[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100230777":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":26,"locations":36,"responsibleParty":760,"collaborators":762,"id":767,"slug":768,"hasResults":769,"nctId":770,"briefTitle":771,"officialTitle":772,"acronym":773,"eligibilityCriteria":774,"healthyVolunteers":775,"sex":776,"minAge":777,"maxAge":778,"enrollmentInfo":779,"targetDuration":26,"studyType":782,"phases":783,"briefSummary":785,"conditions":786,"keywords":788,"overallStatus":790,"whyStopped":26,"lastUpdateSubmitDate":791,"lastUpdatePostDateStruct":792,"startDateStruct":794,"completionDateStruct":796,"leadSponsor":798,"locationsCount":799},{"fullName":5,"class":6},"AstraZeneca","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"1\u002FOLAPARIB","EXPERIMENTAL","olaparib 300mg oral tablets; twice daily",[13],"Drug: OLAPARIB",{"label":15,"type":16,"description":17,"interventionNames":18},"2\u002FCHEMOTHERAPY","ACTIVE_COMPARATOR","Physician's choice single agent chemotherapy",[19],"Drug: Single agent chemotherapy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","OLAPARIB","300 mg olaparib tablets taken orally twice daily. All patients should continue to receive study treatment until objective radiological disease progression as per RECIST 1.1 as assessed by the investigator or the patient experiences unacceptable toxicity or they meet any other discontinuation criteria.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Single agent chemotherapy","Treatment of relapsed disease with single agent chemotherapy based on physician's choice of weekly paclitaxel, topotecan, pegylated liposomal doxorubicin, or gemcitabine. All patients should continue to receive study treatment until objective radiological disease progression as per RECIST 1.1 as assessed by the investigator or the patient experiences unacceptable toxicity or they meet any other discontinuation criteria",[15],[32],{"name":33,"affiliation":34,"role":35},"Richard T Penson, Associate Prof. of Medicine","Harvard Medical School (HMS and HSDM)","PRINCIPAL_INVESTIGATOR",[37,50,58,67,75,84,92,101,110,119,128,137,146,154,163,172,181,190,199,207,216,224,233,243,246,249,257,265,273,283,291,301,309,317,322,330,338,346,351,362,367,376,385,388,396,404,414,419,424,432,440,448,458,466,474,482,487,495,503,511,519,526,534,544,552,560,565,570,578,586,591,601,606,614,624,627,635,643,651,659,667,676,684,689,694,699,704,714,719,724,731,739,747,755],{"facility":38,"status":26,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":26},"Research Site","Birmingham","Alabama","35233","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-86.80249,33.52066,{"lat":48,"lon":47},{"facility":38,"status":26,"city":51,"state":40,"zip":52,"country":42,"countryCode":43,"cosmosGeoPoint":53,"geoPoint":57,"contacts":26},"Mobile","36604",{"type":45,"coordinates":54},[55,56],-88.04305,30.69436,{"lat":56,"lon":55},{"facility":38,"status":26,"city":59,"state":60,"zip":61,"country":42,"countryCode":43,"cosmosGeoPoint":62,"geoPoint":66,"contacts":26},"Sacramento","California","95817",{"type":45,"coordinates":63},[64,65],-121.4944,38.58157,{"lat":65,"lon":64},{"facility":38,"status":26,"city":68,"state":60,"zip":69,"country":42,"countryCode":43,"cosmosGeoPoint":70,"geoPoint":74,"contacts":26},"San