[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100329289":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":37,"centralContacts":36,"locations":41,"responsibleParty":741,"collaborators":743,"id":746,"slug":747,"hasResults":748,"nctId":749,"briefTitle":750,"officialTitle":751,"acronym":752,"eligibilityCriteria":753,"healthyVolunteers":754,"sex":755,"minAge":756,"maxAge":757,"enrollmentInfo":758,"targetDuration":36,"studyType":761,"phases":762,"briefSummary":764,"conditions":765,"keywords":767,"overallStatus":770,"whyStopped":771,"lastUpdateSubmitDate":772,"lastUpdatePostDateStruct":773,"startDateStruct":775,"completionDateStruct":777,"leadSponsor":779,"locationsCount":780},{"fullName":5,"class":6},"Teva Branded Pharmaceutical Products R&D, Inc.","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"TEV-50717- Part A","EXPERIMENTAL","All patients will undergo TEV-50717 dose titration in this study. Patients will receive 6 mg of TEV-50717 with food on the evening of day 1. The titration scheme and maximum dose will be determined by body weight and cytochrome P450 2D6 (CYP2D6) impairment status from the parent study.",[13],"Drug: TEV-50717",{"label":15,"type":10,"description":16,"interventionNames":17},"TEV-50717- Part B RW","TEV-50717 is administered during Part B Randomized Drug Withdrawal (RW) 2-week period.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Placebo- Part B RW","PLACEBO_COMPARATOR","Placebo is administered during Part B Randomized Drug Withdrawal (RW) 2-week period only.",[23],"Drug: Placebo",[25,32],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","TEV-50717","6, 9, and 12 mg oral tablets",[9,15],[31],"deutetrabenazine, SD-809",{"type":26,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Placebo","Placebo comparator",[19],null,[38],{"name":39,"affiliation":5,"role":40},"Teva Medical Expert, MD","STUDY_DIRECTOR",[42,55,65,75,84,93,103,112,121,130,136,145,155,165,171,180,190,200,209,219,229,238,244,253,263,273,283,293,302,311,320,330,340,350,361,367,376,385,396,408,417,428,437,448,457,468,477,488,497,506,517,526,535,541,552,561,570,579,588,599,608,619,624,633,643,649,655,666,672,681,690,701,710,716,725,732],{"facility":43,"status":36,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":36},"Teva Investigational Site 046-0104","Dothan","Alabama","36303","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-85.39049,31.22323,{"lat":53,"lon":52},{"facility":56,"status":36,"city":57,"state":58,"zip":59,"country":47,"countryCode":48,"cosmosGeoPoint":60,"geoPoint":64,"contacts":36},"Teva Investigational Site 046-0107","Rogers","Arkansas","72758",{"type":50,"coordinates":61},[62,63],-94.11854,36.33202,{"lat":63,"lon":62},{"facility":66,"status":36,"city":67,"state":68,"zip":69,"country":47,"countryCode":48,"cosmosGeoPoint":70,"geoPoint":74,"contacts":36},"Teva Investigational Site 046-0126","Anaheim","California","92805",{"type":50,"coordinates":71},[72,73],-117.9145,33.83529,{"lat":73,"lon":72},{"facility":76,"status":36,"city":77,"state":68,"zip":78,"country":47,"countryCode":48,"cosmosGeoPoint":79,"geoPoint":83,"contacts":36},"Teva Investigational Site 046-0101","Sacramento","95815",{"type":50,"coordinates":80},[81,82],-121.4944,38.58157,{"lat":82,"lon":81},{"facility":85,"status":36,"city":86,"state":68,"zip":87,"country":47,"countryCode":48,"cosmosGeoPoint":88,"geoPoint":92,"contacts":36},"Teva Investigational Site 046-0111","San