[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100106061":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":41,"centralContacts":11,"locations":45,"responsibleParty":602,"collaborators":11,"id":604,"slug":605,"hasResults":606,"nctId":607,"briefTitle":608,"officialTitle":609,"acronym":11,"eligibilityCriteria":610,"healthyVolunteers":606,"sex":611,"minAge":612,"maxAge":11,"enrollmentInfo":613,"targetDuration":11,"studyType":616,"phases":617,"briefSummary":619,"conditions":620,"keywords":11,"overallStatus":622,"whyStopped":11,"lastUpdateSubmitDate":623,"lastUpdatePostDateStruct":624,"startDateStruct":627,"completionDateStruct":629,"leadSponsor":631,"locationsCount":633},{"fullName":5,"class":6},"Pfizer","INDUSTRY",[8,14,17,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1","ACTIVE_COMPARATOR",null,[13],"Drug: sildenafil",{"label":15,"type":10,"description":11,"interventionNames":16},"Arm 2",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Arm 3",[13],{"label":21,"type":22,"description":11,"interventionNames":23},"Arm 4","PLACEBO_COMPARATOR",[24],"Drug: placebo",[26,31,34,38],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":11},"DRUG","sildenafil","sildenafil 40 mg by mouth three times daily (TID), with doses at least 6 hours apart, for 12 weeks",[15],{"type":27,"name":28,"description":32,"armGroupLabels":33,"otherNames":11},"sildenafil 80 mg by mouth three times daily (TID), with doses at least 6 hours apart, for 12 weeks; initially, patients received 40mg TID for one week and were then up-titrated to 80mg TID",[18],{"type":27,"name":35,"description":36,"armGroupLabels":37,"otherNames":11},"placebo","placebo by mouth three times daily (TID), with doses at least 6 hours apart, for 12 weeks",[21],{"type":27,"name":28,"description":39,"armGroupLabels":40,"otherNames":11},"sildenafil 20 mg by mouth three times daily (TID), with doses at least 6 hours apart, for 12 weeks",[9],[42],{"name":43,"affiliation":5,"role":44},"Pfizer CT.gov Call Center","STUDY_DIRECTOR",[46,59,64,69,78,83,91,96,101,108,116,121,130,138,147,156,165,174,183,192,200,209,218,227,236,247,256,266,274,284,293,298,308,318,328,336,341,349,357,361,367,376,386,394,404,412,417,427,436,446,456,466,474,479,487,496,506,514,521,530,540,545,553,563,571,582,591,599],{"facility":47,"status":11,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":11},"Pfizer Investigational Site","Birmingham","Alabama","35233","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-86.80249,33.52066,{"lat":57,"lon":56},{"facility":47,"status":11,"city":48,"state":49,"zip":60,"country":51,"countryCode":52,"cosmosGeoPoint":61,"geoPoint":63,"contacts":11},"35294-0006",{"type":54,"coordinates":62},[56,57],{"lat":57,"lon":56},{"facility":47,"status":11,"city":48,"state":49,"zip":65,"country":51,"countryCode":52,"cosmosGeoPoint":66,"geoPoint":68,"contacts":11},"35294",{"type":54,"coordinates":67},[56,57],{"lat":57,"lon":56},{"facility":47,"status":11,"city":70,"state":71,"zip":72,"country":51,"countryCode":52,"cosmosGeoPoint":73,"geoPoint":77,"contacts":11},"La Jolla","California","92037",{"type":54,"coordinates":74},[75,76],-117.2742,32.84727,{"lat":76,"lon":75},{"facility":47,"status":11,"city":70,"state":71,"zip":79,"country":51,"countryCode":52,"cosmosGeoPoint":80,"geoPoint":82,"contacts":11},"92093",{"type":54,"coordinates":81},[75,76],{"lat":76,"lon":75},{"facility":47,"status":11,"city":84,"state":71,"zip":85,"country":51,"countryCode":52,"cosmosGeoPoint":86,"geoPoint":90,"contacts":11},"Los