[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100372846":3},{"organization":4,"armGroups":7,"interventions":39,"overallOfficials":59,"centralContacts":45,"locations":63,"responsibleParty":1056,"collaborators":1058,"id":1061,"slug":1062,"hasResults":1063,"nctId":1064,"briefTitle":1065,"officialTitle":1066,"acronym":1067,"eligibilityCriteria":1068,"healthyVolunteers":1069,"sex":1070,"minAge":1071,"maxAge":45,"enrollmentInfo":1072,"targetDuration":45,"studyType":1075,"phases":1076,"briefSummary":1078,"conditions":1079,"keywords":1081,"overallStatus":1086,"whyStopped":45,"lastUpdateSubmitDate":1087,"lastUpdatePostDateStruct":1088,"startDateStruct":1090,"completionDateStruct":1092,"leadSponsor":1094,"locationsCount":1095},{"fullName":5,"class":6},"GlaxoSmithKline","INDUSTRY",[8,15,19,26,31,35],{"label":9,"type":10,"description":11,"interventionNames":12},"GSK3196165 90 mg","EXPERIMENTAL","Entire treatment period (24 Weeks): GSK3196165 90 mg SC injection once weekly. Participants will also receive a stable dose of csDMARD(s) as standard of care (SoC).",[13,14],"Biological: GSK3196165 (Otilimab)","Drug: csDMARDs",{"label":16,"type":10,"description":17,"interventionNames":18},"GSK3196165 150 mg","Entire treatment period (24 Weeks): GSK3196165 150 mg SC injection once weekly. Participants will also receive a stable dose of csDMARD(s) as SoC.",[13,14],{"label":20,"type":21,"description":22,"interventionNames":23},"Sarilumab 200 mg","ACTIVE_COMPARATOR","Entire treatment period (24 Weeks): Sarilumab 200 mg SC injection every other week + placebo SC injection in the intervening weeks. Participants will also receive a stable dose of csDMARD(s) as SoC.",[24,25,14],"Biological: Sarilumab","Drug: Placebo to GSK3196165\u002F Sarilumab",{"label":27,"type":28,"description":29,"interventionNames":30},"Placebo sequence 1","PLACEBO_COMPARATOR","From Week 0-11: Placebo SC injection once weekly. From Week 12 onwards: GSK3196165 90 mg SC injection once weekly. Participants will also receive a stable dose of csDMARD(s) as SoC.",[13,25,14],{"label":32,"type":28,"description":33,"interventionNames":34},"Placebo sequence 2","From Week 0-11: Placebo SC injection once weekly. From Week 12 onwards: GSK3196165 150 mg SC injection once weekly. Participants will also receive a stable dose of csDMARD(s) as SoC.",[13,25,14],{"label":36,"type":28,"description":37,"interventionNames":38},"Placebo sequence 3","From Week 0-11: Placebo SC injection once weekly. From Week 12 onwards: Sarilumab 200 mg SC injection every other week + placebo SC injection in the intervening weeks. Participants will also receive a stable dose of csDMARD(s) as SoC.",[24,25,14],[40,46,50,55],{"type":41,"name":42,"description":43,"armGroupLabels":44,"otherNames":45},"BIOLOGICAL","GSK3196165 (Otilimab)","GSK3196165 solution in vial\u002Fpre-filled syringe (PFS) to be administered SC.",[16,9,27,32],null,{"type":41,"name":47,"description":48,"armGroupLabels":49,"otherNames":45},"Sarilumab","Sarilumab solution in PFS to be administered SC.",[36,20],{"type":51,"name":52,"description":53,"armGroupLabels":54,"otherNames":45},"DRUG","Placebo to GSK3196165\u002F Sarilumab","Placebo sterile 0.9 percentage (%) weight by volume (w\u002Fv) sodium chloride solution in vial\u002FPFS to be administered SC.",[27,32,36,20],{"type":51,"name":56,"description":57,"armGroupLabels":58,"otherNames":45},"csDMARDs","Stable dose of csDMARD(s) as SoC.",[16,9,27,32,36,20],[60],{"name":61,"affiliation":5,"role":62},"GSK Clinical Trials","STUDY_DIRECTOR",[64,77,85,93,101,110,118,126,134,142,151,159,167,175,180,185,190,198,206,211,220,228,237,245,254,263,272,281,290,298,307,312,321,330,338,346,354,362,367,372,380,388,396,404,412,420,428,434,436,438,441,444,452,460,468,475,480,488,498,509,517,526,535,540,548,556,561,566,574,582,593,601,609,619,627,635,646,656,661,666,674,682,685,687,695,700,708,716,724,732,740,748,756,764,772,777,787,795,805,813,821,829,837,842,850,858,866,871,879,887,895,900,905,910,918,929,938,946,954,959,967,976,984,989,994,1004,1012,1020,1028,1036,1047],{"facility":65,"status":45,"city":66,"state":67,"zip":68,"country":69,"countryCode":70,"cosmosGeoPoint":71,"geoPoint":76,"contacts":45},"GSK Investigational Site","Mesa","Arizona","85210","United States","US",{"type":72,"coordinates":73},"Point",[74,75],-111.82264,33.42227,{"lat":75,"lon":74},{"facility":65,"status":45,"city":78,"state":67,"zip":79,"country":69,"countryCode":70,"cosmosGeoPoint":80,"geoPoint":84,"contacts":45},"Phoenix","85032",{"type":72,"coordinates":81},[82,83],-112.07404,33.44838,{"lat":83,"lon":82},{"facility":65,"status":45,"city":86,"state":67,"zip":87,"country":69,"countryCode":70,"cosmosGeoPoint":88,"geoPoint":92,"contacts":45},"Sun