[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100437856":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":24,"locations":33,"responsibleParty":881,"collaborators":24,"id":883,"slug":884,"hasResults":885,"nctId":886,"briefTitle":887,"officialTitle":888,"acronym":24,"eligibilityCriteria":889,"healthyVolunteers":890,"sex":891,"minAge":892,"maxAge":24,"enrollmentInfo":893,"targetDuration":24,"studyType":896,"phases":897,"briefSummary":899,"conditions":900,"keywords":902,"overallStatus":906,"whyStopped":907,"lastUpdateSubmitDate":908,"lastUpdatePostDateStruct":909,"startDateStruct":911,"completionDateStruct":913,"leadSponsor":915,"locationsCount":916},{"fullName":5,"class":6},"Regeneron Pharmaceuticals","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"REGN1908-1909","EXPERIMENTAL","Randomized 1:1",[13],"Drug: REGN1908-1909",{"label":15,"type":16,"description":11,"interventionNames":17},"Placebo","PLACEBO_COMPARATOR",[18],"Drug: Matching Placebo",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Subcutaneous (SC) for a total of 5 administrations",[9],null,{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Matching Placebo","SC for a total of 5 administrations",[15],[30],{"name":31,"affiliation":5,"role":32},"Clinical Trial Management","STUDY_DIRECTOR",[34,47,56,65,74,84,93,103,113,123,132,141,151,161,170,180,189,199,209,219,229,239,248,258,267,276,285,294,304,312,321,331,341,350,359,369,379,388,398,408,417,427,437,449,459,468,477,489,498,507,516,525,534,540,549,559,568,577,589,601,610,620,630,639,648,658,668,674,680,689,695,704,710,722,732,741,751,757,767,773,782,789,799,809,819,829,838,848,853,859,865,871],{"facility":35,"status":24,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":24},"Allergy and Asthma Associates of Southern California - CRN - PPDS","Mission Viejo","California","92691","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-117.672,33.60002,{"lat":45,"lon":44},{"facility":48,"status":24,"city":49,"state":37,"zip":50,"country":39,"countryCode":40,"cosmosGeoPoint":51,"geoPoint":55,"contacts":24},"Integrated Research of Inland, Inc","Riverside","92506",{"type":42,"coordinates":52},[53,54],-117.39616,33.95335,{"lat":54,"lon":53},{"facility":57,"status":24,"city":58,"state":37,"zip":59,"country":39,"countryCode":40,"cosmosGeoPoint":60,"geoPoint":64,"contacts":24},"Peninsula Research Associates - CRN - PPDS","Rolling Hills Estates","90274",{"type":42,"coordinates":61},[62,63],-118.35813,33.78779,{"lat":63,"lon":62},{"facility":66,"status":24,"city":67,"state":37,"zip":68,"country":39,"countryCode":40,"cosmosGeoPoint":69,"geoPoint":73,"contacts":24},"Allergy and Asthma Medical Group and Research Center - CRN - PPDS","San Diego","92123",{"type":42,"coordinates":70},[71,72],-117.16472,32.71571,{"lat":72,"lon":71},{"facility":75,"status":24,"city":76,"state":77,"zip":78,"country":39,"countryCode":40,"cosmosGeoPoint":79,"geoPoint":83,"contacts":24},"Asthma and Allergy Associates PC - CRN - PPDS","Colorado Springs","Colorado","80907",{"type":42,"coordinates":80},[81,82],-104.82136,38.83388,{"lat":82,"lon":81},{"facility":85,"status":24,"city":86,"state":77,"zip":87,"country":39,"countryCode":40,"cosmosGeoPoint":88,"geoPoint":92,"contacts":24},"Colorado Allergy and Asthma Centers PC - CRN - PPDS","Denver","80230",{"type":42,"coordinates":89},[90,91],-104.9847,39.73915,{"lat":91,"lon":90},{"facility":94,"status":24,"city":95,"state":96,"zip":97,"country":39,"countryCode":40,"cosmosGeoPoint":98,"geoPoint":102,"contacts":24},"Emory University","Atlanta","Georgia","30322",{"type":42,"coordinates":99},[100,101],-84.38798,33.749,{"lat":101,"lon":100},{"facility":104,"status":24,"city":105,"state":106,"zip":107,"country":39,"countryCode":40,"cosmosGeoPoint":108,"geoPoint":112,"contacts":24},"Velocity Clinical Research, Inc. (Meridan)","Meridian","Idaho","83642",{"type":42,"coordinates":109},[110,111],-116.39151,43.61211,{"lat":111,"lon":110},{"facility":114,"status":24,"city":115,"state":116,"zip":117,"country":39,"countryCode":40,"cosmosGeoPoint":118,"geoPoint":122,"contacts":24},"Rush University Medical