Angeles","90024",{"type":54,"coordinates":87},[88,89],-118.24368,34.05223,{"lat":89,"lon":88},{"facility":47,"status":11,"city":84,"state":71,"zip":92,"country":51,"countryCode":52,"cosmosGeoPoint":93,"geoPoint":95,"contacts":11},"90033",{"type":54,"coordinates":94},[88,89],{"lat":89,"lon":88},{"facility":47,"status":11,"city":84,"state":71,"zip":97,"country":51,"countryCode":52,"cosmosGeoPoint":98,"geoPoint":100,"contacts":11},"90095",{"type":54,"coordinates":99},[88,89],{"lat":89,"lon":88},{"facility":47,"status":11,"city":102,"state":71,"zip":72,"country":51,"countryCode":52,"cosmosGeoPoint":103,"geoPoint":107,"contacts":11},"San Diego",{"type":54,"coordinates":104},[105,106],-117.16472,32.71571,{"lat":106,"lon":105},{"facility":47,"status":11,"city":109,"state":71,"zip":110,"country":51,"countryCode":52,"cosmosGeoPoint":111,"geoPoint":115,"contacts":11},"Torrance","90502",{"type":54,"coordinates":112},[113,114],-118.34063,33.83585,{"lat":114,"lon":113},{"facility":47,"status":11,"city":109,"state":71,"zip":117,"country":51,"countryCode":52,"cosmosGeoPoint":118,"geoPoint":120,"contacts":11},"90509",{"type":54,"coordinates":119},[113,114],{"lat":114,"lon":113},{"facility":47,"status":11,"city":122,"state":123,"zip":124,"country":51,"countryCode":52,"cosmosGeoPoint":125,"geoPoint":129,"contacts":11},"Aurora","Colorado","80010",{"type":54,"coordinates":126},[127,128],-104.83192,39.72943,{"lat":128,"lon":127},{"facility":47,"status":11,"city":131,"state":123,"zip":132,"country":51,"countryCode":52,"cosmosGeoPoint":133,"geoPoint":137,"contacts":11},"Denver","80262",{"type":54,"coordinates":134},[135,136],-104.9847,39.73915,{"lat":136,"lon":135},{"facility":47,"status":11,"city":139,"state":140,"zip":141,"country":51,"countryCode":52,"cosmosGeoPoint":142,"geoPoint":146,"contacts":11},"Chicago","Illinois","60612",{"type":54,"coordinates":143},[144,145],-87.65005,41.85003,{"lat":145,"lon":144},{"facility":47,"status":11,"city":148,"state":149,"zip":150,"country":51,"countryCode":52,"cosmosGeoPoint":151,"geoPoint":155,"contacts":11},"Shreveport","Louisiana","71103",{"type":54,"coordinates":152},[153,154],-93.75018,32.52515,{"lat":154,"lon":153},{"facility":47,"status":11,"city":157,"state":158,"zip":159,"country":51,"countryCode":52,"cosmosGeoPoint":160,"geoPoint":164,"contacts":11},"Baltimore","Maryland","21205",{"type":54,"coordinates":161},[162,163],-76.61219,39.29038,{"lat":163,"lon":162},{"facility":47,"status":11,"city":166,"state":167,"zip":168,"country":51,"countryCode":52,"cosmosGeoPoint":169,"geoPoint":173,"contacts":11},"Boston","Massachusetts","02111",{"type":54,"coordinates":170},[171,172],-71.05977,42.35843,{"lat":172,"lon":171},{"facility":47,"status":11,"city":175,"state":176,"zip":177,"country":51,"countryCode":52,"cosmosGeoPoint":178,"geoPoint":182,"contacts":11},"Ann Arbor","Michigan","48109",{"type":54,"coordinates":179},[180,181],-83.74088,42.27756,{"lat":181,"lon":180},{"facility":47,"status":11,"city":184,"state":185,"zip":186,"country":51,"countryCode":52,"cosmosGeoPoint":187,"geoPoint":191,"contacts":11},"Rochester","Minnesota","55905",{"type":54,"coordinates":188},[189,190],-92.4699,44.02163,{"lat":190,"lon":189},{"facility":47,"status":11,"city":193,"state":193,"zip":194,"country":51,"countryCode":52,"cosmosGeoPoint":195,"geoPoint":199,"contacts":11},"New York","10032",{"type":54,"coordinates":196},[197,198],-74.00597,40.71427,{"lat":198,"lon":197},{"facility":47,"status":11,"city":201,"state":202,"zip":203,"country":51,"countryCode":52,"cosmosGeoPoint":204,"geoPoint":208,"contacts":11},"Durham","North