City","85351",{"type":72,"coordinates":89},[90,91],-112.27182,33.59754,{"lat":91,"lon":90},{"facility":65,"status":45,"city":94,"state":67,"zip":95,"country":69,"countryCode":70,"cosmosGeoPoint":96,"geoPoint":100,"contacts":45},"Tucson","85704",{"type":72,"coordinates":97},[98,99],-110.92648,32.22174,{"lat":99,"lon":98},{"facility":65,"status":45,"city":102,"state":103,"zip":104,"country":69,"countryCode":70,"cosmosGeoPoint":105,"geoPoint":109,"contacts":45},"Covina","California","91722",{"type":72,"coordinates":106},[107,108],-117.89034,34.09001,{"lat":108,"lon":107},{"facility":65,"status":45,"city":111,"state":103,"zip":112,"country":69,"countryCode":70,"cosmosGeoPoint":113,"geoPoint":117,"contacts":45},"San Diego","92128",{"type":72,"coordinates":114},[115,116],-117.16472,32.71571,{"lat":116,"lon":115},{"facility":65,"status":45,"city":119,"state":103,"zip":120,"country":69,"countryCode":70,"cosmosGeoPoint":121,"geoPoint":125,"contacts":45},"Tujunga","91042",{"type":72,"coordinates":122},[123,124],-118.28841,34.25223,{"lat":124,"lon":123},{"facility":65,"status":45,"city":127,"state":103,"zip":128,"country":69,"countryCode":70,"cosmosGeoPoint":129,"geoPoint":133,"contacts":45},"Upland","91786",{"type":72,"coordinates":130},[131,132],-117.64839,34.09751,{"lat":132,"lon":131},{"facility":65,"status":45,"city":135,"state":103,"zip":136,"country":69,"countryCode":70,"cosmosGeoPoint":137,"geoPoint":141,"contacts":45},"Whittier","90602",{"type":72,"coordinates":138},[139,140],-118.03284,33.97918,{"lat":140,"lon":139},{"facility":65,"status":45,"city":143,"state":144,"zip":145,"country":69,"countryCode":70,"cosmosGeoPoint":146,"geoPoint":150,"contacts":45},"Brandon","Florida","33511",{"type":72,"coordinates":147},[148,149],-82.28592,27.9378,{"lat":149,"lon":148},{"facility":65,"status":45,"city":152,"state":144,"zip":153,"country":69,"countryCode":70,"cosmosGeoPoint":154,"geoPoint":158,"contacts":45},"DeBary","32713",{"type":72,"coordinates":155},[156,157],-81.30868,28.88305,{"lat":157,"lon":156},{"facility":65,"status":45,"city":160,"state":144,"zip":161,"country":69,"countryCode":70,"cosmosGeoPoint":162,"geoPoint":166,"contacts":45},"Jacksonville","32207",{"type":72,"coordinates":163},[164,165],-81.65565,30.33218,{"lat":165,"lon":164},{"facility":65,"status":45,"city":168,"state":144,"zip":169,"country":69,"countryCode":70,"cosmosGeoPoint":170,"geoPoint":174,"contacts":45},"Miami","33134",{"type":72,"coordinates":171},[172,173],-80.19366,25.77427,{"lat":173,"lon":172},{"facility":65,"status":45,"city":168,"state":144,"zip":176,"country":69,"countryCode":70,"cosmosGeoPoint":177,"geoPoint":179,"contacts":45},"33155",{"type":72,"coordinates":178},[172,173],{"lat":173,"lon":172},{"facility":65,"status":45,"city":168,"state":144,"zip":181,"country":69,"countryCode":70,"cosmosGeoPoint":182,"geoPoint":184,"contacts":45},"33165",{"type":72,"coordinates":183},[172,173],{"lat":173,"lon":172},{"facility":65,"status":45,"city":168,"state":144,"zip":186,"country":69,"countryCode":70,"cosmosGeoPoint":187,"geoPoint":189,"contacts":45},"33173",{"type":72,"coordinates":188},[172,173],{"lat":173,"lon":172},{"facility":65,"status":45,"city":191,"state":144,"zip":192,"country":69,"countryCode":70,"cosmosGeoPoint":193,"geoPoint":197,"contacts":45},"Miami Lakes","33014",{"type":72,"coordinates":194},[195,196],-80.30866,25.90871,{"lat":196,"lon":195},{"facility":65,"status":45,"city":199,"state":144,"zip":200,"country":69,"countryCode":70,"cosmosGeoPoint":201,"geoPoint":205,"contacts":45},"Tampa","33613",{"type":72,"coordinates":202},[203,204],-82.45843,27.94752,{"lat":204,"lon":203},{"facility":65,"status":45,"city":199,"state":144,"zip":207,"country":69,"countryCode":70,"cosmosGeoPoint":208,"geoPoint":210,"contacts":45},"33614",{"type":72,"coordinates":209},[203,204],{"lat":204,"lon":203},{"facility":65,"status":45,"city":212,"state":213,"zip":214,"country":69,"countryCode":70,"cosmosGeoPoint":215,"geoPoint":219,"contacts":45},"Atlanta","Georgia","30318",{"type":72,"coordinates":216},[217,218],-84.38798,33.749,{"lat":218,"lon":217},{"facility":65,"status":45,"city":221,"state":213,"zip":222,"country":69,"countryCode":70,"cosmosGeoPoint":223,"geoPoint":227,"contacts":45},"Newnan","30265",{"type":72,"coordinates":224},[225,226],-84.79966,33.38067,{"lat":226,"lon":225},{"facility":65,"status":45,"city":229,"state":230,"zip":231,"country":69,"countryCode":70,"cosmosGeoPoint":232,"geoPoint":236,"contacts":45},"Chicago","Illinois","60607",{"type":72,"coordinates":233},[234,235],-87.65005,41.85003,{"lat":235,"lon":234},{"facility":65,"status":45,"city":238,"state":230,"zip":239,"country":69,"countryCode":70,"cosmosGeoPoint":240,"geoPoint":244,"contacts":45},"Skokie","60076",{"type":72,"coordinates":241},[242,243],-87.73339,42.03336,{"lat":243,"lon":242},{"facility":65,"status":45,"city":246,"state":247,"zip":248,"country":69,"countryCode":70,"cosmosGeoPoint":249,"geoPoint":253,"contacts":45},"St