Center","Chicago","Illinois","60612",{"type":42,"coordinates":119},[120,121],-87.65005,41.85003,{"lat":121,"lon":120},{"facility":124,"status":24,"city":125,"state":116,"zip":126,"country":39,"countryCode":40,"cosmosGeoPoint":127,"geoPoint":131,"contacts":24},"Asthma and Allergy Center of Chicago Sc-Oak Park","Oak Park","60301",{"type":42,"coordinates":128},[129,130],-87.7845,41.88503,{"lat":130,"lon":129},{"facility":133,"status":24,"city":134,"state":116,"zip":135,"country":39,"countryCode":40,"cosmosGeoPoint":136,"geoPoint":140,"contacts":24},"Sneeze Wheeze and Itch Associates LLC","Springfield","62702",{"type":42,"coordinates":137},[138,139],-89.64371,39.80172,{"lat":139,"lon":138},{"facility":142,"status":24,"city":143,"state":144,"zip":145,"country":39,"countryCode":40,"cosmosGeoPoint":146,"geoPoint":150,"contacts":24},"South Bend Clinic","South Bend","Indiana","46617",{"type":42,"coordinates":147},[148,149],-86.25001,41.68338,{"lat":149,"lon":148},{"facility":152,"status":24,"city":153,"state":154,"zip":155,"country":39,"countryCode":40,"cosmosGeoPoint":156,"geoPoint":160,"contacts":24},"Bluegrass Allergy Research","Lexington","Kentucky","40509",{"type":42,"coordinates":157},[158,159],-84.47772,37.98869,{"lat":159,"lon":158},{"facility":162,"status":24,"city":163,"state":154,"zip":164,"country":39,"countryCode":40,"cosmosGeoPoint":165,"geoPoint":169,"contacts":24},"Allergy and Asthma Specialists PSC","Owensboro","42301",{"type":42,"coordinates":166},[167,168],-87.11333,37.77422,{"lat":168,"lon":167},{"facility":171,"status":24,"city":172,"state":173,"zip":174,"country":39,"countryCode":40,"cosmosGeoPoint":175,"geoPoint":179,"contacts":24},"Charleston Allergy and Asthma","Baltimore","Maryland","21224",{"type":42,"coordinates":176},[177,178],-76.61219,39.29038,{"lat":178,"lon":177},{"facility":181,"status":24,"city":182,"state":173,"zip":183,"country":39,"countryCode":40,"cosmosGeoPoint":184,"geoPoint":188,"contacts":24},"Institute For Asthma and Allergy","Chevy Chase","20815",{"type":42,"coordinates":185},[186,187],-77.07115,39.00287,{"lat":187,"lon":186},{"facility":190,"status":24,"city":191,"state":192,"zip":193,"country":39,"countryCode":40,"cosmosGeoPoint":194,"geoPoint":198,"contacts":24},"Respiratory Medicine Research Institute of Michigan PLC","Ypsilanti","Michigan","48187",{"type":42,"coordinates":195},[196,197],-83.61299,42.24115,{"lat":197,"lon":196},{"facility":200,"status":24,"city":201,"state":202,"zip":203,"country":39,"countryCode":40,"cosmosGeoPoint":204,"geoPoint":208,"contacts":24},"Clinical Research Institute, Inc - CRN - PPDS","Plymouth","Minnesota","55441",{"type":42,"coordinates":205},[206,207],-93.45551,45.01052,{"lat":207,"lon":206},{"facility":210,"status":24,"city":211,"state":212,"zip":213,"country":39,"countryCode":40,"cosmosGeoPoint":214,"geoPoint":218,"contacts":24},"University of Missouri - Hospital","Columbia","Missouri","65212",{"type":42,"coordinates":215},[216,217],-92.33407,38.95171,{"lat":217,"lon":216},{"facility":220,"status":24,"city":221,"state":222,"zip":223,"country":39,"countryCode":40,"cosmosGeoPoint":224,"geoPoint":228,"contacts":24},"Montana Medical Research","Missoula","Montana","59808",{"type":42,"coordinates":225},[226,227],-113.994,46.87215,{"lat":227,"lon":226},{"facility":230,"status":24,"city":231,"state":232,"zip":233,"country":39,"countryCode":40,"cosmosGeoPoint":234,"geoPoint":238,"contacts":24},"Somnos Clinical Research","Lincoln","Nebraska","68505",{"type":42,"coordinates":235},[236,237],-96.66696,40.8,{"lat":237,"lon":236},{"facility":240,"status":24,"city":241,"state":232,"zip":242,"country":39,"countryCode":40,"cosmosGeoPoint":243,"geoPoint":247,"contacts":24},"Nebraska Medical Research Institute, Inc. - CRN - PPDS","Papillion","68046",{"type":42,"coordinates":244},[245,246],-96.04224,41.15444,{"lat":246,"lon":245},{"facility":249,"status":24,"city":250,"state":251,"zip":252,"country":39,"countryCode":40,"cosmosGeoPoint":253,"geoPoint":257,"contacts":24},"Riverside Medical Group - Circuit - PPDS","Belleville","New Jersey","07109",{"type":42,"coordinates":254},[255,256],-74.15014,40.79371,{"lat":256,"lon":255},{"facility":259,"status":24,"city":260,"state":251,"zip":261,"country":39,"countryCode":40,"cosmosGeoPoint":262,"geoPoint":266,"contacts":24},"Atlantic