Carolina","27710",{"type":54,"coordinates":205},[206,207],-78.89862,35.99403,{"lat":207,"lon":206},{"facility":47,"status":11,"city":210,"state":211,"zip":212,"country":51,"countryCode":52,"cosmosGeoPoint":213,"geoPoint":217,"contacts":11},"Nashville","Tennessee","37232",{"type":54,"coordinates":214},[215,216],-86.78444,36.16589,{"lat":216,"lon":215},{"facility":47,"status":11,"city":219,"state":220,"zip":221,"country":51,"countryCode":52,"cosmosGeoPoint":222,"geoPoint":226,"contacts":11},"Houston","Texas","77030",{"type":54,"coordinates":223},[224,225],-95.36327,29.76328,{"lat":225,"lon":224},{"facility":47,"status":11,"city":228,"state":229,"zip":230,"country":51,"countryCode":52,"cosmosGeoPoint":231,"geoPoint":235,"contacts":11},"Milwaukee","Wisconsin","53215",{"type":54,"coordinates":232},[233,234],-87.90647,43.0389,{"lat":234,"lon":233},{"facility":47,"status":11,"city":237,"state":238,"zip":239,"country":240,"countryCode":241,"cosmosGeoPoint":242,"geoPoint":246,"contacts":11},"Darlinghurst","New South Wales","2010","Australia","AU",{"type":54,"coordinates":243},[244,245],151.21925,-33.87939,{"lat":245,"lon":244},{"facility":47,"status":11,"city":248,"state":249,"zip":250,"country":240,"countryCode":241,"cosmosGeoPoint":251,"geoPoint":255,"contacts":11},"Melbourne","Victoria","3004",{"type":54,"coordinates":252},[253,254],144.96332,-37.814,{"lat":254,"lon":253},{"facility":47,"status":11,"city":257,"state":11,"zip":258,"country":259,"countryCode":260,"cosmosGeoPoint":261,"geoPoint":265,"contacts":11},"Brussels","1070","Belgium","BE",{"type":54,"coordinates":262},[263,264],4.34878,50.85045,{"lat":264,"lon":263},{"facility":47,"status":11,"city":267,"state":11,"zip":268,"country":259,"countryCode":260,"cosmosGeoPoint":269,"geoPoint":273,"contacts":11},"Leuven","3000",{"type":54,"coordinates":270},[271,272],4.70093,50.87959,{"lat":272,"lon":271},{"facility":47,"status":11,"city":275,"state":275,"zip":276,"country":277,"countryCode":278,"cosmosGeoPoint":279,"geoPoint":283,"contacts":11},"São Paulo","05403-900","Brazil","BR",{"type":54,"coordinates":280},[281,282],-46.63611,-23.5475,{"lat":282,"lon":281},{"facility":47,"status":11,"city":285,"state":11,"zip":286,"country":287,"countryCode":11,"cosmosGeoPoint":288,"geoPoint":292,"contacts":11},"Prague","140 00","Czechia",{"type":54,"coordinates":289},[290,291],14.42076,50.08804,{"lat":291,"lon":290},{"facility":47,"status":11,"city":285,"state":11,"zip":294,"country":287,"countryCode":11,"cosmosGeoPoint":295,"geoPoint":297,"contacts":11},"140 21",{"type":54,"coordinates":296},[290,291],{"lat":291,"lon":290},{"facility":47,"status":11,"city":299,"state":11,"zip":300,"country":301,"countryCode":302,"cosmosGeoPoint":303,"geoPoint":307,"contacts":11},"Copenhagen","2100","Denmark","DK",{"type":54,"coordinates":304},[305,306],12.56553,55.67594,{"lat":306,"lon":305},{"facility":47,"status":11,"city":309,"state":11,"zip":310,"country":311,"countryCode":312,"cosmosGeoPoint":313,"geoPoint":317,"contacts":11},"Clamart","92141","France","FR",{"type":54,"coordinates":314},[315,316],2.26692,48.80299,{"lat":316,"lon":315},{"facility":47,"status":11,"city":319,"state":11,"zip":320,"country":321,"countryCode":322,"cosmosGeoPoint":323,"geoPoint":327,"contacts":11},"Berlin","13353","Germany","DE",{"type":54,"coordinates":324},[325,326],13.41053,52.52437,{"lat":326,"lon":325},{"facility":47,"status":11,"city":329,"state":11,"zip":330,"country":321