Francisco","94118",{"type":45,"coordinates":71},[72,73],-122.41942,37.77493,{"lat":73,"lon":72},{"facility":38,"status":26,"city":76,"state":77,"zip":78,"country":42,"countryCode":43,"cosmosGeoPoint":79,"geoPoint":83,"contacts":26},"Aurora","Colorado","80045",{"type":45,"coordinates":80},[81,82],-104.83192,39.72943,{"lat":82,"lon":81},{"facility":38,"status":26,"city":85,"state":77,"zip":86,"country":42,"countryCode":43,"cosmosGeoPoint":87,"geoPoint":91,"contacts":26},"Littleton","80120",{"type":45,"coordinates":88},[89,90],-105.01665,39.61332,{"lat":90,"lon":89},{"facility":38,"status":26,"city":93,"state":94,"zip":95,"country":42,"countryCode":43,"cosmosGeoPoint":96,"geoPoint":100,"contacts":26},"Hartford","Connecticut","06106",{"type":45,"coordinates":97},[98,99],-72.68509,41.76371,{"lat":99,"lon":98},{"facility":38,"status":26,"city":102,"state":103,"zip":104,"country":42,"countryCode":43,"cosmosGeoPoint":105,"geoPoint":109,"contacts":26},"Fort Gordon","Georgia","30905",{"type":45,"coordinates":106},[107,108],-82.16206,33.42097,{"lat":108,"lon":107},{"facility":38,"status":26,"city":111,"state":112,"zip":113,"country":42,"countryCode":43,"cosmosGeoPoint":114,"geoPoint":118,"contacts":26},"Covington","Louisiana","70433",{"type":45,"coordinates":115},[116,117],-90.10042,30.47549,{"lat":117,"lon":116},{"facility":38,"status":26,"city":120,"state":121,"zip":122,"country":42,"countryCode":43,"cosmosGeoPoint":123,"geoPoint":127,"contacts":26},"Towson","Maryland","21204",{"type":45,"coordinates":124},[125,126],-76.60191,39.4015,{"lat":126,"lon":125},{"facility":38,"status":26,"city":129,"state":130,"zip":131,"country":42,"countryCode":43,"cosmosGeoPoint":132,"geoPoint":136,"contacts":26},"Detroit","Michigan","48201",{"type":45,"coordinates":133},[134,135],-83.04575,42.33143,{"lat":135,"lon":134},{"facility":38,"status":26,"city":138,"state":139,"zip":140,"country":42,"countryCode":43,"cosmosGeoPoint":141,"geoPoint":145,"contacts":26},"Albany","New York","12208",{"type":45,"coordinates":142},[143,144],-73.75623,42.65258,{"lat":144,"lon":143},{"facility":38,"status":26,"city":147,"state":139,"zip":148,"country":42,"countryCode":43,"cosmosGeoPoint":149,"geoPoint":153,"contacts":26},"Mineola","11501",{"type":45,"coordinates":150},[151,152],-73.64068,40.74927,{"lat":152,"lon":151},{"facility":38,"status":26,"city":155,"state":156,"zip":157,"country":42,"countryCode":43,"cosmosGeoPoint":158,"geoPoint":162,"contacts":26},"Chapel Hill","North Carolina","27599",{"type":45,"coordinates":159},[160,161],-79.05584,35.9132,{"lat":161,"lon":160},{"facility":38,"status":26,"city":164,"state":165,"zip":166,"country":42,"countryCode":43,"cosmosGeoPoint":167,"geoPoint":171,"contacts":26},"Columbus","Ohio","43210",{"type":45,"coordinates":168},[169,170],-82.99879,39.96118,{"lat":170,"lon":169},{"facility":38,"status":26,"city":173,"state":174,"zip":175,"country":42,"countryCode":43,"cosmosGeoPoint":176,"geoPoint":180,"contacts":26},"Springfield","Oregon","97477",{"type":45,"coordinates":177},[178,179],-123.02203,44.04624,{"lat":179,"lon":178},{"facility":38,"status":26,"city":182,"state":183,"zip":184,"country":42,"countryCode":43,"cosmosGeoPoint":185,"geoPoint":189,"contacts":26},"Abington","Pennsylvania","19001",{"type":45,"coordinates":186},[187,188],-75.11795,40.12067,{"lat":188,"lon":187},{"facility":38,"status":26,"city":191,"state":192,"zip":193,"country":42,"countryCode":43,"cosmosGeoPoint":194,"geoPoint":198,"contacts":26},"Knoxville","Tennessee","37920",{"type":45,"coordinates":195},[196,197],-83.92074,35.96064,{"lat":197,"lon":196},{"facility":38,"status":26,"city":200,"state":192,"zip":201,"country":42,"countryCode":43,"cosmosGeoPoint":202,"geoPoint":206,"contacts":26},"Nashville","37232",{"type":45,"coordinates":203},[204,205],-86.78444,36.16589,{"lat":205,"lon":204},{"facility":38,"status":26,"city":208,"state":209,"zip":210,"country":42,"countryCode":43,"cosmosGeoPoint":211,"geoPoint":215,"contacts":26},"Bedford","Texas","76022",{"type":45,"coordinates":212},[213,214],-97.14307,32.84402,{"lat":214,"lon":213},{"facility":38,"status":26,"city":217,"state":209,"zip":218,"country":42,"countryCode":43,"cosmosGeoPoint":219,"geoPoint":223,"contacts":26},"Houston","77030",{"type":45,"coordinates":220},[221,222],-95.36327,29.76328,{"lat":222,"lon":221},{"facility":38,"status":26,"city":225,"state":226,"zip":227,"country":42,"countryCode":43,"cosmosGeoPoint":228,"geoPoint":232,"contacts":26},"Milwaukee","Wisconsin","53226",{"type":45,"coordinates":229},[230,231],-87.90647,43.0389,{"lat":231,"lon":230},{"facility":38,"status":26,"city":234,"state":26,"zip":235,"country":236,"countryCode":237,"cosmosGeoPoint":238,"geoPoint":242,"contacts":26},"Berazategui","B1884BBF","Argentina","AR",{"type":45,"coordinates":239},[240,241],-58.21278,-34.76531,{"lat":241,"lon":240},{"facility":38,"status":26,"city":244,"state":26,"zip":245,"country":236,"countryCode":237,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"CABA","C1280AEB",{"facility":38,"status":26,"city":247,"state":26,"zip":248,"country":236,"countryCode":237,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"Ciudad de Buenos Aires","C1180AAX",{"facility":38,"status":26,"city":250,"state":26,"zip":251,"country":236,"countryCode":237,"cosmosGeoPoint":252,"geoPoint":256,"contacts":26},"Córdoba","5000",{"type":45,"coordinates":253},[254,255],-64.18853,-31.40648,{"lat":255,"lon":254},{"facility":38,"status":26,"city":258,"state":26,"zip":259,"country":236,"countryCode":237,"cosmosGeoPoint":260,"geoPoint":264,"contacts":26},"La Plata","B1897GPD",{"type":45,"coordinates":261},[262,263],-57.95442,-34.92126,{"lat":263,"lon":262},{"facility":38,"status":26,"city":266,"state":26,"zip":267,"country":236,"countryCode":237,"cosmosGeoPoint":268,"geoPoint":272,"contacts":26},"San Miguel de Tucumán","T4000IAK",{"type":45,"coordinates":269},[270,271],-65.21051,-26.81601,{"lat":271,"lon":270},{"facility":38,"status":26,"city":274,"state":26,"zip":275,"country":276,"countryCode":277,"cosmosGeoPoint":278,"geoPoint":282,"contacts":26},"Ghent","9000","Belgium","BE",{"type":45,"coordinates":279},[280,281],3.71667,51.05,{"lat":281,"lon":280},{"facility":38,"status":26,"city":284,"state":26,"zip":285,"country":276,"countryCode":277,"cosmosGeoPoint":286,"geoPoint":290,"contacts":26},"Leuven","3000",{"type":45,"coordinates":287},[288,289],4.70093,50.87959,{"lat":289,"lon":288},{"facility":38,"status":26,"city":292,"state":26,"zip":293,"country":294,"countryCode":295,"cosmosGeoPoint":296,"geoPoint":300,"contacts":26},"Ijuí","98700-000","Brazil","BR",{"type":45,"coordinates":297},[298,299],-53.91472,-28.38778,{"lat":299,"lon":298},{"facility":38,"status":26,"city":302,"state":26,"zip":303,"country":294,"countryCode":295,"cosmosGeoPoint":304,"geoPoint":308,"contacts":26},"Passo Fundo","99010 260",{"type":45,"coordinates":305},[306,307],-52.40667,-28.26278,{"lat":307,"lon":306},{"facility":38,"status":26,"city":310,"state":26,"zip":311,"country":294,"countryCode":295,"cosmosGeoPoint":312,"geoPoint":316,"contacts":26},"Porto Alegre","90035-003",{"type":45,"coordinates":313},[314,315],-51.23019,-30.03283,{"lat":315,"lon":314},{"facility":38,"status":26,"city":310,"state":26,"zip":318,"country":294,"countryCode":295,"cosmosGeoPoint":319,"geoPoint":321,"contacts":26},"90610-000",{"type":45,"coordinates":320},[314,315],{"lat":315,"lon":314},{"facility":38,"status":26,"city":323,"state":26,"zip":324,"country":294,"countryCode":295,"cosmosGeoPoint":325,"geoPoint":329,"contacts":26},"Rio