Research Center LLC","Ocean City","07712",{"type":42,"coordinates":263},[264,265],-74.5746,39.27762,{"lat":265,"lon":264},{"facility":268,"status":24,"city":269,"state":251,"zip":270,"country":39,"countryCode":40,"cosmosGeoPoint":271,"geoPoint":275,"contacts":24},"Princeton Center For Clinical Research - CRN - PPDS","Skillman","08558",{"type":42,"coordinates":272},[273,274],-74.7146,40.42011,{"lat":274,"lon":273},{"facility":277,"status":24,"city":278,"state":251,"zip":279,"country":39,"countryCode":40,"cosmosGeoPoint":280,"geoPoint":284,"contacts":24},"Allergy Partners of NJ, P.C.","Teaneck","07666",{"type":42,"coordinates":281},[282,283],-74.01597,40.8976,{"lat":283,"lon":282},{"facility":286,"status":24,"city":287,"state":251,"zip":288,"country":39,"countryCode":40,"cosmosGeoPoint":289,"geoPoint":293,"contacts":24},"Allergy Consultants PA","Verona","07044",{"type":42,"coordinates":290},[291,292],-74.24015,40.82982,{"lat":292,"lon":291},{"facility":295,"status":24,"city":296,"state":297,"zip":298,"country":39,"countryCode":40,"cosmosGeoPoint":299,"geoPoint":303,"contacts":24},"SUNY Downstate Health Science University","Brooklyn","New York","11203",{"type":42,"coordinates":300},[301,302],-73.94958,40.6501,{"lat":302,"lon":301},{"facility":305,"status":24,"city":297,"state":297,"zip":306,"country":39,"countryCode":40,"cosmosGeoPoint":307,"geoPoint":311,"contacts":24},"NYU Langone Medical Center","10029",{"type":42,"coordinates":308},[309,310],-74.00597,40.71427,{"lat":310,"lon":309},{"facility":313,"status":24,"city":314,"state":297,"zip":315,"country":39,"countryCode":40,"cosmosGeoPoint":316,"geoPoint":320,"contacts":24},"Montefiore Medical Center","The Bronx","10461",{"type":42,"coordinates":317},[318,319],-73.86641,40.84985,{"lat":319,"lon":318},{"facility":322,"status":24,"city":323,"state":324,"zip":325,"country":39,"countryCode":40,"cosmosGeoPoint":326,"geoPoint":330,"contacts":24},"Allergy Partners of Western North Carolina","Asheville","North Carolina","28801",{"type":42,"coordinates":327},[328,329],-82.55402,35.60095,{"lat":329,"lon":328},{"facility":332,"status":24,"city":333,"state":334,"zip":335,"country":39,"countryCode":40,"cosmosGeoPoint":336,"geoPoint":340,"contacts":24},"Bernstein Clinical Research Center Inc","Cincinnati","Ohio","45231",{"type":42,"coordinates":337},[338,339],-84.51439,39.12711,{"lat":339,"lon":338},{"facility":342,"status":24,"city":343,"state":334,"zip":344,"country":39,"countryCode":40,"cosmosGeoPoint":345,"geoPoint":349,"contacts":24},"Optimed Research Ltd - Clinedge - PPDS","Columbus","43235",{"type":42,"coordinates":346},[347,348],-82.99879,39.96118,{"lat":348,"lon":347},{"facility":351,"status":24,"city":352,"state":334,"zip":353,"country":39,"countryCode":40,"cosmosGeoPoint":354,"geoPoint":358,"contacts":24},"Aventiv Research Inc - Columbus - HyperCore - PPDS","Dublin","43016",{"type":42,"coordinates":355},[356,357],-83.11408,40.09923,{"lat":357,"lon":356},{"facility":360,"status":24,"city":361,"state":362,"zip":363,"country":39,"countryCode":40,"cosmosGeoPoint":364,"geoPoint":368,"contacts":24},"Allergy Asthma and Clinical Research Center","Oklahoma City","Oklahoma","73120",{"type":42,"coordinates":365},[366,367],-97.51643,35.46756,{"lat":367,"lon":366},{"facility":370,"status":24,"city":371,"state":372,"zip":373,"country":39,"countryCode":40,"cosmosGeoPoint":374,"geoPoint":378,"contacts":24},"PDX Allergy, LLC dba Portland Research","Happy Valley","Oregon","97068",{"type":42,"coordinates":375},[376,377],-122.53037,45.44679,{"lat":377,"lon":376},{"facility":380,"status":24,"city":381,"state":372,"zip":382,"country":39,"countryCode":40,"cosmosGeoPoint":383,"geoPoint":387,"contacts":24},"Northwest Research Center - CRN - PPDS","Portland","97202",{"type":42,"coordinates":384},[385,386],-122.67621,45.52345,{"lat":386,"lon":385},{"facility":389,"status":24,"city":390,"state":391,"zip":392,"country":39,"countryCode":40,"cosmosGeoPoint":393,"geoPoint":397,"contacts":24},"Allergy and Clinical Immunology Associates","Pittsburgh","Pennsylvania","15241",{"type":42,"coordinates":394},[395,396],-79.99589,40.44062,{"lat":396,"lon":395},{"facility":399,"status":24,"city":400,"state":401,"zip":402,"country":39,"countryCode":40,"cosmosGeoPoint":403,"geoPoint":407,"contacts":24},"Asthma, Nasal