,"countryCode":322,"cosmosGeoPoint":331,"geoPoint":335,"contacts":11},"Giessen","35385",{"type":54,"coordinates":332},[333,334],8.67554,50.58727,{"lat":334,"lon":333},{"facility":47,"status":11,"city":329,"state":11,"zip":337,"country":321,"countryCode":322,"cosmosGeoPoint":338,"geoPoint":340,"contacts":11},"35392",{"type":54,"coordinates":339},[333,334],{"lat":334,"lon":333},{"facility":47,"status":11,"city":342,"state":11,"zip":343,"country":321,"countryCode":322,"cosmosGeoPoint":344,"geoPoint":348,"contacts":11},"Hanover","30625",{"type":54,"coordinates":345},[346,347],9.73322,52.37052,{"lat":347,"lon":346},{"facility":47,"status":11,"city":350,"state":11,"zip":351,"country":321,"countryCode":322,"cosmosGeoPoint":352,"geoPoint":356,"contacts":11},"Leipzig","04103",{"type":54,"coordinates":353},[354,355],12.37129,51.33962,{"lat":355,"lon":354},{"facility":47,"status":11,"city":358,"state":11,"zip":11,"country":359,"countryCode":360,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"Shatin N T","Hong Kong","HK",{"facility":47,"status":11,"city":362,"state":363,"zip":364,"country":365,"countryCode":366,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"Budapest","Pest County","1529","Hungary","HU",{"facility":47,"status":11,"city":368,"state":369,"zip":370,"country":365,"countryCode":366,"cosmosGeoPoint":371,"geoPoint":375,"contacts":11},"Zalaegerszeg","Zala County","8900",{"type":54,"coordinates":372},[373,374],16.84401,46.83695,{"lat":374,"lon":373},{"facility":47,"status":11,"city":377,"state":11,"zip":378,"country":379,"countryCode":380,"cosmosGeoPoint":381,"geoPoint":385,"contacts":11},"Petah Tikva","49100","Israel","IL",{"type":54,"coordinates":382},[383,384],34.88747,32.08707,{"lat":384,"lon":383},{"facility":47,"status":11,"city":387,"state":11,"zip":388,"country":379,"countryCode":380,"cosmosGeoPoint":389,"geoPoint":393,"contacts":11},"Tel Litwinsky","52621",{"type":54,"coordinates":390},[391,392],34.84588,32.05096,{"lat":392,"lon":391},{"facility":47,"status":11,"city":395,"state":11,"zip":396,"country":397,"countryCode":398,"cosmosGeoPoint":399,"geoPoint":403,"contacts":11},"Bologna","40138","Italy","IT",{"type":54,"coordinates":400},[401,402],11.33875,44.49381,{"lat":402,"lon":401},{"facility":47,"status":11,"city":405,"state":11,"zip":406,"country":397,"countryCode":398,"cosmosGeoPoint":407,"geoPoint":411,"contacts":11},"Pisa","56124",{"type":54,"coordinates":408},[409,410],10.4036,43.70853,{"lat":410,"lon":409},{"facility":47,"status":11,"city":405,"state":11,"zip":413,"country":397,"countryCode":398,"cosmosGeoPoint":414,"geoPoint":416,"contacts":11},"56126",{"type":54,"coordinates":415},[409,410],{"lat":410,"lon":409},{"facility":47,"status":11,"city":418,"state":11,"zip":419,"country":420,"countryCode":421,"cosmosGeoPoint":422,"geoPoint":426,"contacts":11},"Kuala Lumpur","59100","Malaysia","MY",{"type":54,"coordinates":423},[424,425],101.68653,3.1412,{"lat":425,"lon":424},{"facility":47,"status":11,"city":428,"state":11,"zip":11,"country":429,"countryCode":430,"cosmosGeoPoint":431,"geoPoint":435,"contacts":11},"Tlalpan","Mexico","MX",{"type":54,"coordinates":432},[433,434],-99.16206,19.29513,{"lat":434,"lon":433},{"facility":47,"status":11,"city":437,"state":11,"zip":438,"country":439,"countryCode":440,"cosmosGeoPoint":441,"geoPoint":445,"contacts":11},"Amsterdam","1081 