Diego","92108",{"type":50,"coordinates":89},[90,91],-117.16472,32.71571,{"lat":91,"lon":90},{"facility":94,"status":36,"city":95,"state":96,"zip":97,"country":47,"countryCode":48,"cosmosGeoPoint":98,"geoPoint":102,"contacts":36},"Teva Investigational Site 060-0160","Gainesville","Florida","32608",{"type":50,"coordinates":99},[100,101],-82.32483,29.65163,{"lat":101,"lon":100},{"facility":104,"status":36,"city":105,"state":96,"zip":106,"country":47,"countryCode":48,"cosmosGeoPoint":107,"geoPoint":111,"contacts":36},"Teva Investigational Site 060-0166","Gulf Breeze","32561-4458",{"type":50,"coordinates":108},[109,110],-87.16386,30.35714,{"lat":110,"lon":109},{"facility":113,"status":36,"city":114,"state":96,"zip":115,"country":47,"countryCode":48,"cosmosGeoPoint":116,"geoPoint":120,"contacts":36},"Teva Investigational Site 060-0161","Miami","33136-2107",{"type":50,"coordinates":117},[118,119],-80.19366,25.77427,{"lat":119,"lon":118},{"facility":122,"status":36,"city":123,"state":96,"zip":124,"country":47,"countryCode":48,"cosmosGeoPoint":125,"geoPoint":129,"contacts":36},"Teva Investigational Site 046-0115","Orlando","32803",{"type":50,"coordinates":126},[127,128],-81.37924,28.53834,{"lat":128,"lon":127},{"facility":131,"status":36,"city":123,"state":96,"zip":132,"country":47,"countryCode":48,"cosmosGeoPoint":133,"geoPoint":135,"contacts":36},"Teva Investigational Site 060-0153","32819",{"type":50,"coordinates":134},[127,128],{"lat":128,"lon":127},{"facility":137,"status":36,"city":138,"state":96,"zip":139,"country":47,"countryCode":48,"cosmosGeoPoint":140,"geoPoint":144,"contacts":36},"Teva Investigational Site 046-0114","St. Petersburg","33701",{"type":50,"coordinates":141},[142,143],-82.67927,27.77086,{"lat":143,"lon":142},{"facility":146,"status":36,"city":147,"state":148,"zip":149,"country":47,"countryCode":48,"cosmosGeoPoint":150,"geoPoint":154,"contacts":36},"Teva Investigational Site 046-0116","Atlanta","Georgia","30331",{"type":50,"coordinates":151},[152,153],-84.38798,33.749,{"lat":153,"lon":152},{"facility":156,"status":36,"city":157,"state":158,"zip":159,"country":47,"countryCode":48,"cosmosGeoPoint":160,"geoPoint":164,"contacts":36},"Teva Investigational Site 060-0155","Chicago","Illinois","60612",{"type":50,"coordinates":161},[162,163],-87.65005,41.85003,{"lat":163,"lon":162},{"facility":166,"status":36,"city":157,"state":158,"zip":167,"country":47,"countryCode":48,"cosmosGeoPoint":168,"geoPoint":170,"contacts":36},"Teva Investigational Site 060-0164","60634",{"type":50,"coordinates":169},[162,163],{"lat":163,"lon":162},{"facility":172,"status":36,"city":173,"state":158,"zip":174,"country":47,"countryCode":48,"cosmosGeoPoint":175,"geoPoint":179,"contacts":36},"Teva Investigational Site 046-0133","Naperville","60563",{"type":50,"coordinates":176},[177,178],-88.14729,41.78586,{"lat":178,"lon":177},{"facility":181,"status":36,"city":182,"state":183,"zip":184,"country":47,"countryCode":48,"cosmosGeoPoint":185,"geoPoint":189,"contacts":36},"Teva Investigational Site 046-0128","Boston","Massachusetts","02114",{"type":50,"coordinates":186},[187,188],-71.05977,42.35843,{"lat":188,"lon":187},{"facility":191,"status":36,"city":192,"state":193,"zip":194,"country":47,"countryCode":48,"cosmosGeoPoint":195,"geoPoint":199,"contacts":36},"Teva Investigational Site 060-0170","Bridgeton","Missouri","63044",{"type":50,"coordinates":196},[197,198],-90.41151,38.767,{"lat":198,"lon":197},{"facility":201,"status":36,"city":202,"state":193,"zip":203,"country":47,"countryCode":48,"cosmosGeoPoint":204,"geoPoint":208,"contacts":36},"Teva