Disease and Allergy Research Center of New England","East Providence","Rhode Island","02914",{"type":42,"coordinates":404},[405,406],-71.37005,41.81371,{"lat":406,"lon":405},{"facility":409,"status":24,"city":410,"state":401,"zip":411,"country":39,"countryCode":40,"cosmosGeoPoint":412,"geoPoint":416,"contacts":24},"Asthma & Allergy Physicians of Rhode Island Clinical Research Institute (AAPRI CRI)","Warwick","02886",{"type":42,"coordinates":413},[414,415],-71.41617,41.7001,{"lat":415,"lon":414},{"facility":418,"status":24,"city":419,"state":420,"zip":421,"country":39,"countryCode":40,"cosmosGeoPoint":422,"geoPoint":426,"contacts":24},"Seattle Allergy & Asthma Research Institute","Seattle","Washington","98115",{"type":42,"coordinates":423},[424,425],-122.33207,47.60621,{"lat":425,"lon":424},{"facility":428,"status":24,"city":429,"state":430,"zip":431,"country":39,"countryCode":40,"cosmosGeoPoint":432,"geoPoint":436,"contacts":24},"The Medical College of Wisconsin, Inc.","Greenfield","Wisconsin","53228",{"type":42,"coordinates":433},[434,435],-88.01259,42.9614,{"lat":435,"lon":434},{"facility":438,"status":24,"city":439,"state":440,"zip":441,"country":442,"countryCode":443,"cosmosGeoPoint":444,"geoPoint":448,"contacts":24},"UZ Gent","Ghent","Oost-Vlaanderen","9000","Belgium","BE",{"type":42,"coordinates":445},[446,447],3.71667,51.05,{"lat":447,"lon":446},{"facility":450,"status":24,"city":451,"state":452,"zip":453,"country":442,"countryCode":443,"cosmosGeoPoint":454,"geoPoint":458,"contacts":24},"UZ Leuven","Leuven","Vlaams Brabant","3000",{"type":42,"coordinates":455},[456,457],4.70093,50.87959,{"lat":457,"lon":456},{"facility":460,"status":24,"city":461,"state":24,"zip":462,"country":442,"countryCode":443,"cosmosGeoPoint":463,"geoPoint":467,"contacts":24},"Private Practice Dr Jean Benoit Martinot","Erpent","5101",{"type":42,"coordinates":464},[465,466],4.90557,50.45116,{"lat":466,"lon":465},{"facility":469,"status":24,"city":470,"state":24,"zip":471,"country":442,"countryCode":443,"cosmosGeoPoint":472,"geoPoint":476,"contacts":24},"CHR de la Citadelle","Liège","4000",{"type":42,"coordinates":473},[474,475],5.56749,50.63373,{"lat":475,"lon":474},{"facility":478,"status":24,"city":479,"state":480,"zip":481,"country":482,"countryCode":483,"cosmosGeoPoint":484,"geoPoint":488,"contacts":24},"Aggarwal and Associates Ltd","Brampton","Ontario","L6T 0G1","Canada","CA",{"type":42,"coordinates":485},[486,487],-79.76633,43.68341,{"lat":487,"lon":486},{"facility":490,"status":24,"city":491,"state":480,"zip":492,"country":482,"countryCode":483,"cosmosGeoPoint":493,"geoPoint":497,"contacts":24},"Hamilton Allergy","Hamilton","L8S 1G5",{"type":42,"coordinates":494},[495,496],-79.84963,43.25011,{"lat":496,"lon":495},{"facility":499,"status":24,"city":500,"state":480,"zip":501,"country":482,"countryCode":483,"cosmosGeoPoint":502,"geoPoint":506,"contacts":24},"Kingston Health Science Centre","Kingston","K7L 2V7",{"type":42,"coordinates":503},[504,505],-76.48098,44.22976,{"lat":505,"lon":504},{"facility":508,"status":24,"city":509,"state":480,"zip":510,"country":482,"countryCode":483,"cosmosGeoPoint":511,"geoPoint":515,"contacts":24},"Red Maple Trials","Ottawa","K1Y 4G2",{"type":42,"coordinates":512},[513,514],-75.69812,45.41117,{"lat":514,"lon":513},{"facility":517,"status":24,"city":518,"state":480,"zip":519,"country":482,"countryCode":483,"cosmosGeoPoint":520,"geoPoint":524,"contacts":24},"Stouffville Medical Clinic","Stouffville","L4A 1H2",{"type":42,"coordinates":521},[522,523],-79.2496,43.96682,{"lat":523,"lon":522},{"facility":526,"status":24,"city":527,"state":480,"zip":528,"country":482,"countryCode":483,"cosmosGeoPoint":529,"geoPoint":533,"contacts":24},"Gordon Sussman Clinical Research Inc","Toronto","M4V 1R2",{"type":42,"coordinates":530},[531,532],-79.39864,43.70643,{"lat":532,"lon":531},{"facility":535,"status":24,"city":527,"state":480,"zip":536,"country":482,"countryCode":483,"cosmosGeoPoint":537,"geoPoint":539,"contacts":24},"Toronto Allergy Clinic","M5G 