de Janeiro","22793-080",{"type":45,"coordinates":326},[327,328],-43.18223,-22.90642,{"lat":328,"lon":327},{"facility":38,"status":26,"city":331,"state":26,"zip":332,"country":294,"countryCode":295,"cosmosGeoPoint":333,"geoPoint":337,"contacts":26},"São José do Rio Preto","15090-000",{"type":45,"coordinates":334},[335,336],-49.37944,-20.81972,{"lat":336,"lon":335},{"facility":38,"status":26,"city":339,"state":26,"zip":340,"country":294,"countryCode":295,"cosmosGeoPoint":341,"geoPoint":345,"contacts":26},"São Paulo","01246-000",{"type":45,"coordinates":342},[343,344],-46.63611,-23.5475,{"lat":344,"lon":343},{"facility":38,"status":26,"city":339,"state":26,"zip":347,"country":294,"countryCode":295,"cosmosGeoPoint":348,"geoPoint":350,"contacts":26},"01317-000",{"type":45,"coordinates":349},[343,344],{"lat":344,"lon":343},{"facility":38,"status":26,"city":352,"state":353,"zip":354,"country":355,"countryCode":356,"cosmosGeoPoint":357,"geoPoint":361,"contacts":26},"Toronto","Ontario","M4N 3M5","Canada","CA",{"type":45,"coordinates":358},[359,360],-79.39864,43.70643,{"lat":360,"lon":359},{"facility":38,"status":26,"city":352,"state":353,"zip":363,"country":355,"countryCode":356,"cosmosGeoPoint":364,"geoPoint":366,"contacts":26},"M5G 1X6",{"type":45,"coordinates":365},[359,360],{"lat":360,"lon":359},{"facility":38,"status":26,"city":368,"state":369,"zip":370,"country":355,"countryCode":356,"cosmosGeoPoint":371,"geoPoint":375,"contacts":26},"Montreal","Quebec","H2L 4M1",{"type":45,"coordinates":372},[373,374],-73.58781,45.50884,{"lat":374,"lon":373},{"facility":38,"status":26,"city":377,"state":26,"zip":378,"country":379,"countryCode":26,"cosmosGeoPoint":380,"geoPoint":384,"contacts":26},"Hradec Králové","500 05","Czechia",{"type":45,"coordinates":381},[382,383],15.83277,50.20923,{"lat":383,"lon":382},{"facility":38,"status":26,"city":386,"state":26,"zip":387,"country":379,"countryCode":26,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"Ostrava-Poruba","708 52",{"facility":38,"status":26,"city":389,"state":26,"zip":390,"country":379,"countryCode":26,"cosmosGeoPoint":391,"geoPoint":395,"contacts":26},"Prague","128 08",{"type":45,"coordinates":392},[393,394],14.42076,50.08804,{"lat":394,"lon":393},{"facility":38,"status":26,"city":397,"state":26,"zip":398,"country":379,"countryCode":26,"cosmosGeoPoint":399,"geoPoint":403,"contacts":26},"Zlín","762 75",{"type":45,"coordinates":400},[401,402],17.67065,49.22645,{"lat":402,"lon":401},{"facility":38,"status":26,"city":405,"state":26,"zip":406,"country":407,"countryCode":408,"cosmosGeoPoint":409,"geoPoint":413,"contacts":26},"Budapest","1088","Hungary","HU",{"type":45,"coordinates":410},[411,412],19.04045,47.49835,{"lat":412,"lon":411},{"facility":38,"status":26,"city":405,"state":26,"zip":415,"country":407,"countryCode":408,"cosmosGeoPoint":416,"geoPoint":418,"contacts":26},"1115",{"type":45,"coordinates":417},[411,412],{"lat":412,"lon":411},{"facility":38,"status":26,"city":405,"state":26,"zip":420,"country":407,"countryCode":408,"cosmosGeoPoint":421,"geoPoint":423,"contacts":26},"1122",{"type":45,"coordinates":422},[411,412],{"lat":412,"lon":411},{"facility":38,"status":26,"city":425,"state":26,"zip":426,"country":407,"countryCode":408,"cosmosGeoPoint":427,"geoPoint":431,"contacts":26},"Debrecen","4032",{"type":45,"coordinates":428},[429,430],21.62444,47.53167,{"lat":430,"lon":429},{"facility":38,"status":