Investigational Site 046-0110","Saint Charles","63304",{"type":50,"coordinates":205},[206,207],-90.48123,38.78394,{"lat":207,"lon":206},{"facility":210,"status":36,"city":211,"state":212,"zip":213,"country":47,"countryCode":48,"cosmosGeoPoint":214,"geoPoint":218,"contacts":36},"Teva Investigational Site 046-0134","Lincoln","Nebraska","68526-9467",{"type":50,"coordinates":215},[216,217],-96.66696,40.8,{"lat":217,"lon":216},{"facility":220,"status":36,"city":221,"state":222,"zip":223,"country":47,"countryCode":48,"cosmosGeoPoint":224,"geoPoint":228,"contacts":36},"Teva Investigational Site 046-0109","Voorhees Township","New Jersey","08043",{"type":50,"coordinates":225},[226,227],-74.49062,40.4795,{"lat":227,"lon":226},{"facility":230,"status":36,"city":231,"state":231,"zip":232,"country":47,"countryCode":48,"cosmosGeoPoint":233,"geoPoint":237,"contacts":36},"Teva Investigational Site 046-0124","New York","10029",{"type":50,"coordinates":234},[235,236],-74.00597,40.71427,{"lat":236,"lon":235},{"facility":239,"status":36,"city":231,"state":231,"zip":240,"country":47,"countryCode":48,"cosmosGeoPoint":241,"geoPoint":243,"contacts":36},"Teva Investigational Site 060-0154","10036",{"type":50,"coordinates":242},[235,236],{"lat":236,"lon":235},{"facility":245,"status":36,"city":246,"state":231,"zip":247,"country":47,"countryCode":48,"cosmosGeoPoint":248,"geoPoint":252,"contacts":36},"Teva Investigational Site 046-0102","Rochester","14618",{"type":50,"coordinates":249},[250,251],-77.61556,43.15478,{"lat":251,"lon":250},{"facility":254,"status":36,"city":255,"state":256,"zip":257,"country":47,"countryCode":48,"cosmosGeoPoint":258,"geoPoint":262,"contacts":36},"Teva Investigational Site 046-0106","Oklahoma City","Oklahoma","73116",{"type":50,"coordinates":259},[260,261],-97.51643,35.46756,{"lat":261,"lon":260},{"facility":264,"status":36,"city":265,"state":266,"zip":267,"country":47,"countryCode":48,"cosmosGeoPoint":268,"geoPoint":272,"contacts":36},"Teva Investigational Site 060-0169","Charleston","South Carolina","29414-5834",{"type":50,"coordinates":269},[270,271],-79.93275,32.77632,{"lat":271,"lon":270},{"facility":274,"status":36,"city":275,"state":276,"zip":277,"country":47,"countryCode":48,"cosmosGeoPoint":278,"geoPoint":282,"contacts":36},"Teva Investigational Site 060-0156","Nashville","Tennessee","37232-2551",{"type":50,"coordinates":279},[280,281],-86.78444,36.16589,{"lat":281,"lon":280},{"facility":284,"status":36,"city":285,"state":286,"zip":287,"country":47,"countryCode":48,"cosmosGeoPoint":288,"geoPoint":292,"contacts":36},"Teva Investigational Site 046-0113","Dallas","Texas","75243",{"type":50,"coordinates":289},[290,291],-96.80667,32.78306,{"lat":291,"lon":290},{"facility":294,"status":36,"city":295,"state":286,"zip":296,"country":47,"countryCode":48,"cosmosGeoPoint":297,"geoPoint":301,"contacts":36},"Teva Investigational Site 060-0163","Fort Worth","76104",{"type":50,"coordinates":298},[299,300],-97.32085,32.72541,{"lat":300,"lon":299},{"facility":303,"status":36,"city":304,"state":286,"zip":305,"country":47,"countryCode":48,"cosmosGeoPoint":306,"geoPoint":310,"contacts":36},"Teva Investigational Site 046-0108","Houston","77030",{"type":50,"coordinates":307},[308,309],-95.36327,29.76328,{"lat":309,"lon":308},{"facility":312,"status":36,"city":313,"state":286,"zip":314,"country":47,"countryCode":48,"cosmosGeoPoint":315,"geoPoint":319,"contacts":36},"Teva