Louis","Missouri","63141",{"type":72,"coordinates":250},[251,252],-90.19789,38.62727,{"lat":252,"lon":251},{"facility":65,"status":45,"city":255,"state":256,"zip":257,"country":69,"countryCode":70,"cosmosGeoPoint":258,"geoPoint":262,"contacts":45},"Lincoln","Nebraska","68516",{"type":72,"coordinates":259},[260,261],-96.66696,40.8,{"lat":261,"lon":260},{"facility":65,"status":45,"city":264,"state":265,"zip":266,"country":69,"countryCode":70,"cosmosGeoPoint":267,"geoPoint":271,"contacts":45},"Lebanon","New Hampshire","03756",{"type":72,"coordinates":268},[269,270],-72.25176,43.64229,{"lat":270,"lon":269},{"facility":65,"status":45,"city":273,"state":274,"zip":275,"country":69,"countryCode":70,"cosmosGeoPoint":276,"geoPoint":280,"contacts":45},"Minot","North Dakota","58701",{"type":72,"coordinates":277},[278,279],-101.29627,48.23251,{"lat":279,"lon":278},{"facility":65,"status":45,"city":282,"state":283,"zip":284,"country":69,"countryCode":70,"cosmosGeoPoint":285,"geoPoint":289,"contacts":45},"Cincinnati","Ohio","45242",{"type":72,"coordinates":286},[287,288],-84.51439,39.12711,{"lat":288,"lon":287},{"facility":65,"status":45,"city":291,"state":283,"zip":292,"country":69,"countryCode":70,"cosmosGeoPoint":293,"geoPoint":297,"contacts":45},"Dayton","45417",{"type":72,"coordinates":294},[295,296],-84.19161,39.75895,{"lat":296,"lon":295},{"facility":65,"status":45,"city":299,"state":300,"zip":301,"country":69,"countryCode":70,"cosmosGeoPoint":302,"geoPoint":306,"contacts":45},"Oklahoma City","Oklahoma","73104",{"type":72,"coordinates":303},[304,305],-97.51643,35.46756,{"lat":305,"lon":304},{"facility":65,"status":45,"city":299,"state":300,"zip":308,"country":69,"countryCode":70,"cosmosGeoPoint":309,"geoPoint":311,"contacts":45},"73112",{"type":72,"coordinates":310},[304,305],{"lat":305,"lon":304},{"facility":65,"status":45,"city":313,"state":314,"zip":315,"country":69,"countryCode":70,"cosmosGeoPoint":316,"geoPoint":320,"contacts":45},"Greenville","South Carolina","29601",{"type":72,"coordinates":317},[318,319],-82.39401,34.85262,{"lat":319,"lon":318},{"facility":65,"status":45,"city":322,"state":323,"zip":324,"country":69,"countryCode":70,"cosmosGeoPoint":325,"geoPoint":329,"contacts":45},"Austin","Texas","78731",{"type":72,"coordinates":326},[327,328],-97.74306,30.26715,{"lat":328,"lon":327},{"facility":65,"status":45,"city":331,"state":323,"zip":332,"country":69,"countryCode":70,"cosmosGeoPoint":333,"geoPoint":337,"contacts":45},"Baytown","77521",{"type":72,"coordinates":334},[335,336],-94.97743,29.7355,{"lat":336,"lon":335},{"facility":65,"status":45,"city":339,"state":323,"zip":340,"country":69,"countryCode":70,"cosmosGeoPoint":341,"geoPoint":345,"contacts":45},"College Station","77845",{"type":72,"coordinates":342},[343,344],-96.33441,30.62798,{"lat":344,"lon":343},{"facility":65,"status":45,"city":347,"state":323,"zip":348,"country":69,"countryCode":70,"cosmosGeoPoint":349,"geoPoint":353,"contacts":45},"Colleyville","76034",{"type":72,"coordinates":350},[351,352],-97.15501,32.88096,{"lat":352,"lon":351},{"facility":65,"status":45,"city":355,"state":323,"zip":356,"country":69,"countryCode":70,"cosmosGeoPoint":357,"geoPoint":361,"contacts":45},"Houston","77065",{"type":72,"coordinates":358},[359,360],-95.36327,29.76328,{"lat":360,"lon":359},{"facility":65,"status":45,"city":355,"state":323,"zip":363,"country":69,"countryCode":70,"cosmosGeoPoint":364,"geoPoint":366,"contacts":45},"77089",{"type":72,"coordinates":365},[359,360],{"lat":360,"lon":359},{"facility":65,"status":45,"city":355,"state":323,"zip":368,"country":69,"countryCode":70,"cosmosGeoPoint":369,"geoPoint":371,"contacts":45},"77090",{"type":72,"coordinates":370},[359,360],{"lat":360,"lon":359},{"facility":65,"status":45,"city":373,"state":323,"zip":374,"country":69,"countryCode":70,"cosmosGeoPoint":375,"geoPoint":379,"contacts":45},"Lubbock","79410",{"type":72,"coordinates":376},[377,378],-101.85517,33.57786,{"lat":378,"lon":377},{"facility":65,"status":45,"city":381,"state":323,"zip":382,"country":69,"countryCode":70,"cosmosGeoPoint":383,"geoPoint":387,"contacts":45},"Plano","75024",{"type":72,"coordinates":384},[385,386],-96.69889,33.01984,{"lat":386,"lon":385},{"facility":65,"status":45,"city":389,"state":323,"zip":390,"country":69,"countryCode":70,"cosmosGeoPoint":391,"geoPoint":395,"contacts":45},"San Antonio","78229",{"type":72,"coordinates":392},[393,394],-98.49363,29.42412,{"lat":394,"lon":393},{"facility":65,"status":45,"city":397,"state":323,"zip":398,"country":69,"countryCode":70,"cosmosGeoPoint":399,"geoPoint":403,"contacts":45},"San Marcos","78666",{"type":72,"coordinates":400},[401,402],-97.94139,29.88327,{"lat":402,"lon":401},{"facility":65,"status":45,"city":405,"state":323,"zip":406,"country":69,"countryCode":70,"cosmosGeoPoint":407,"geoPoint":411,"contacts":45},"The