26,"city":433,"state":26,"zip":434,"country":407,"countryCode":408,"cosmosGeoPoint":435,"geoPoint":439,"contacts":26},"Győr","9024",{"type":45,"coordinates":436},[437,438],17.63512,47.68333,{"lat":438,"lon":437},{"facility":38,"status":26,"city":441,"state":26,"zip":442,"country":407,"countryCode":408,"cosmosGeoPoint":443,"geoPoint":447,"contacts":26},"Miskolc","3526",{"type":45,"coordinates":444},[445,446],20.77806,48.10327,{"lat":446,"lon":445},{"facility":38,"status":26,"city":449,"state":26,"zip":450,"country":451,"countryCode":452,"cosmosGeoPoint":453,"geoPoint":457,"contacts":26},"Afula","18101","Israel","IL",{"type":45,"coordinates":454},[455,456],35.2892,32.60907,{"lat":456,"lon":455},{"facility":38,"status":26,"city":459,"state":26,"zip":460,"country":451,"countryCode":452,"cosmosGeoPoint":461,"geoPoint":465,"contacts":26},"Haifa","31096",{"type":45,"coordinates":462},[463,464],34.99928,32.81303,{"lat":464,"lon":463},{"facility":38,"status":26,"city":467,"state":26,"zip":468,"country":451,"countryCode":452,"cosmosGeoPoint":469,"geoPoint":473,"contacts":26},"Holon","58100",{"type":45,"coordinates":470},[471,472],34.77918,32.01034,{"lat":472,"lon":471},{"facility":38,"status":26,"city":475,"state":26,"zip":476,"country":451,"countryCode":452,"cosmosGeoPoint":477,"geoPoint":481,"contacts":26},"Jerusalem","9103102",{"type":45,"coordinates":478},[479,480],35.21633,31.76904,{"lat":480,"lon":479},{"facility":38,"status":26,"city":475,"state":26,"zip":483,"country":451,"countryCode":452,"cosmosGeoPoint":484,"geoPoint":486,"contacts":26},"91120",{"type":45,"coordinates":485},[479,480],{"lat":480,"lon":479},{"facility":38,"status":26,"city":488,"state":26,"zip":489,"country":451,"countryCode":452,"cosmosGeoPoint":490,"geoPoint":494,"contacts":26},"Petah Tikva","4941492",{"type":45,"coordinates":491},[492,493],34.88747,32.08707,{"lat":493,"lon":492},{"facility":38,"status":26,"city":496,"state":26,"zip":497,"country":451,"countryCode":452,"cosmosGeoPoint":498,"geoPoint":502,"contacts":26},"Ramat Gan","52621",{"type":45,"coordinates":499},[500,501],34.81065,32.08227,{"lat":501,"lon":500},{"facility":38,"status":26,"city":504,"state":26,"zip":505,"country":451,"countryCode":452,"cosmosGeoPoint":506,"geoPoint":510,"contacts":26},"Rehovot","7661041",{"type":45,"coordinates":507},[508,509],34.81199,31.89421,{"lat":509,"lon":508},{"facility":38,"status":26,"city":512,"state":26,"zip":513,"country":451,"countryCode":452,"cosmosGeoPoint":514,"geoPoint":518,"contacts":26},"Tel Aviv","6423906",{"type":45,"coordinates":515},[516,517],34.78057,32.08088,{"lat":517,"lon":516},{"facility":38,"status":26,"city":520,"state":26,"zip":497,"country":451,"countryCode":452,"cosmosGeoPoint":521,"geoPoint":525,"contacts":26},"Tel Litwinsky",{"type":45,"coordinates":522},[523,524],34.84588,32.05096,{"lat":524,"lon":523},{"facility":38,"status":26,"city":527,"state":26,"zip":528,"country":451,"countryCode":452,"cosmosGeoPoint":529,"geoPoint":533,"contacts":26},"Ẕerifin","70300",{"type":45,"coordinates":530},[531,532],34.84852,31.95731,{"lat":532,"lon":531},{"facility":38,"status":26,"city":535,"state":26,"zip":536,"country":537,"countryCode":538,"cosmosGeoPoint":539,"geoPoint":543,"contacts":26},"Meldola","47014","Italy","IT",{"type":45,"coordinates":540},[541,542],12.0626,44.12775,{"lat":542,"lon":541},{"facility":38,"status":26,"city":545,"state":26,"zip":546,"country":537,"countryCode":538,"cosmosGeoPoint":547,"geoPoint":551,"contacts":26},"Messina","98158",{"type":45,"coordinates":548},[549,550],15.55256,38.19394,{"lat