Investigational Site 046-0120","San Antonio","78249",{"type":50,"coordinates":316},[317,318],-98.49363,29.42412,{"lat":318,"lon":317},{"facility":321,"status":36,"city":322,"state":323,"zip":324,"country":47,"countryCode":48,"cosmosGeoPoint":325,"geoPoint":329,"contacts":36},"Teva Investigational Site 046-0105","Orem","Utah","84058",{"type":50,"coordinates":326},[327,328],-111.69465,40.2969,{"lat":328,"lon":327},{"facility":331,"status":36,"city":332,"state":333,"zip":334,"country":47,"countryCode":48,"cosmosGeoPoint":335,"geoPoint":339,"contacts":36},"Teva Investigational Site 046-0118","Petersburg","Virginia","23805",{"type":50,"coordinates":336},[337,338],-77.40193,37.22793,{"lat":338,"lon":337},{"facility":341,"status":36,"city":342,"state":343,"zip":344,"country":47,"countryCode":48,"cosmosGeoPoint":345,"geoPoint":349,"contacts":36},"Teva Investigational Site 060-0162","Everett","Washington","98201-4077",{"type":50,"coordinates":346},[347,348],-122.20208,47.97898,{"lat":348,"lon":347},{"facility":351,"status":36,"city":352,"state":36,"zip":353,"country":354,"countryCode":355,"cosmosGeoPoint":356,"geoPoint":360,"contacts":36},"Teva Investigational Site 060-1407","Buenos Aires","C1023AAB","Argentina","AR",{"type":50,"coordinates":357},[358,359],-58.37723,-34.61315,{"lat":359,"lon":358},{"facility":362,"status":36,"city":352,"state":36,"zip":363,"country":354,"countryCode":355,"cosmosGeoPoint":364,"geoPoint":366,"contacts":36},"Teva Investigational Site 060-1402","C1425AHQ",{"type":50,"coordinates":365},[358,359],{"lat":359,"lon":358},{"facility":368,"status":36,"city":369,"state":36,"zip":370,"country":354,"countryCode":355,"cosmosGeoPoint":371,"geoPoint":375,"contacts":36},"Teva Investigational Site 060-1403","La Plata","1900",{"type":50,"coordinates":372},[373,374],-57.95442,-34.92126,{"lat":374,"lon":373},{"facility":377,"status":36,"city":378,"state":36,"zip":379,"country":354,"countryCode":355,"cosmosGeoPoint":380,"geoPoint":384,"contacts":36},"Teva Investigational Site 060-1404","Mendoza","5500",{"type":50,"coordinates":381},[382,383],-68.84582,-32.88946,{"lat":383,"lon":382},{"facility":386,"status":36,"city":387,"state":36,"zip":388,"country":389,"countryCode":390,"cosmosGeoPoint":391,"geoPoint":395,"contacts":36},"Teva Investigational Site 060-1802","Liverpool","2170","Australia","AU",{"type":50,"coordinates":392},[393,394],150.92588,-33.91938,{"lat":394,"lon":393},{"facility":397,"status":36,"city":398,"state":399,"zip":400,"country":401,"countryCode":402,"cosmosGeoPoint":403,"geoPoint":407,"contacts":36},"Teva Investigational Site 046-0201","Ajax","Ontario","L1Z0M1","Canada","CA",{"type":50,"coordinates":404},[405,406],-79.03288,43.85012,{"lat":406,"lon":405},{"facility":409,"status":36,"city":410,"state":399,"zip":411,"country":401,"countryCode":402,"cosmosGeoPoint":412,"geoPoint":416,"contacts":36},"Teva Investigational Site 046-0202","Ottawa","K2G 1W2",{"type":50,"coordinates":413},[414,415],-75.69812,45.41117,{"lat":415,"lon":414},{"facility":418,"status":36,"city":419,"state":36,"zip":420,"country":421,"countryCode":422,"cosmosGeoPoint":423,"geoPoint":427,"contacts":36},"Teva Investigational Site 060-1503","Bello","051050","Colombia","CO",{"type":50,"coordinates":424},[425,426],-75.55795,6.33732,{"lat":426,"lon":425},{"facility":429,"status":36,"city":430,"state":36,"zip":431,"country":421,"countryCode":422,"cosmosGeoPoint":432,"geoPoint":436,"contacts":36},"Teva