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Confirmed breast cancer with bone metastasis. Pretreated with Zometa®, or Aredia (pamidronate) or all sequential regimens of both, for a minimum of 9 doses;\n\nExclusion Criteria:\n\nAbnormal kidney function determined by serum creatinine levels. Current active dental problems including: ongoing infection of the teeth or jawbone; current exposed bone in the mouth; and current or prior diagnosis of osteonecrosis of the jaw.\n\nRecent (within 8 weeks) or planned dental or jaw surgery (e.g., extraction, implants).\n\nDiagnosis of metabolic bone disease other than osteoporosis (e.g., Paget's disease of bone).\n\nKnown hypersensitivity to Zometa. Treatment with other investigational drugs within 30 days prior to randomization.\n\nOther protocol-defined exclusion criteria may have applied.",false,"FEMALE","18 Years",{"count":877,"type":878},416,"ACTUAL","INTERVENTIONAL",[881],"PHASE3","Clinical trial in breast cancer patients with bone metastases pretreated for approximately 1 year with a standard zoledronic acid regimen. Looking at the continued effectiveness and safety of giving zoledronic acid every 4 weeks versus every 12 weeks given over 1 year. This study is prospective, double-blind, stratified, multi-center, and two-arm.",[884],"Breast Cancer",[886,887,888],"Breast cancer","zoledronic acid","bone metastases","COMPLETED","2014-08-18",{"date":892,"type":893},"2014-08-22","ESTIMATED",{"date":895,"type":37},"2006-02",{"date":897,"type":878},"2013-07",{"name":40,"class":6},92]