":550,"lon":549},{"facility":38,"status":26,"city":553,"state":26,"zip":554,"country":537,"countryCode":538,"cosmosGeoPoint":555,"geoPoint":559,"contacts":26},"Milan","20132",{"type":45,"coordinates":556},[557,558],12.59836,42.78235,{"lat":558,"lon":557},{"facility":38,"status":26,"city":553,"state":26,"zip":561,"country":537,"countryCode":538,"cosmosGeoPoint":562,"geoPoint":564,"contacts":26},"20133",{"type":45,"coordinates":563},[557,558],{"lat":558,"lon":557},{"facility":38,"status":26,"city":553,"state":26,"zip":566,"country":537,"countryCode":538,"cosmosGeoPoint":567,"geoPoint":569,"contacts":26},"20141",{"type":45,"coordinates":568},[557,558],{"lat":558,"lon":557},{"facility":38,"status":26,"city":571,"state":26,"zip":572,"country":537,"countryCode":538,"cosmosGeoPoint":573,"geoPoint":577,"contacts":26},"Naples","80131",{"type":45,"coordinates":574},[575,576],14.26811,40.85216,{"lat":576,"lon":575},{"facility":38,"status":26,"city":579,"state":26,"zip":580,"country":537,"countryCode":538,"cosmosGeoPoint":581,"geoPoint":585,"contacts":26},"Roma","00144",{"type":45,"coordinates":582},[583,584],11.10642,44.99364,{"lat":584,"lon":583},{"facility":38,"status":26,"city":579,"state":26,"zip":587,"country":537,"countryCode":538,"cosmosGeoPoint":588,"geoPoint":590,"contacts":26},"00168",{"type":45,"coordinates":589},[583,584],{"lat":584,"lon":583},{"facility":38,"status":26,"city":592,"state":26,"zip":593,"country":594,"countryCode":595,"cosmosGeoPoint":596,"geoPoint":600,"contacts":26},"México","07760","Mexico","MX",{"type":45,"coordinates":597},[598,599],-108.15213,31.00435,{"lat":599,"lon":598},{"facility":38,"status":26,"city":592,"state":26,"zip":602,"country":594,"countryCode":595,"cosmosGeoPoint":603,"geoPoint":605,"contacts":26},"6760",{"type":45,"coordinates":604},[598,599],{"lat":599,"lon":598},{"facility":38,"status":26,"city":607,"state":26,"zip":608,"country":594,"countryCode":595,"cosmosGeoPoint":609,"geoPoint":613,"contacts":26},"Oaxaca City","68000",{"type":45,"coordinates":610},[611,612],-96.72544,17.06025,{"lat":612,"lon":611},{"facility":38,"status":26,"city":615,"state":26,"zip":616,"country":617,"countryCode":618,"cosmosGeoPoint":619,"geoPoint":623,"contacts":26},"Gdansk","80-219","Poland","PL",{"type":45,"coordinates":620},[621,622],18.64912,54.35227,{"lat":622,"lon":621},{"facility":38,"status":26,"city":625,"state":26,"zip":626,"country":617,"countryCode":618,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"Grzepnica","72-003",{"facility":38,"status":26,"city":628,"state":26,"zip":629,"country":617,"countryCode":618,"cosmosGeoPoint":630,"geoPoint":634,"contacts":26},"Lodz","93-513",{"type":45,"coordinates":631},[632,633],19.47395,51.77058,{"lat":633,"lon":632},{"facility":38,"status":26,"city":636,"state":26,"zip":637,"country":617,"countryCode":618,"cosmosGeoPoint":638,"geoPoint":642,"contacts":26},"Lublin","20-090",{"type":45,"coordinates":639},[640,641],22.57009,51.25058,{"lat":641,"lon":640},{"facility":38,"status":26,"city":644,"state":26,"zip":645,"country":617,"countryCode":618,"cosmosGeoPoint":646,"geoPoint":650,"contacts":26},"Olsztyn","10-561",{"type":45,"coordinates":647},[648,649],20.49272,53.78376,{"lat":649,"lon":648},{"facility":38,"status":26,"city":652,"state":26,"zip":653,"country":617,"countryCode":618,"cosmosGeoPoint":654,"geoPoint":658,"contacts":26},"Poznan","60-569",{"type":45,"coordinates":655},[656,657],16.92993,52.40692,{"lat":657,"lon":656},{"facility":38,"status":26,"city":660,"state":26,"zip":661,"country":617,"countryCode":618,"cosmosGeoPoint":662,"geoPoint":666,"contacts":26},"Warsaw","02-781",{"type":45,"coordinates":663},[664,665],21.01178,52.22977,{"lat":665,"lon":664},{"facility":38,"status":26,"city":668,"state":26,"zip":669,"country":670,"countryCode":26,"cosmosGeoPoint":671,"geoPoint":675,"contacts":26},"Goyang-si","10408","South