1E2",{"type":42,"coordinates":538},[531,532],{"lat":532,"lon":531},{"facility":541,"status":24,"city":542,"state":480,"zip":543,"country":482,"countryCode":483,"cosmosGeoPoint":544,"geoPoint":548,"contacts":24},"Joel Liem Medicine Professional Corporation","Windsor","N8X 2G1",{"type":42,"coordinates":545},[546,547],-83.01654,42.30008,{"lat":547,"lon":546},{"facility":550,"status":24,"city":551,"state":552,"zip":553,"country":482,"countryCode":483,"cosmosGeoPoint":554,"geoPoint":558,"contacts":24},"LMC Manna Research - Quebec - HyperCore - PPDS","Lévis","Quebec","G6W 5M6",{"type":42,"coordinates":555},[556,557],-71.17793,46.80326,{"lat":557,"lon":556},{"facility":560,"status":24,"city":561,"state":552,"zip":562,"country":482,"countryCode":483,"cosmosGeoPoint":563,"geoPoint":567,"contacts":24},"Centre d'investigation Clinique Mauricie","Trois-Rivières","G8T 7A1",{"type":42,"coordinates":564},[565,566],-72.5477,46.34515,{"lat":566,"lon":565},{"facility":569,"status":24,"city":570,"state":24,"zip":571,"country":482,"countryCode":483,"cosmosGeoPoint":572,"geoPoint":576,"contacts":24},"Clinique Spécialisée en Allergie de la Capitale","Québec","G1V 4M6",{"type":42,"coordinates":573},[574,575],-71.21454,46.81228,{"lat":575,"lon":574},{"facility":578,"status":24,"city":579,"state":580,"zip":581,"country":582,"countryCode":583,"cosmosGeoPoint":584,"geoPoint":588,"contacts":24},"Nouvel Hopital Civil","Strasbourg","Bas-Rhin","67000","France","FR",{"type":42,"coordinates":585},[586,587],7.74553,48.58392,{"lat":587,"lon":586},{"facility":590,"status":24,"city":591,"state":592,"zip":593,"country":594,"countryCode":595,"cosmosGeoPoint":596,"geoPoint":600,"contacts":24},"HNO Praxis am Neckar","Heidelberg","Baden-Wurttemberg","69120","Germany","DE",{"type":42,"coordinates":597},[598,599],8.69079,49.40768,{"lat":599,"lon":598},{"facility":602,"status":24,"city":603,"state":592,"zip":604,"country":594,"countryCode":595,"cosmosGeoPoint":605,"geoPoint":609,"contacts":24},"Klinikum Stuttgart","Stuttgart","70374",{"type":42,"coordinates":606},[607,608],9.17702,48.78232,{"lat":608,"lon":607},{"facility":611,"status":24,"city":612,"state":613,"zip":614,"country":594,"countryCode":595,"cosmosGeoPoint":615,"geoPoint":619,"contacts":24},"Beldio Research GmbH","Memmingen","Bavaria","87700",{"type":42,"coordinates":616},[617,618],10.18527,47.98372,{"lat":618,"lon":617},{"facility":621,"status":24,"city":622,"state":623,"zip":624,"country":594,"countryCode":595,"cosmosGeoPoint":625,"geoPoint":629,"contacts":24},"Praxis Dr. med. Elke Decot","Dreieich","Hesse","63303",{"type":42,"coordinates":626},[627,628],8.69611,50.01997,{"lat":628,"lon":627},{"facility":631,"status":24,"city":632,"state":623,"zip":633,"country":594,"countryCode":595,"cosmosGeoPoint":634,"geoPoint":638,"contacts":24},"Praxis Dr. med. Claus Keller","Frankfurt am Main","60389",{"type":42,"coordinates":635},[636,637],8.68417,50.11552,{"lat":637,"lon":636},{"facility":640,"status":24,"city":641,"state":623,"zip":642,"country":594,"countryCode":595,"cosmosGeoPoint":643,"geoPoint":647,"contacts":24},"Praxis Dr. med. Gerhard Schindlbeck","Viernheim","68519",{"type":42,"coordinates":644},[645,646],8.5782,49.54033,{"lat":646,"lon":645},{"facility":649,"status":24,"city":650,"state":651,"zip":652,"country":594,"countryCode":595,"cosmosGeoPoint":653,"geoPoint":657,"contacts":24},"Universitatsklinikum Munster","Münster","North Rhine-Westphalia","48149",{"type":42,"coordinates":654},[655,656],7.62571,51.96236,{"lat":656,"lon":655},{"facility":659,"status":24,"city":660,"state":661,"zip":662,"country":594,"countryCode":595,"cosmosGeoPoint":663,"geoPoint":667,"contacts":24},"Klinische Forschung Dresden GmbH (KFGN)","Dresden","Saxony","01069",{"type":42,"coordinates":664},[665,666],13.73832,51.05089,{"lat":666,"lon":665},{"facility":669,"status":24,"city":660,"state":661,"zip":670,"country":594,"countryCode":595,"cosmosGeoPoint":671,"geoPoint":673,"contacts":24},"Praxis für HNO und Allergologie","01139",{"type":42,"coordinates":672},[665,666],{"lat":666,"lon":665},{"facility":675,"status":24,"city":660,"state":661,"zip":676,"country":594,"countryCode":595,"cosmosGeoPoint":677,"geoPoint":679,"contacts":24},"Universitätsklinikum Carl Gustav