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Participants received treatment for 12 weeks with the exception of treatment-experienced, genotype 3-infected participants who received treatment for 16 weeks.",[13],"Drug: Glecaprevir\u002FPibrentasvir",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","Coformulated tablet for oral administration",[9],[20,21],"ABT-493\u002FABT-530","MAVYRET™",[23],{"name":24,"affiliation":5,"role":25},"AbbVie Inc.","STUDY_DIRECTOR",null,[28,41,51,57,63,69,79,85,95,105,115,121,127,137,143,149,155,161,170,179,185,191,200,209,215,219,230,240,250,260,270,276,282,288],{"facility":29,"status":26,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":26},"Peking University Peoples Hospit \u002FID# 156851","Beijing","Beijing Municipality","100044","China","CN",{"type":36,"coordinates":37},"Point",[38,39],116.39723,39.9075,{"lat":39,"lon":38},{"facility":42,"status":26,"city":43,"state":44,"zip":45,"country":33,"countryCode":34,"cosmosGeoPoint":46,"geoPoint":50,"contacts":26},"Guangzhou Eighth People's Hosp \u002FID# 156865","Guangzhou","Guangdong","510060",{"type":36,"coordinates":47},[48,49],113.25,23.11667,{"lat":49,"lon":48},{"facility":52,"status":26,"city":43,"state":44,"zip":53,"country":33,"countryCode":34,"cosmosGeoPoint":54,"geoPoint":56,"contacts":26},"Guangdong General Hospital \u002FID# 156827","510080",{"type":36,"coordinates":55},[48,49],{"lat":49,"lon":48},{"facility":58,"status":26,"city":43,"state":44,"zip":59,"country":33,"countryCode":34,"cosmosGeoPoint":60,"geoPoint":62,"contacts":26},"Nanfang Hospital of Southern Medical University \u002FID# 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Municipality","200025",{"type":36,"coordinates":111},[112,113],121.45806,31.22222,{"lat":113,"lon":112},{"facility":116,"status":26,"city":107,"state":108,"zip":117,"country":33,"countryCode":34,"cosmosGeoPoint":118,"geoPoint":120,"contacts":26},"Huashan Hospital of Fudan University \u002FID# 156909","200040",{"type":36,"coordinates":119},[112,113],{"lat":113,"lon":112},{"facility":122,"status":26,"city":107,"state":108,"zip":123,"country":33,"countryCode":34,"cosmosGeoPoint":124,"geoPoint":126,"contacts":26},"Shanghai Public Health Cli Ctr \u002FID# 156837","201508",{"type":36,"coordinates":125},[112,113],{"lat":113,"lon":112},{"facility":128,"status":26,"city":129,"state":130,"zip":131,"country":33,"countryCode":34,"cosmosGeoPoint":132,"geoPoint":136,"contacts":26},"West China Hospital \u002FID# 156835","Chengdu","Sichuan","610041",{"type":36,"coordinates":133},[134,135],104.06667,30.66667,{"lat":135,"lon":134},{"facility":138,"status":26,"city":30,"state":26,"zip":139,"country":33,"countryCode":34,"cosmosGeoPoint":140,"geoPoint":142,"contacts":26},"Beijing Di Tan Hospital, Capital Medical University \u002FID# 156852","100015",{"type":36,"coordinates":141},[38,39],{"lat":39,"lon":38},{"facility":144,"status":26,"city":30,"state":26,"zip":145,"country":33,"countryCode":34,"cosmosGeoPoint":146,"geoPoint":148,"contacts":26},"1st Hospital of Peking Uni \u002FID# 156850","100034",{"type":36,"coordinates":147},[38,39],{"lat":39,"lon":38},{"facility":150,"status":26,"city":30,"state":26,"zip":151,"country":33,"countryCode":34,"cosmosGeoPoint":152,"geoPoint":154,"contacts":26},"Beijing Friendship Hospital \u002FID# 