Korea",{"type":45,"coordinates":672},[673,674],126.835,37.65639,{"lat":674,"lon":673},{"facility":38,"status":26,"city":677,"state":26,"zip":678,"country":670,"countryCode":26,"cosmosGeoPoint":679,"geoPoint":683,"contacts":26},"Seoul","03080",{"type":45,"coordinates":680},[681,682],126.9784,37.566,{"lat":682,"lon":681},{"facility":38,"status":26,"city":677,"state":26,"zip":685,"country":670,"countryCode":26,"cosmosGeoPoint":686,"geoPoint":688,"contacts":26},"06273",{"type":45,"coordinates":687},[681,682],{"lat":682,"lon":681},{"facility":38,"status":26,"city":677,"state":26,"zip":690,"country":670,"countryCode":26,"cosmosGeoPoint":691,"geoPoint":693,"contacts":26},"06351",{"type":45,"coordinates":692},[681,682],{"lat":682,"lon":681},{"facility":38,"status":26,"city":677,"state":26,"zip":695,"country":670,"countryCode":26,"cosmosGeoPoint":696,"geoPoint":698,"contacts":26},"138-736",{"type":45,"coordinates":697},[681,682],{"lat":682,"lon":681},{"facility":38,"status":26,"city":677,"state":26,"zip":700,"country":670,"countryCode":26,"cosmosGeoPoint":701,"geoPoint":703,"contacts":26},"139-706",{"type":45,"coordinates":702},[681,682],{"lat":682,"lon":681},{"facility":38,"status":26,"city":705,"state":26,"zip":706,"country":707,"countryCode":708,"cosmosGeoPoint":709,"geoPoint":713,"contacts":26},"Barcelona","08035","Spain","ES",{"type":45,"coordinates":710},[711,712],2.15899,41.38879,{"lat":712,"lon":711},{"facility":38,"status":26,"city":705,"state":26,"zip":715,"country":707,"countryCode":708,"cosmosGeoPoint":716,"geoPoint":718,"contacts":26},"08036",{"type":45,"coordinates":717},[711,712],{"lat":712,"lon":711},{"facility":38,"status":26,"city":705,"state":26,"zip":720,"country":707,"countryCode":708,"cosmosGeoPoint":721,"geoPoint":723,"contacts":26},"08907",{"type":45,"coordinates":722},[711,712],{"lat":712,"lon":711},{"facility":38,"status":26,"city":250,"state":26,"zip":725,"country":707,"countryCode":708,"cosmosGeoPoint":726,"geoPoint":730,"contacts":26},"14004",{"type":45,"coordinates":727},[728,729],-4.77275,37.89155,{"lat":729,"lon":728},{"facility":38,"status":26,"city":732,"state":26,"zip":733,"country":707,"countryCode":708,"cosmosGeoPoint":734,"geoPoint":738,"contacts":26},"Girona","17007",{"type":45,"coordinates":735},[736,737],2.82493,41.98311,{"lat":737,"lon":736},{"facility":38,"status":26,"city":740,"state":26,"zip":741,"country":707,"countryCode":708,"cosmosGeoPoint":742,"geoPoint":746,"contacts":26},"Granada","18014",{"type":45,"coordinates":743},[744,745],-3.60667,37.18817,{"lat":745,"lon":744},{"facility":38,"status":26,"city":748,"state":26,"zip":749,"country":707,"countryCode":708,"cosmosGeoPoint":750,"geoPoint":754,"contacts":26},"Madrid","28040",{"type":45,"coordinates":751},[752,753],-3.70256,40.4165,{"lat":753,"lon":752},{"facility":38,"status":26,"city":748,"state":26,"zip":756,"country":707,"countryCode":708,"cosmosGeoPoint":757,"geoPoint":759,"contacts":26},"28050",{"type":45,"coordinates":758},[752,753],{"lat":753,"lon":752},{"type":761,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[763,765],{"name":764,"class":6},"Myriad Genetic Laboratories, Inc.",{"name":766,"class":6},"Merck Sharp & Dohme