Carus an der TU Dresden","01307",{"type":42,"coordinates":678},[665,666],{"lat":666,"lon":665},{"facility":681,"status":24,"city":682,"state":661,"zip":683,"country":594,"countryCode":595,"cosmosGeoPoint":684,"geoPoint":688,"contacts":24},"Salvus-Klinische Studien GmbH","Leipzig","04207",{"type":42,"coordinates":685},[686,687],12.37129,51.33962,{"lat":687,"lon":686},{"facility":690,"status":24,"city":682,"state":661,"zip":691,"country":594,"countryCode":595,"cosmosGeoPoint":692,"geoPoint":694,"contacts":24},"BAG Prof. Dr. G. Hoheisel Dr. A. Bonitz","04275",{"type":42,"coordinates":693},[686,687],{"lat":687,"lon":686},{"facility":696,"status":24,"city":697,"state":24,"zip":698,"country":594,"countryCode":595,"cosmosGeoPoint":699,"geoPoint":703,"contacts":24},"Charité - Universitätsmedizin Berlin","Berlin","10117",{"type":42,"coordinates":700},[701,702],13.41053,52.52437,{"lat":702,"lon":701},{"facility":705,"status":24,"city":697,"state":24,"zip":706,"country":594,"countryCode":595,"cosmosGeoPoint":707,"geoPoint":709,"contacts":24},"Emovis GmbH","10629",{"type":42,"coordinates":708},[701,702],{"lat":702,"lon":701},{"facility":711,"status":24,"city":712,"state":713,"zip":714,"country":715,"countryCode":716,"cosmosGeoPoint":717,"geoPoint":721,"contacts":24},"Centrum Alergologii Teresa Hofman","Piła","Greater Poland Voivodeship","64-920","Poland","PL",{"type":42,"coordinates":718},[719,720],16.73782,53.15145,{"lat":720,"lon":719},{"facility":723,"status":24,"city":724,"state":725,"zip":726,"country":715,"countryCode":716,"cosmosGeoPoint":727,"geoPoint":731,"contacts":24},"Centrum Nowoczesnych Terapii Dobry Lekarz Sp. z o.o.","Krakow","Lesser Poland Voivodeship","31-011",{"type":42,"coordinates":728},[729,730],19.93658,50.06143,{"lat":730,"lon":729},{"facility":733,"status":24,"city":734,"state":725,"zip":735,"country":715,"countryCode":716,"cosmosGeoPoint":736,"geoPoint":740,"contacts":24},"Alergo-Med Specjalistyczna Przychodnia Lekarska Sp. z.o.o","Tarnów","33-100",{"type":42,"coordinates":737},[738,739],20.98698,50.01381,{"lat":739,"lon":738},{"facility":742,"status":24,"city":743,"state":744,"zip":745,"country":715,"countryCode":716,"cosmosGeoPoint":746,"geoPoint":750,"contacts":24},"AES - DRS - Synexus Polska Sp. z o.o. Oddzial we Wroclawiu","Wroclaw","Lower Silesian Voivodeship","50-088",{"type":42,"coordinates":747},[748,749],17.03006,51.10286,{"lat":749,"lon":748},{"facility":752,"status":24,"city":743,"state":744,"zip":753,"country":715,"countryCode":716,"cosmosGeoPoint":754,"geoPoint":756,"contacts":24},"ALL-MED - Specjalistyczna Opieka Medyczna - Medyczny Instytut Badawczy","53-201",{"type":42,"coordinates":755},[748,749],{"lat":749,"lon":748},{"facility":758,"status":24,"city":759,"state":760,"zip":761,"country":715,"countryCode":716,"cosmosGeoPoint":762,"geoPoint":766,"contacts":24},"ETG Lublin - PPDS","Lublin","Lublin Voivodeship","20-089",{"type":42,"coordinates":763},[764,765],22.57009,51.25058,{"lat":765,"lon":764},{"facility":768,"status":24,"city":759,"state":760,"zip":769,"country":715,"countryCode":716,"cosmosGeoPoint":770,"geoPoint":772,"contacts":24},"Centrum Alergologii Specjalistyczna Przychodnia Alergologiczna","20-552",{"type":42,"coordinates":771},[764,765],{"lat":765,"lon":764},{"facility":774,"status":24,"city":775,"state":760,"zip":776,"country":715,"countryCode":716,"cosmosGeoPoint":777,"geoPoint":781,"contacts":24},"ETG Zamosc - PPDS","Zamość","22-400",{"type":42,"coordinates":778},[779,780],23.25196,50.72314,{"lat":780,"lon":779},{"facility":783,"status":24,"city":724,"state":784,"zip":785,"country":715,"countryCode":716,"cosmosGeoPoint":786,"geoPoint":788,"contacts":24},"Malopolskie Centrum Alergologii","Malopolski","31-624",{"type":42,"coordinates":787},[729,730],{"lat":730,"lon":729},{"facility":790,"status":24,"city":791,"state":792,"zip":793,"country":715,"countryCode":716,"cosmosGeoPoint":794,"geoPoint":798,"contacts":24},"ETG Warszawa - PPDS","Piaseczno","Masovian Voivodeship","05-500",{"type":42,"coordinates":795},[796,797],21.02397,52.0814,{"lat":797,"lon":796},{"facility":800,"status":24,"city":801,"state":802,"zip":803,"country":715,"countryCode":716,"cosmosGeoPoint":804,"geoPoint":808,"contacts":24},"EMed