Woodlands","77382",{"type":72,"coordinates":408},[409,410],-95.48938,30.15799,{"lat":410,"lon":409},{"facility":65,"status":45,"city":413,"state":323,"zip":414,"country":69,"countryCode":70,"cosmosGeoPoint":415,"geoPoint":419,"contacts":45},"Tomball","77375",{"type":72,"coordinates":416},[417,418],-95.61605,30.09716,{"lat":418,"lon":417},{"facility":65,"status":45,"city":421,"state":323,"zip":422,"country":69,"countryCode":70,"cosmosGeoPoint":423,"geoPoint":427,"contacts":45},"Waco","76710",{"type":72,"coordinates":424},[425,426],-97.14667,31.54933,{"lat":426,"lon":425},{"facility":65,"status":45,"city":429,"state":430,"zip":431,"country":432,"countryCode":433,"cosmosGeoPoint":45,"geoPoint":45,"contacts":45},"Ciudad Autonoma Buenos Aires","Buenos Aires","C1046AAQ","Argentina","AR",{"facility":65,"status":45,"city":429,"state":430,"zip":435,"country":432,"countryCode":433,"cosmosGeoPoint":45,"geoPoint":45,"contacts":45},"C1417",{"facility":65,"status":45,"city":429,"state":430,"zip":437,"country":432,"countryCode":433,"cosmosGeoPoint":45,"geoPoint":45,"contacts":45},"C1430EGF",{"facility":65,"status":45,"city":439,"state":430,"zip":440,"country":432,"countryCode":433,"cosmosGeoPoint":45,"geoPoint":45,"contacts":45},"Ciudad Autonoma de Buenos Aires","1426",{"facility":65,"status":45,"city":442,"state":430,"zip":443,"country":432,"countryCode":433,"cosmosGeoPoint":45,"geoPoint":45,"contacts":45},"La Palta","B1900AXI",{"facility":65,"status":45,"city":445,"state":430,"zip":446,"country":432,"countryCode":433,"cosmosGeoPoint":447,"geoPoint":451,"contacts":45},"Mar del Plata","B7600FYK",{"type":72,"coordinates":448},[449,450],-57.5562,-38.00042,{"lat":450,"lon":449},{"facility":65,"status":45,"city":453,"state":430,"zip":454,"country":432,"countryCode":433,"cosmosGeoPoint":455,"geoPoint":459,"contacts":45},"San Isidro","1643",{"type":72,"coordinates":456},[457,458],-58.52111,-34.46971,{"lat":458,"lon":457},{"facility":65,"status":45,"city":461,"state":430,"zip":462,"country":432,"countryCode":433,"cosmosGeoPoint":463,"geoPoint":467,"contacts":45},"San Nicolás de los Arroyos","B2900DMH",{"type":72,"coordinates":464},[465,466],-60.2108,-33.33425,{"lat":466,"lon":465},{"facility":65,"status":45,"city":430,"state":45,"zip":469,"country":432,"countryCode":433,"cosmosGeoPoint":470,"geoPoint":474,"contacts":45},"C1426BOR",{"type":72,"coordinates":471},[472,473],-58.37723,-34.61315,{"lat":473,"lon":472},{"facility":65,"status":45,"city":430,"state":45,"zip":476,"country":432,"countryCode":433,"cosmosGeoPoint":477,"geoPoint":479,"contacts":45},"C1430CKE",{"type":72,"coordinates":478},[472,473],{"lat":473,"lon":472},{"facility":65,"status":45,"city":481,"state":45,"zip":482,"country":432,"countryCode":433,"cosmosGeoPoint":483,"geoPoint":487,"contacts":45},"San Juan","5400",{"type":72,"coordinates":484},[485,486],-68.52568,-31.53726,{"lat":486,"lon":485},{"facility":65,"status":45,"city":489,"state":45,"zip":490,"country":491,"countryCode":492,"cosmosGeoPoint":493,"geoPoint":497,"contacts":45},"Mons","7000","Belgium","BE",{"type":72,"coordinates":494},[495,496],3.95229,50.45413,{"lat":496,"lon":495},{"facility":65,"status":45,"city":499,"state":500,"zip":501,"country":502,"countryCode":503,"cosmosGeoPoint":504,"geoPoint":508,"contacts":45},"Barrie","Ontario","L4M 6L2","Canada","CA",{"type":72,"coordinates":505},[506,507],-79.66634,44.40011,{"lat":507,"lon":506},{"facility":65,"status":45,"city":510,"state":500,"zip":511,"country":502,"countryCode":503,"cosmosGeoPoint":512,"geoPoint":516,"contacts":45},"Brampton","L6T 0G1",{"type":72,"coordinates":513},[514,515],-79.76633,43.68341,{"lat":515,"lon":514},{"facility":65,"status":45,"city":518,"state":519,"zip":520,"country":502,"countryCode":503,"cosmosGeoPoint":521,"geoPoint":525,"contacts":45},"Trois-Rivières","Quebec","G8Z 1Y2",{"type":72,"coordinates":522},[523,524],-72.5477,46.34515,{"lat":524,"lon":523},{"facility":65,"status":45,"city":527,"state":45,"zip":528,"country":529,"countryCode":45,"cosmosGeoPoint":530,"geoPoint":534,"contacts":45},"Brno","638 00","Czechia",{"type":72,"coordinates":531},[532,533],16.60796,49.19522,{"lat":533,"lon":532},{"facility":65,"status":45,"city":527,"state":45,"zip":536,"country":529,"countryCode":45,"cosmosGeoPoint":537,"geoPoint":539,"contacts":45},"65691",{"type":72,"coordinates":538},[532,533],{"lat":533,"lon":532},{"facility":65,"status":45,"city":541,"state":45,"zip":542,"country":529,"countryCode":45,"cosmosGeoPoint":543,"geoPoint":547,"contacts":45},"Ostrava","70200",{"type":72,"coordinates":544},[545,546],18.28204,49.83465,{"lat":546,"lon":545},{"facility":65,"status":45,"city":549,"state":45,"zip":550,"country":529,"countryCode":45,"cosmosGeoPoint":551,"geoPoint":555,"contacts":45},"Prague","128 50",{"type":72,"coordinates":552},[553,554],14.42076,50.08804,{"lat":554,"lon":553},{"facility":65,"status":45,"city":549,"state":45,"zip":557,"country":529,"countryCode":45,"cosmosGeoPoint":558,"geoPoint":560,"contacts":45},"148 