Investigational Site 060-1504","Pereira","660003",{"type":50,"coordinates":433},[434,435],-75.69488,4.81428,{"lat":435,"lon":434},{"facility":438,"status":36,"city":439,"state":36,"zip":440,"country":441,"countryCode":442,"cosmosGeoPoint":443,"geoPoint":447,"contacts":36},"Teva Investigational Site 046-0302","Herlev","2730","Denmark","DK",{"type":50,"coordinates":444},[445,446],12.43998,55.72366,{"lat":446,"lon":445},{"facility":449,"status":36,"city":450,"state":36,"zip":451,"country":441,"countryCode":442,"cosmosGeoPoint":452,"geoPoint":456,"contacts":36},"Teva Investigational Site 046-0301","Odense","5000",{"type":50,"coordinates":453},[454,455],10.38831,55.39594,{"lat":455,"lon":454},{"facility":458,"status":36,"city":459,"state":36,"zip":460,"country":461,"countryCode":462,"cosmosGeoPoint":463,"geoPoint":467,"contacts":36},"Teva Investigational Site 060-0901","Budapest","1021","Hungary","HU",{"type":50,"coordinates":464},[465,466],19.04045,47.49835,{"lat":466,"lon":465},{"facility":469,"status":36,"city":470,"state":36,"zip":471,"country":461,"countryCode":462,"cosmosGeoPoint":472,"geoPoint":476,"contacts":36},"Teva Investigational Site 060-0902","Szeged","6725",{"type":50,"coordinates":473},[474,475],20.14824,46.253,{"lat":475,"lon":474},{"facility":478,"status":36,"city":479,"state":36,"zip":480,"country":481,"countryCode":482,"cosmosGeoPoint":483,"geoPoint":487,"contacts":36},"Teva Investigational Site 060-1005","Cagliari","09121","Italy","IT",{"type":50,"coordinates":484},[485,486],9.11917,39.23054,{"lat":486,"lon":485},{"facility":489,"status":36,"city":490,"state":36,"zip":491,"country":481,"countryCode":482,"cosmosGeoPoint":492,"geoPoint":496,"contacts":36},"Teva Investigational Site 060-1001","Catania","95123",{"type":50,"coordinates":493},[494,495],15.07041,37.49223,{"lat":495,"lon":494},{"facility":498,"status":36,"city":499,"state":36,"zip":500,"country":481,"countryCode":482,"cosmosGeoPoint":501,"geoPoint":505,"contacts":36},"Teva Investigational Site 060-1003","Naples","80131",{"type":50,"coordinates":502},[503,504],14.26811,40.85216,{"lat":504,"lon":503},{"facility":507,"status":36,"city":508,"state":36,"zip":509,"country":510,"countryCode":511,"cosmosGeoPoint":512,"geoPoint":516,"contacts":36},"Teva Investigational Site 060-1601","Culiacán","80020","Mexico","MX",{"type":50,"coordinates":513},[514,515],-107.39421,24.80209,{"lat":515,"lon":514},{"facility":518,"status":36,"city":519,"state":36,"zip":520,"country":510,"countryCode":511,"cosmosGeoPoint":521,"geoPoint":525,"contacts":36},"Teva Investigational Site 060-1603","León","37000",{"type":50,"coordinates":522},[523,524],-103.47698,25.60187,{"lat":524,"lon":523},{"facility":527,"status":36,"city":528,"state":36,"zip":529,"country":510,"countryCode":511,"cosmosGeoPoint":530,"geoPoint":534,"contacts":36},"Teva Investigational Site 060-1602","Monterrey","64460",{"type":50,"coordinates":531},[532,533],-100.31721,25.68435,{"lat":533,"lon":532},{"facility":536,"status":36,"city":528,"state":36,"zip":537,"country":510,"countryCode":511,"cosmosGeoPoint":538,"geoPoint":540,"contacts":36},"Teva Investigational Site 060-1604","64610",{"type":50,"coordinates":539},[532,533],{"lat":533,"lon":532},{"facility":542,"status":36,"city":543,"state":36,"zip":544,"country":545,"countryCode":546,"cosmosGeoPoint":547,"geoPoint":551,"contacts":36},"Teva Investigational Site 