HV","Netherlands","NL",{"type":54,"coordinates":442},[443,444],4.88969,52.37403,{"lat":444,"lon":443},{"facility":47,"status":11,"city":447,"state":11,"zip":448,"country":449,"countryCode":450,"cosmosGeoPoint":451,"geoPoint":455,"contacts":11},"Oslo","NO-0027","Norway","NO",{"type":54,"coordinates":452},[453,454],10.74609,59.91273,{"lat":454,"lon":453},{"facility":47,"status":11,"city":457,"state":11,"zip":458,"country":459,"countryCode":460,"cosmosGeoPoint":461,"geoPoint":465,"contacts":11},"Katowice","40-057","Poland","PL",{"type":54,"coordinates":462},[463,464],19.02173,50.2597,{"lat":464,"lon":463},{"facility":47,"status":11,"city":467,"state":11,"zip":468,"country":459,"countryCode":460,"cosmosGeoPoint":469,"geoPoint":473,"contacts":11},"Warsaw","01-138",{"type":54,"coordinates":470},[471,472],21.01178,52.22977,{"lat":472,"lon":471},{"facility":47,"status":11,"city":467,"state":11,"zip":475,"country":459,"countryCode":460,"cosmosGeoPoint":476,"geoPoint":478,"contacts":11},"03-709",{"type":54,"coordinates":477},[471,472],{"lat":472,"lon":471},{"facility":47,"status":11,"city":480,"state":11,"zip":481,"country":459,"countryCode":460,"cosmosGeoPoint":482,"geoPoint":486,"contacts":11},"Zabrze","41-800",{"type":54,"coordinates":483},[484,485],18.78576,50.32492,{"lat":485,"lon":484},{"facility":47,"status":11,"city":488,"state":11,"zip":489,"country":488,"countryCode":490,"cosmosGeoPoint":491,"geoPoint":495,"contacts":11},"Singapore","168752","SG",{"type":54,"coordinates":492},[493,494],103.85007,1.28967,{"lat":494,"lon":493},{"facility":47,"status":11,"city":497,"state":11,"zip":498,"country":499,"countryCode":500,"cosmosGeoPoint":501,"geoPoint":505,"contacts":11},"Cape Town","7700","South Africa","ZA",{"type":54,"coordinates":502},[503,504],18.42322,-33.92584,{"lat":504,"lon":503},{"facility":47,"status":11,"city":507,"state":11,"zip":508,"country":499,"countryCode":500,"cosmosGeoPoint":509,"geoPoint":513,"contacts":11},"Johannesburg","2193",{"type":54,"coordinates":510},[511,512],28.04363,-26.20227,{"lat":512,"lon":511},{"facility":47,"status":11,"city":515,"state":11,"zip":11,"country":499,"countryCode":500,"cosmosGeoPoint":516,"geoPoint":520,"contacts":11},"Parow",{"type":54,"coordinates":517},[518,519],18.59992,-33.89723,{"lat":519,"lon":518},{"facility":47,"status":11,"city":522,"state":11,"zip":523,"country":524,"countryCode":11,"cosmosGeoPoint":525,"geoPoint":529,"contacts":11},"Suwon","442-721","South Korea",{"type":54,"coordinates":526},[527,528],127.00889,37.29111,{"lat":528,"lon":527},{"facility":47,"status":11,"city":531,"state":11,"zip":532,"country":533,"countryCode":534,"cosmosGeoPoint":535,"geoPoint":539,"contacts":11},"Barcelona","08035","Spain","ES",{"type":54,"coordinates":536},[537,538],2.15899,41.38879,{"lat":538,"lon":537},{"facility":47,"status":11,"city":531,"state":11,"zip":541,"country":533,"countryCode":534,"cosmosGeoPoint":542,"geoPoint":544,"contacts":11},"08036",{"type":54,"coordinates":543},[537,538],{"lat":538,"lon":537},{"facility":47,"status":11,"city":546,"state":11,"zip":547,"country":533,"countryCode":534,"cosmosGeoPoint":548,"geoPoint":552,"contacts":11},"Madrid","28041",{"type":54,"coordinates":549},[550,551],-3.70256,40.4165,{"lat":551,"lon":550},{"facility":47,"status":11,"city":554,"state":11,"zip":555,"country":556,"countryCode":557,"cosmosGeoPoint":558,"geoPoint":562,"contacts":11},"Gothenburg","413 45","Sweden","SE",{"type":54,"coordinates":559},[560,561],11.96679,57.70716,{"lat":561,"lon":560},{"facility":47,"status":11,"city":564,"state":11,"zip":565,"country":556,"countryCode":557,"cosmosGeoPoint":566,"geoPoint":570,"contacts":11},"Mölndal","431 