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This prior line should be an oxaliplatin based chemotherapy (participants who relapse within 6 months of completion of oxaliplatin based adjuvant chemotherapy are eligible)\n* Prior treatment with bevacizumab is permitted.\n\nExclusion Criteria:\n\n* Prior therapy with irinotecan\n* Eastern Cooperative Oncology Group performance status \\>2\n\nThe above information is not intended to contain all considerations relevant to participation in a clinical trial.",false,"ALL","18 Years",{"count":1947,"type":1948},1226,"ACTUAL","INTERVENTIONAL",[1951],"PHASE3","The main objective of the study was to evaluate the effectiveness of aflibercept (versus placebo) in increasing the overall survival in participants with metastatic colorectal cancer treated with FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin) and that have previously failed an oxaliplatin based treatment for metastatic disease.\n\nThe secondary objectives were to compare progression-free survival, to evaluate overall response rate, to evaluate the safety profile, to assess immunogenicity of intravenous (IV) aflibercept, and to assess pharmacokinetics of IV aflibercept in both treatment arms.",[1954,1955],"Colorectal Neoplasms","Neoplasm Metastasis",[1957,1958,1959,1960,1961,1962],"colorectal cancer","metastatic","anti-angiogenic","irinotecan","5-FU","FOLFIRI","COMPLETED","2012-09-27",{"date":1966,"type":1967},"2012-09-28","ESTIMATED",{"date":1969,"type":27},"2007-11",{"date":1971,"type":1948},"2012-06",{"name":5,"class":6},221]