060-1104","Gdansk","80-542","Poland","PL",{"type":50,"coordinates":548},[549,550],18.64912,54.35227,{"lat":550,"lon":549},{"facility":553,"status":36,"city":554,"state":36,"zip":555,"country":545,"countryCode":546,"cosmosGeoPoint":556,"geoPoint":560,"contacts":36},"Teva Investigational Site 060-1101","Katowice","40-123",{"type":50,"coordinates":557},[558,559],19.02173,50.2597,{"lat":559,"lon":558},{"facility":562,"status":36,"city":563,"state":36,"zip":564,"country":545,"countryCode":546,"cosmosGeoPoint":565,"geoPoint":569,"contacts":36},"Teva Investigational Site 060-1105","Krakow","31503",{"type":50,"coordinates":566},[567,568],19.93658,50.06143,{"lat":568,"lon":567},{"facility":571,"status":36,"city":572,"state":36,"zip":573,"country":545,"countryCode":546,"cosmosGeoPoint":574,"geoPoint":578,"contacts":36},"Teva Investigational Site 060-1102","Poznan","60-693",{"type":50,"coordinates":575},[576,577],16.92993,52.40692,{"lat":577,"lon":576},{"facility":580,"status":36,"city":581,"state":36,"zip":582,"country":545,"countryCode":546,"cosmosGeoPoint":583,"geoPoint":587,"contacts":36},"Teva Investigational Site 060-1103","Warsaw","02-793",{"type":50,"coordinates":584},[585,586],21.01178,52.22977,{"lat":586,"lon":585},{"facility":589,"status":36,"city":590,"state":36,"zip":591,"country":592,"countryCode":593,"cosmosGeoPoint":594,"geoPoint":598,"contacts":36},"Teva Investigational Site 046-0704","Tomsk","634050","Russia","RU",{"type":50,"coordinates":595},[596,597],84.98216,56.50049,{"lat":597,"lon":596},{"facility":600,"status":36,"city":601,"state":36,"zip":602,"country":592,"countryCode":593,"cosmosGeoPoint":603,"geoPoint":607,"contacts":36},"Teva Investigational Site 046-0703","Voronezh","394024",{"type":50,"coordinates":604},[605,606],39.19204,51.66833,{"lat":606,"lon":605},{"facility":609,"status":36,"city":610,"state":36,"zip":611,"country":612,"countryCode":613,"cosmosGeoPoint":614,"geoPoint":618,"contacts":36},"Teva Investigational Site 046-1702","Belgrade","11000","Serbia","RS",{"type":50,"coordinates":615},[616,617],20.46513,44.80401,{"lat":617,"lon":616},{"facility":620,"status":36,"city":610,"state":36,"zip":611,"country":612,"countryCode":613,"cosmosGeoPoint":621,"geoPoint":623,"contacts":36},"Teva Investigational Site 046-1703",{"type":50,"coordinates":622},[616,617],{"lat":617,"lon":616},{"facility":625,"status":36,"city":626,"state":36,"zip":627,"country":612,"countryCode":613,"cosmosGeoPoint":628,"geoPoint":632,"contacts":36},"Teva Investigational Site 046-1701","Novi Sad","21000",{"type":50,"coordinates":629},[630,631],19.83694,45.25167,{"lat":631,"lon":630},{"facility":634,"status":36,"city":635,"state":36,"zip":636,"country":637,"countryCode":36,"cosmosGeoPoint":638,"geoPoint":642,"contacts":36},"Teva Investigational Site 060-1901","Seoul","110-744","South Korea",{"type":50,"coordinates":639},[640,641],126.9784,37.566,{"lat":641,"lon":640},{"facility":644,"status":36,"city":635,"state":36,"zip":645,"country":637,"countryCode":36,"cosmosGeoPoint":646,"geoPoint":648,"contacts":36},"Teva Investigational Site 060-1903","138-736",{"type":50,"coordinates":647},[640,641],{"lat":641,"lon":640},{"facility":650,"status":36,"city":635,"state":36,"zip":651,"country":637,"countryCode":36,"cosmosGeoPoint":652,"geoPoint":654,"contacts":36},"Teva Investigational Site 060-1902","6351",{"type":50,"coordinates":653},[640,641],{"lat":641,"lon":640},{"facility":656,"status":36,"city":657,"state":36,"zip":658,"country":659,"countryCode":660,"cosmosGeoPoint":661,"geoPoint":665,"contacts":36},"Teva