00",{"type":72,"coordinates":559},[553,554],{"lat":554,"lon":553},{"facility":65,"status":45,"city":549,"state":45,"zip":562,"country":529,"countryCode":45,"cosmosGeoPoint":563,"geoPoint":565,"contacts":45},"150 06",{"type":72,"coordinates":564},[553,554],{"lat":554,"lon":553},{"facility":65,"status":45,"city":567,"state":45,"zip":568,"country":529,"countryCode":45,"cosmosGeoPoint":569,"geoPoint":573,"contacts":45},"Uherské Hradiště","686 01",{"type":72,"coordinates":570},[571,572],17.45969,49.06975,{"lat":572,"lon":571},{"facility":65,"status":45,"city":575,"state":45,"zip":576,"country":529,"countryCode":45,"cosmosGeoPoint":577,"geoPoint":581,"contacts":45},"Zlín","760 01",{"type":72,"coordinates":578},[579,580],17.67065,49.22645,{"lat":580,"lon":579},{"facility":65,"status":45,"city":583,"state":584,"zip":585,"country":586,"countryCode":587,"cosmosGeoPoint":588,"geoPoint":592,"contacts":45},"Rendsburg","Schleswig-Holstein","24768","Germany","DE",{"type":72,"coordinates":589},[590,591],9.67175,54.30182,{"lat":591,"lon":590},{"facility":65,"status":45,"city":594,"state":45,"zip":595,"country":586,"countryCode":587,"cosmosGeoPoint":596,"geoPoint":600,"contacts":45},"Hamburg","D-20095",{"type":72,"coordinates":597},[598,599],9.99302,53.55073,{"lat":599,"lon":598},{"facility":65,"status":45,"city":602,"state":45,"zip":603,"country":586,"countryCode":587,"cosmosGeoPoint":604,"geoPoint":608,"contacts":45},"Magdeburg","39120",{"type":72,"coordinates":605},[606,607],11.63189,52.13129,{"lat":607,"lon":606},{"facility":65,"status":45,"city":610,"state":45,"zip":611,"country":612,"countryCode":613,"cosmosGeoPoint":614,"geoPoint":618,"contacts":45},"Budapest","1023","Hungary","HU",{"type":72,"coordinates":615},[616,617],19.04045,47.49835,{"lat":617,"lon":616},{"facility":65,"status":45,"city":620,"state":45,"zip":621,"country":612,"countryCode":613,"cosmosGeoPoint":622,"geoPoint":626,"contacts":45},"Székesfehérvár","8000",{"type":72,"coordinates":623},[624,625],18.41034,47.18995,{"lat":625,"lon":624},{"facility":65,"status":45,"city":628,"state":45,"zip":629,"country":612,"countryCode":613,"cosmosGeoPoint":630,"geoPoint":634,"contacts":45},"Veszprém","H-8200",{"type":72,"coordinates":631},[632,633],17.91149,47.09327,{"lat":633,"lon":632},{"facility":65,"status":45,"city":636,"state":637,"zip":638,"country":639,"countryCode":640,"cosmosGeoPoint":641,"geoPoint":645,"contacts":45},"Verona","Veneto","37126","Italy","IT",{"type":72,"coordinates":642},[643,644],10.9938,45.43854,{"lat":644,"lon":643},{"facility":65,"status":45,"city":647,"state":45,"zip":648,"country":649,"countryCode":650,"cosmosGeoPoint":651,"geoPoint":655,"contacts":45},"Aichi","455-8530","Japan","JP",{"type":72,"coordinates":652},[653,654],130.62158,32.51879,{"lat":654,"lon":653},{"facility":65,"status":45,"city":647,"state":45,"zip":657,"country":649,"countryCode":650,"cosmosGeoPoint":658,"geoPoint":660,"contacts":45},"457-8511",{"type":72,"coordinates":659},[653,654],{"lat":654,"lon":653},{"facility":65,"status":45,"city":647,"state":45,"zip":662,"country":649,"countryCode":650,"cosmosGeoPoint":663,"geoPoint":665,"contacts":45},"460-0001",{"type":72,"coordinates":664},[653,654],{"lat":654,"lon":653},{"facility":65,"status":45,"city":667,"state":45,"zip":668,"country":649,"countryCode":650,"cosmosGeoPoint":669,"geoPoint":673,"contacts":45},"Chiba","270-2296",{"type":72,"coordinates":670},[671,672],140.11667,35.6,{"lat":672,"lon":671},{"facility":65,"status":45,"city":675,"state":45,"zip":676,"country":649,"countryCode":650,"cosmosGeoPoint":677,"geoPoint":681,"contacts":45},"Fukuoka","807-8555",{"type":72,"coordinates":678},[679,680],130.41667,33.6,{"lat":680,"lon":679},{"facility":65,"status":45,"city":683,"state":45,"zip":684,"country":649,"countryCode":650,"cosmosGeoPoint":45,"geoPoint":45,"contacts":45},"Hokkaido","060-8648",{"facility":65,"status":45,"city":683,"state":45,"zip":686,"country":649,"countryCode":650,"cosmosGeoPoint":45,"geoPoint":45,"contacts":45},"063-0811",{"facility":65,"status":45,"city":688,"state":45,"zip":689,"country":649,"countryCode":650,"cosmosGeoPoint":690,"geoPoint":694,"contacts":45},"Hyōgo","673-1462",{"type":72,"coordinates":691},[692,693],144.43333,43.36667,{"lat":693,"lon":692},{"facility":65,"status":45,"city":688,"state":45,"zip":696,"country":649,"countryCode":650,"cosmosGeoPoint":697,"geoPoint":699,"contacts":45},"675-1392",{"type":72,"coordinates":698},[692,693],{"lat":693,"lon":692},{"facility":65,"status":45,"city":701,"state":45,"zip":702,"country":649,"countryCode":650,"cosmosGeoPoint":703,"geoPoint":707,"contacts":45},"Ibaraki","312-0057",{"type":72,"coordinates":704},[705,706],135.56828,34.81641,{"lat":706,"lon":705},{"facility":65,"status":45,"city":709,"state":45,"zip":710,"country":649,"countryCode":650,"cosmosGeoPoint":711,"geoPoint":715,"contacts":45},"Kagoshima","891-0133",{"type":72,"coordinates":712},[713,714],130.55,31.56667,{"lat":714,"lon":713},{"facility":65,"status":45,"city