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Opsoclonus, in particular, may be intermittent or late in onset. A video example will be available at www.dancingeyes.org.uk. If uncertain, please contact the national coordinator for support in interpreting clinical features.\n\n  * Age 6 months or over up to less than 8 years (\\\u003C 8th birthday) The date of diagnosis of OMS\u002FDES is the date on which a doctor confirms the condition to be OMS\u002FDES. The date of symptom onset needs also to be documented.\n  * Treatment start with the standard corticosteroid treatment with dexamethasone pulses as proposed by the guidelines given in this trial protocol (see 11.10, page 71).\n  * In patients with presumed NB-neg OMS\u002FDES, neuroblastoma must be excluded according the guidelines of this trial (see chapter 4.4.1.4, page 30, and appendix 11.9, page 70)\n  * Documented informed consent for treatment and enrolment in the trial by parents \u002F legal representatives.\n\nExclusion Criteria:\n\n•Patients with opsoclonus, myoclonus or ataxia caused by other identified disease (e.g. current active CNS infection, neurometabolic disorder or demyelination).\n\nAn identified viral precursor is not an exclusion criterion.\n\n* prior or parallel use of chemotherapy (other than required for treatment of the neuroblastoma)\n* Corticoid steroid for OMS\u002FDES or other reasons lasting 14 days or more immediately before treatment start according the standard treatment proposed (treatment with corticosteroids for less than 14 days will be allowed)\n* contre-indication of use of one of the experimental study drug (cf Summary of Product Characteristics used in this study)","ALL","6 Months","8 Years",{"count":394,"type":395},102,"ACTUAL","INTERVENTIONAL",[398],"PHASE3","The OMS\u002FDES study is a multinational European Trial for Children with the Opsoclonus Myoclonus Syndrome \u002F Dancing Eye Syndrome.\n\nThis trial brought on the way by specialists of the EPNS (European Paediatric Neurology Society), the GPOH (Gesellschaft für Pädiatrische Hematologic und Oncologie) and the SIOPEN (SIOP (International Society Oncology Pediatric) Europe Neuroblastoma).\n\nThis protocol will investigate an escalating treatment schedule starting with a corticosteroid standard treatment with dexamethasone pulses (first step), which is followed, if response has been inadequate after 3 months of treatment, by the addition of CP (second step) and, if still no sufficient improvement, by the replacement of CP by Rituximab (third step). Treatment intensification is decided on the basis of standardized scoring of OMS\u002FDES severity.",[401,402],"Opsoclonus Myoclonus Syndrome","Neuroblastoma","COMPLETED","2025-01-31",{"date":406,"type":395},"2025-02-03",{"date":408,"type":395},"2013-04-18",{"date":410,"type":395},"2025-01-17",{"name":5,"class":6},36]