Investigational Site 046-0605","Madrid","28009","Spain","ES",{"type":50,"coordinates":662},[663,664],-3.70256,40.4165,{"lat":664,"lon":663},{"facility":667,"status":36,"city":657,"state":36,"zip":668,"country":659,"countryCode":660,"cosmosGeoPoint":669,"geoPoint":671,"contacts":36},"Teva Investigational Site 046-0602","28922",{"type":50,"coordinates":670},[663,664],{"lat":664,"lon":663},{"facility":673,"status":36,"city":674,"state":36,"zip":675,"country":659,"countryCode":660,"cosmosGeoPoint":676,"geoPoint":680,"contacts":36},"Teva Investigational Site 046-0603","Málaga","29620",{"type":50,"coordinates":677},[678,679],-4.42034,36.72016,{"lat":679,"lon":678},{"facility":682,"status":36,"city":683,"state":36,"zip":684,"country":659,"countryCode":660,"cosmosGeoPoint":685,"geoPoint":689,"contacts":36},"Teva Investigational Site 046-0601","Seville","41013",{"type":50,"coordinates":686},[687,688],-5.97317,37.38283,{"lat":688,"lon":687},{"facility":691,"status":36,"city":692,"state":36,"zip":693,"country":694,"countryCode":695,"cosmosGeoPoint":696,"geoPoint":700,"contacts":36},"Teva Investigational Site 060-2003","Dnipropetrovsk","49101","Ukraine","UA",{"type":50,"coordinates":697},[698,699],35.04066,48.46664,{"lat":699,"lon":698},{"facility":702,"status":36,"city":703,"state":36,"zip":704,"country":694,"countryCode":695,"cosmosGeoPoint":705,"geoPoint":709,"contacts":36},"Teva Investigational Site 060-2001","Kharkiv","61068",{"type":50,"coordinates":706},[707,708],36.25475,49.98177,{"lat":708,"lon":707},{"facility":711,"status":36,"city":703,"state":36,"zip":712,"country":694,"countryCode":695,"cosmosGeoPoint":713,"geoPoint":715,"contacts":36},"Teva Investigational Site 060-2002","61153",{"type":50,"coordinates":714},[707,708],{"lat":708,"lon":707},{"facility":717,"status":36,"city":718,"state":36,"zip":719,"country":694,"countryCode":695,"cosmosGeoPoint":720,"geoPoint":724,"contacts":36},"Teva Investigational Site 060-2007","Kiev","4080",{"type":50,"coordinates":721},[722,723],30.5238,50.45466,{"lat":723,"lon":722},{"facility":726,"status":36,"city":727,"state":36,"zip":728,"country":694,"countryCode":695,"cosmosGeoPoint":729,"geoPoint":731,"contacts":36},"Teva Investigational Site 060-2005","Kyiv","4209",{"type":50,"coordinates":730},[722,723],{"lat":723,"lon":722},{"facility":733,"status":36,"city":734,"state":36,"zip":735,"country":694,"countryCode":695,"cosmosGeoPoint":736,"geoPoint":740,"contacts":36},"Teva Investigational Site 060-2006","Vinnytsia","21005",{"type":50,"coordinates":737},[738,739],28.46871,49.2322,{"lat":739,"lon":738},{"type":742,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR",[744],{"name":745,"class":6},"Nuvelution TS Pharma, Inc.","100329289","phase-3-evaluation-of-safety-and-tolerability-of-long-term-tev-50717-deutetrabenazine-for-treatment-of-tourette-syndrome-in-children-and-adolescents-100329289",true,"NCT03567291","Evaluation of Safety and Tolerability of Long-term TEV-50717 (Deutetrabenazine) for Treatment of Tourette Syndrome in Children and Adolescents","An Open-Label, Long-Term Safety Study Including a Double-Blind, Placebo-Controlled, Randomized Withdrawal Period of TEV-50717 (Deutetrabenazine) for the Treatment of Tourette Syndrome in Children and Adolescents","ARTISTS","Inclusion Criteria:\n\n* Patient is younger than 18 years of age on day 1\n* Patient weighs at least 44 pounds (20 kg)\n* The patient's active tics are causing distress or impairment\n* Patient is able to swallow study medication whole\n* Patient is in good general health\n* Women\u002Fgirls of childbearing potential whose male partners are of childbearing potential must use contraception for the duration of the study -- Additional criteria apply, please contact the investigator for more information\n\nExclusion Criteria:\n\n* Patient is 18 years of age or older.