":717,"state":45,"zip":718,"country":649,"countryCode":650,"cosmosGeoPoint":719,"geoPoint":723,"contacts":45},"Kanagawa","245-8575",{"type":72,"coordinates":720},[721,722],139.91667,37.58333,{"lat":722,"lon":721},{"facility":65,"status":45,"city":725,"state":45,"zip":726,"country":649,"countryCode":650,"cosmosGeoPoint":727,"geoPoint":731,"contacts":45},"Kochi","781-0112",{"type":72,"coordinates":728},[729,730],133.53333,33.55,{"lat":730,"lon":729},{"facility":65,"status":45,"city":733,"state":45,"zip":734,"country":649,"countryCode":650,"cosmosGeoPoint":735,"geoPoint":739,"contacts":45},"Kumamoto","862-0976",{"type":72,"coordinates":736},[737,738],130.69181,32.80589,{"lat":738,"lon":737},{"facility":65,"status":45,"city":741,"state":45,"zip":742,"country":649,"countryCode":650,"cosmosGeoPoint":743,"geoPoint":747,"contacts":45},"Miyagi","980-8574",{"type":72,"coordinates":744},[745,746],128.18236,26.62566,{"lat":746,"lon":745},{"facility":65,"status":45,"city":749,"state":45,"zip":750,"country":649,"countryCode":650,"cosmosGeoPoint":751,"geoPoint":755,"contacts":45},"Nagasaki","857-1195",{"type":72,"coordinates":752},[753,754],129.88333,32.75,{"lat":754,"lon":753},{"facility":65,"status":45,"city":757,"state":45,"zip":758,"country":649,"countryCode":650,"cosmosGeoPoint":759,"geoPoint":763,"contacts":45},"Saitama","359-1111",{"type":72,"coordinates":760},[761,762],139.65657,35.90807,{"lat":762,"lon":761},{"facility":65,"status":45,"city":765,"state":45,"zip":766,"country":649,"countryCode":650,"cosmosGeoPoint":767,"geoPoint":771,"contacts":45},"Tokyo","104-8560",{"type":72,"coordinates":768},[769,770],139.69171,35.6895,{"lat":770,"lon":769},{"facility":65,"status":45,"city":765,"state":45,"zip":773,"country":649,"countryCode":650,"cosmosGeoPoint":774,"geoPoint":776,"contacts":45},"142-0054",{"type":72,"coordinates":775},[769,770],{"lat":770,"lon":769},{"facility":65,"status":45,"city":778,"state":45,"zip":779,"country":780,"countryCode":781,"cosmosGeoPoint":782,"geoPoint":786,"contacts":45},"Klaipėda","LT-92288","Lithuania","LT",{"type":72,"coordinates":783},[784,785],21.13912,55.7068,{"lat":785,"lon":784},{"facility":65,"status":45,"city":788,"state":45,"zip":789,"country":780,"countryCode":781,"cosmosGeoPoint":790,"geoPoint":794,"contacts":45},"Šiauliai","76231",{"type":72,"coordinates":791},[792,793],23.31667,55.93333,{"lat":793,"lon":792},{"facility":65,"status":45,"city":796,"state":45,"zip":797,"country":798,"countryCode":799,"cosmosGeoPoint":800,"geoPoint":804,"contacts":45},"Bialystok","15-879","Poland","PL",{"type":72,"coordinates":801},[802,803],23.16433,53.13333,{"lat":803,"lon":802},{"facility":65,"status":45,"city":806,"state":45,"zip":807,"country":798,"countryCode":799,"cosmosGeoPoint":808,"geoPoint":812,"contacts":45},"Bydgoszcz","85-168",{"type":72,"coordinates":809},[810,811],18.00762,53.1235,{"lat":811,"lon":810},{"facility":65,"status":45,"city":814,"state":45,"zip":815,"country":798,"countryCode":799,"cosmosGeoPoint":816,"geoPoint":820,"contacts":45},"Gdansk","80-382",{"type":72,"coordinates":817},[818,819],18.64912,54.35227,{"lat":819,"lon":818},{"facility":65,"status":45,"city":822,"state":45,"zip":823,"country":798,"countryCode":799,"cosmosGeoPoint":824,"geoPoint":828,"contacts":45},"Gdynia","81-537",{"type":72,"coordinates":825},[826,827],18.53188,54.51889,{"lat":827,"lon":826},{"facility":65,"status":45,"city":830,"state":45,"zip":831,"country":798,"countryCode":799,"cosmosGeoPoint":832,"geoPoint":836,"contacts":45},"Katowice","40-040",{"type":72,"coordinates":833},[834,835],19.02173,50.2597,{"lat":835,"lon":834},{"facility":65,"status":45,"city":830,"state":45,"zip":838,"country":798,"countryCode":799,"cosmosGeoPoint":839,"geoPoint":841,"contacts":45},"40-282",{"type":72,"coordinates":840},[834,835],{"lat":835,"lon":834},{"facility":65,"status":45,"city":843,"state":45,"zip":844,"country":798,"countryCode":799,"cosmosGeoPoint":845,"geoPoint":849,"contacts":45},"Krakow","30-363",{"type":72,"coordinates":846},[847,848],19.93658,50.06143,{"lat":848,"lon":847},{"facility":65,"status":45,"city":851,"state":45,"zip":852,"country":798,"countryCode":799,"cosmosGeoPoint":853,"geoPoint":857,"contacts":45},"Lodz","90-127",{"type":72,"coordinates":854},[855,856],19.47395,51.77058,{"lat":856,"lon":855},{"facility":65,"status":45,"city":859,"state":45,"zip":860,"country":798,"countryCode":799,"cosmosGeoPoint":861,"geoPoint":865,"contacts":45},"Poznan","60-702",{"type":72,"coordinates":862},[863,864],16.92993,52.40692,{"lat":864,"lon":863},{"facility":65,"status":45,"city":859,"state":45,"zip":867,"country":798,"countryCode":799,"cosmosGeoPoint":868,"geoPoint":870,"contacts":45},"60-773",{"type":72,"coordinates":869},[863,864],{"lat":864,"lon":863},{"facility":65,"status":45,"city":872,"state":45,"zip":873,"country":798,"countryCode":799,"cosmosGeoPoint":874,"geoPoint":878,"contacts":45},"Sochaczew","96-500",{"type":72,"coordinates":875},[876,877],20.23838,52.22944,{"lat":877,"lon":876},{"facility":65,"status":45,"city":880,"state":45,"zip":881,"country":798,"countryCode":799,"cosmosGeoPoint":882,"geoPoint":886,"contacts":45},"Torun","87-100",{"type":72,"coordinates":883},[884,885],18.59814,53.01375,{"lat":885,"lon":884},{"facility":65,"status":45,"city":888,"state":45,"zip":889,"country":798,"countryCode":799,"cosmosGeoPoint":890,"geoPoint":894,"contacts":45},"Warsaw","00-465",{"type":72,"coordinates":891},[892,893],21.01178,52.22977,{"lat":893,"lon":892},{"facility":65,"status":45,"city":888,"state":45,"zip":896,"country":798,"countryCode":799,"cosmosGeoPoint":897,"geoPoint":899,"contacts":45},"00-874",{"type":72,"coordinates":898},[892,893],{"lat":893,"lon":892},{"facility":65,"status":45,"city":888,"state":45,"zip":901,"country":798,"countryCode":799,"cosmosGeoPoint":902,"geoPoint":904,"contacts":45},"01-192",{"type":72,"coordinates":903},[892,893],{"lat":893,"lon":892},{"facility":65,"status":45,"city":888,"state":45,"zip":906,"country":798,"countryCode":799,"cosmosGeoPoint":907,"geoPoint":909,"contacts":45},"02-118",{"type":72,"coordinates":908},[892,893],{"lat":893,"lon":892},{"facility":65,"status":45,"city":911,"state":45,"zip":912,"country":798,"countryCode":799,"cosmosGeoPoint":913,"geoPoint":917,"contacts":45},"Wroclaw","50-381",{"type":72,"coordinates":914},[915,916],17.03006,51.10286,{"lat":916,"lon":915},{"facility":65,"status":45,"city":919,"state":920,"zip":921,"country":922,"countryCode":923,"cosmosGeoPoint":924,"geoPoint":928,"contacts":45},"Pretoria","Gauteng","184","South Africa","ZA",{"type":72,"coordinates":925},[926,927],28.18783,-25.74486,{"lat":927,"lon":926},{"facility":65,"status":45,"city":930,"state":931,"zip":932,"country":922,"countryCode":923,"cosmosGeoPoint":933,"geoPoint":937,"contacts":45},"Durban","KwaZulu-Natal","4319",{"type":72,"coordinates":934},[935,936],31.0292,-29.8579,{"lat":936,"lon":935},{"facility":65,"status":45,"city":939,"state":45,"zip":940,"country":922,"countryCode":923,"cosmosGeoPoint":941,"geoPoint":945,"contacts":45},"Cape Town","7500",{"type":72,"coordinates":942},[943,944],18.42322,-33.92584,{"lat":944,"lon":943},{"facility":65,"status":45,"city":947,"state":45,"zip":948,"country":922,"countryCode":923,"cosmosGeoPoint":949,"geoPoint":953,"contacts":45},"Kempton Park","1619",{"type":72,"coordinates":950},[951,952],28.2377,-26.10859,{"lat":952,"lon":951},{"facility":65,"status":45,"city":919,"state":45,"zip":955,"country":922,"countryCode":923,"cosmosGeoPoint":956,"geoPoint":958,"contacts":45},"0002",{"type":72,"coordinates":957},[926,927],{"lat":927,"lon":926},{"facility":65,"status":45,"city":960,"state":45,"zip":961,"country":922,"countryCode":923,"cosmosGeoPoint":962,"geoPoint":966,"contacts":45},"Stellenbosch","7600",{"type":72,"coordinates":963},[964,965],18.86676,-33.93462,{"lat":965,"lon":964},{"facility":65,"status":45,"city":968,"state":45,"zip":969,"country":970,"countryCode":45,"cosmosGeoPoint":971,"geoPoint":975,"contacts":45},"Incheon","400-711","South Korea",{"type":72,"coordinates":972},[973,974],126.70515,37.45646,{"lat":974,"lon":973},{"facility":65,"status":45,"city":977,"state":45,"zip":978,"country":970,"countryCode":45,"cosmosGeoPoint":979,"geoPoint":983,"contacts":45},"Seoul","03722",{"type":72,"coordinates":980},[981,982],126.9784,37.566,{"lat":982,"lon":981},{"facility":65,"status":45,"city":977,"state":45,"zip":985,"country":970,"countryCode":45,"cosmosGeoPoint":986,"geoPoint":988,"contacts":45},"04763",{"type":72,"coordinates":987},[981,982],{"lat":982,"lon":981},{"facility":65,"status":45,"city":977,"state":45,"zip":990,"country":970,"countryCode":45,"cosmosGeoPoint":991,"geoPoint":993,"contacts":45},"3080",{"type":72,"coordinates":992},[981,982],{"lat":982,"lon":981},{"facility":65,"status":45,"city":995,"state":45,"zip":996,"country":997,"countryCode":998,"cosmosGeoPoint":999,"geoPoint":1003,"contacts":45},"A Coruña","15006","Spain","ES",{"type":72,"coordinates":1000},[1001,1002],-8.396,43.37135,{"lat":1002,"lon":1001},{"facility":65,"status":45,"city":1005,"state":45,"zip":1006,"country":997,"countryCode":998,"cosmosGeoPoint":1007,"geoPoint":1011,"contacts":45},"Elche","03203",{"type":72,"coordinates":1008},[1009,1010],-0.70107,38.26218,{"lat":1010,"lon":1009},{"facility":65,"status":45,"city":1013,"state":45,"zip":1014,"country":997,"countryCode":998,"cosmosGeoPoint":1015,"geoPoint":1019,"contacts":45},"Santander","39008",{"type":72,"coordinates":1016},[1017,1018],-3.80493,43.46589,{"lat":1018,"lon":1017},{"facility":65,"status":45,"city":1021,"state":45,"zip":1022,"country":997,"countryCode":998,"cosmosGeoPoint":1023,"geoPoint":1027,"contacts":45},"Santiago de