LLC","100230777","phase-3-olaparib-treatment-in-relapsed-germline-breast-cancer-susceptibility-gene-brca-mutated-ovarian-cancer-patients-who-have-progressed-at-least-6-months-after-last-platinum-treatment-and-have-received-at-least-2-prior-platinum-treatments-100230777",true,"NCT02282020","Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received at Least 2 Prior Platinum Treatments","A Phase III, Open Label, Randomised, Controlled, Multi-centre Study to Assess the Efficacy and Safety of Olaparib Monotherapy Versus Physician's Choice Single Agent Chemotherapy in the Treatment of Platinum Sensitive Relapsed Ovarian Cancer in Patients Carrying Germline BRCA1\u002F2 Mutations.","SOLO3","Inclusion Criteria:\n\n* Patients must be ≥ 18 years of age\n* Patients with histologically diagnosed relapsed high grade serous ovarian cancer (including primary peritoneal and\u002For fallopian tube cancer) or high grade endometrioid cancer. Patients are eligible to undergo BRCA testing even if they have not yet had recurrence or progression of disease \\>6 months (\\>\u002F=183 days) after completion of their last platinum therapy.\n* Documented germline mutation in Breast Cancer susceptibility genes: BRCA1 and\u002For BRCA2 that is predicted to be deleterious or suspected deleterious (known or predicted to be detrimental\u002Flead to loss of function)\n* At least one lesion that can be accurately assessed at baseline by CT\u002FMRI and is suitable for repeated assessment.\n* Patients must have received at least 2 prior platinum based lines of chemotherapy - Patients must be partially platinum sensitive or platinum sensitive\n* Patients must be suitable to start treatment with single agent chemotherapy based on physician's choice\n* Patients must have normal organ and bone marrow function measured within 28 days of randomisation,\n* Eastern Cooperative Oncology Group (ECOG) performance status 0-2\n* Patients must have a life expectancy ≥ 16 weeks\n* Formalin fixed, paraffin embedded tumour sample from the primary or recurrent cancer must be available for central testing.\n\nExclusion Criteria:\n\n* BRCA 1 and\u002For BRCA2 mutations that are considered to be non detrimental\n* Exposure to any investigational product within 30 days or 5 half lives (whichever is longer) prior to randomisation\n* Any previous treatment with a Polyadenosine 5'diphosphoribose polymerisation (PARP) inhibitor, including olaparib.\n* Patients who have platinum resistant or refractory disease\n* Patients receiving any systemic chemotherapy within 3 weeks prior to first dose of study treatment\n* Previous single agent exposure to the selected chemotherapy regimen for randomisation. - Prior malignancy in the last 5 years, unless curatively treated and recurrence free (few exceptions apply).",false,"FEMALE","18 Years","130 Years",{"count":780,"type":781},266,"ACTUAL","INTERVENTIONAL",[784],"PHASE3","Comparison of olaparib vs. physician's choice of single agent standard of care non-platinum based chemotherapy in patients with germline Breast Cancer susceptibility gene (gBRCA) mutated ovarian cancer who have progressed at least 6 months after the last platinum based chemotherapy. Patient should have received at least 2 prior lines of platinum based chemotherapy. The aim of the study is to assess the efficacy and safety of olaparib tablets.",[787],"Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity",[789],"BRCA, ovarian, platinum, chemotherapy,","COMPLETED","2022-07-25",{"date":793,"type":781},"2022-07-26",{"date":795,"type":781},"2015-02-06",{"date":797,"type":781},"2022-07-19",{"name":5,"class":6},94]