\n* Patient has a neurologic disorder other than TS that could obscure the evaluation of tics.\n* The patient's predominant movement disorder is stereotypy (coordinated movements that repeat continually and identically) associated with autism spectrum disorder.\n* Patient has a confirmed diagnosis of bipolar disorder, schizophrenia, or another psychotic disorder.\n* Patient has clinically significant depression at screening or day 1. Note: Patients receiving antidepressant therapy may be enrolled if on a stable dose for at least 6 weeks before screening.\n* Patient has a history of suicidal intent or related behaviors within 2 years of screening\n* Patient has a history of a previous actual, interrupted, or aborted suicide attempt.\n* Patient has a first-degree relative who has completed suicide.\n* Patient has clinically significant obsessive-compulsive disorder (OCD) on day 1 that, in the opinion of the investigator, is the primary cause of impairment.\n* Patient has received comprehensive behavioral intervention for tics for TS or cognitive behavioral therapy for OCD within 4 weeks of screening.\n* Patient has received treatment with deep brain stimulation, transmagnetic stimulation, or transcranial direct current stimulation for reduction of tics within 4 weeks of the screening visit.\n* Patient has an unstable or serious medical illness at screening or day 1\n* Patients with a history of torsade de pointes, congenital long QT syndrome, bradyarrhythmias, or uncompensated heart failure.\n* Patient has received a monoamine oxidase inhibitor within 14 days of the day 1 visit.\n* Patient has participated in an investigational drug or device study (with the exception of Study SD-809-C-17, Study TV50717-CNS-30046, or Study TV50717-CNS-30060) and received IMP\u002Fintervention within 30 days or 5 drug half-lives of day 1, whichever is longer.\n* The patient is a pregnant or lactating female, or plans to become pregnant during the study.\n* Patient has a history of, or acknowledges, alcohol-related disorder in the previous 12 months -- Additional criteria apply, please contact the investigator for more information",false,"ALL","6 Years","17 Years",{"count":759,"type":760},228,"ACTUAL","INTERVENTIONAL",[763],"PHASE3","This is an otherwise open-label, single-arm study that includes a 2-week, double-blind, placebo controlled, randomized drug withdrawal period followed by a 3 week blinded maintenance or re-titration, and then a maintenance period. This study aims to evaluate the safety and efficacy of TEV-50717 tablets in patients with tics associated with TS who have previously completed participation in any of the parent studies.",[766],"Tourette Syndrome",[768,769],"adolescents","children","TERMINATED","The parent trials did not meet the primary endpoints of reduction in motor and phonic tics.","2021-11-05",{"date":774,"type":760},"2021-11-09",{"date":776,"type":760},"2018-05-25",{"date":778,"type":760},"2020-05-15",{"name":5,"class":6},76]