Compostela","15706",{"type":72,"coordinates":1024},[1025,1026],-8.54569,42.88052,{"lat":1026,"lon":1025},{"facility":65,"status":45,"city":1029,"state":45,"zip":1030,"country":997,"countryCode":998,"cosmosGeoPoint":1031,"geoPoint":1035,"contacts":45},"Valencia","46010",{"type":72,"coordinates":1032},[1033,1034],-0.37966,39.47391,{"lat":1034,"lon":1033},{"facility":65,"status":45,"city":1037,"state":1038,"zip":1039,"country":1040,"countryCode":1041,"cosmosGeoPoint":1042,"geoPoint":1046,"contacts":45},"Romford","Essex","RM1 3PJ","United Kingdom","UK",{"type":72,"coordinates":1043},[1044,1045],0.18582,51.57515,{"lat":1045,"lon":1044},{"facility":65,"status":45,"city":1048,"state":1049,"zip":1050,"country":1040,"countryCode":1041,"cosmosGeoPoint":1051,"geoPoint":1055,"contacts":45},"Northwood","Middlesex","HA6 2RN",{"type":72,"coordinates":1052},[1053,1054],-0.42454,51.61162,{"lat":1054,"lon":1053},{"type":1057,"investigatorFullName":45,"investigatorTitle":45,"investigatorAffiliation":45,"oldNameTitle":45,"oldOrganization":45},"SPONSOR",[1059],{"name":1060,"class":6},"IQVIA Pty Ltd","100372846","phase-3-efficacy-and-safety-of-gsk3196165-otilimab-versus-placebo-and-sarilumab-in-participants-with-moderately-to-severely-active-rheumatoid-arthritis-who-have-an-inadequate-response-to-biological-disease-modifying-antirheumatic-drug-dmards-andor-janus-kinase-jak-inhibitors-100372846",true,"NCT04134728","Efficacy and Safety of GSK3196165 (Otilimab) Versus Placebo and Sarilumab in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biological Disease-modifying Antirheumatic Drug (DMARDs) and\u002For Janus Kinase (JAK) Inhibitors","A 24-week, Phase 3, Multicentre, Randomised, Double-blind, Efficacy and Safety Study, Comparing GSK3196165 With Placebo and With Sarilumab, in Combination With Conventional Synthetic DMARDs, in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biological DMARDs and\u002For Janus Kinase Inhibitors","contRAst 3","Key inclusion criteria:\n\n* \\>=18 years of age\n* Has had RA for \\>=6 months and was not diagnosed before 16 years of age\n* Has active disease, as defined by having both:\\*\n\n  * \\>=6\u002F68 tender\u002Fpainful joints (tender joint count \\[TJC\\]), and\n  * \\>=6\u002F66 swollen joints (swollen joint count \\[SJC\\])\n* Has had an inadequate response despite currently taking at least one and at the most two concomitant csDMARDs for at least 12 weeks, from the following:\n\n  * Methotrexate (MTX)\n  * Hydroxychloroquine or chloroquine\n  * Sulfasalazine\n  * Leflunomide\n  * Bucillamine\n  * Iguratimod\n  * Tacrolimus\n* Has had inadequate response to at least one bDMARD at an approved dose and\u002For at least one JAK inhibitors at an approved dose. In both cases this may be with or without combination with a csDMARD.\n\n  * If surgical treatment of a joint has been performed, that joint cannot be counted in the TJC or SJC.\n\nKey exclusion criteria:\n\n* Has had any active and\u002For recurrent infections (excluding recurrent fungal infections of the nail bed) or has required management of acute or chronic infections.\n* Has received prior treatment with an antagonist of GM-CSF or its receptor.\n* Has known infection with human immunodeficiency virus (HIV) or current acute or chronic hepatitis B and\u002For hepatitis C.",false,"ALL","18 Years",{"count":1073,"type":1074},550,"ACTUAL","INTERVENTIONAL",[1077],"PHASE3","This study (contRAst 3 \\[202018: NCT04134728\\]) is a Phase 3, randomized, multicenter, double-blind study to assess the safety and efficacy of GSK3196165 in combination with conventional (cs) DMARD\\[s\\]) or the treatment of adult participants with moderate to severe active rheumatoid arthritis (RA) who have had an inadequate response to biologic (b) DMARD\\[s\\]) and\u002For JAK inhibitors. The study will consist of a screening phase of up to 6 weeks followed by 24 week treatment phase in which participants will be randomized in ratio of 6:6:6:1:1:1 to GSK3196165 150 milligrams (mg) subcutaneously (SC) weekly,GSK3196165 90 mg SC weekly, sarilumab 200 mg SC every other week or placebo (three arms) respectively, all in combination with background csDMARD(s). At Week 12, participants in the three placebo arms will switch from placebo to active intervention (either GSK3196165 150 mg SC weekly, GSK3196165 90 mg SC weekly, or sarilumab 200 mg SC every other week). Participants who, in investigator's judgement will benefit from extended treatment with GSK3196165, may be included in the long-term extension study (contRAst X \\[209564: NCT04333147\\]). Any participant who does not transition into study 209564 will undergo a safety follow-up visit at Week 34 (corresponding to 12 weeks after the last potential dose of sarilumab, at Week 22).",[1080],"Arthritis, Rheumatoid",[1082,1083,1084,47,1085],"bDMARD","GSK3196165","Rheumatoid Arthritis","Otilimab","COMPLETED","2023-07-11",{"date":1089,"type":1074},"2023-07-17",{"date":1091,"type":1074},"2019-10-31",{"date":1093,"type":1074},"2022-02-01",{"name":5,"class":6},131]