156843","100050",{"type":36,"coordinates":153},[38,39],{"lat":39,"lon":38},{"facility":156,"status":26,"city":30,"state":26,"zip":157,"country":33,"countryCode":34,"cosmosGeoPoint":158,"geoPoint":160,"contacts":26},"Beijing Youan Hosp, Cap Med Un \u002FID# 163418","100069",{"type":36,"coordinates":159},[38,39],{"lat":39,"lon":38},{"facility":162,"status":26,"city":163,"state":26,"zip":164,"country":33,"countryCode":34,"cosmosGeoPoint":165,"geoPoint":169,"contacts":26},"2nd Affiliated Hosp Chongqing \u002FID# 156838","Chongqing","400010",{"type":36,"coordinates":166},[167,168],106.55771,29.56026,{"lat":168,"lon":167},{"facility":171,"status":26,"city":172,"state":26,"zip":173,"country":33,"countryCode":34,"cosmosGeoPoint":174,"geoPoint":178,"contacts":26},"Mengchao Hepatobiliary Hospita \u002FID# 156907","Fuzhou","350025",{"type":36,"coordinates":175},[176,177],119.30611,26.06139,{"lat":177,"lon":176},{"facility":180,"status":26,"city":71,"state":26,"zip":181,"country":33,"countryCode":34,"cosmosGeoPoint":182,"geoPoint":184,"contacts":26},"Chinese People's Liberation Army 81 Hospital \u002FID# 156868","210002",{"type":36,"coordinates":183},[76,77],{"lat":77,"lon":76},{"facility":186,"status":26,"city":97,"state":26,"zip":187,"country":33,"countryCode":34,"cosmosGeoPoint":188,"geoPoint":190,"contacts":26},"Shengjing Hospital of China Medical University \u002FID# 156829","110004",{"type":36,"coordinates":189},[102,103],{"lat":103,"lon":102},{"facility":192,"status":26,"city":193,"state":26,"zip":194,"country":33,"countryCode":34,"cosmosGeoPoint":195,"geoPoint":199,"contacts":26},"1st Aff Hosp Xinjiang Med Uni \u002FID# 156891","Ürümqi","830054",{"type":36,"coordinates":196},[197,198],87.60046,43.80096,{"lat":198,"lon":197},{"facility":201,"status":26,"city":202,"state":26,"zip":203,"country":33,"countryCode":34,"cosmosGeoPoint":204,"geoPoint":208,"contacts":26},"Fourth Military Medical University Tangdu Hospital, PLA \u002FID# 156767","Xi'an","710038",{"type":36,"coordinates":205},[206,207],108.92861,34.25833,{"lat":207,"lon":206},{"facility":210,"status":26,"city":202,"state":26,"zip":211,"country":33,"countryCode":34,"cosmosGeoPoint":212,"geoPoint":214,"contacts":26},"First Affiliated Hospital of Medical College of Xi'an Jiaotong University \u002FID# 163420","710061",{"type":36,"coordinates":213},[206,207],{"lat":207,"lon":206},{"facility":216,"status":26,"city":217,"state":26,"zip":218,"country":33,"countryCode":34,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"Henan Provincial Peoples Hosp \u002FID# 157371","Zhengzhou, Henan","450000",{"facility":220,"status":26,"city":221,"state":222,"zip":223,"country":224,"countryCode":26,"cosmosGeoPoint":225,"geoPoint":229,"contacts":26},"Pusan National University Hosp \u002FID# 163411","Busan","Busan Gwang Yeogsi","602-739","South Korea",{"type":36,"coordinates":226},[227,228],129.03004,35.10168,{"lat":228,"lon":227},{"facility":231,"status":26,"city":232,"state":233,"zip":234,"country":224,"countryCode":26,"cosmosGeoPoint":235,"geoPoint":239,"contacts":26},"Seoul National Univ Bundang ho \u002FID# 163408","Seongnam","Gyeonggido","13620",{"type":36,"coordinates":236},[237,238],127.7548,36.4052,{"lat":238,"lon":237},{"facility":241,"status":26,"city":242,"state":243,"zip":244,"country":224,"countryCode":26,"cosmosGeoPoint":245,"geoPoint":249,"contacts":26},"Inje