Centrum Uslug Medycznych","Rzeszów","Podkarpackie Voivodeship","35-205",{"type":42,"coordinates":805},[806,807],21.99901,50.04132,{"lat":807,"lon":806},{"facility":810,"status":24,"city":811,"state":812,"zip":813,"country":715,"countryCode":716,"cosmosGeoPoint":814,"geoPoint":818,"contacts":24},"Homeo Medicus Szczesiul sp. j.","Bialystok","Podlaskie Voivodeship","15-687",{"type":42,"coordinates":815},[816,817],23.16433,53.13333,{"lat":817,"lon":816},{"facility":820,"status":24,"city":821,"state":822,"zip":823,"country":715,"countryCode":716,"cosmosGeoPoint":824,"geoPoint":828,"contacts":24},"Clinica Vitae Sp z o o","Gdansk","Pomeranian Voivodeship","80-382",{"type":42,"coordinates":825},[826,827],18.64912,54.35227,{"lat":827,"lon":826},{"facility":830,"status":24,"city":831,"state":24,"zip":832,"country":715,"countryCode":716,"cosmosGeoPoint":833,"geoPoint":837,"contacts":24},"Specjalistyczna Przychodnia Lekarska Alergo-Med Sp. z.o.o","Poznan","61-578",{"type":42,"coordinates":834},[835,836],16.92993,52.40692,{"lat":836,"lon":835},{"facility":839,"status":24,"city":840,"state":841,"zip":842,"country":715,"countryCode":716,"cosmosGeoPoint":843,"geoPoint":847,"contacts":24},"SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im Norberta Barlickiego Uniwersytetu Medycznego w Lodzi","Lodz","Łódź Voivodeship","90-153",{"type":42,"coordinates":844},[845,846],19.47395,51.77058,{"lat":846,"lon":845},{"facility":849,"status":24,"city":840,"state":841,"zip":842,"country":715,"countryCode":716,"cosmosGeoPoint":850,"geoPoint":852,"contacts":24},"Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Centralny Szpital Weteranow",{"type":42,"coordinates":851},[845,846],{"lat":846,"lon":845},{"facility":854,"status":24,"city":840,"state":841,"zip":855,"country":715,"countryCode":716,"cosmosGeoPoint":856,"geoPoint":858,"contacts":24},"ETG Lodz - PPDS","90-302",{"type":42,"coordinates":857},[845,846],{"lat":846,"lon":845},{"facility":860,"status":24,"city":840,"state":841,"zip":861,"country":715,"countryCode":716,"cosmosGeoPoint":862,"geoPoint":864,"contacts":24},"Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi","90-329",{"type":42,"coordinates":863},[845,846],{"lat":846,"lon":845},{"facility":866,"status":24,"city":840,"state":841,"zip":867,"country":715,"countryCode":716,"cosmosGeoPoint":868,"geoPoint":870,"contacts":24},"IP Clinic Sp. z o. o.","90-752",{"type":42,"coordinates":869},[845,846],{"lat":846,"lon":845},{"facility":872,"status":24,"city":873,"state":874,"zip":875,"country":715,"countryCode":716,"cosmosGeoPoint":876,"geoPoint":880,"contacts":24},"ETG Kielce","Kielce","Świętokrzyskie Voivodeship","25-355",{"type":42,"coordinates":877},[878,879],20.62752,50.87033,{"lat":879,"lon":878},{"type":882,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100437856","phase-3-a-study-to-examine-the-efficacy-and-safety-of-anti-fel-d-1-antibodies-injections-in-cat-allergic-adolescent-and-adult-patients-with-allergic-rhinitis-who-live-with-a-cat-100437856",true,"NCT04981717","A Study to Examine the Efficacy and Safety of Anti-Fel d 1 Antibodies Injections in Cat-allergic Adolescent and Adult Patients With Allergic Rhinitis Who Live With a Cat","A Randomized, Double-Blind, Placebo-Controlled Study in Cat-Allergic Patients With Allergic Rhinitis Who Live With a Cat to Assess the Efficacy and Safety of Anti-Fel d 1 Antibodies During Natural Cat Exposure in the Home","Key Inclusion Criteria:\n\n1. Generally healthy males and females who are 12 years and older at the time of screening.\n2. Weight must be ≥40 kg at the time of screening\n3. Documented or patient reported history (for at least 2 years) of symptomatic cat allergen-triggered allergic rhinitis with or without conjunctivitis and with or without asthma as defined by all of the following criteria:\n\n   1. Positive skin prick test (SPT) with cat hair extract (mean wheal diameter at least 5 mm greater than a negative control) at screening\n   2. Positive allergen-specific IgE (sIgE) tests for cat and Fel d 1 (both ≥0.7 kUa\u002FL at screening)\n   3. Documented or patient reported history of nasal and\u002For ocular symptoms upon cat exposure\n   4. Symptomatic despite the use of medications to treat their nasal and\u002For ocular symptoms\n4. At least 1 generally healthy cat (that is unlikely to die during the study) living in the home resulting in regular exposure\n5. A daily total rhinitis\u002Fconjunctivitis symptom score (total symptom score \\[TSS\\]) of at least 8 of 18 during at least 8 days of the 15-day baseline assessment period and use of standard, therapeutic doses of pharmacotherapy for the treatment of allergic rhinoconjunctivitis on at least 8 days of the 15-day baseline assessment period.