80",{"type":54,"coordinates":567},[568,569],12.01378,57.6554,{"lat":569,"lon":568},{"facility":47,"status":11,"city":572,"state":573,"zip":574,"country":575,"countryCode":576,"cosmosGeoPoint":577,"geoPoint":581,"contacts":11},"Papworth Everard","Cambridgeshire","CB3 8RE","United Kingdom","UK",{"type":54,"coordinates":578},[579,580],-0.11827,52.24893,{"lat":580,"lon":579},{"facility":47,"status":11,"city":583,"state":584,"zip":585,"country":575,"countryCode":576,"cosmosGeoPoint":586,"geoPoint":590,"contacts":11},"Sheffield","South Yorkshire","S10 2JF",{"type":54,"coordinates":587},[588,589],-1.4659,53.38297,{"lat":589,"lon":588},{"facility":47,"status":11,"city":592,"state":11,"zip":593,"country":575,"countryCode":576,"cosmosGeoPoint":594,"geoPoint":598,"contacts":11},"Glasgow","G11 6NT",{"type":54,"coordinates":595},[596,597],-4.25763,55.86515,{"lat":597,"lon":596},{"facility":47,"status":11,"city":600,"state":11,"zip":601,"country":575,"countryCode":576,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"HIGH Heaton, Newcastle-upon-tyne","NE7 7DW",{"type":603,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100106061","phase-3-a-study-to-assess-the-efficacy-and-safety-of-20-40-and-80mg-of-sildenafil-three-times-a-day-in-the-treatment-of-pulmonary-arterial-hypertension-100106061",false,"NCT00644605","A Study to Assess the Efficacy and Safety of 20, 40, and 80mg of Sildenafil Three Times a Day in the Treatment of Pulmonary Arterial Hypertension","A Multinational, Multi-centre, Randomised, Double-blind, Double-dummy, Placebo-controlled Study to Assess the Efficacy and Safety of 20, 40, and 80mg TID Sildenafil in the Treatment of Pulmonary Arterial Hypertension in Subjects Aged 18 Years and Over","Inclusion Criteria:\n\nIncluded patients had primary pulmonary arterial hypertension, pulmonary hypertension secondary to connective tissue disease, or pulmonary hypertension with surgical repair at least 5 years previously; a mean pulmonary artery pressure greater than or equal to 25 mmHg and a pulmonary artery wedge pressure of less than or equal to 15 mmHg at rest, via right heart catheterisation within 21 days prior to randomisation; and a baseline 6-Minute Walk test distance of 100 m to 450 m.\n\nExclusion Criteria:\n\nSubjects with congenital heart disease, pulmonary hypertension due to thromboembolism, HIV, chronic obstructive airway disease, congestive heart failure or schistosomiasis; subjects with significant (ie \\> 2+) valvular disease other than tricuspid regurgitation or pulmonary regurgitation; and acutely decompensated heart failure within the previous 30 days; subjects with pulmonary hypertension secondary to any other etiology other than those specified in the inclusion criteria.","ALL","18 Years",{"count":614,"type":615},275,"ESTIMATED","INTERVENTIONAL",[618],"PHASE3","To evaluate the effect of three doses of oral sildenafil (20, 40 and 80 mg three times a day \\[TID\\]) on exercise capacity, as measured by the 6-Minute Walk test, as well as the safety and tolerability, after 12 weeks of treatment in subjects with pulmonary arterial hypertension who are aged 18 years and over. To investigate the plasma concentration-effect relationship and to determine the population pharmacokinetic (PK) parameters.",[621],"Hypertension, Pulmonary","COMPLETED","2021-01-28",{"date":625,"type":626},"2021-02-01","ACTUAL",{"date":628,"type":11},"2002-10",{"date":630,"type":626},"2003-11",{"name":632,"class":6},"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.",68]