University Busan Paik Hospital \u002FID# 163384","Pusan","Gyeongsangbuk-do","47392",{"type":36,"coordinates":246},[247,248],128.3681,36.3809,{"lat":248,"lon":247},{"facility":251,"status":26,"city":252,"state":253,"zip":254,"country":224,"countryCode":26,"cosmosGeoPoint":255,"geoPoint":259,"contacts":26},"Pusan Nat Univ Yangsan Hosp \u002FID# 163385","Yangsan","Gyeongsangnam-do","50612",{"type":36,"coordinates":256},[257,258],129.03358,35.34199,{"lat":258,"lon":257},{"facility":261,"status":26,"city":262,"state":263,"zip":264,"country":224,"countryCode":26,"cosmosGeoPoint":265,"geoPoint":269,"contacts":26},"Severance Hospital \u002FID# 163399","Seoul","Seoul Teugbyeolsi","03722",{"type":36,"coordinates":266},[267,268],126.9784,37.566,{"lat":268,"lon":267},{"facility":271,"status":26,"city":262,"state":263,"zip":272,"country":224,"countryCode":26,"cosmosGeoPoint":273,"geoPoint":275,"contacts":26},"Samsung Medical Center \u002FID# 163402","06351",{"type":36,"coordinates":274},[267,268],{"lat":268,"lon":267},{"facility":277,"status":26,"city":262,"state":263,"zip":278,"country":224,"countryCode":26,"cosmosGeoPoint":279,"geoPoint":281,"contacts":26},"Korea University Guro Hospital \u002FID# 163412","08308",{"type":36,"coordinates":280},[267,268],{"lat":268,"lon":267},{"facility":283,"status":26,"city":262,"state":26,"zip":284,"country":224,"countryCode":26,"cosmosGeoPoint":285,"geoPoint":287,"contacts":26},"Seoul National University Hospital \u002FID# 163401","03080",{"type":36,"coordinates":286},[267,268],{"lat":268,"lon":267},{"facility":289,"status":26,"city":262,"state":26,"zip":290,"country":224,"countryCode":26,"cosmosGeoPoint":291,"geoPoint":293,"contacts":26},"Asan Medical Center \u002FID# 163398","05505",{"type":36,"coordinates":292},[267,268],{"lat":268,"lon":267},{"type":295,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100303835","phase-3-efficacy-and-safety-of-glecaprevirpibrentasvir-abt-493abt-530-in-treatment-naive-and-treatment-experienced-asian-adults-with-chronic-hepatitis-c-virus-genotype-gt-1-to-gt6-infection-with-compensated-cirrhosis-and-with-or-without-human-immunodeficiency-virus-co-infection-100303835",true,"NCT03235349","Efficacy and Safety of Glecaprevir\u002FPibrentasvir (ABT-493\u002FABT-530) in Treatment-Naive and Treatment-Experienced Asian Adults With Chronic Hepatitis C Virus Genotype (GT) 1 to GT6 Infection With Compensated Cirrhosis and With or Without Human Immunodeficiency Virus Co-Infection","An Open-Label Study to Evaluate the Efficacy and Safety of ABT-493\u002FABT-530 in Treatment-Naïve and Treatment-Experienced Asian Adults With Chronic Hepatitis C Virus Genotype (GT) 1 to GT6 Infection With Compensated Cirrhosis and With or Without Human Immunodeficiency Virus Co-Infection","VOYAGE-2","Inclusion Criteria:\n\n* Must be of Asian descent.\n* Screening laboratory result indicating hepatitis C virus (HCV) genotype (GT) 1, 2, 3, 4, 5 or 6 infection.\n* Positive anti-HCV antibody (Ab) and HCV ribonucleic acid (RNA) greater than or equal to 1000 IU\u002F mL at Screening Visit.