\n\nKey Exclusion Criteria:\n\n1. History of significant multiple and\u002For severe allergies, as assessed by the investigator, that would potentially interfere with the assessments during the baseline and 12-week efficacy assessment periods or confound results, per investigator discretion, including significant rhinitis or sinusitis due to daily contact with other allergens causing symptoms that are expected to coincide with the baseline period or any of the efficacy assessment periods\n2. Received REGN1908-1909 in a prior REGN1908-1909 clinical trial (receipt of placebo in a previous trial is allowed)\n3. Active lung disease other than asthma\n4. FEV1 less than 70% of predicted at screening or randomization\n5. Treatment with an investigational drug within 2 months or within 5 half-lives (if known), whichever is longer, prior to screening\n6. Persistent chronic or recurring acute infection requiring treatment with antibiotics, antivirals, or antifungals, or any untreated respiratory infections within 4 weeks prior to screening. Patients may be re-evaluated after resolution of symptoms and specified time duration\n\nNOTE: Other protocol-defined Inclusion\u002F Exclusion Criteria apply",false,"ALL","12 Years",{"count":894,"type":895},446,"ACTUAL","INTERVENTIONAL",[898],"PHASE3","The primary objective of the study is to determine the efficacy of REGN1908-1909, as compared to placebo, to reduce allergic rhinitis\u002Fconjunctivitis symptoms and allergy rescue medication use during natural cat exposure.\n\nThe Secondary Objectives are:\n\n* To assess the reduction of allergic symptoms and use of allergy rescue medications after treatment with REGN1908-1909 versus placebo, as measured by the individual components of the CSMS\n* To assess health-related quality of life (HRQoL) as measured by the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ\\[S\\])\n* To determine the efficacy of REGN1908-1909, as compared to placebo, to inhibit a wheal-and-flare response to a skin prick test with cat allergen\n* To assess the durability of effect in allergic rhinitis and conjunctivitis symptom and medication scores after multiple doses of REGN1908-1909 compared to placebo given every 12 weeks (Q12W)\n* To determine the efficacy following multiple doses of REGN1908-1909 compared to placebo at inhibiting a wheal-and-flare response to a skin prick test with cat allergen\n* To estimate the effect of REGN1908-1909 on lung function, as compared to placebo, in patients with asthma\n* To determine the efficacy of REGN1908-1909 as compared to placebo to reduce asthma symptoms in patients with asthma\n* To assess whether there is a difference in asthma rescue medication use in patients with asthma who are treated with REGN1908-1909 compared to placebo\n* To assess whether there is a difference in nighttime awakenings in patients with asthma treated with REGN1908-1909 compared to placebo\n* To evaluate the short-term and long-term safety and tolerability of REGN1908-1909, including the incidence of hypersensitivity reactions, local injection site reactions, and asthma exacerbations\n* To determine systemic exposure of total (free and antigen-bound) antibodies as measured by concentration of REGN1908 and REGN1909\n* To assess the immunogenicity of REGN1908 and REGN1909",[901],"Allergic Rhinitis Due to Cat Allergy",[903,904,905],"Cat allergy induced allergic rhinitis","Allergic conjunctivitis","Asthma","TERMINATED","Lack of efficacy","2024-05-15",{"date":910,"type":895},"2024-06-11",{"date":912,"type":895},"2021-07-30",{"date":914,"type":895},"2023-04-24",{"name":5,"class":6},92]