prednisone or equivalent, for purposes other than lymphoma symptom control\n* Participants with central nervous system (CNS) lymphoma (primary or secondary involvement), primary effusion DLBCL, and primary cutaneous DLBCL\n* Vaccination with live vaccines within 28 days prior to the start of Cycle 1\n* Any investigational therapy within 28 days prior to the start of Cycle 1\n* History of other malignancy that could affect compliance with the protocol or interpretation of results\n* Evidence of significant, uncontrolled, concomitant diseases that could affect compliance with the protocol or interpretation of results, including significant cardiovascular disease or pulmonary disease\n* Recent major surgery (within 4 weeks prior to the start of Cycle 1), other than for diagnosis\n* History or presence of an abnormal electrocardiogram (ECG) that is clinically significant in the investigator's opinion, including complete left bundle branch block, second- or third-degree heart block, or evidence of prior myocardial infarction\n* Known active bacterial, viral, fungal, mycobacterial, parasitic, or other infection (excluding fungal infections of nail beds) at study enrollment or significant infections within 2 weeks before the start of Cycle 1\n* Clinically significant liver disease, including active viral or other hepatitis, current alcohol abuse, or cirrhosis\n* Prior radiotherapy to the mediastinal\u002Fpericardial region\n* Participants with suspected active or latent tuberculosis\n* Positive test results for chronic hepatitis B and hepatitis C infection\n* Known history of human immunodeficiency virus (HIV) seropositive status\n* Positive results for the human T-lymphotrophic 1 virus (HTLV-1)\n* Participants with a history of progressive multifocal leukoencephalopathy","ALL","18 Years","80 Years",{"count":1929,"type":1930},1000,"ACTUAL","INTERVENTIONAL",[1933],"PHASE3","This Phase III, randomized, double-blind, placebo-controlled study will compare the efficacy, safety, and pharmacokinetics of polatuzumab vedotin plus R-CHP versus R-CHOP in participants with previously untreated diffuse large B-cell lymphoma (DLBCL).",[1936],"Diffuse Large B-Cell Lymphoma","COMPLETED","2026-05-07",{"date":1940,"type":1930},"2026-05-08",{"date":1942,"type":1930},"2017-11-16",{"date":1944,"type":1930},"2026-04-30",{"name":5,"class":6},209]