\n* Chronic HCV infection defined as one of the following:\n\n  * Positive for anti-HCV Ab or HCV RNA at least 6 months before Screening; or\n  * A liver biopsy consistent with chronic HCV infection;\n* HCV treatment-naïve to any approved or investigational HCV treatment or treatment-experienced with interferon (IFN) (alpha, beta or pegylated interferon \\[pegIFN\\] with or without ribavirin (RBV) OR sofosbuvir with RBV with or without IFN. Previous treatment must have been completed \\>= 8 weeks prior to screening.\n* Compensated cirrhosis defined as Child-Pugh score of ≤ 6 at Screening and no current or past clinical evidence of Child-Pugh B or C Classification or clinical history of liver decompensation including ascites noted on physical exam, bleeding varices, use of diuretics for ascites, or hepatic encephalopathy.\n* Absence of hepatocellular carcinoma (HCC)\n\nParticipants enrolled with human immunodeficiency virus (HIV)-1 and HCV co-infection must also meet the following criteria:\n\n* Positive test result for human immunodeficiency virus antibody (HIV Ab) at Screening.\n* Naïve to treatment with any antiretroviral therapy (ART) with a cluster of differentiation (CD)4+ count greater than or equal to 500 cells\u002Fmm³ (or CD4+ % \\>= 29%), or\n* On a stable, qualifying HIV-1 ART regimen with CD4+ count \\>= 200 cells\u002Fmm³ (or CD4+ % \\>= 14%) at Screening; and plasma HIV-1 RNA below lower limit of quantification (LLOQ) by an approved plasma HIV-1 RNA quantitative assay at Screening and at least once during the 12 months prior to Screening.\n\nExclusion Criteria:\n\n* Positive test result for hepatitis B surface antigen (HbsAg) or positive test result for hepatitis B virus (HBV) deoxyribonucleic acid (DNA) if HBsAg is negative.\n* Any cause of liver disease other than chronic HCV-infection.\n* HCV genotype performed during screening indicating co-infection with more than one HCV genotype\n* Clinically significant abnormalities, other than HCV infection or HCV\u002FHIV co-infection\n* Chronic human immunodeficiency virus, type 2 (HIV-2) infection\n\nAdditional Exclusion Criteria for participants with HCV\u002FHIV Co-Infection:\n\n* For participants on stable ART, taking anti-retroviral agent(s) other than those permitted\n* Treatment for an acquired immunodeficiency syndrome (AIDS)-associated opportunistic infection within 12 months of Screening or prophylaxis for an AIDS-associated opportunistic infection within 6 months of screening\n* Diagnosis of any clinical AIDS-defining event within 12 months prior to Screening.",false,"ALL","18 Years",{"count":308,"type":309},160,"ACTUAL","INTERVENTIONAL",[312],"PHASE3","This study will evaluate the efficacy and safety of glecaprevir\u002Fpibrentasvir (ABT-493\u002FABT-530) in chronic hepatitis C virus (HCV) genotype (GT)1 to GT6-infected Asian participants with compensated cirrhosis with or without human immunodeficiency virus (HIV) co-infection who are HCV treatment-naïve or treatment-experienced with interferon (IFN) (alpha, beta or pegylated interferon \\[pegIFN\\]) with or without ribavirin (RBV) OR sofosbuvir with RBV with or without IFN.",[315],"Hepatitis C Virus (HCV)",[317,318,319,320,321,322,323,324,325,326],"Chronic Hepatitis C Virus (HCV)","Genotype 1 to 6","Cirrhosis","Compensated Cirrhosis","Human Immunodeficiency Virus","co-infection","Treatment-naïve","treatment-experienced","interferon","Asian","COMPLETED","2019-11-04",{"date":330,"type":309},"2019-11-21",{"date":332,"type":309},"2017-09-29",{"date":334,"type":309},"2019-02-25",{"name":5,"class":6},34]