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\\\u003C1% or FIX level ≤2%) as evidenced by a central laboratory measurement at screening or documented medical record evidence.\n* For participants currently not on prophylaxis (CFC or BPA on-demand): A minimum of 4 bleeding episodes requiring BPA (inhibitor participants) or CFC (non-inhibitor participants) treatment within the last 6 months prior to screening.\n* Willing and able to comply with the study requirements and to provide written informed consent and assent in the case of participants under the age of legal consent, per local and national requirements\n\nExclusion Criteria:\n\n* Known co-existing bleeding disorders other than congenital hemophilia A or B\n* History of arterial or venous thromboembolism, not associated with an indwelling venous access\n* History of intolerance to SC injection(s).\n* Current participation in immune tolerance induction therapy (ITI)\n* Prior gene therapy\n* Current or prior participation in a fitusiran trial\n* Current or prior participation 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