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Treatment of Glabellar Frown Lines","A Prospective, Open-label, Multicenter, Repeat-dose Trial to Investigate the Safety and Efficacy of NT 201, Free of Complexing Proteins, in the Treatment of Glabellar Frown Lines","Inclusion Criteria:\n\nParticipants with 'moderate' or 'severe' glabellar frown lines at maximum frown at the beginning of each treatment cycle (as assessed by the investigator according to FWS) , stable medical condition; Completion of one former study in the Merz NT 201 glabellar program\n\nExclusion Criteria:\n\nParticipants with preexisting neuromuscular diseases (e.g. myasthenia gravis, Lambert-Eaton syndrome) putting the participant at risk, History of Facial Nerve Palsy, Previous treatment with Botulinum Toxin in the glabellar area during the last 12 months, Previous treatment with biodegradable fillers or other procedures (e.g. chemical peeling, photo rejuvenation) in the glabellar area during the last 12 months, Previous insertion of permanent material in the glabellar area; Planned treatment with Botulinum toxin of any serotype in any body region during the study period, Any other planned facial aesthetic procedure in the glabellar area during the trial period; Any surgery in the glabellar area including surgical removal of the corrugator, procerus or depressor supercili muscles or a combination of these or scars in the glabellar area, Inability to substantially lessen glabellar frown lines even by physically spreading apart, Marked facial asymmetry or ptosis of eyelid and\u002For eyebrow; Any infection in the area of the injection sites.",false,"ALL","18 Years",{"count":281,"type":282},801,"ACTUAL","INTERVENTIONAL",[285],"PHASE3","The study objective was to investigate the safety and efficacy of incobotulinumtoxinA (Xeomin) during repeat dose treatment of glabellar frown lines. 801 participants with moderate to severe glabellar frown lines at maximum frown who completed participation in one of the studies in this program, i.e. MRZ 60201-0520\u002F1, MRZ 60201-0527\u002F1, MRZ 60201-0724\u002F1, or MRZ 60201-0741\u002F1 were eligible to participate in this repeat-dose study.",[288],"Glabellar Lines","COMPLETED","2021-03-08",{"date":292,"type":282},"2021-04-02",{"date":294,"type":282},"2007-06-18",{"date":296,"type":282},"2009-12-28",{"name":5,"class":6},25]